Professor Calum McNeil
Professor of Biological Sensor Systems

Research Interests

The work of the Diagnostic & Therapeutic Technologies Research Group (D&TT) group aims to utilise Biomedical Engineering to improve rapid clinical diagnostic technologies and to engineer technological approaches which can help to elucidate the molecular pathways that cause degenerative diseases.  This work involves the design and development of highly specific 'bioelectronic' interfaces between inorganic surfaces and biological species (antibodies, microbial cells, enzymes and redox proteins) and has led to the production of a number of electrochemical and microelectromechanical sensor systems capable of the direct, rapid measurement of biological and chemical species in complex matrices. The current research programmes being carried out by the D&TT group can be broadly defined in three inter-related, multi-disciplinary areas. These are:

  1. Development of microbial and biological sensors based on electrical impedance or microelectromechanical systems  - Collaboration with Dr Neil Keegan.
  2. Development of near-patient technology platforms for rapid, quantitative immunometric measurement of biochemical markers of disease and their use in remote monitoring and management.
  3. Development of multi-analyte sensor array platforms for direct, simultaneous intra- and extra-cellular monitoring of reactive oxygen species and the application of these to understanding related biochemical mechanisms involved in disease processes - Collaboration with Dr Phil Manning.

Our work has been highlighted in a number of public engagement and outreach activities including producing news items and videos aimed at public education of the D&TT vision of successful outcomes of collaborative multi-disciplinary research and also using social media to highlight achievements.

Current Major Research Funding

The Multi-Corder: EPSRC Programme Grant (£3.4M, May 2013 - Oct 2017).

Early-Warning Sensing Systems for Infectious Diseases (i-sense): EPSRC IRC (£11.1M, Oct 2013 - Sept 2018).

Personal Risk Assessment in Febrile Illness to Optimize Real-life Management Across the EU (PERFORM): EC H2020 (Jan 2016 - Dec 2020).

Projects

  • d-LIVER
    Project Leader(s): Professor Calum McNeil, Dr Philip Manning, Professor Dave Jones, Professor Matt Wright

    This research is funded by the European Commission Framework 7 Programme.

  • High Frequency Acoustic Sensors for Medical Diagnostics (DSAW)
    Project Leader(s): Dr Neil Keegan, Professor Calum McNeil, Dr Barry Gallacher, Dr John Hedley

    This research is funded by the Engineering and Physical Sciences Research Council.

  • IRC in Early Warning Sensing Systems for Infectious Diseases
    Project Leader(s): Calum McNeil, Dr Neil Keegan, Dr Philip Manning, Dr John Hedley, Professor Colin Harwood, Professor Anil Wipat
    This research is funded by the Engineering and Physical Sciences Research Council.
  • The Multi-Corder
    Project Leader(s): Dr Neil Keegan, Professor Calum McNeil
    This research is funded by the Engineering and Physical Sciences Research Council.