Newcastle University

Projects

• Cognitive Function After Stroke (COGFAST) study
  Project Leader(s): Professor Raj N Kalaria

• Kero M, Paetau A, Polvikoski T, Tanskanen M, Sulkava R, Jansson L, Myllykangas L, Tienari PJ. Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population. Neurobiology of Aging 2013, 34(5), 1518.e1-1518.e3.
• Lax NZ, Gnanapavan S, Dowson SJ, Alston CL, He LP, Polvikoski TM, Jaros E, O'Donovan DG, Yarham JW, Turnbull DM, Dean AF, Taylor RW. Early-Onset Cataracts, Spastic Paraparesis, and Ataxia Caused by a Novel Mitochondrial tRNA(Glu) (MT-TE) Gene Mutation Causing Severe Complex I Deficiency: A Clinical, Molecular, and Neuropathologic Study. Journal of Neuropathology and Experimental Neurology 2013, 72(2), 164-175.
• Lee K, Santibanez-Koref M, Polvikoski T, Birchall D, Mendelow AD, Keavney B. Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture. Atherosclerosis 2013, 226(1), 74-81.
• Hooshmand B, Polvikoski T, Kivipelto M, Tanskanen M, Myllykangas L, Erkinjuntti T, Makela M, Oinas M, Paetau A, Scheltens P, van Straaten ECW, Sulkava R, Solomon A. Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study. Brain 2013, 136(9), 2707-2716.
• Wagner M, Chaouch A, Muller JS, Polvikoski T, Willis TA, Sarkozy A, Eagle M, Bushby K, Straub V, Lochmuller H. Presymptomatic late-onset Pompe disease identified by the dried blood spot test. Neuromuscular Disorders 2013, 23(1), 89-92.
• Davis DH, Muniz TG, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, Maclullich AM, Brayne C. Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain 2012, 135(9), 2809-2816.
• Bates T, DuPlessis D, Polvikoski T, Sloan P, McQueen A, Meikle D, Kelly C, Robinson M. Ganglioneuroblastic transformation in olfactory neuroblastoma. Head and Neck Pathology 2012, 6(1), 150-155.
• Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN. Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Poststroke and Aging-Related Dementias. Stroke 2012, 43(3), 808-814.
• Tanskanen M, Makela M, Myllykangas L, Notkola IL, Polvikoski T, Sulkava R, Kalimo H, Paetau A. Prevalence and severity of cerebral amyloid angiopathy: a population-based study on very elderly Finns (Vantaa 85+). Neuropathology and Applied Neurobiology 2012, 38(4), 329-336.
• Sarkozy A, Polvikoski T, Eagle M, Lochmuller H, Bushby K, Straub V. Progressive core myopathy with dilated cardiomyopathy, respiratory failure and severe scoliosis caused by a novel mutation in the MYH7 gene. In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Peuralinna T, Tanskanen M, Makeal M, Polvikoski T, Paetau A, Kalimo H, Sulkava R, Hardy J, Lai SL, Arepalli S, Hernandez D, Traynor BJ, Singleton A, Tienari PJ, Myllykangas L. APOE and AβPP Gene Variation in Cortical and Cerebrovascular Amyloid-β Pathology and Alzheimer’s Disease: A Population-Based Analysis. Journal of Alzheimer's Disease 2011, 26(2), 377-385.
• Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN. Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. Brain 2011, 134(12), 3716-3727.
• Wilson BT, Douglas SF, Polvikoski T. Astrocytoma in a Breast Cancer Lineage: Part of the BRCA2 Phenotype?. Journal of Clinical Oncology 2010, 28(30), E596-E598.
• Mäkitie L, Kanerva K, Polvikoski T, Paetau A, Andersson L. Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease. Brain Pathology 2010, 20(3), 571-580.
• Ahtiluoto S, Polvikoski T, Peltonen M, Solomon A, Tuomilehto J, Winblad B, Sulkava R, Kivipelto M. Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study. Neurology 2010, 75(13), 1195-1202.
• Oinas M, Paetau A, Myllykangas L, Notkola I, Kalimo H, Polvikoski T. α-Synuclein pathology in the spinal cord autonomic nuclei associates with α-synuclein pathology in the brain: a population-based Vantaa 85+ study. Acta Neuropathologica 2010, 119(6), 715-722.
• Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T. Towards defining the neuropathological substrates of vascular dementia. In: 1st Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003). 2004, Goteborg, Sweden: Journal of the Neurological Sciences: Elsevier.
• Myllykangas L, Polvikoski T, Reunanen K, Wavrant-de Vrieze F, Ellis C, Hernandez D, Sulkava R, Kontula K, Verkkoniemi A, Notkola I-L, Hardy J, Pérez-Tur J, Haltia M, Tienari PJ. ApoE ε3-Haplotype Modulates Alzheimer's Beta-Amyloid Deposition in the Brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2002, 114(3), 288-291.
• Myllykangas L, Polvikoski T, Sulkava R, Notkola I-L, Rastas S, Verkkoniemi A, Tienari PJ, Niinistö L, Hardy J, Pérez-Tur J, Kontula K, Haltia M. Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study. Annals of Medicine 2001, 33(7), 486-492.
• Polvikoski T, Sulkava R, Myllykangas L, Notkola IL, Niinisto L, Verkkoniemi A, Kainulainen K, Kontula K, Pérez-Tur J, Hardy J, Haltia M. Prevalence of Alzheimer’s disease in very elderly people: a prospective neuropathological study. Neurology 2001, 56(12), 1690-1696.