Newcastle University

Qualifications

MBChB, MD, MMus, FRCS (Eng), FRCS (Tr & Orth)

Research Interests

My clinical interest is in lower limb joint replacement. In particular I am interested in innovation and improvement in the performance of arthroplasty. This includes research into new implants and new techniques e.g. minimally invasive techniques and computer guided surgery. I am also interested in service delivery and outcome measurement. More recently we have been evaluating the incidence of osteoporosis in arthroplasty patients.

I am also intersted in basic science research. Initially this was concerned with biomaterials and more recently has addressed the biological aspects of materials; particularly cell adhesion and bone formation on surfaces. This has lead to and involvement in nanoscale science - particularly in the formation of novel surfaces.

From an institutional point of view, I facilitate the MRC IDBA award to the university: Medicine and Nanotechnology. This initiative aims to bring together relevant researchers and clinicians to develop nanoscience for real-world patient applications.

Esteem Indicators

Associate Editor: The Journal of Bone and Joint Surgery

Undergraduate Teaching

I am the vertical strand leader for trauma and orthopaedic surgery with input into TSM, CIDR and senior rotations. In addition I am a module lead on the Biomedical Nanotechology MSC course

Postgraduate Teaching

I am a memeber of the STC and organise the basic science term for specialist registrar training.

• McCaskie AW, Kenny DT, Deshmukh S. How can surgical training benefit from theories of skilled motor development, musical skill acquisition and performance psychology?. Medical Journal of Australia 2011, 194(9), 463-465.
• Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD, arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, SchulteMerker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD, Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA). Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Annals of the Rheumatic Diseases 2011, 70(2), 349-355.
• Roberts S, Genever P, McCaskie A, De Bari C. Prospects of stem cell therapy in osteoarthritis. Regenerative Medicine 2011, 6(3), 351-366.
• Cooke NJ, Rodgers L, Rawlings D, McCaskie AW, Holland JP. Bone density of the femoral neck following Birmingham hip resurfacing A 2-year prospective study in 27 hips. Acta Orthopaedica 2009, 80(6), 660-665.
• Cloke DJ, Khatri M, Pinder IM, McCaskie AW, Lingard EA. 284 press-fit Kinemax total knee arthroplasties followed for 10 years: poor survival of uncemented prostheses.. Acta Orthopaedica 2008, 79(1), 28-33.
• Rankin KS, Lakey RL, Gerrand CH, Sprowson AP, McCaskie AW, Birch MA. A novel in vitro model of osteoarthritis facilitates improved understanding of human articular chondrocyte behaviour. In: Calcified Tissue International: Abstracts Presented at the Bone Research Society Meeting. 2008, Manchester, UK: Springer New York LLC.
• Sprowson AP, McCaskie AW, Birch MA. ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion. Journal of Orthopaedic Research 2008, 26(9), 1256-1262.
• Rankin KS, Gerrand CH, Lakey RL, Sprowson AP, McCaskie AW, Birch MA. Hypoxia facilitates bone invasion by increasing breast cancer cell expression of matrix metalloproteinase-1. In: Calcified Tissue International: Abstracts Presented at the Bone Research Society Meeting. 2008, Manchester, UK: Springer New York LLC.
• Jameson SS, Howcroft DWJ, McCaskie AW, Gerrand CH. Injury to the lateral femoral cutaneous nerve during minimally invasive hip surgery: A cadaver study. Annals of the Royal College of Surgeons of England 2008, 90(3), 216-220.
• Johnson-Lynn SE, Francis RM, McCaskie AW. Osteoporosis treatments and their effect on fracture healing. Current Orthopaedics 2008, 22(5), 336-340.
• Loughead JM, Malhan K, Mitchell SY, Pinder IM, McCaskie AW, Deehan DJ, Lingard EA. Outcome following knee arthroplasty beyond 15 years. The Knee 2008, 15(2), 85-90.
• Deehan DJ, Bell K, McCaskie AW. Adolescent musculoskeletal injuries in a football academy. Journal of Bone and Joint Surgery: British Volume 2007, 89-B(1), 5-8.
• Malviya A, McCaskie AW. Minimally invasive hip replacement. In: Limb, D; Hay, SM, ed. Evidence for Orthopaedic Surgery. Shrewsbury, UK: TFM Publishing Ltd, 2007, pp. 223-232.
• Loughead JM, Starks I, Chesney D, Matthews JNS, McCaskie AW, Holland JP. Removal of acetabular bone in resurfacing arthroplasty of the hip - A comparison with hybrid total hip arthroplasty. Journal of Bone and Joint Surgery: British Volume 2006, 88B(1), 31-34.
• Muller SD, Deehan DJ, Holland JP, Outterside SE, Kirk LMG, Gregg PJ, McCaskie AW. Should we reconsider all-polyethylene tibial implants in total knee replacement?. Journal of Bone and Joint Surgery: British Volume 2006, 88B(12), 1596-1602.
• McCaskie AW. Chapter 6.4 Femoral Pressurisation. In:Breusch, S.J., Malchau, H., ed. TheThe Well-Cemented Total Hip Arthroplasty: Theory and Practice.Berlin; New York:Springer,2005, pp. 160-163.
• Loughead JM, Chesney D, Holland JP, McCaskie AW. Comparison of offset in Birmingham hip resurfacing and hybrid total hip arthroplasty. Journal of Bone and Joint Surgery: British Volume 2005,87B 2 163-166.
• Liu CZ, Green SM, Watkins ND, Baker D, Mccaskie AW. Dynamic creep and mechanical characteristics of SmartSet GHV bone cement. Journal of Materials Science: Materials in Medicine 2005,16 2 153-160.
• Martin D, McCaskie A. Nanomedicine. Student British Medical Journal 2005,13 90.
• Elfick APD, Green SM, McCaskie AW, Birch MA. Opsonization of polyethylene wear particles regulates macrophage and osteoblast responses in vitro. Journal of Biomedical Materials Research - Part B Applied Biomaterials 2004,71B 2 244-251.
• Jafri AA, Green SM, Partington PF, McCaskie AW, Muller SD. Pre-heating of components in cemented total hip arthroplasty. Journal of Bone and Joint Surgery - British Volume 2004,86-B 8 1214-1219.
• Elfick APD, Green SM, McCaskie A, Birch M. The agglomeration of polyethylene particles in the cell culture environment. In: 7th World Biomaterials Congress. 2004, Sydney, Australia: Australian Society for Biomaterials, Inc..
• Reed MR, Murray JRD, Abdy SE, Francis RM, McCaskie AW. The use of digital X-ray radiogrammetry and peripheral dual energy X-ray absorptiometry in patients attending fracture clinic after distal forearm fracture. Bone 2004,34 4 716-719.
• Liu C, Green SM, Watkins ND, Gregg PJ, McCaskie AW. A preliminary hip joint simulator study of the migration of a cemented femoral stem. In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2003.
• Muthukumar N, Smith RM, McCaskie AW, Batchelor AGG, Joyce AD. A rare presentation of pelvic fracture as haematuria. Injury 2003,34 7 540-542.
• Muthukumar N, Smith RM, McCaskie AW, Batchelor AGG, Joyce AD. A rare presentation of pelvic fracture as haematuria. Injury 2003, 34(7), 540-542.
• Oakley MJ, Perry JD, Jones AL, Morgan S, McCaskie AW. Mechanical prophylaxis: Bacterial colonisation and sterilisation. Hip International 2003,13 32-35.
• Liu C, Green SM, Watkins ND, McCaskie AW. On the particle size and molecular weight distributions of clinical bone cements. Journal of Materials Science Letters 2003,22 9 709-712.
• Candal-Couto JJ, McCaskie A, Briggs PJ, Ledingham S. The below elbow cast: a cause of median and radial nerve injury after coronary bypass surgery. Injury 2001, 32(1), 78-79.
• J. R. W. Hardy, A. W. McCaskie, S. J. Calder and G. T. R. Pattison. Inflatable trays for the prevention of contamination in surgery. Injury-International Journal of the Care of the Injured 1999, 30, 309-312.
• A. D. Reading, A. W. McCaskie and P. J. Gregg. The inadequacy of standard radiographs in detecting flaws in the cement mantle. Journal of Bone and Joint Surgery-British Volume 1999, 81B, 167-170.
• A. J. Best, D. Fender, W. M. Harper, A. W. McCaskie, K. Oliver and P. J. Gregg. Current practice in primary total hip replacement: results from the National Hip Replacement Outcome Project. Annals of the Royal College of Surgeons of England 1998, 80, 350-355.
• A. W. McCaskie, J. B. Richardson and P. J. Gregg. Further uses of polymethlymethacrylate in orthopaedic surgery. Journal of the Royal College of Surgeons of Edinburgh 1998, 43, 37-39.
• A. W. McCaskie, D. J. Deehan, T. P. Green, K. R. Lock, J. R. Thompson, W. M. Harper and P. J. Gregg. Randomised, prospective study comparing cemented and cementless total knee replacement - Results of press-fit condylar total knee replacement at five years. Journal of Bone and Joint Surgery-British Volume 1998, 80B, 971-975.
• A. W. McCaskie, M. R. Barnes, E. Lin, W. M. Harper and P. J. Gregg. Cement pressurisation during hip replacement. Journal of Bone and Joint Surgery-British Volume 1997, 79B, 379-384.
• A. W. McCaskie, S. J. Calder, M. Roberts and P. J. Gregg. Sectioning fresh human bone: The reduction of aerosol and physical hazards. British Journal of Biomedical Science 1997, 54, 88-90.
• A. W. McCaskie, A. R. Brown, J. R. Thompson and P. J. Gregg. Radiological evaluation of the interfaces after cemented total hip replacement - Interobserver and intraobserver agreement. Journal of Bone and Joint Surgery-British Volume 1996, 78B, 191-194.
• Birch MA, Nouraei S, Wu QB, Ngalim S, Lu WJ, Watchorn C, Yang TY, McCaskie AW, Roy S. Effect of electrochemical structuring of Ti6Al64V on osteoblast behaviour in vitro. Journal of Biomaterials 2012. In Press.
• Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJM, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WER, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K, arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JBJ, Zhang W, Valdes AM, Doherty M, Zeggini E. A variant in MCF2L is associated with osteoarthritis. American Journal of Human Genetics 2011, 89(3), 446-450.
• Liu C, Green SM, Watkins ND, Gregg PJ, McCaskie AW. Creep behavior comparison of CMW1 and palacos R-40 clinical bone cements. Journal of Materials Science: Materials in Medicine 2002, 13(11), 1021-1028.
• Liu C, Green SM, Watkins ND, Gregg PJ, McCaskie AW. Effect of restraint on the creep behavior of clinical bone cement. Journal of Materials Science Letters 2002, 21(12), 959-962.
• Muller SD, Green SM, McCaskie AW. The dynamic volume changes of polymerising polymethyl methacrylate bone cement. Acta Orthopaedica Scandinavica 2002, 73(6), 684-687.
• Scott S, McCaskie AW, Calder SJ, Wildin C, Gregg PJ. Current cementing techniques in hip hemi-arthroplasty. Injury 2001, 32(6), 461-464.
• Chambers IR, Fender D, McCaskie AW, Reeves BC, Gregg PJ. Radiological features predictive of aseptic loosening in cemented Charnley femoral stems. Journal of Bone and Joint Surgery (British Volume) 2001, 83(6), 838-842.
• Liu C, Green SM, Watkins ND, Gregg PJ, McCaskie AW. Some failure modes of four clinical bone cements. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 2001, 215(4), 359-366.
• Candal-Couto JJ, McCaskie A, Briggs PJ, Ledingham S. The below elbow cast: a cause of median and radial nerve injury after coronary bypass surgery. Injury 2001, 32(1), 78-79.
• Reading AD, McCaskie AW, Barnes MR, Gregg PJ. A comparison of 2 modern femoral cementing techniques: Analysis by cement-bone interface pressure measurements, computerized image analysis, and static mechanical testing. Journal of Arthroplasty 2000, 15(4), 479-487.
• Mackay D, Gower A, Mawhinney B, Gregg PJ, McCaskie AW. Metallic instrument debris - A source of third-body wear particles?. Journal of Arthroplasty 2000, 15(6), 816-818.