Biology of Ageing
Intrinsic cellular and molecular mechanisms and biomarkers of the ageing process
Our work aims to develop further understanding of the essential networks of stress responses and signalling processes that govern ageing at the molecular and cellular scale, aided by a combination of experimentation and mathematical modelling.
Present research foci are:
- Telomere biology
- Mitochondrial biology
- Genomic stability
- Evolutionary Biology
Interactions between these four have great relevance for cell cycle and senescence regulation. We are looking for interventions aimed at slowing down the ageing process and at identifying better candidates for markers of biological age, which will be evaluated and tested for their predictive power in population-based, pre-clinical and clinical human studies.
Much of the research in this theme is conducted under the auspices of the BBSRC Centre for Integrated Systems Biology in Ageing and Nutrition (CISBAN), the Centre for Brain Ageing and Vitality and the Mitochondrial Research Group
Biology of Ageing Theme Leader
Professor Thomas von Zglinicki
Institute for Ageing and Health staff involved:
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Professor Zofia Chrzanowska-Lightowlers
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Professor Thomas Kirkwood CBE
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Dr Laura Maringele
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Professor John Mathers
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Professor Marion Petrie
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Dr Carole Proctor
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Dr Gabriele Saretzki
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Dr Daryl Shanley
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Professor Doug Turnbull
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Professor Tim Cowen
