Institute of Cellular Medicine

Staff Profile

Dr Amy Anderson

Senior Research Associate

Background

Introduction

I did my PhD at Imperial College London identifying host genetic loci responsible for the outcome of Helicobacter pylori infection. After my PhD I remained at Imperial College and worked as a Research Assistant studying seasonal changes in the suppressive capacity of Tregs in hayfever sufferers. I moved to Newcastle University in 2006 and have since worked as a Research Associate.

Research

Projects

Since coming to Newcastle I have been involved in a number of projects focusing on the development of biomarkers for the diagnosis of rheumatoid arthritis in addition to development of novel immunotherapies for rheumatoid arthritis, with a particular interest in therapeutic tolerance induction.

 

The main project I having been working on, in collaboration with Professor John Isaacs and Dr Catharien Hilkens, is the development of autologous tolerogenic dendritic cells for the treatment of rheumatoid arthritis. This project is now in phase I clinical trial (AuToDeCRA study, funded by Arthritis Research UK).

 

I have recently been involved in a project, in collaboration with Professor John Isaacs and Dr Arthur Pratt, to identify a potential transcriptional biomarker for the early diagnosis of seronegative rheumatoid arthritis. We have demonstrated that interleukin-6 and downstream STAT3 signalling are potential therapeutic targets in the early stages of clinical disease.

 

In addition I have also been involved in projects analysing T cell and B cell repopulation following alemtuzumab therapy; dissecting the mechanism of Th17 differentiation; and assessing Tregs in rheumatoid arthritis patients.

 



Teaching

Postgraduate Teaching

I co-supervise PhD and MRes students
I lecture on the 'Current Research Trends in Musculoskeletal Disease' MRes module


Publications