People - Institute of Cellular Medicine

Dr Jelena Mann
Lecturer

Email: jelena.mann@ncl.ac.uk
Telephone: +44 (0) 191 222 3852
Fax: +44 (0) 191 222 5455
Personal Website: http://www.ncl.ac.uk/biomedicine/research/groups/liver.htm
Address: Liver Research Group
Institute of Cellular Medicine
4th Floor, Catherine Cookson Building
Medical School
Newcastle University
Newcastle-upon-Tyne
NE2 4HH

Publications

Hewitt G, Jurk D, Marques FDM, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nature Communications 2012, 3, 708.
Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. The histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology 2012, (epub ahead of print).
Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamano JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F. The NF-kappa B Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis. American Journal of Pathology 2012, 180(3), 929-939.
Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. In: Hepatology Research: Single Topic Conference on NASH. 2011, Tokyo, Japan: Wiley-Blackwell Publishing Ltd.
Perugorria M, Wilson C, Zeybel M, Amin S, Oakley F, Tsukamoto H, Mann D, Mann J. Expression profiling of epigenetic regulators identifies ASH1 as a key activator of pro-fibrogenic genes. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
Robinson SM, Mann J, Burt AD, Manas DM, Mann DA, White SA. Pathogenesis of chemotherapy associated liver injury prior to major hepatic resection. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
Zeybel M, Oakley F, Burt AD, Mann DA, Mann J. Protective adaptation to liver fibrosis in a single generation by heritable epigenetic modifications. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Maroteaux L, Mann DA. Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease. Nature Medicine 2011, 17(12), 1668-U189.
Suwara MI, Mahiba R, Borthwick LA, Mann J, Corris PA, Farrow SN, Mann DA, Fisher A. The Epithelial Alarmin, Interleukin 1 alpha (IL-1 alpha), Is a Potential Fibrogenic Factor in Bronchiolitis Obliterans Syndrome (BOS). In: Journal of Heart and Lung Transplantation: 31st Annual Meeting and Scientific Sessions on International Society for Heart and Lung Transplantation. 2011, San Diego, California, USA: Elsevier Inc.
Perugorria M, Oakley F, Mann J, Sharif O, Knapp S, Mann D. TREM-2 expression is induced during the regeneration phase of liver injury and acts as a negative regulator of neutrophillic infiltration and hepatocyte proliferation. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
Kendrick SFW, O'Boyle G, Mann J, Zeybel M, Palmer J, Jones DEJ, Day CP. Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis. Hepatology 2010, 51(6), 1988-1997.
Souslova V, Townsend PA, Mann J, van der Loos CM, Motterle A, D'Acquisto F, Mann DA, Ye S. Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NF kappa B. PLoS ONE 2010,5 3 -.
Hannigan A, Smith P, Kalna G, Lo Nigro C, Orange C, O'Brien DI, Shah R, Syed N, Spender LC, Herrera B, Thurlow JK, Lattanzio L, Monteverde M, Maurer ME, Buffa FM, Mann J, Chu DCK, West CML, Patridge M, Oien KA, Cooper JA, Frame MC, Harris AL, Hiller L, Nicholson LJ, Gasco M, Crook T, Inman GJ. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. Journal of Clinical Investigation 2010, 120(8), 2842-2857.
Mann J, Oakley F, Burt AD, Tsukamoto H, Mann D. Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Purvis HA, Stoop JN, Mann J, Woods S, Kozijn AE, Hambleton S, Robinson JH, Isaacs JD, Anderson AE, Hilkens CMU. Low-strength T-cell activation promotes Th17 responses. Blood 2010,116 23 4829-4837.
Mann J, Chu DCK, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA. MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis. Gastroenterology 2010, 138(2), 705-714.e4.
Chakraborty JB, Mann J, Oakley F, Burt AD, Mann DA. NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
O'Gorman A, Colleran A, Ryan A, Mann J, Egan LJ. Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells. American Journal of Physiology: Gastrointestinal and Liver Physiology 2010, 299(1), G96-G105.
Yang M, Chiang YM, Wang C, Mann D, Mann J, Tsukamoto H. Rosmarinic acid lifts PPAR gamma epigenetic repression and restores stellate cell quiescence via induction of MIR132 and MIR137 and suppression of MeCP2 and EZH2. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Gieling RG, Elsharkawy AM, Caamano JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA. The c-Rel Subunit of Nuclear Factor-kappa B Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation. Hepatology 2010, 51(3), 922-931.
Elsharkawy AM, Oakley F, Lin F, Packham G, Mann DA, Mann J. The NF-kappa B p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. Journal of Hepatology 2010,53 3 519-527.
Perugorria M, Oakley F, Mann J, Sharif O, Knapp S, Mann DA. TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Mann J, Tsukamoto H, Mann D. Epigenetic Relay Controls Expression of the Master Fibrogenic and Metabolic Regulator PPAR Gamma and is Essential for Actovation of Hepatic Stellate Cells. In: Journal of Hepatology: 44th Annual Meeting of the European Association for the Study of the Liver.2009,Copenhagen, Denmark:Elsevier BV
Mann J, Xu X, Oakley F, Maxwell A, Elsharkawy AM, Mann DA, Burt AD. Epigenetically Inherited Resistance to Liver Fibrosis. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases.2009,Boston, Massachusetts, USA:John Wiley & Sons, Inc.
Maxwell A, Mann DA, Mann J. Innate Immune Functions for Hepatic Stellate. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases.2009,Boston, Massachusetts, USA:John Wiley & Sons, Inc.
Mann J, Mann DA. Transcriptional regulation of hepatic stellate cells. Advanced Drug Delivery Reviews 2009, 61(7-8), 497-512.
Mann DA, Mann J. Epigenetic regulation of hepatic stellate cell activation. In: Journal of Gastroenterology and Hepatology: 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis. 2008, Kobe, Japan: Wiley-Blackwell Publishing Asia.
Parker A, Amin S, Zwiefelhofer T, Gregory B, White H, Best OG, Cross N, Mann J, Ehrich M, Oscier DG. Epigenetic Regulation of ZAP70 in Chronic Lymphocytic Leukemia. Blood 2008, 112(11), 783-784 no. 2246.
Elshorkawy AM, Mann J, Mann DA. Phosphorylation of serine 343 on the NF-kappa B P50 subunit is a pivotal regulator of inflammation. In: Hepatology: 59th Annual Meeting of the American Association for the Study of Liver Diseases.2008,San Francisco, California, USA:John Wiley & Sons, Inc.
Amin S, Parker A, Mann J. ZAP70 in chronic lymphocytic leukaemia. International Journal of Biochemistry and Cell Biology 2008, 40(9), 1654-1658.
Mann DA, Mann J. Epigenetic regulation of hepatic stellate cell activation. In: 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis. 2007, Kobe, Japan: Journal of Gastroenterology and Hepatology: Blackwell Publishing.
Kendrick S, O'Boyle G, Mann J, Jones DE, Day CP. Ethanol-induced histone acetylation: A novel mechanism for enhancement of inflammation in alcoholic hepatitis?. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, MA: Hepatology, Wiley-Blackwell.
Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death and Differentiation 2007, 14(2), 275-285.
Smart DE, Green K, Oakley F, Weitzman JB, Yaniv M, Reynolds G, Mann J, Millward-Sadler H, Mann DA. JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. Hepatology 2006, 44(6), 1432-1440.
Mann J, Patrick CN, Cragg MS, Honeychurch J, Mann DA, Harris M. Functional Analysis of HIV Type 1 Nef Reveals a Role for PAK2 as a Regulator of Cell Phenotype and Function in the Murine Dendritic Cell Line, DC2.4. Journal of Immunology 2005,175 10 6560-6569.
Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C, Ali S, Wilson SJ, Millward-Sadler H, Iredale JP, Mann DA. Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury. American Journal of Pathology 2005,166 3 695-708.
Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Vecchio GDelBlanco, Tersigni R, Alessandroni L, Mann D, Pallone F, MacDonald TT. A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. Journal of Biological Chemistry 2004,279 6 3925-32.
Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA. Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1. Journal of Biological Chemistry 2003, 278(27), 24359-24370.
Mann J, Oakley F, Johnson PW, Mann DA. CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells REGULATION BY TRAF2, AP-1, NF-κB, AND CBF1. Journal of Biological Chemistry 2002, 277(19), 17125-17138.
Smart DE, Vincent KJ, Arthur MJ, Eickelberg O, Castellazzi M, Mann J, Mann DA. JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells. Journal of Biological Chemistry 2001, 276(26), 24414-24421.
Bergeron, C., Tafese, T., Kerbl, R., Craft, A. W., Mann, J., Frappaz, D. European experience with screening for neuroblastoma before the age of 12
. In: monthsConference on Should Infants be Screened for Neuroblastoma?. 1998, Lyon, France: Medical and Pediatric Oncology: John Wiley & Sons, Inc..

Newcastle University

Institute of Cellular Medicine

Dr Jelena Mann Lecturer

Dr Jelena Mann
Lecturer