Newcastle University

Roles and Responsibilities

Professor of Clinical Rheumatology, University of Newcastle
Honorary Consultant Rheumatologist, James Cook University Hospital, Middlesbrough

Qualifications

MD, University of Leiden, The Netherlands, 8 July 1988
PhD, University of Leiden, The Netherlands, 23 February 1993

Previous Positions

2000-2004 Assistant Professor, Department of Rheumatology, Leiden University Medical Center, The Netherlands.
2002-2004 Research Fellow, National Institute of Arthritis and Musculoskeletal and Skin Diseases, USA.
2004-2007 Associate Professor, Department of Rheumatology, Leiden University Medical Center, The Netherlands.

Memberships

Dutch Society for Rheumatology. Dutch Society of Internal Medicine. British Society of Rheumatology.

Honours and Awards

Marie Parijs Award, 2003, Leiden University Medical Center, The Netherlands.

Research Interests

Stem cell transplantation of rheumatic, autoimmune disease. Pathogenesis of rheumatoid arthritis and systemic sclerosis.
B cell biology including regulation of autoantibody production.

• Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L, Gorlova OY, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, de la Pena PG, Oreiro N, Roman-Ivorra JA, Castillo MJ, Gonzalez-Gay MA, Saez-Comet L, Castellvi I, Schuerwegh AJ, Voskuyl AE, Hoffmann-Vold AM, Hesselstrand R, Nordin A, Lunardi C, Scorza R, van Laar JM, Shiels PG, Herrick A, Worthington J, Fonseca C, Denton C, Tan FK, Arnett FC, Assassi S, Koeleman BP, Mayes MD, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the Rheumatic Diseases 2013, 72(4), 602-607.
• Lafeber FPJG, van Laar JM. Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug?. Annals of the Rheumatic Diseases 2013, 72(2), 157-161.
• Carmona FD, Martin JE, Beretta L, Simeon CP, Carreira PE, Callejas JL, Fernandez-Castro M, Saez-Comet L, Beltran E, Camps MT, Egurbide MV, Airo P, Scorza R, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JHW, Madhok R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Schuerwegh AJ, Vonk MC, Voskuyl AE, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis. PLoS One 2013, 8(1), e54419.
• Hugle T, O'Reilly S, Simpson R, Kraaij MD, Bigley V, Collin M, Krippner-Heidenreich A, van Laar JM. Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts. Arthritis & Rheumatism 2013, 65(2), 481-491.
• Bossini-Castillo L, Simeon CP, Beretta L, Broen J, Vonk MC, Callejas JL, Carreira P, Rodriguez-Rodriguez L, Garcia-Portales R, Gonzalez-Gay MA, Castellvi I, Camps MT, Tolosa C, Vicente-Rabaneda E, Egurbide MV, Schuerwegh AJ, Hesselstrand R, Lunardi C, van Laar JM, Shiels P, Herrick A, Worthington J, Denton C, Radstake TRDJ, Fonseca C, Martin J, Spanish Scleroderma Grp. KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Research & Therapy 2012, 14(6), R273.
• Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeon CP, Beretta L, Vonk MC, Callejas JL, Castellvi I, Carreira P, Garcia-Hernandez FJ, Castro MF, Coenen MJH, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JHW, Koeleman BP, Voskuyl AE, Schuerwegh AJ, Palm O, Hesselstrand R, Nordin A, Airo P, Lunardi C, Scorza R, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Tan FK, Arnett FC, Agarwal SK, Assassi S, Fonseca C, Mayes MD, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics 2012, 21(4), 926-933.
• Bossini-Castillo L, Simeon CP, Beretta L, Broen JC, Vonk MC, Rios-Fernandez R, Espinosa G, Carreira P, Camps MT, Castillo MJ, Gonzalez-Gay MA, Beltran E, Freire MD, Narvaez J, Tolosa C, Witte T, Kreuter A, Schuerwegh AJ, Hoffmann-Vold AM, Hesselstrand R, Lunardi C, van Laar JM, Chee MM, Herrick A, Koeleman BPC, Denton CP, Fonseca C, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis. Arthritis Research & Therapy 2012, 14(2), R85.
• Castillo LB, Simeon CP, Beretta L, Broen J, Rios-Fernandez R, Carreira P, Gonzalez-Gay MA, Witte T, Kreuter A, Schuerwegh AJ, Hoffmann-Vold AM, Hesselstrand R, Lunardi C, van Laar JM, Chee MM, Herrick A, Fonseca C, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. A multicentre study confirms CD226 gene association with SSc-related pulmonary fibrosis. In: 2nd Systemic Sclerosis World Congress. 2012, Madrid, Spain: Oxford University Press.
• Ciechomska M, Huigens CA, Hugle T, Gessner A, O'Reilly S, van Laar JM. A novel role of monocytes in the induction of profibrotic tissue-inhibitor of metalloproteinase-1 mediated by toll-like receptors stimulation in SSC. In: 2nd Systemic Sclerosis World Congress. 2012, Madrid, Spain: Oxford University Press.
• Atkins HL, Muraro PA, van Laar JM, Pavletic SZ. Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease-Is It Now Ready for Prime Time?. Biology of Blood and Marrow Transplantation 2012, 18(1 S), S177–S183.
• Huegle T, White K, van Laar JM. Cell-to-cell contact of activated mast cells with fibroblasts and lymphocytes in systemic sclerosis. Annals of the Rheumatic Diseases 2012, 71(9), 1582-U223.
• Binai N, O'Reilly S, Griffiths B, van Laar JM, Hugle T. Differentiation Potential of CD14(+) Monocytes into Myofibroblasts in Patients with Systemic Sclerosis. PLoS One 2012, 7(3), e33508.
• Hugle T, White K, van Laar JM. Direct vesicle transmission by mast cells to fibroblasts and lymphocytes in SSc. In: 2nd Systemic Sclerosis World Congress. 2012, Madrid, Spain: Oxford University Press.
• Snowden JA, Saccardi R, Allez M, Ardizzone S, Arnold R, Cervera R, Denton C, Hawkey C, Labopin M, Mancardi G, Martin R, Moore JJ, Passweg J, Peters C, Rabusin M, Rovira M, van Laar JM, Farge D, EBMT ADWP, PDWP. Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplantation 2012, 47(6), 770-790.
• Sullivan KM, Wigley FM, Denton CP, van Laar JM, Furst DE. Haemopoietic stem-cell transplantation for systemic sclerosis. Lancet 2012, 379(9812), 219-219.
• van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, Schuerwegh A, Vonk MC, Matucci-Cerinic M, Voskuyl AE, Gratwohl A, Tyndall AG. High Dose Immunoablation and Autologous Hematopoietic Stem Cell Transplantation Versus Monthly Intravenous Pulse Therapy Cyclophosphamide in Severe Systemic Sclerosis. In: Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals. 2012, Washington, DC, USA: John Wiley & Sons, Inc.
• Martin JE, Broen JC, Carmona FD, Teruel M, Simeon CP, Vonk MC, van 't Slot R, Rodriguez-Rodriguez L, Vicente E, Fonollosa V, Ortego-Centeno N, Gonzalez-Gay MA, Garcia-Hernandez FJ, de la Pena PG, Carreira P, Voskuyl AE, Schuerwegh AJ, van Riel PLCM, Kreuter A, Witte T, Riemekasten G, Airo P, Scorza R, Lunardi C, Hunzelmann N, Distler JHW, Beretta L, van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Tan FK, Arnett FC, Assassi S, Fonseca C, Mayes MD, Radstake TRDJ, Koeleman BPC, Martin J, Spanish Schleroderma Grp. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up. Human Molecular Genetics 2012, 21(12), 2825-2835.
• Teng YKO, Wheater G, Hogan VE, Stocks P, Levarht EWN, Huizinga TWJ, Toes REM, van Laar JM. Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity. Arthritis Research & Therapy 2012, 14(2), R57.
• Cenit MC, Simeon CP, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Blanco FJ, Narvaez J, Tolosa C, Roman-Ivorra JA, Gomez-Garcia I, Garcia-Hernandez FJ, Gallego M, Garcia-Portales R, Egurbide MV, Fonollosa V, de la Pena PG, Lopez-Longo FJ, Gonzalez-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Fonseca C, Denton C, Nordin A, Palm O, van Laar JM, Hunzelmann N, Distler JHW, Kreuter A, Herrick A, Worthington J, Koeleman BP, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. Journal of Rheumatology 2012, 39(12), 2294-2302.
• O'Reilly S, Ciechomska M, Cant R, Hugle T, van Laar JM. Interleukin-6, its role in fibrosing conditions. Cytokine & Growth Factor Reviews 2012, 23(3), 99-107.
• Hogan VE, Holweg CTJ, Choy DF, Kummerfeld SK, Hackney JA, Teng YKO, Townsend MJ, van Laar JM. Pretreatment synovial transcriptional pro le is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab. Annals of the Rheumatic Diseases 2012, 71(11), 1888-1894.
• Burmester GR, Pratt AG, Scherer HU, van Laar JM. Rheumatoid arthritis: Pathogenesis and clinical aspects. In: Bijlsma, H, ed. EULAR Textbook on Rheumatic Diseases. London: BMJ Publications, 2012, pp.206-231.
• O'Reilly S, Hugle T, Griffiths B, Krippner A, van Laar JM. T cell derived IL-6 and IL-13 drive fibroblast fibrosis: Implications for systemic sclerosis. In: 32nd European Workshop for Rheumatology Research. 2012, Stockholm, Sweden: BMJ Group.
• O'Reilly S, Hugle T, van Laar JM. T cells in systemic sclerosis: a reappraisal. Rheumatology 2012, 51(9), 1540-1549.
• Martin JE, Carmona FD, Broen JCA, Simeon CP, Vonk MC, Carreira P, Rios-Fernandez R, Espinosa G, Vicente-Rabaneda E, Tolosa C, Garcia-Hernandez FJ, Castellvi I, Fonollosa V, Gonzalez-Gay MA, Saez-Comet L, Portales RG, de la Pena PG, Fernandez-Castro M, Diaz B, Martinez-Estupinan L, Coenen M, Voskuyl AE, Schuerwegh AJ, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm O, Chee MM, van Laar JM, Denton C, Herrick A, Worthington J, Koeleman BPC, Radstake TRDJ, Fonseca C, Martin J, Spanish Scleroderma Grp. The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes and Immunity 2012, 13(2), 191-196.
• Ciechomska M, Huigens CA, Hugle T, Gessner A, O'Reilly S, van Laar JM. Toll-like receptor-mediated expression of profibrotic tissue-inhibitor of metalloproteinase-1 by circulating monocytes in Systemic sclerosis. In: 46th Annual Scientific Meeting of the European Society for Clinical Investigation. 2012, Budapest, Hungary: Wiley-Blackwell Publishing Ltd.
• Bossini-Castillo L, Broen JCA, Simeon CP, Beretta L, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, Camps MT, Navarrete N, Gonzalez-Escribano MF, Vicente-Rabaneda E, Rodriguez L, Tolosa C, Roman-Ivorra JA, Gomez-Gracia I, Garcia-Hernandez FJ, Castellvi I, Gallego M, Fernandez-Nebro A, Garcia-Portales R, Egurbide MV, Fonollosa V, de la Pena PG, Pros A, Gonzalez-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Coenen MJH, Koeleman BP, Houssiau F, Smith V, de Keyser F, Westhovens R, De Langhe E, Voskuyl AE, Schuerwegh AJ, Chee MM, Madhok R, Shiels P, Fonseca C, Denton C, Claes K, Padykov L, Nordin A, Palm O, Lie BA, Airo P, Scorza R, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Radstake TRDJ, Martin J, Rueda B. A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Annals of the Rheumatic Diseases 2011, 70(4), 638-641.
• Carmona FD, Simeon CP, Beretta L, Carreira P, Vonk MC, Rios-Fernandez R, Espinosa G, Navarrete N, Vicente-Rabaneda E, Rodriguez-Rodriguez L, Tolosa C, Garcia-Hernandez FJ, Castellvi I, Egurbide MV, Fonollosa V, Gonzalez-Gay MA, Rodriguez-Carballeira M, Diaz-Gonzalez F, Saez-Comet L, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Shiels P, Fonseca C, Denton C, Nordin A, Palm O, Hoffmann-Vold AM, Airo P, Scorza R, Lunardi C, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Koeleman BPC, Radstake TRDJ, Martin J. Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Annals of the Rheumatic Diseases 2011, 70(11), 2050-U203.
• Hogan V, Holweg C, Kummerfeld S, Teng O, Townsend M, van Laar JM. Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab. In: Rheumatology: Annual Meeting of the British Society for Rheumatology. 2011, Brighton, UK: Oxford University Press.
• Hogan V, Holweg C, Kummerfeld S, Teng YKO, Townsend M, van Laar JM. Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab. In: Annals of the Rheumatic Diseases: 31st European Workshop for Rheumatology Research. 2011, Amsterdam, Netherlands: BMJ Group.
• Bossini-Castillo L, Simeon CP, Beretta L, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Camps MT, Rodriguez-Rodriguez L, Rodriguez-Carballeira M, Garcia-Hernandez FJ, Lopez-Longo FJ, Hernandez-Hernandez V, Saez-Comet L, Egurbide MV, Hesselstrand R, Nordin A, Hoffmann-Vold AM, Vanthuyne M, Smith V, De Langhe E, Kreuter A, Riemekasten G, Witte T, Hunzelmann N, Voskuyl AE, Schuerwegh AJ, Lunardi C, Airo P, Scorza R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Koeleman BP, Rueda B, Radstake TRDJ, Martin J, Spanish Scleroderma Grp. Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology 2011, 50(11), 1976-1981.
• Naraghi K, Booth M, Russell AJ, van Laar JM. Determination of smoking status of rheumatoid arthritis patients by means of a self-reported questionnaire and serum cotinine assay: a cross-sectional study. Annals of the Rheumatic Diseases 2011, 70(12), 2235-2236.
• Beyer C, Distler JHW, Allanore Y, Aringer M, Avouac J, Czirjak L, Cutolo M, Damjanov N, Del Galdo F, Fligelstone K, Guiducci S, Kowal-Bielecka O, van Laar JM, Martucci-Cerinic M, Muller-Ladner U, Riemekasten G, Tarner IH, Tyndall A, Kennedy AT, Valentini G, Vettori S, Walker UA, Denton C, Distler O, EUSTAR Biobanking Grp. EUSTAR biobanking: recommendations for the collection, storage and distribution of biospecimens in scleroderma research. Annals of the Rheumatic Diseases 2011, 70(7), 1178-1182.
• Gorlova O, Martin JE, Rueda B, Koeleman BPC, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJH, Voskuyl AE, Schuerwegh AJ, van Riel PLCM, Vanthuyne M, van't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, Gonzalez-Gay MA, Garcia-Hernandez FJ, Gonzalez-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, de la Pena PG, Carreira P, Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Hummers J, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TRDJ, Mayes MD, Martin J, Spanish Scleroderma Grp. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLoS Genetics 2011, 7(7), e1002178.
• Riemekasten G, Philippe A, Nather M, Slowinski T, Muller DN, Heidecke H, Matucci-Cerinic M, Czirjak L, Lukitsch I, Becker M, Kill A, van Laar JM, Catar R, Luft FC, Burmester GR, Hegner B, Dragun D. Involvement of functional autoantibodies against vascular receptors in systemic sclerosis. Annals of the Rheumatic Diseases 2011, 70(3), 530-536.
• Distler JHW, Jordan S, Airo P, Alegre-Sancho JJ, Allanore Y, Gurman AB, Caporali R, Caramaschi P, Carreira PE, Chizzolini C, Cutolo M, Duruoz MT, Farge-Bancel D, Hesselstrand R, Iannone F, De Keyser F, Kucharz EJ, Launay D, Lefebvre PGD, Lukacova O, Marasini B, Martinovic D, Neto JFM, Radic M, Rednic S, Riemekasten G, Rovensky J, Seidel MF, Senel S, Smith V, Sunderkotter C, Ton E, van Laar JM, Matucci-Cerinic M, Muller-Ladner U, Distler O, EUSTAR Study Grp. Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique. Clinical and Experimental Rheumatology 2011, 29(2), S40-S45.
• Hugle T, Schuetz P, Daikeler T, Tyndall A, Matucci-Cerinic M, Walker UA, van Laar JM. Late onset systematic sclerosis: A systematic survey of the eular scleroderma trials and research group database. In: Rheumatology: Annual Meeting of the British Society for Rheumatology. 2011, Brighton, UK: Oxford University Press.
• Hugle T, Hogan V, White KE, van Laar JM. Mast Cells Are a Source of Transforming Growth Factor beta in Systemic Sclerosis. Arthritis & Rheumatism 2011, 63(3), 795-799.
• Schouffoer AA, Zirkzee EJM, Henquet SM, Caljouw MAA, Steup-Beekman GM, van Laar JM, Vlieland TPMV. Needs and preferences regarding health care delivery as perceived by patients with systemic sclerosis. Clinical Rheumatology 2011, 30(6), 815-824.
• Hogan VE, Holweg CTJ, Choy DF, Kummerfeld S, Hackney J, Teng Y, Townsend MJ, Van Laar JM. Pretreatment Synovial Transcriptional Profile Predicts Early and Late Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab. In: Arthritis & Rheumatism: 75th Annual Scientific Meeting of the American College of Rheumatology. 2011, Chicago, Illinois, USA: John Wiley & Sons, Inc.
• Schouffoer AA, Ninaber MK, Beaart-van de Voorde LJJ, van der Giesen FJ, de Jong Z, Stolk J, Voskuyl AE, Scherptong RWC, van Laar JM, Schuerwegh AJM, Huizinga TWJ, Vlieland TPMV. Randomized Comparison of a Multidisciplinary Team Care Program With Usual Care in Patients With Systemic Sclerosis. Arthritis Care & Research 2011, 63(6), 909-917.
• Binai N, Hugle T, van Laar J. Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systematic sclerosis. In: Annals of the Rheumatic Diseases: 31st European Workshop for Rheumatology Research. 2011, Amsterdam, Netherlands: BMJ Group.
• Binai N, Huegle T, van Laar J. Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systemic sclerosis. In: Rheumatology: Annual Meeting of the British Society for Rheumatology. 2011, Brighton: Oxford University Press.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Tuck SP, Lafeber FP, Huizinga TW, Bijlsma JW, Francis RM, Datta HK, van Laar J. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis. In: Annual Meeting of the British Society for Rheumatology. 2011, Brighton, UK: Rheumatology: Oxford University Press.
• Wheater G, Hogan V, Teng Y, Tekstra J, Lafeber F, Huizinga T, Bijlsma J, Francis RM, Tuck S, Datta HK, vanLaar J. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis. Osteoporosis International 2011, 22(12), 3067-3072.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Lafeber FP, Bijlsma JWJ, Francis RM, Tuck SP, Datta HK, van Laar JM. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis. Osteoporosis International 2011, 22(12), 3067-3072.
• O'Reilly S, Huegle T, Krippner A, Van Laar J. T cell-derived IL-6 and IL-13 drive dermal fibrosis: implications for systemic sclerosis. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Gessner A, Huigens C, Stanly T, Huegle T, van Laar J. TIMP-1 production by monocytes may contribute to SSC skin fibrosis. In: Annals of the Rheumatic Diseases: 31st European Workshop for Rheumatology Research. 2011, Amsterdam, Netherlands: BMJ Group.
• Hugle T, Krippner-Heidenreich A, Simpson R, Kraaij M, O'Reilly S, Bigley V, Collin M, Iversen L, van Laar JM. Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta. In: Annals of the Rheumatic Diseases: 31st European Workshop for Rheumatology Research. 2011, Amsterdam, Netherlands: BMJ Group.
• Hügle T, Van Laar J. Allogeneic stem cell transplantation for rheumatic autoimmune diseases. F1000 Medicine Reports 2010, 2(1), 22.
• Avouac J, Walker U, Tyndall A, Kahan A, Matucci-Cerinic M, Allanore Y, Miniati I, Müller A, Iannone F, Giacomelli R, Distler O, Becvar R, Sierakowsky S, Kowal-Bielecka O, Coelho P, Cabane J, Cutolo M, Shoenfeld Y, Valentini G, Rovensky J, Riemekasten G, Nicoara I, Vlachoyiannopoulos P, Caporali R, Jiri S, Inanc M, Gorska I, Carreira P, Novak S, Czirjak L, Ramos F, Jendro M, Chizzolini C, Kucharz E, Richter J, Cozzi F, Rozman B, Mallia C, Gabrielli A, Farge D, Kiener H, Schöffel D, Sticherling M, Airo P, Wollheim F, Martinovic D, Trotta F, Hunzelmann N, Jablonska S, Reich K, Bombardieri S, Siakka P, Pellerito R, Bambara L, Morovic-Vergles J, Denton C, Hinrichs R, Van Den Hoogen F, Damjanov N, Kötter I, Ortiz V, Heitmann S, Krasowska D, Seidel M, Hasler P, Van Laar J, Kaltwasser J, Foeldvari I, Juan Mas A, Bajocchi G, Wislowska M, Pereira Da Silva J, Jacobsen S, Worm M, Graniger W, Kuhn A, Stankovic A, Cossutta R, Majdan M, Rajcevska L, Tikly M, Nasonov E, Steinbrink K, Herrick A, Müller-Ladner U, Dinc A, Scorza R, Sondergaard K, Indiveri F, Nielsen H, Szekanecz Z, Silver R, Antivalle M, Espinosa I, García De La Pena Lefebvre P, Midtvedt O, Launay D, Valesini F, Tuvik P, Ionescu R, Del Papa N, Pinto S, Wigley F, Mihai C, Capranu M, Sunderkötter C, Jun J, Derk C, Alhasani S, Distler J, Ton E, Soukup T, Seibold J, Zeni S, Nash P, Mouthon L, De Keyser F, Duruöz M, Cantatore F, Strauss G, Von Mülhen C, Pozzi M, Eyerich K, Szechinski J, Keiserman M, Houssiau F, Rom-Ivorra J, Krummel-Lorenz B, Aringer M, Westhovens R, Bellisai F, Mayer M, Stoeckl F, Üprus M, Volpe A, Buslau M, Yavuz S, Granel B, Feijó A, Del Galdo F, Popa S, Zenone T, Machado X, Pileckyte M, Stebbings S, Mathieu A, Tulli A, Tourinho T, Souza R, Acayaba De Toledo R, Stamp L, Solanki K, Veale D, Neto J, Bagnato G, Loyo E, Toloza S, Li M, Mohamed W, Cobankara V, Olas J, Salsano F, Oksel F, Tanaseanu C, Foti R, Ancuta C, Vonk M, Caramashi P, Beretta L, Balbir A, Shine B, Chiàla A, Simic K, Ghio M, Stamenkovic B, Rednic S, Host N, Pellerito R, Hachulla E, Furst D. Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. Journal of Rheumatology 2010, 37(7), 1488-1501.
• Radstake T, Gorlova O, Rueda B, Martin J, Alizadeh B, Palomino-Morales R, Coenen M, Vonk M, Voskuyl A, Schuerwegh A, Broen J, Van Riel P, Van 'T Slot R, Italiaander A, Ophoff R, Riemekasten G, Hunzelmann N, Simeon C, Ortego-Centeno N, González-Gay M, González-Escribano M, Airo P, Van Laar J, Herrick A, Worthington J, Hesselstrand R, Smith V, De Keyser F, Houssiau F, Chee M, Madhok R, Shiels P, Westhovens R, Kreuter A, Kiener H, De Baere E, Witte T, Padykov L, Klareskog L, Beretta L, Scorza R, Lie B, Hoffmann-Vold A, Carreira P, Varga J, Hinchcliff M, Gregersen P, Lee A, Ying J, Han Y, Weng S, Amos C, Wigley F, Hummers L, Nelson J, Agarwal S, Assassi S, Gourh P, Tan F, Koeleman B, Arnett F, Martin J, Mayes M. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics 2010, 42(5), 426-429.
• Schouffoer A, Ter Kuile M, Vliet Vlieland T, Van Laar J. Reply. Arthritis Care and Research 2010, 62(8), 1200-1201.
• Tyndall A, Van Laar J. Stem cells in the treatment of inflammatory arthritis. Best Practice and Research: Clinical Rheumatology 2010, 24(4), 565-574.
• Wheater G, Hogan VE, Teng YKO, Tekstra J, Tuck SP, Lafeber FP, Huizinga TWJ, Bijlsma JWJ, Francis RM, Datta HK, van Laar JM. Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis (Premier Poster-Award Candidate). In: Osteoporosis Conference. 2010, Liverpool, UK: Osteoporosis International: Springer.
• Hügle T, Huigens C, Van Laar J. New pathogenic and therapeutic concepts in systemic sclerosis. Arzneimittel-Forschung/Drug Research 2009, 59(12), 615-624.
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