Newcastle University

Projects

• Non-invasive detection of disease processes in the brain in neurodegenerative diseases - The Sir Jules Thorn Imaging Study
  Project Leader(s): Andrew Blamire

• Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P. Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease. New England Journal of Medicine 2012, 366(10), 893-903.
• Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN. Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(3), 263-267.
• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. Neurobiology of Aging 2012, 33(7), 1228–1236.
• Watson R, O'Brien JT, Barber R, Blamire AM. Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study. International Psychogeriatrics 2012, 24(4), 532-540.
• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia. International Journal of Geriatric Psychiatry 2012, 27(12), 1267-1274.
• Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He J, O'Brien JT. Using diffusion tensor imaging to characterise patterns of white matter tract degeneration in dementia with Lewy bodies. In: The Australian and New Zealand Society for Geriatric Medicine Annual Scientific Meetin. 2012, Sydney, Australia: Wiley-Blackwell Publishing Asia.
• Watson R, O'Brien J, Blamire A, Barber R, Wood J. White matter changes in dementia with Lewy bodies: A diffusion tensor imaging study. In: International Psychogeriatrics: 15th International Congress on International Psychogeriatric Association Reinventing Aging through Innovation. 2011, The Hague, Netherlands: Cambridge University Press.
• Wiseman RM, Burton EJ, Barber R, O'Brien JT, Ford GA. Reduced whole brain volumes, increased white matter lesions but normal hippocampal volume in older hypertensive subjects. In: Journal of Hypertension: 13th European Meeting on Hypertension. 2003, Milan, Italy: Lippincott Williams & Wilkins, Ltd.
• Thomas AJ, O'Brien JT, Davis S, Ballard C, Barber R, Kalaria RN, Perry RH. Ischemic basis for deep white matter hyperintensities in major depression - A neuropathological study. Archives of General Psychiatry 2002, 59(9), 785-792.
• Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT. Pathologies and pathological mechanisms for white matter hyperintensities in depression. In: Alzheimer's Disease: Vascular Etiology and Pathology. 2002, Kyoto, Japan: New York Academy of Sciences.
• Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. NeuroImage 2002, 17(2), 618-630.
• Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT. A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: Magnetic resonance imaging volumetric study. Dementia and Geriatric Cognitive Disorders 2001, 12(3), 198-205.
• Middelkoop HAM, Van Der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT. Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI. Neurology 2001, 57(11), 2117-2120.
• Barber R, Panikkar A, McKeith IG. Dementia with Lewy bodies: diagnosis and management. International Journal of Geriatric Psychiatry 2001, 16(1), S12-S18.
• O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, Gholkar A, Crum WR, Rossor MN, Fox NC. Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia. Neurology 2001, 56(10), 1386-1388.
• Ballard C, O'Brien J, Morris CM, Barber R, Swann A, Neill D, McKeith I. The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease. International Journal of Geriatric Psychiatry 2001, 16(5), 499-503.
• Wiseman RM, Barber R, O'Brien J, Ford GA. White matter lesions on magnetic resonance imaging in older hypertensives and normotensives. In: Journal of the American Geriatrics Society. 2001, Wiley-Blackwell Publishing, Inc.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT. MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2000, 15(10), 911-916.
• Barber R, Ballard C, McKeith IG, Gholkar A, O'Brien JT. MRI volumetric study of dementia with Lewy bodies - A comparison with AD and vascular dementia. Neurology 2000, 54(6), 1304-1309.
• O'Brien JT, Paling S, Barber R, Ballard C, McKeith I. Progressive brain atrophy on serial MRI in dementia with Lewy bodies: A comparison with Alzheimer's disease and vascular dementia. Neurobiology of Aging 2000, 21(1S), S130.
• Paling S, Williams ED, LLoyd A, Barber R, Burton EJ, Gholkar A, Crum WR, Fox NC, McKeith I, Ballard C, O'Brien JT. Serial MR image registration and analysis techniques applied to studies of differential cerebral atrophy in late-onset dementia. In: International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences. 2000, Las Vegas, Nevada, USA: CSREA PRESS.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT. Apolipoprotein E epsilon 4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Archives of Neurology 1999, 56(8), 961-965.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT. Medial temporal lobe atrophy on MRI in dementia with Lewy bodies. Neurology 1999, 52(6), 1153-1158.
• Barber R. Psychopharmacology across the life span. International Journal of Geriatric Psychiatry 1999, 14(9), 792-792.
• Barber R, Scheltens F, Gholkar A, Ballard C, McKeith I, Ince P, Perry R, O'Brien J. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging. Journal of Neurology, Neurosurgery and Psychiatry 1999, 67(1), 66-72.
• O'Donovan J, Watson R, Colloby SJ, Firbank MJ, Burton EJ, Barber R, Blamire AM, O'Brien JT. Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?. International Psychogeriatrics 2013, 25(1), 111-119.
• Wood JS, Watson R, Firbank MJ, Mosimann UP, Barber R, Blamire AM, O'Brien JT. Longitudinal testing of visual perception in dementia with Lewy bodies and Alzheimer’s disease. International Journal of Geriatric Psychiatry 2013, (epub ahead of print).
• Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He JB, O'Brien JT. Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. Neurology 2012, 79(9), 906-914.
• O'Brien JT, Barber R. MRI in the diagnosis of dementia. In: O’Brien, J.T., Ames, D., Burns, A, ed. Dementia. London: Edward Arnold, 2000.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT. Medial temporal lobe atrophy on MRI in dementia with Lewy bodies: A comparison with Alzheimer's disease, vascular dementia and normal ageing. Neurology 1999, 52(6), 1153-1158.