Newcastle University

Introduction

Position: Senior Lecturer in Old Age Psychiatry, Institute for Ageing and Health, and Honorary Consultant in Old Age Psychiatry, Northumberland, Tyne and Wear NHS Foundation Trust

Qualifications:

MCMI (Chartered Management Institute)

PhD (University of Cambridge)

MRCPsych (UK)

Diploma in Management (Gateshead College)

MMedSci (University of Skopje)

MD (University of Skopje)

Graduate Pianist (University of Skopje)

Roles and Responsibilities 

Honorary Consultant, Newcastle Older People's Liaison Psychiatry Team, Northumberland, Tyne and Wear NHS Foundation Trust

Associate Editor Age and Ageing

Member of the Editorial Board of Journal of Neuropathology and Experimental Neurology

Associate Editor European Journal of Medicinal Plants

Academic Editor ISRN Pathology

Review Editor Frontiers in Dementia 

Scientific Correspondent Vox Medici

Member Steering Group  Autism and Maturity project, National Autistic Society, London (UK)

Visiting Professor of Psychiatry, Medical School, University Cyril and Methodius, Skopje, Macedonia

My academic interests are influenced both by my clinical and laboratory based educational and research background. I am driven by the objective of improving clinical outcomes from molecular and cellular discoveries, to the benefit of the patient.  This is reflected in my areas of academic interest that include:

(a)  understanding the molecular substrates underlying age-associated cognitive impairment in elderly, and how they are related to the development of the 2 major neurodegenerative diseases, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB);

(b)  developing biomarkers with high sensitivity and specificity to detect various forms of dementia, and their implementation in routine clinical setting with an aim to monitor the progression of the disease and treatment;

(c)   relating this knowledge to further neuropathological and neuobiochemical knowledge of ageing in neurodevelopmental disorders, such as ageing and neurodegeneration in Down syndrome and autism; and

(d)  relating the laboratory based knowledge of ethiopathogenesis of dementia and ageing to (i) clinical practice (neuropharmacology of cognitive impairment and behavioral problems in neurodegenerative diseases ,delirium and depression) and (ii) teaching old age psychiatry and medicine to undergraduate and postgraduate students, trainees and professionals.

Undergraduate Teaching

TSM module

MBBS stage 3 and 4 medical students

MBBS stage 2 SSC examiner 

MBBS stage 4 SSC examiner 

CMB1006 Timed assay examiner 

CMB3000 Laboratory projects

Postgraduate Teaching 

MRCPsych Course

What Makes a Good Poster?  

Postgraduate supervision of MD and PhD students (Newcastle University and Coimbra University, Portugal)

Internal and external PhD examiner 

• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia. International Journal of Geriatric Psychiatry 2012, (epub ahead of print).
• Mukaetova-Ladinska EB, Perry E, Baron M, Povey C. Ageing in people with autistic spectrum disorder. International Journal of Geriatric Psychiatry 2011, (online before print).
• Cerejeira JMS, Nogueira VMM, Luis PHB, Vaz-Serra AS, Mukaetova-Ladinska EB. Cholinergic system and inflammation: common pathways in delirium pathophysiology. Journal of the American Geriatrics Society 2012, 60(4), 669-675.
• Atkinson P, Mukaetova-Ladinska EB. Nurse-led liaison mental health service for older adults: service development using lean thinking methodology. Journal of Psychosomatic Research 2012, 72(4), 328-331.
• Mukaetova-Ladinska EB, Abdel-All Z, Dodds S, Andrade J, AlvesdaSilva J, Kalaria RN, O'Brien JT. Platelet immunoglobulin and amyloid precursor protein (APP) as potential peripheral biomarkers for Alzheimer’s Disease. Findings from a pilot study. Age and Ageing 2012, 41(3), 408-412.
• Perry EK, Mukaetova-Ladinska EB, Baron M. Autism: What about old age?. Bruxelles: Autism Europe, 2009. Available at: http://www.autismeurope.org/campaigns/right-to-adapted-care/autism-and-ageing/autism-what-about-old-age.html.
• Mukaetova-Ladinska EB, Cosker G, Coppock M, Henderson M, AliAshgar Y, Hill A, Scully A, Robinson D, Sells K, Brotherton S, Lowthian C. Liaison Old Age Psychiatry Service in a Medical Setting:Description of the Newcastle Clinical Service. Nursing Research and Practice 2011, Article ID 587457.
• Cerejeira J, Mukaetova-Ladinska EB. A Clinical Update on Delirium: From Early Recognition to Effective Management. Nursing Research and Practice 2011, Article ID 875196.
• Mukaetova-Ladinska EB, Perry E, Baron M, Povey C. Ageing in people with autistic spectrum disorder. International Journal of Geriatric Psychiatry 2012, 27(2), 109-118.
• Mukaetova-Ladinska EB, Westwood J, Perry EK. Biochemistry of autism: changes in serotonin, reelin and oxytocin. In: Roth, I., Rezaie, P, ed. Researching the Autism Spectrum: Contemporary Perspectives. Cambridge, UK: Cambridge University Press, 2011, pp.190-215.
• Mukaetova-Ladinska EB, Schaffer W, Bronnikova TV, Westwood J, Perry EK. Cholinergic therapy for autistic spectrum disorder. In: White, C.J., Tait, J.E, ed. Cholinesterase: Production, Uses and Health Effects. New York: Nova Science Publishers Inc, 2012, pp.33-66.
• Cerejeira J, Batista P, Nogueir V, Firmino H, Vaz-Serra A, Mukaetova-Ladinska EB. Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. Age & Ageing 2011, 40(5), 621-626.
• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. Neurobiology of Aging 2012, 33(7), 1228–1236.
• Mukaetova-Ladinska EB. Parkinson’s disease: diagnostic relevance of elevated levels of soluble α-synuclein oligomers in cerebrospinal fluid. Future Neurology 2011, 6(2), 159-163.
• Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z, da Silva JA, Brayne C, Honer WG, Mann DMA. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathology and Applied Neurobiology 2011, 37(4), 366-380.
• Mukaetova-Ladinska E, da Silva J, Darley J. Antipsychotic augmentation with venlafaxine for treatment of negative symptoms in chronic schizophrenia - A case series. Macedonian Journal of Medical Sciences 2010, 3(2), 164-168.
• Mukaetova-Ladinska E, Monteith R, Perry E. Cerebrospinal fluid biomarkers for Dementia with Lewy Bodies. International Journal of Alzheimer's Disease 2010, 536538.
• Mukaetova-Ladinska EB, Westwood J, Perry EK. Cholinergic component of autism spectrum disorder. In: Blatt, G.J, ed. The Neurochemical Basis of Autism: From Molecules to Minicolumns. Boston, Massachusetts, USA: Springer, 2010, pp.129-160.
• Teodroczuk A, Mukaetova-Ladinska EB, Corbett S, Welfare M. Implementing the NICE guidance for Delirium: a role for Liaison Teams. London: BMJ Group, 2010. Available at: http://www.bmj.com/content/341/bmj.c3704?tab=responses.
• Mukaetova-Ladinska E, Korneti-Pekevska K. Macedonian biomedical science: Current standing and suggestions for improvement. Macedonian Journal of Medical Sciences 2010, 3(1), 5-8.
• Purshouse K, Mukaetova-Ladinska E. Dance therapy for Alzheimer's disease. Student BMJ 2009, 17, 112-113.
• Mukaetova-Ladinska EB, Hurt J, Honer WG, Harrington CR, Wischik CM. Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia. In: Schizophrenia Research. 2001, Elsevier BV.
• Mukaetova-Ladinska EB, Hurt J, Honer WG, Harrington CR, Wischik CM. Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics. Neuroscience Letters 2002, 317(3), 161-165.
• Pakrasi S, Mukaetova-Ladinska EB, McKeith IG, O'Brien JT. Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle. International Journal of Geriatric Psychiatry 2003, 18(10), 879-886.
• Mukaetova-Ladinska EB, Arnold H, Jaros E, Perry R, Perry E. Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals. Neuropathology and Applied Neurobiology 2004, 30(6), 615-623.
• Mukaetova-Ladinska EB, McKeith IG. Pathophysiology of synuclein aggregation in Lewy body disease. Mechanisms of Ageing and Development 2006, 127(2), 188-202.
• McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology 2005, 65(12), 1863-1872.
• Naidu A, James I, Mukatoeva-Ladinska E, Briel R. Diagnosis of Asperger Syndrome in a 66-year-old male presenting with depression. International Psychogeriatrics 2006, 18(1), 171-173.
• Mukaetova-Ladinska EB, McKeith IG. Delirium and dementia. Medicine 2004, 32(8), 44-47.
• Mukaetova-Ladinska EB, Xuereb J, Honer WG, Wischik CM. Alpha-Synuclein Inclusions in Alzheimer and Lewy Body Diseases. Journal of Neuropathology and Experimental Neurology 2000, 59(5), 408-417.
• Mukaetova-Ladinska EB, Honer WG, Brayne C, Wischik CM. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. American Journal of Pathology 2000, 157(2), 623-636.
• Mukaetova-Ladinska EB, Baron M. Ageing in people with autistic spectrum disorder: an 2012 up-date. 2012.
• Cerejeira J, Lagarto L, Mukaetova-Ladinska EB. Behavioral and Psychological Symptoms of Dementia. Frontiers in Dementia 2012. In Press.
• Mukaetova-Ladinska EB, Purshouse K, Andrade J, Krishnan M, Jagger C, Kalaria RN. Can healthy lifestyle modify risk factors for dementia? Findings from a pilot community-based survey in Chennai (India) amd Newcastle (UK). Neuroepidemiology 2012, 39(3), 163-170.
• Kalaria RN, Mukaetova-Ladinska EB. Delirium, dementia and senility. Brain 2012, 135(9), 2582-2584.
• Shepherd DJ, Mawson T, Stoker C, Jalali J, Jay R, Cosker G, Mukaetova-Ladinska EB. Depression, dementia and delirium in older adults presenting with hip fractures to orthopaedic services at a general hospital. Macedonian Journal of Medical Sciences 2012. In Press.
• Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, McNally RJ, James PW, Kalaria RN, O'Brien JT. Increase in platelet immunoglobulin in Alzheimer's disease is lowered following cholinesterase inhibitor treatment: preliminary results. Journal of Alzheimer's Disease 2012, 32(2), 431-436.
• Teodorczuk A, Mukaetova-Ladinska E, Corbett S, Welfare M. Reconceptualising models of delirium education: Findings of a Grounded Theory study. International Psychogeriatrics 2012. In Press.
• Mukaetova-Ladinska EB, Cerejeira C, Teodorczuk A. Subsyndromal delirium: Relevance to dementia. Annals of Delirium 2012, 7(March), 13-18.