Dr Anthony De Soyza
Clinical Senior Lecturer/Consultant

  • Email: anthony.de-soyza@ncl.ac.uk
  • Telephone: +44 (0) 191 2227043 or 2137468 (clinical)
  • Fax: +44 (0) 191 208 7038
  • Address: Institute of Cellular Medicine
    Newcastle University
    Medical School
    Framlington Place
    Newcastle upon Tyne
    NE2 4HH

Introduction

I am an Academic Clinician / Physician-Researcher and an Honorary Consultant Physician at Newcastle upon Tyne Hospitals NHS Foundation Trust. My interests are in both early (discovery) and late (first into man – clinical implementation)  translational gaps.

I lead a group looking at bacteria, chronic lung infections and use both basic science approaches and clinical trials activity to tackle these.

I have an interest in pulmonary infections. A focus on Gram negative infections in Cystic Fibrosis formed part of my early (PhD) research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. I also research inflammatory pathways, biomarkers and am developing in vitro models for studying these.

I am VC of a multinational COST action in Cystic fibrosis pathogens (COST action BM1003) and led a consensus approach to developing an International reference panel of Pseudomonas strains.

Second translational gap work includes the developing clinical services for non cystic fibrosis bronchiectasis (Bronchiectasis) and severe smoking related lung disease (emphysema/ COPD).  

I have led a recent multicentre grant funded by the MRC that will develop scientific partnerships (academia-clinical-industry) and a national patient biobank/ registry in Bronchiectasis

I also lead a clinical trials unit based at Freeman Hospital which has globally leading recruitment rates.  Collectively these have opened up new translational research avenues.

An interest in developing newer techniques to improve diagnosis of infection is also a current research theme.

My particular interest in respiratory clinical trials means I am involved in investigator led and commercial/industry trials of new therapies in bronchiectasis and COPD.

I have undertaken UK Chief investigator roles and recently started International lead investigator roles. These activities map to my role working for the UK National Institute for Health research Clinical trials network as Deputy Chair to Prof peter Calverley for the National Respiratory group. I enjoy networking in clinical trials and have supported a number of industry and academic studies in COPD and also in bronchiectasis.


Undergraduate at University of Dundee
Postgraduate Medical training in Newcastle
Higher Specialist Training in Northern Deanery in Respiratory Medicine
PhD attained from Newcastle University 2005

Qualifications

BMSC Hons
MBChB Hons MRCP UK
PhD

Positions 

National Institute for Health Research CLRN Deputy Chair National respiratory specialty group

CLRN Regional lead Northumbria Tyne and Wear  Specialty group lead for Respiratory Medicine

Associate Director for Industry studies (cross specialty) Northumbria Tyne and Wear  CLRN

Medical Lead Respiratory Medicine Trials Centre "Sir William Leech Centre" Freeman Hospital

Bronchiectasis Service lead Freeman Hospital, Newcastle upon Tyne

Lead applicant for MRC "BRONCH-UK" Bronchiectasis National registry and Biobank (10 centre project) 2014-2017

Admin lead- UK Bronchiectasis Research and Academic Network (BRAN) - 15 centres

Honours and Awards

In set up;

BRONCH-UK MRC funded multicentre research partnership and national registry of adult nonCF bronchiectasis £700,000 2014-2017 (lead applicant)

TWICS  NIHR-HTA award- Novel use of Theophylline in COPD £2.2M co applicant leads Profs. Devereux and Price University of Aberdeen 2014-17

Completed/ Active 

1) Higher Education Council For England Senior Lecturer Award 5 Year Tenure University of Newcastle
Funded £250,000 over 5 years. This post is complemented with a 50% clinical component funded by Newcastle Upon Tyne Hospitals Teaching Trust under the Biomedicine initiative.

2) Newcastle Hospital Special Trustees 2005-2006 Funded £38,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant. 3 publications.

3) Wellcome Clinical Training Fellowship 2001-2003 Funded £138,000
(work led to 4 publications as below)

4) Breathe North Research Fellowship
1999-2001 Funded £90,000
Bedside to bench research in cystic fibrosis and lung transplantation. Audit led to a change in management of patients allowing certain high risk groups to be transplanted successfully

5)3M Pharmaceuticals Small airways research award

6)British Lung Foundation Young Investigator of the Year Award 2003

7) FFC Italian Cystic Fibrosis Charity / Newcastle Hospital Special Trustees 2008-10 Funded £56,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant. 2 publications. 

8) Newcastle Hospital Special Trustees 2007 Funded £17,000
I co-supervised a RA developing mass spectrometry data on volatiles emitted from Pseudomonas. 1 publication

9) BRC Research Grant 50,000 2010 2 publications in press

 

Languages

English

 

Research Interests

My main interest is in pulmonary infections.
A focus on Gram negative infections in Cystic Fibrosis has formed part of my early research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. Clinical research in bronchiectasis and severe smoking related lung disease (COPD) is underway in collaboration with many clinical and academic colleagues

Expertise in protein extraction, LPS extraction, PCR, electron microsopy, tissue culture, FACS and ELISA.

Other Expertise

Clinical Trial design, conduct and research.

Current Work

Structure and biological activity of LPS extracted from pathogens infecting patients with a variety of respiratory conditions (Cystic Fibrosis, Bronchiectasis and COPD).

Signalling pathways for LPS signal transduction.

Research Roles

Principal Investigator,

National/ Global Chief Investigator

Postgraduate Supervision

The post-graduate supervision of research candidates started in October 2007. Three MRES students have completed to merit/distinction levels and publications arisen through this

Esteem Indicators

3M Pharmaceuticals Small Airways Research Prize 1999
University of Newcastle, School of Medicine Annual Research presentation, First prize, 2000
Wellcome Trust Clinical Training Fellowship,Sep 2001 - October 2003
British Lung Foundation Young Investigator of the Year 2003
One of two national HECFE award winners in Respiratory Medicine 2007

Funding > 1.5M

Wellcome Clinical Training Fellowship 2001-2003 (work led to 4 publications) Funded £138,000

HEFCE award £250,000 2007-2012

GSK investigator led grant £10K 2008
FFC Charity grant £24,000 2009


I learned clinical study design, ethics application and database design. Audit led to a change in management of patients allowing certain high risk groups to be transplanted successfully

Newcastle Hospital Special Trustees 2005-2006
(1 Publication with a further in press) Funded £38,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant.

Higher Education Council For England Senior Lecturer Award
5 Year Tenure University of Newcastle
Funded £250,000 over 5 years towards wages. This post is complemented with a 50% clinical component funded by Newcastle Teaching Trusts.

I am a coapplicant on the 2.2M https://w3.abdn.ac.uk/hsru/twics/


I am the lead applicant on the £700K MRC Funded Partnership grant in bronchiectasis "Bronch -UK" starts October 2014

Industrial Relevance

Significant input into UK clinical trials by recruitment at Sir William Leech Trials Centre.
Prior UK Chief Investigator duties undertaken
Facilitated Industrial contact with UKCRN adoption process improving trials throughput
Co supervisor to Wellcome Translational PhD student part funded by AstraZeneca

Keywords

Cystic Fibrosis, microbiology, bronchiectasis, lipopolysaccharide, virulence, Pseudomonas aeruginosa, Burkholderia, cepacia, cenocepacia, COPD

Undergraduate Teaching

MRES student supervision / cosupervision Syba Sunny, S Maloney, J Birch
3 Biology honours undergraduates B Johnson, K Laws and I Laher

Postgraduate Teaching

1. Academic clinical fellow in ENT Dr SL Ball
2. Academic clinical fellow Dr Jary
3. CoSupervisor to Dr L Moisey
4  Lead supervisor to Jodie Birch

I also lead module 3 in the PG Clin Certificate in Clinical Research