Newcastle University

Background

I am a Chemical Pathologists with clinical and scientific interest in metabolic disease.

Qualifications

MBBS, PhD, FRCPath

Previous Positions

MRC Clinical Training Fellow
Wellcome Research Fellow

Memberships

American Society fro Bone and Mineral Research
Society for Endocrinology

Research Interests

Genetics and molecular biology metabolic bone disease.

Other Expertise

Nanobiology studies and cell signalling.

Current Work

Genetics of osteoporosis and osteopetrosis.
Isolation and characterzation of novel osteoblast genes.

Future Research

We have isolated three novel gene from rat osteoblasts which are regulated by oxidative stress, we intend to characterize the genes by in vitro cell and mice knock-outs.

Postgraduate Supervision

Genetics and molecular biology studies.

Funding

EU
EPSRC
BBSRC & Local Biotech Industry

Undergraduate Teaching

NME seminars to Stage 1
Lecture to Satge 11

• Al-Oanzi ZH, Tuck SP, Mastana SS, Summers GD, Cook DB, Francis RM, Datta HK. Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men. Osteoporosis International 2008, 19(7), 951-960.
• Al-Oanzi ZH, Tuck SP, Raj N, Harrop JS, Summers GD, Cook DB, Francis RM, Datta HK. Assessment of vitamin D status in male osteoporosis. Clinical Chemistry 2006, 52(2), 248-254.
• Varanasi SS, Datta HK. Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells. Bone 2005,36 2 243-253.
• Del Fattore A, Peruzzi B, Rucci N, Recchia I, Cappariello A, Longo M, Fortunati D, Ballanti P, Iacobini M, Luciani M, Devito R, Pinto R, Caniglia M, Lanino E, Messina C, Cesaro S, Letizia C, Bianchini G, Fryssira H, Grabowski P, Shaw N, Bishop N, Hughes D, Kapur RP, Datta HK, Taranta A, Fornari R, Migliaccio S, Teti A. Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: Implications for diagnosis and treatment. Journal of Medical Genetics 2006, 43(4), 315-325.
• Datta HK, Ng WF, Walker JA, Tuck SP, Varanasi SS. The cell biology of bone metabolism. Journal of Clinical Pathology 2008, 61(5), 577-587.
• Datta HK, Wu JJ, Tuck S, Walker J. Emerging Evidence of Osteocytes as Mechanosensors and Regulators of Mineralisation. European Musculoskeletal Review 2008. Touch Briefings, 3(2), 48-52.
• Dickinson FM, Alsop TA, Al-Sharif N, Berger CEM, Datta HK, Siller L, Chao Y, Tuite EM, Houlton A, Horrocks BR. Dispersions of alkyl-capped silicon nanocrystals in aqueous media: photoluminescence and ageing. Analyst 2008, 133(11), 1573-1580.
• Datta HK, Malik M, Neely RDG. Hepatic surgery-related hypophosphatemia. Clinica Chimica Acta 2007, 380(1-2), 13-23.
• Jabbar S, Drury J, Fordham JN, Datta HK, Francis RM, Tuck SP. Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis. Journal of Clinical Pathology 2011, 64(4), 354-357.
• Berger CEM, Datta HK, Horrocks BR. Simulation of generation-collection experiments with homogeneous kinetics: application to electrochemical investigation of superoxide radical anion generation by osteoclasts on bone. Physical Chemistry Chemical Physics 2011, 13(12), 5288-5297.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Tuck SP, Lafeber FP, Huizinga TW, Bijlsma JW, Francis RM, Datta HK, van Laar J. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis. In: Annual Meeting of the British Society for Rheumatology. 2011, Brighton, UK: Rheumatology: Oxford University Press.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Lafeber FP, Bijlsma JWJ, Francis RM, Tuck SP, Datta HK, van Laar JM. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis. Osteoporosis International 2011, 22(12), 3067-3072.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Tuck SP, Lafeber FP, Huizinga TWJ, Bijlsma JWJ, Francis RM, Datta HK, van Laar JM. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis (Premier Poster-Award Candidate). In: Osteoporosis Conference. 2010, Liverpool, UK: Osteoporosis International: Springer.
• Varanasi SS, Datta HK. FK506 modulates osteoblast-specific transcription factors Cbfa1 and Osterix gene expression in ROS 17/2.8 cells. In: 26th Annual Meeting of the American Society for Bone and Mineral Research. 2004, Seattle: Journal of Bone and Mineral Research: American Society for Bone and Mineral Research.
• Tuck SP, Al-oanzi ZH, Varanasi SS, Raj N, Summers GD, Datta HK, Francis RM. Vitamin D binding protein gene (TAAA) n-Alu element polymorphism and its association with bone density and osteoporosis in men. In: Rheumatology. 2004, Oxford University Press.
• Berger CEM, Datta HK. Forskolin has a bimodal cAMP-independent effect on superoxide anion generation in isolated osteoclasts. Experimental Physiology 2000, 85(1), 57-60.
• Kanan RM, Cook DB, Datta HK. Lectin immunoassay for macrophage-activating factor (Gc-MAF) produced by deglycosylation of Gc-globulin: Evidence for noninducible generation of Gc- MAF. Clinical Chemistry 2000, 46(3), 412-414.
• Kanan RM, Varanasi SS, Francis RM, Parker L, Datta HK. Vitamin D receptor gene start codon polymorphism (Fokl) and bone mineral density in healthy male subjects. Clinical Endocrinology 2000, 53(1), 93-98.
• Berger CEM, Horrocks BR, Datta HK. Application of ion-selective microelectrodes to the detection of calcium release during bone resorption. Electrochimica Acta 1999, 44(16), 2677-2683.
• Varanasi SS, Athanasou NA, Briceno I, Papiha SS, Datta HK. Association of HLA-DRB1 alleles with giant cell tumour of bone. Journal of Clinical Pathology 1999, 52(10), 782-784.
• Berger CEM, Horrocks BR, Datta HK. Direct non-genomic effect of steroid hormones on superoxide anion generation in the bone resorbing osteoclasts. Molecular and Cellular Endocrinology 1999, 149(1-2), 53-59.