Dr Christopher Duncan
Clinical Fellow/Honorary Consultant in Infectious Diseases
- Email: email@example.com
- Telephone: +44 (0)191 2082796
- Fax: +44 (0) 191 2085455
- Address: Room M3.121
3rd Floor, Leech Building
Newcastle upon Tyne
- Clinical Fellowship, Institute of Cellular Medicine, Newcastle University
- Honorary Consultant in Infectious Diseases, Newcastle upon Tyne Hospitals NHS Foundation Trust
- NIHR Academic Clinical Lecturer in Infectious Diseases, Newcastle University, 2014-2016
- Specialty Registrar in Infectious Diseases and G(I)M, Northern Deanery, 2013-2017
- Welcome Trust Research Training Fellowship for Clinicians, University of Oxford 2010-2013
- Phizackerley Senior Scholarship, Balliol College Oxford 2012-2013
- Clinical Research Fellow, University of Oxford, 2009-2010
- Specialty Registrar in Infectious Diseases and G(I)M, West of Scotland Deanery, 2007-2013
- BMed Sci (1st Class Hons.) University of Aberdeen, 2001
- MB ChB (Distinction) University of Aberdeen, 2003
- DPhil University of Oxford, 2014
- Sample access committee, Newcastle Academic Health Partners Bioresource
- Joint Research Scientific Executive Committee
- Member, Genomics England Clinical Interpretation Partnership (GeCIP)
- Member: BIA, BSI, NIAAD
- Peer reviewer (NEJM, BMJ etc.)
My research aims to define the contribution of innate immunity to the pathogenesis of severe viral disease and immunopathology. I seek mechanistic insight through the detailed analysis of monogenic viral susceptibility variants at the cellular and molecular level, and via targeted genetic perturbation of primary cells with the CRISPR/Cas9 system.
I work closely with Professor Sophie Hambleton's Primary Immunodeficiency Group: http://www.ncl.ac.uk/icm/people/profile/sophie.hambleton
I have a clinical interest in severe manifestations of viral infection, including in the immunocompromised host.
- British Infection Association, Research Fellowship (2017-2018, £70,000)
- Academy of Medical Sciences, Starter Grant for Clinical Lecturers (2014-2016, £30,000)
- British Infection Association, Project Grant (2014-2016, £25,000)
I am responsible for coordinating Infectious Diseases teaching for the Physician Associate PG Diploma.
I supervise MRes and PhD students, and welcome enquiries.
- Duncan CJA, Mohamad SMB, Young DF, Skelton AJ, Leahy TR, Munday DC, Butler KM, Morfopoulou S, Brown JR, Hubank M, Connell J, Gavin PJ, McMahon C, Dempsey E, Lynch NE, Jacques TS, Valappil M, Cant AJ, Breuer J, Engelhardt KR, Randall RE, Hambleton S. Human IFNAR2 deficiency: lessons for antiviral immunity. Science Translational Medicine 2015, 7(307), 307ra154.
- Duncan CJA, Hambleton S. Varicella zoster virus immunity: A primer. Journal of Infection 2015, 71(Suppl. 1), S47-S53.
- Duncan CJA, Schmid ML, Schwab U, Price DA, Ong E. Futility of CD4+ monitoring in HIV-1 patients with CD4+ cell count above 350 cells/[mu]l on suppressive antiretroviral therapy. AIDS 2014, 28(17), 2638-2639.
- Duncan CJA, Hambleton S. Host genetic factors in susceptibility to mycobacterial disease. Clinical Medicine 2014, 14(Suppl. 6), s17-s21.
- Duncan C, Mohamad S, Young D, Skelton A, Leahy R, Munday D, Butler K, Morfopoulou S, Brown J, Hubank M, Connell J, Gavin P, McMahon C, Dempsey E, Lynch N, Jacques T, Valappil M, Cant A, Engelhardt K, Breuer J, Randall R, Hambleton S. Human IFNAR2 Deficiency: Lessons For Antiviral Immunity. In: UKPIN 2015 Meeting. 2015, Belfast, Northern Ireland: Wiley-Blackwell Publishing Ltd.
- Dixon J, Duncan CJA. Importance of antimicrobial stewardship to the English National Health Service. Infection and Drug Resistance 2014, 7, 145-152.
- Duncan CJA, Dinnigan E, Theobald R, Grainger A, Skelton AJ, Hussain R, Willet JDP, Swan DJ, Coxhead J, Thomas MF, Thomas J, Zamvar V, Slatter MA, Cant AJ, Engelhardt KR, Hambleton S. Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20). Annals of the Rheumatic Diseases 2017, Epub ahead of print.
- Duncan CJA, Charlton F, Bower M, Price DA. The unholy trinity of human herpesvirus 8-associated malignancy in a person living with HIV-1. AIDS 2017. In Press.