I am an Academic Clinician / Physician-Researcher and an Honorary Consultant Physician at Newcastle upon Tyne Hospitals NHS Foundation Trust. My interests are in both early (discovery) and late (first into man – clinical implementation) translational gaps.
I have an interest in pulmonary infections. A focus on Gram negative infections in Cystic Fibrosis formed part of my early (PhD) research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. I also research inflammatory pathways, biomarkers and am developing in vitro models for studying these. I am VC of a multinational COST action in Cystic fibrosis pathogens (COST action BM1003).
Second translational gap work includes the developing clinical services for non cystic fibrosis bronchiectasis (Bronchiectasis) and severe smoking related lung disease (emphysema/ COPD). I also lead a clinical trials unit based at Freeman Hospital which has globally leading recruitment rates. Collectively these have opened up new translational research avenues. An interest in developing newer techniques to improve diagnosis of infection is also a research theme.
My particular interest in respiratory clinical trials means I involved in investigator led and commercial/industry trials of new therapies in bronchiectasis and COPD. I have undertaken UK Chief investigator roles and recently started International lead investigator roles. These activities map to my role working for the UK National Institute for Health research Clinical trials network as Deputy Chair to Prof peter Calverley for the National Respiratory group. I enjoy networking in clinical trials and have supported a number of industry and academic studies in COPD and also in bronchiectasis.
Undergraduate at University of Dundee
Postgraduate Medical training in Newcastle
Higher Specialist Training in Northern Deanery in Respiratory Medicine
PhD attained from Newcastle University 2005
MBChB Hons MRCP UK
National Institute for Health Research CLRN Deputy Chair respiratory specialty group
CLRN Regional lead Northumbria Tyne and Wear Specialty group lead for Respiratory Medicine
Associate Director for Industry studies (cross specialty) Northumbria Tyne and Wear CLRN
Medical Lead Respiratory Medicine Trials Centre "Sir William Leech Centre" Freeman Hospital
Bronchiectasis Service lead Freeman Hospital
1) Higher Education Council For England Senior Lecturer Award 5 Year Tenure University of Newcastle
Funded £250,000 over 5 years. This post is complemented with a 50% clinical component funded by Newcastle Upon Tyne Hospitals Teaching Trust under the Biomedicine initiative.
2) Newcastle Hospital Special Trustees 2005-2006 Funded £38,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant. 3 publications.
3) Wellcome Clinical Training Fellowship 2001-2003 Funded £138,000
(work led to 4 publications as below)
4) Breathe North Research Fellowship
1999-2001 Funded £90,000
Bedside to bench research in cystic fibrosis and lung transplantation. Audit led to a change in management of patients allowing certain high risk groups to be transplanted successfully
5)3M Pharmaceuticals Small airways research award
6)British Lung Foundation Young Investigator of the Year Award 2003
7) FFC Italian Cystic Fibrosis Charity / Newcastle Hospital Special Trustees 2008-10 Funded £56,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant. 2 publications.
8) Newcastle Hospital Special Trustees 2007 Funded £17,000
I co-supervised a RA developing mass spectrometry data on volatiles emitted from Pseudomonas. 1 publication
9) BRC Research Grant 50,000 2010 2 publications in press
10) NIHR-HTA award- Novel use of Theophylline in COPD £2M co applicant leads Profs. Devereux and Price University of Aberdeen
My main interest is in pulmonary infections.
A focus on Gram negative infections in Cystic Fibrosis has formed part of my early research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. Clinical research in bronchiectasis and severe smoking related lung disease (COPD) is underway in collaboration with many clinical and academic colleagues
Expertise in protein extraction, LPS extraction, PCR, electron microsopy, tissue culture, FACS and ELISA.
Clinical Trial design, conduct and research.
Structure and biological activity of LPS extracted from pathogens infecting patients with a variety of respiratory conditions (Cystic Fibrosis, Bronchiectasis and COPD).
Signalling pathways for LPS signal transduction.
The post-graduate supervision of research candidates started in October 2007. Three MRES students have completed to merit/distinction levels and publications arisen through this
Funding of ~500K
3M Pharmaceuticals Small Airways Research Prize 1999
University of Newcastle, School of Medicine Annual Research presentation, First prize, 2000
Wellcome Trust Clinical Training Fellowship,Sep 2001 - October 2003
British Lung Foundation Young Investigator of the Year 2003
One of two national HECFE award winners in Respiratory Medicine 2007
Wellcome Clinical Training Fellowship 2001-2003 (work led to 4 publications) Funded £138,000
HEFCE award £250,000 2007
GSK investigator led grant £10K 2008
FFC Charity grant £24,000 2009
Breathe North Research Fellowship 1999-2001 (work led to 4 publications) Funded £90,000
I learned clinical study design, ethics application and database design. Audit led to a change in management of patients allowing certain high risk groups to be transplanted successfully
Newcastle Hospital Special Trustees 2005-2006
(1 Publication with a further in press) Funded £38,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant.
Higher Education Council For England Senior Lecturer Award
5 Year Tenure University of Newcastle
Funded £250,000 over 5 years towards wages. This post is complemented with a 50% clinical component funded by Newcastle Teaching Trusts.
Significant input into UK clinical trials by recruitment at Sir William Leech Trials Centre.
Prior UK Chief Investigator duties undertaken
Facilitated Industrial contact with UKCRN adoption process improving trials throughput
Co supervisor to Wellcome Translational PhD student part funded by AstraZeneca
Cystic Fibrosis, microbiology, bronchiectasis, lipopolysaccharide, virulence, Pseudomonas aeruginosa, Burkholderia, cepacia, cenocepacia, COPD
MRES student supervision / cosupervision Syba Sunny, S Maloney
3 Biology honours undergraduates B Johnson, K Laws and I Laher
1 Academic clinical fellow in ENT Dr SL Ball
2 Academic clinical fellow Dr Jary
3 CoSupervisor to Dr L Moisey
4 CoSupervisor to Jodie Birch
I also teach on the Masters of Clinical Research