Newcastle University

Roles and Responsibilities

currently co-organise the Liver Group Research Seminars with Dr Stephen Stewart.

Qualifications

1994-1997 – BSc Physiology and Biochemistry, university of Southampton
December 2000 - PhD awarded, University of Southampton

Previous Positions

1/10/05-31/08/06 School of Medicine Career Track Award, University of Southampton
02/04/03-30/08/05 Post doctoral scientist Wellcome Trust, University of Southampton
01/07/00- 31/03/03 Post doctoral scientist MRC, University of Southampton

Memberships

British Association for the Study of Liver disease (BASL), Basic Science committee member.

Honours and Awards

Dame Sheila Sherlock Young Investigator Award 2006.

Research Interests

Understanding how NF-kappaB and serotonin signaling regulates liver inflammation, fibrosis and regeneration. Other current research projects include investigating the discrete biological functions of the individual NF-kB subunits in heart and skin physiology and disease.

Postgraduate Supervision

currently supervise one postgraduate student

Funding

Awarded May 2008: Wellcome Trust, the role of hepatic myofibroblasts in hepatic injury and regeneration. PI Matthew Wright, co-applicants Derek Mann, Fiona Oakley and Alastair Burt.

Awarded March 2008: MRC Mres/PhD Studentship - NF-Kappaβ Signalling is a Critical Regulator of Skin Ageing – Do Manipulating Specific Components of NF-kappaβ Signalling Rejuvenate Skin? Fiona Oakley, Derek Mann, Nick Reynolds, Mark Birch-Machin.

Awarded November 2007, MRC research grant: A functional dissection of the serotonin system in liver disease. 2 years. PI Derek Mann, co-applicants Fiona Oakley and Matthew Wright.

Gerald kerkut charitable Trust funded PhD studentship. The role of nfkb1 in cardiovascular physiology. Co-applicants Prof. Derek Mann (Newcastle, ICM) and Dr Paul Townsend (University of Southampton)

Undergraduate Teaching

Supervised one undergraduate student, 2008

Postgraduate Teaching

co-supervising one Mres student, 2008

• Axon A, Cowie DE, Oakley F, Williams FM, Blain PG, Wright MC. Acute oestradiol (E2) administration to mice results in liver portal tract inflammation. In: Toxicology: Annual Spring Meeting of the British Toxicological Society. 2010, Edinburgh, UK: Elsevier Ireland Ltd.
• Mann J, Oakley F, Burt AD, Tsukamoto H, Mann D. Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Marshall HL, Oakley F, Wright MC. Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy. In: Toxicology: Annual Spring Meeting of the British Toxicological Society. 2010, Edinburgh, UK: Elsevier Ireland Ltd.
• Chakraborty JB, Mann J, Oakley F, Burt AD, Mann DA. NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Perugorria M, Oakley F, Mann J, Sharif O, Knapp S, Mann DA. TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Oakley F, Teoh V, Ching-A-Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Angiotensin II Activates I kappa B Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis. Gastroenterology 2009, 136(7), 2334-2344.
• Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, Oakley F. NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. Journal of Hepatology 2008, 48(4), 589-597.
• Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis. Gastroenterology 2005,128 1 108-120.
• Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A. Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging. Gene Therapy 2005,12 19 1465-1476.
• Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C, Ali S, Wilson SJ, Millward-Sadler H, Iredale JP, Mann DA. Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury. American Journal of Pathology 2005,166 3 695-708.
• Oakley F, Horn NM, Thomas AL. Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.7. Journal of Physiology 2004, 561(2), 525-534.
• Oakley F, Trim N, Constandinou CM, Ye W, Gray AM, Frantz G, Hillan K, Kendall T, Benyon RC, Mann DA, Iredale JP. Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis. The American Journal of Pathology 2003, 163(5), 1849-1858.