Newcastle University

Publication:

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old (2013)

Author(s): Collerton J, Ashok D, Martin Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P

Abstract: Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.

• Date: 30-04-2013
• Journal: Neurobiology of Aging
• Issue: epub ahead of print
• Publisher: Elsevier Inc.
• Publication type: Article
• Bibliographic status: Published

• URL: http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001
• DOI: 10.1016/j.neurobiolaging.2013.04.001
• ISSN (electronic): 1558-1497

Keywords: Mitochondrial DNA; Aging; Frailty; Genetics

Staff

Professor Patrick Chinnery Wellcome Senior Fellow in Clinical Science, Professor of Neurogenetics and Honorary Consultant	Email: patrick.chinnery@ncl.ac.uk Telephone: +44 (0) 191 222 5101
Dr Joanna Collerton Principal Clinical Research Associate	Email: joanna.collerton@ncl.ac.uk Telephone: +44 (0) 191 248 1107
Karen Davies Senior Clinical Research Nurse Manager	Email: karen.davies@ncl.ac.uk Telephone: +44 (0) 191 248 1111
Professor Carol Jagger AXA Prof of Epidemiology of Ageing	Email: carol.jagger@ncl.ac.uk Telephone: +44 (0) 191 248 1117
Professor Thomas Kirkwood CBE Associate Dean for Ageing	Email: tom.kirkwood@ncl.ac.uk Telephone: +44 (0) 191 248 1103
Professor Thomas von Zglinicki Professor of Cellular Gerontology	Email: t.vonzglinicki@ncl.ac.uk Telephone: +44 (0) 191 248 1104
Mohammad Yadegarfar Research Assistant (Statistician)	Email: mohammad.yadegarfar@ncl.ac.uk