Location: Great Gable Meeting Room, Clinical Ageing Research Unit, Campus for Ageing and Vitality
Time/Date: 13th September 2012, 12:15 - 13:00
You are invited to the IAH research seminar which will take place on Thursday 13 September 2012 in the Great Gable meeting room of the Clinical Ageing Research Unit. The meeting will start at 12.15 and will be followed at approximately 13.00 by a sandwich lunch.
The presentation today will be given by Dr David Young, Senior Lecturer, Institute of Cellular Medicine and the title of his talk will be 'Epigenetics: Marks For Future Osteoarthritis Research'.
Osteoarthritis (OA) is a complex multifactorial disease which is strongly age-related. Several studies have suggested or identified epigenetic events, which include DNA methylation, histone modifications, and microRNAs, that may play a role in OA progression and the gene expression changes observed in diseased cartilage.
Collectively epigenetic modifications allow the cell to respond quickly to environmental changes and these can be inherited during cell division. However, aberrant epigenetic modifications are associated with a number of pathological conditions, including OA.
The aim of this talk is to inform about current research in epigenetics and epigenetics in OA. DNA methylation and chromatin changes in OA are currently understudied, with most work focussing on microRNAs which clearly have a role in skeletal development. Recent advancements in epigenetic research suggest that global analysis of such modifications in OA are now possible, however, with the exception of microRNAs, it will be a significant challenge to demonstrate how such modifications impact on the disease or how they could be readdressed to limit disease progression.
Published: 13th July 2012