Newcastle University

Roles and Responsibilities

Faculty Postgraduate Tutor.

Qualifications

BA Biochemistry; 1st Class hons.
DPhil Immunopathology

Previous Positions

BHF Fellow
Lecturer in Transplant Immunology
Senior Lecturer in Transplant Immunology
Reader in Immunobiology

Memberships

International Transplantation Society
British Transplantation Society (elected Council member)
British Society for Immunology
Editorial Board of 'Transplantation'
Editorial Board of 'Transplant Immunology'
Scientific Advisory Committee of the ROTRF

Research Interests

Immunobiology of allograft rejection
Primary graft dysfunction
acute rejection
chronic graft failure
Chemokine function
Protein-glycosaminoglycan interactions
Immune cell chemotaxis and adhesion
T cell apoptosis
Renal tubulitis
T cell - epithelial cell interactions
CD103

Future Research

T cell memory factors; IL-15 and TGFbeta
Oral tolerance
Regulation of chemokine function

Postgraduate Supervision

>22 PhD and MD student successfully completed since 1996

Funding

Wellcome Trust
MRC
National Kidney Research Fund
British Heart Foundation
Roche Organ Transplantation Research Fund
Northern Counties Kidney Research Fund

Patents

PCT patent application registered for anti-inflammatory chemokine mutants

Postgraduate Teaching

Faculty Postgraduate Tutor - lead and teach several modules for MRes and research students and academic staff within the Graduate School. Contact the Grad. School for full details.

• O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proceedings of the National Academy of Sciences of the USA 2012, 109(12), 4598-4603.
• Gorowiec MR, Borthwick LA, Parker SM, Kirby JA, Saretzki GC, Fisher AJ. Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism. Free Radical Biology & Medicine 2012, 52(6), 1024-1032.
• Sultan J, Griffin SM, Di Franco F, Kirby JA, Shenton BK, Seal CJ, Davis P, Viswanath YKS, Preston SR, Hayes N. Randomized clinical trial of omega-3 fatty acid-supplementedenteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery. British Journal of Surgery 2012, 99(3), 305-447.
• Naemi FMA, Ali S, Kirby JA. Antibody-mediated allograft rejection: The emerging role of endothelial cell signalling and transcription factors. Transplantation Immunology 2011, 25(2-3), 96-103.
• Ciechomska M, Lennard TWJ, Kirby JA, Knight AM. B lymphocytes acquire and present intracellular antigens that have relocated to the surface of apoptotic target cells. European Journal of Immunology 2011, 41(7), 1850–1861.
• Britton KM, Kirby JA, Lennard TWJ, Meeson AP. Cancer Stem Cells and Side Population Cells in Breast Cancer and Metastasis. Cancers 2011, 3(2), 2106-2130.
• Overbeck-Zubrzycka D, Ali S, Kirby J, Lennard T. FOXP3 transcription factor regulates metastatic spread of breast cancer via control of expression of CXCR4 chemokine receptor. In: British Journal of Surgery: International Surgical Congress of the Association of Surgeons of Great Britain and Ireland. 2011, Bournemouth, UK: John Wiley & Sons Ltd.
• Hatch E, Ingham VJ, Parker L, Smith A, Kirby J, Sheerin N. Infiltrating renal T cells are activated and respond to self antigen. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Brain J, Burt AD, Kirby JA, Robertson H. Investigation of the Fate of Cholangiocytes in Cholestatic Liver Disease. In: Journal of Pathology: 199th Scientific Meeting of the Pathological Society of Great Britain and Ireland. 2011, Cambridge, UK: John Wiley & Sons Ltd.
• Kirby JA, O'Boyle G. Lung Transplantation: The Yin and Yang of Mesenchymal Stem Cells. Transplantation 2011, 92(2), 129-130.
• Walden HR, Vallance AE, Knights DPH, Karamanou DM, Fox CR, Rostron AJ, Simpson J, Kirby JA, Dark JH, Fisher A. The Alarmin HMGB1 Is an Inflammatory Mediator in Brain Death Induced Lung Damage. In: Journal of Heart and Lung Transplantation: 31st Annual Meeting and Scientific Sessions on International Society for Heart and Lung Transplantation. 2011, San Diego, California, USA: Elsevier Inc.
• Walden HR, Karamanou DM, Fox CR, Rostron AJ, Kirby JA, Simpson AJ, Dark JH, Fisher AJ. Evaluation of secretory leucoprotease inhibitor (SLPI) as an anti-inflammatroy therapy for donor lung inflammation. In: British Thoracic Society Winter Meeting. 2010, Westminster, UK: Thorax: BMJ Group.
• Vallance AE, Walden HR, Karamanou DM, Fox CR, Rostron AJ, Kirby JA, Simpson AJ, Dark JH, Fisher AJ. Investigating HMGB1 as a potential inflammatory mediator in brain death induced lung damage. In: British Thoracic Society Winter Meeting. 2010, Westminster, UK: Thorax: BMJ Group.
• Jones DEJ, Robe A, Palmer J, Kirby JA. Adoptive transfer of self-PDC reactive T-cells into naive mice induces portal tract and bile duct changes characteristic of primary biliary cirrhosis (PBC). In: 41st Annual Meeting of the European Association for the Study of the Liver. 2006, Vienna, Austria: ELSEVIER SCIENCE BV.
• Avlonitis VS, Kirby JA, Dark JH. Donor treatment with nitric oxide does not improve reperfusion injury after transplantation of lungs damaged by brain death. The Journal of Heart and Lung Transplantation 2006, 25(2), S64.
• Avlonitis VS, Rostron AJ, Kirby JA, Dark JH. The donor lung improves with time and aprotinin treatment after brain death. In: Journal of Heart and Lung Transplantation: 26th Annual Meeting and Scientific Sessions International Society for Heart and Lung Transplantation. 2006, Madrid, Spain: Elsevier Inc.
• Avlonitis VS, Kirby JA, Dark JH. Early hemodynamic lung injury during donor brain death enhances reperfusion injury after lung transplantation. In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
• Forrest IA, Murphy DM, Lordan JL, Pritchard G, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Ward C, Corris PA. Epithelial to mesenchymal transition in clinically stable lung transplant recipients. In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
• Avlonitis VS, Kirby JA, Dark JH. The effect of time from donor brain death to retrieval on reperfusion injury after lung transplantation. In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
• Macdonald P, Palmer J, Kirby JA, Jones DEJ. Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex. Clinical and Experimental Immunology 2004,136 3 559-567.
• Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA. Chronic Renal Allograft Dysfunction: The Role of T Cell-Mediated Tubular Epithelial to Mesenchymal Cell Transition. Journal of the American Society of Nephrology 2004,15 2 390-397.
• Palmer JM, Robe AJ, Burt AD, Kirby JA, Jones DEJ. Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2004,39 6 1583-1592.
• Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. Epithelial to mesenchymal transition in clinically stable lung transplantation. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Ratanamart J, Scougall KT, Kirby JA, Shaw JAM. Establishment of an in vitro bioassay for immunogenicity of bacterial lipopolysaccharide and unmethylated CpG motifs in plasmid-derived gene therapy vectors. In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc..
• Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Laboratory Investigation 2004,84 1 81-90.
• Chishti AD, Shenton BK, Kirby JA, Baudouin SV. Neutrophil chemotaxis and receptor expression in clinical septic shock. Intensive Care Medicine 2004,30 4 605-611.
• Ellis JS, Morgan CL, Kirby JA, Taylor JJ, Thomason JM. Plasma TGF-β1 as a risk factor for gingival overgrowth. Journal of Clinical Periodontology 2004,31 10 863-868.
• Macdonald P, Jones DEJ, Kirby JA. Cell-surface expression of PDC during apoptosis: A possible route for autoantigen presentation in PBC?. In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
• Dowsland, M., Harvey, J., Lennard, T.W.J., Kirby, J.A., Ali, S. Chemokines and breast cancer: A gateway to revolutionary targeted cancer treatments?. Current Medicinal Chemistry 2003. , 10(7), 579-592.
• Birraux J, Thomason JM, Kirby JA, Taylor JJ. Effects of cyclosporin A on gingival epithelial cells. In: Journal of Dental Research: 1st Annual Meeting of the International Association for Dental Research. 2003, Cardiff, UK: Sage Publications, Inc.
• Carter N, Ali S, Kirby JA. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Journal of Cell Science 2003, 116(7), 3591.
• Carter NM, Ali S, Kirby JA. Endothelial inflammation: The role of differential expression of N-deacetylease/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Journal of Cell Science 2003,116 17 3591-3600.
• Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. Nitric oxide during perfusion improves posttransplantation function of non-heart-beating donor lungs. Transplantation 2003,75 12 1960-1964.
• Atkins H, Davies BR, Kirby JA, Kelly JD. Polarisation of a T-helper cell immune response by activation of dendritic cells with CpG-containing oligonucleotides: A potential therapeutic regime for bladder cancer immunotherapy. British Journal of Cancer 2003,89 12 2312-2319.
• Robertson H, Kirby JA. Post-transplant renal tubulitis: The recruitment, differentiation and persistence of intra-epithelial T cells. American Journal of Transplantation 2003. ,3 1 3-10.
• Avlonitis VS, Fisher AJ, Kirby JA, Dark JH. Pulmonary transplantation: The role of brain death in donor lung injury. Transplantation 2003. ,75 12 1928-1933.
• Kirby JA, Bone M, Robertson H, Hudson M, Jones DEJ. The number of intraepithelial T cells decreases from ascending colon to rectum [1]. Journal of Clinical Pathology 2003. ,56 2 158-.
• Ali S, Hardy LA, Kirby JA. Transplant immunobiology: A crucial role for heparan sulfate glycosaminoglycans?. Transplantation 2003. ,75 11 1773-1782.
• Wong WK, Robertson H, Carroll H, Ali S, Kirby JA. Tubulitis in renal allograft rejection: role of TGFb and IL-15 in development and maintenance of CD103+T cells. Transplantation 2003, 75(4), 505-514.
• Wong WK, Robertson H, Carroll HP, Ali S, Kirby JA. Tubulitis in renal allograft rejection: Role of transforming growth factor-β and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells. Transplantation 2003,75 4 505-514.
• Cresswell J, Wong W, Henry MJ, Robertson H, Neal DE, Kirby JA. Adhesion of lymphocytes to bladder cancer cells: The role of the αEβ7 integrin. Cancer Immunology, Immunotherapy 2002, 51(9), 483-491.
• Wigfield CH, Golledge HDR, Shenton BK, Kirby JA, Dark JH. Ameliorated reperfusion injury in lung transplantation after reduction of brain death induced inflammatory graft damage in the donor. Journal of Heart and Lung Transplantation 2002, 21(1), 57.
• Jones DEJ, Palmer JM, Burt AD, Walker C, Robe AJ, Kirby JA. Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex. Hepatology 2002, 36(3), 679-686.
• Palmer JM, Stewart S, Kirby J, Jones D. Breakdown of tolerance is seen to both PDC-E2 and PDC-E3BP, individual antigens in primary biliary cirrhosis, in a mouse model of PDC autoreactivity. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Macdonald P, Kirby JA, Jones DE. Cell-surface expression of pyruvate dehydrogenase complex during apoptosis: A possible route for autoantigen presentation in primary biliary cirrhosis. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Robe A, Palmer J, Kirby J, Jones D. Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2002, Elsevier BV.
• Ali S, Fritchley SJ, Chaffey BT, Kirby JA. Contribution of the putative heparan sulfate-binding moif BBXB of RANTES to transendothelial migrationwth factor beta(a) expression and rejection grade. Glycobiology 2002, 12(9), 535-543.
• Ali S, Fritchley SJ, Chaffey BT, Kirby JA. Contribution of the putative heparan sulfate-binding motif BBXB of RANTES to transendothelial migration. Glycobiology 2002, 12(9), 535-543.
• Kirby J, Menzies FM, Cookson MR, Bushby K, Shaw PJ. Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease. Human Molecular Genetics 2002, 11(17), 2061-2075.
• Pettit SJ, Neal DE, Kirby JA. Evaluation of dendritic cell immunogenicity after activation and chemical fixation: A mixed lymphocyte reaction model. Journal of Immunotherapy 2002, 25(2), 152-161.
• Dowsland MH, Ali SA, Kirby JA, Lennard TWJ. Heparin blocks stromal derived factor-1 induced migration via CXCR4 in breast cancer cells. British Journal of Surgery 2002, 89(Supplement 1), 40-40.
• Wain JH, Kirby JA, Ali S. Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4. Clinical and Experimental Immunology 2002,127 3 436-444.
• French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA. T cell adhesion and cytolysis of pancreatic cancer cells: A role for E-cadherin in immunotherapy?. British Journal of Cancer 2002,87 9 1034-1041.
• French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA. T-cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy. British Journal of Surgery 2002,89 43-43.
• Palmer JM, Kirby JA, Jones DEJ. The immunology of primary biliary cirrhosis: The end of the beginning?. Clinical and Experimental Immunology 2002. ,129 2 191-197.
• Carroll HP, Ali S, Kirby JA. Accelerating the induction of Fas-mediated T cell apoptosis: A strategy for transplant tolerance?. Clinical and Experimental Immunology 2001, 126(3), 589-597.
• Chishti A, Kirby J, Baudouin SV. CXC chemokine receptor expression in severe sepsis in man. Intensive Care Medicine 2001, 27, 7.
• Cresswell J, Robertson H, Neal DE, Griffiths TRL, Kirby JA. Distribution of lymphocytes of the αEβ7 phenotype and E-cadherin in normal human urothelium and bladder carcinomas. Clinical and Experimental Immunology 2001, 126(3), 397-402.
• Jones DE, Robe AJ, Palmer JM, Kirby JA. Exploration of the immunogenicity of the primary biliary cirrhosis autoantigen pyuvate dehydrogenase complex. Hepatology 2001, 34, 730.
• Chishti AD, Dark JH, Kesteven P, Powell H, Snowden C, Shenton BK, Kirby JA, Baudouin SV. Expression of chemokine receptors CXCR1 and CXCR2 during cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 2001, 122(6), 1162-1166.
• Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. Functional assessment of non-heart-beating donor lungs: Prediction of post-transplant function. European Journal of Cardio-thoracic Surgery 2001, 20(1), 187-194.
• Bassendine MF, Palmer JM, Yeaman SJ, Kirby JA, Jones DEJ. Immunological aspects of chronic cholestatic liver diseases. In "FALK Workshop on Hepatobiliary Diseases: Cholestasis and Gallstones" pp 32-41 Eds. Acalovschi and Paumgartner Pub. Kluwer Academic Publishers<br>(Chapter) 2001.
• Balupuri S, Strong A, Hoernich N, Snowden C, Mohamed M, Manas D, Kirby J, Talbot D. Machine perfusion for kidneys: How to do it at minimal cost. Transplant International 2001, 14(2), 103-107.
• Ali S, Palmer ACV, Fritchley SJ, Maley Y, Kirby JA. Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis. Biochemical Journal 2001, 358(3), 737-745.
• Chishti A, Kirby J, Baudouin SV. Neutrophil CXC chemokine receptor expression in sepsis. In: British Journal of Anaesthesia. 2001, Oxford University Press.
• Robe AJ, Palmer JM, Kirby JA, Jones DE. No role for autoreactive antibody in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex, the autoantigen in primary biliary cirrhosis. In: Hepatology. 2001, John Wiley & Sons, Inc.
• Robertson H, Wong WK, Burt AD, Mohamed MAS, Talbot D, Kirby JA. Relationship between TGF beta(1), intratubular CD103 positive T cells and acute renal allograft rejection. Transplantation Proceedings 2001, 33(1-2), 1159-1159.
• Robertson H, Kirby JA. Renal allograft rejection: The development and function of tubulitis. Transplantation Reviews 2001, 15(3), 109-128.
• Mohammed MAS, Burt AD, Robertson H, Kirby JA, Talbot D. TGF-β expression in protocol transplant liver biopsies: a comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. Transplantation Proceedings 2001, 33(1), 1378-1380.
• Mohamed MAS, Burt A, Robertson H, Kirby JA, Talbot D. TGF-β expression in protocol transplant liver biopsies: A comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. Transplantation Proceedings 2001, 33(1-2), 1378-1380.
• Dowsland MH, Ali S, Kirby JA, Lennard TWJ. TNF-alpha affects CXCR4 gene expression and apoptosis in the breast cancer cell line MCF-7.. Clinical Cancer Research 2001, 7(11), 3758S-3758S.
• Mohamed MAS, Robertson H, Kirby J, Talbot D. Transforming growth factor-beta 1 plasma levels in stable renal allograft recipients under different immunosuppression - Response. Transplantation 2001, 71(4), 587-587.
• Robertson H, Keong Wong W, Talbot D, Burt AD, Kirby JA. Tubulitis after renal transplantation: Demonstration of an association between CD103+ T cells, transforming growth factor β1 expression and rejection grade. Transplantation 2001, 71(2), 306-313.
• Mohamed MAS, Robertson H, Booth TA, Balupuri S, Gerstenkorn C, Kirby JA, Talbot D. Active TGF-β1 expression in kidney transplantation: A comparative study of cyclosporin-A (CyA) and tacrolimus (FK506). Transplant International 2000, 13(S1), S295-S298.
• Balupuri S, Buckley P, Mohamed M, Cornell C, Mantle D, Kirby J, Manas DM, Talbot D. Assessment of non-heart-beating donor (NHBD) kidneys for viability on machine perfusion. Clinical Chemistry and Laboratory Medicine 2000, 38(11), 1103-1106.
• Yeamon SJ, Kirby JA, Jones DEJ. Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. Immunological Reviews 2000, 174(1), 238-249.
• Balupuri S, Talbot D, El-Sheikh M, Snowden C, Manas DM, Kirby J, Mantle D. Comparison of proteolytic enzymes and glutathione S-transferase levels in non-heart-beating donors' (NHBD) kidney perfusates. Clinical Chemistry and Laboratory Medicine 2000, 38(11), 1099-1102.
• Ali S, Palmer ACV, Banerjee B, Fritchley SJ, Kirby JA. Examination of the function of RANTES, MIP-1α, and MIP-1β following interaction with heparin-like glycosaminoglycans. Journal of Biological Chemistry 2000, 275(16), 11721-11727.
• Armstrong F, Kirby J, Higgins CA, Coaker J, Mathers JC. High dose Hylon VII increases tumourigenesis and decreases lymphocyte proliferation in Min mice. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Burt AD, Jones DEJ, Palmer JM, Kirby JA, Cruz DeDJ, McCaughan GW, Sedgewick JD, Yeaman SJ, Bassendine MF. Histopathology of experimental autoimmune cholangitis - a mouse model of primary biliary cirrhosis. Journal of Pathology 2000, 190, 3A-3A.
• Pettit SJ, Seymour K, O'Flaherty E, Kirby JA. Immune selection in neoplasia: towards a microevolutionary model of cancer development. British Journal of Cancer 2000, 82(12), 1900-1906.
• Bennett KM, Robertson H, Bone M, Burt AD, Kirby JA, Jones DE. Immunohistochemical analaysis of portal tract changes in experimental autoimmune cholangitis, a murine model of non-suppurative destructive cholangitis (NSDC). In: HEPATOLOGY. 2000.
• Milne DS, Moy JV, Corris PA, Robertson H, De Soyza A, Kirby JA, Cunningham AC. Intragraft Proliferating T Lymphocytes are associated with Moderate Acute Pulmonary Rejection 1. Transplantation 2000, 69(9), 1981-1984.
• Balupuri S, Mantle DM, Mohamed M, Shenton BK, Gok MA, Soomro NA, Manas DM, Kirby JA, Talbot D. Machine perfusion and viability assessment of non-heart-beating donor kidneys: A single-centre result. In: XVIII International Congress of the Transplantation Society. 2000, Rome, Italy: Transplantation Proceedings: Elsevier.
• Balupuri S, Buckley P, Mantle D, Snowden C, Cornell C, Manas DM, Kirby J, Talbot D, Laskowski IA, Tilney NL. Non-heart-beating kidney donors (multiple letters). Clinical Transplantation 2000, 14(3), 266-267.
• O'Flaherty E, Wong WK, Pettit SJ, Seymour K, Ali S, Kirby JA. Regulation of T-cell apoptosis: a mixed lymphocyte reaction model. Immunology 2000, 100(3), 289-299.
• Robertson H, Morley AR, Talbot D, Callanan K, Kirby JA. Renal allograft rejection: β-Chemokine involvement in the development of tubulitis. Transplantation 2000, 69(4), 684-687.
• Palmer JM, Doshi M, Kirby JA, Yeaman SJ, Bassendine MF, Jones DEJ. Secretory autoantibodies in primary biliary cirrhosis (PBC). Clinical and Experimental Immunology 2000, 122(3), 423-428.
• Seymour K, Pettit SJ, Kirby JA. Selection of metastatic tumour phenotypes - Reply. The Lancet 2000, 355(9204), 655-656.
• Morgan CL, Robertson H, Thomason JM, Kirby JA, Taylor JJ. TGF beta 1 in drug-induced gingival overgrowth: activation or synthesis?. In: Symposia/Behavioural Sciences & Health Services Research. 2000, Washington, USA: Sage Publications.
• Mohamed MAS, Robertson H, Booth TA, Balupuri S, Kirby JA, Talbot D. TGF-β expression in renal transplant biopsies - A comparative study between cyclosporin-A and tacrolimus. Transplantation 2000, 69(5), 1002-1005.
• Fritchley SJ, Kirby JA, Ali S. The antagonism of interferon-gamma (IFN-γ) by heparin: Examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Clinical and Experimental Immunology 2000, 120(2), 247-252.
• Gerstenkorn C, Balupuri S, Mohamed MA, Manas DM, Ali S, Kirby J, Talbot D. The impact of cytomegalovirus serology for 7-year graft survival in cadaveric kidney transplantation - The Newcastle experience. Transplant International 2000, 13(1), S372-S374.
• Cresswell J, Robertson H, Kirby JA, Neal DE. The relationship between lymphocytes of the CD103 phenotype and E-cadherin expressing bladder cancers. In: BRITISH JOURNAL OF CANCER. 2000.
• Jones DE, Robe AJ, Palmer JM, Yeaman SJ, Kirby JA. The role played by gender in breakdown of immune tolerance in experimental autoimmune cholangitis: A mouse model of primary biliary cirrhosis. In: HEPATOLOGY. 2000.
• Balupuri S, Buckley P, Snowden C, Sen MMB, Griffiths P, Hannon M, Manas D, Kirby J, Talbot D. The trouble with kidneys derived from the non heart-beating donor: A single center 10-year experience. Transplantation 2000, 69(5), 842-846.
• Bone MH, Jones DE, Kirby JA, Robertson H, Burt AD, Jawahari A, Hudson M. Ulcerative colitis: An investigation of the potential role played by a B-E(7) +VE T-cells. Gastroenterology 2000, 118(4), A1334-A1334.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA and Bassendine MA. Bacterial motif DNA as ad adjuvant for the development of autoimmunity in primary biliary cirrhosis (PBC). Gut 1999, 44, TH390.
• S. J. Pettit, S. Ali, E. O'Flaherty, T. R. L. Griffiths, D. E. Neal and J. A. Kirby. Bladder cancer immunogenicity: expression of CD80 and CD86 is insufficient to allow primary CD4(+) T cell activation in vitro. Clinical and Experimental Immunology 1999, 116, 48-56.
• Pettit S.J., Ali S., Griffiths T.R.L., Neal D.E. and Kirby J.A. Bladder cancer immunogenicity: study of the potential augmentation of specific Cd4+ T cell activation by transfection of B7-1 and B7-2. Clinical and Experimental Immunology 1999, 116, 48-56.
• Palmer J, Kirby JA, Yeaman SJ, Doshi M and Jones DE. Persistence of secratory autoantibodies in PBC patients post-liver transplant: A potential mechanism for disease recurrance?. Hepatology 1999, 30, 1261.
• K. Seymour, S. Pettit, E. O'Flaherty, R. M. Charnley and J. A. Kirby. Selection of metastatic tumour phenotypes by host immune systems. Lancet 1999, 354, 1989-1991.
• C. L. Morgan, H. Robertson, J. M. Thomason, J. A. Kirby and J. J. Taylor. TGF-beta 1 associated with gingival overgrowth in transplant patients medicated with cyclosporin A. Journal of Dental Research 1999, 78, 1064-1064.
• M. A. S. Mohamed, M. Walmsley, H. Robertson, J. A. Kirby and D. Talbot. The effect of cyclosporin A and tacrolimus on cultured human epithelial cells: The role of TGF-beta. Transplantation Proceedings 1999, 31, 1173-1173.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA, Bassendine MF and Burt AD. The time course of bile duct lesion development in experimental autoimmune cholangitis (A mouse model of primary biliary cirrhosis-PBC). Hepatology 1999, 30, 630.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA, Bassendine MF and Burt AD. The time-course of bile duct lesion development in experimental autoimmune cholangitis (a mouse model of primary biliary cirrhosis-PBC). Hepatology 1999, 30, 1614.
• S. J. Pettit, E. O'Flaherty, S. Ali, T. R. L. Griffiths, D. E. Neal and J. A. Kirby. Antigen presentation and induction of lymphocyte apoptosis by a transitional cell carcinoma line. British Journal of Cancer 1998, 78, P52.
• H. Robertson, J. Wheeler, A. R. Morley, T. A. Booth, D. Talbot and J. A. Kirby. beta-chemokine expression and distribution in paraffin-embedded transplant renal biopsy sections: analysis by scanning laser confocal microscopy. Histochemistry and Cell Biology 1998, 110, 207-213.
• Jones DEJ, Palmer JM, Yeaman SJ, Kirby JA and Bassendine MF. Breakdown cholangitis (EAC), a murine model of primary biliary cirrhosis. Hepatology 1998, 28, 963.
• Zhang J.G., Walmsley M.W., Moy J.V., Cunningham A.C., Talbot D., Dark J.H. and Kirby J.A. Differential effects of cyclosporin A and tacrolimus on the production of TGF-beta: implication for the development of obliterative bronchiolitis after lung transplantation. Transplant International 1998, 11910, S325-327.
• E. O'Flaherty, S. Ali, S. J. Pettit and J. A. Kirby. Examination of the sensitivity of T cells to Fas ligation - Induction of allospecific apoptosis. Transplantation 1998, 66, 1067-1073.
• I. E. Nichol, S. M. Plusa, C. Marshall, J. Kirby, B. K. Shenton and J. S. Varma. Proinflammatory effects of colitic mucosa on neutrophil adhesion. British Journal of Surgery 1998, 85, 13-13.
• Palmer JM, Jones DEJ, Doshi M, Yeaman SJ, Bassendine MF and Kirby JA. Secretory IgA anti-PDC in saliva in primary biliary cirrhosis: A novel mechanism for tissue damage?. Hepatology 1998, 28, 1513.
• Robertson H., Morley A. and Kirby J.A. Study of chemokine expression in rejecting renal allograft tissue by confocal microscopy. Histochem Cell Biol 1998, 110, 207-213.
• I. E. Nichol, S. M. Plusa, J. Kirby, B. K. Shenton, D. A. Browell, W. J. Cunliffe and J. S. Varma. The role of interleukin - 8 in the inflammatory response of ulcerative colitis. Gut 1998, 42, TW189.
• A. C. Cunningham, J. G. Zhang, J. V. Moy, S. Ali and J. A. Kirby. A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cells. Immunology 1997, 91, 458-463.
• C. Marshall, L. Gray, D. Lambert, B. Shenton, S. M. Plusa and J. A. Kirby. A novel flow-cytometric assay to assess neutrophil adhesion in whole blood. Biochemical Society Transactions 1997, 25, 740-743.
• S. C. Clark, J. H. Dark and J. A. Kirby. An assay of neutrophil adhesion to fibronectin and its attenuation by pentoxifylline and nitric oxide. Biochemical Society Transactions 1997, 25, S199-S199.
• M. S. Douglas, D. A. Rix and J. A. Kirby. Antigen presentation by endothelium: heparin reduces the immunogenicity of interferon-gamma-treated endothelial cells. Transplant Immunology 1997, 5, 233-235.
• M. S. Douglas, D. A. Rix, A. Larnkjaer, J. H. Dark, D. Talbot and J. A. Kirby. Blockade of the interaction between interferon-gamma and endothelial glycosaminoglycans: A novel strategy for immunosuppression?. Transplantation Proceedings 1997, 29, 1086-1088.
• J. A. Kirby, M. P. Leon, M. S. Douglas and D. A. Rix. Development of a flow-cytometric assay to identify and quantify lymphocytes that bind to endothelial and epithelial cells. Biochemical Society Transactions 1997, 25, 736-740.
• D. A. Rix, M. S. Douglas, M. P. Leon, S. Ali, D. Talbot and J. A. Kirby. Endothelial cells: Heparin modulates the induction of functional antigen presentation by IFN-gamma. Biochemical Society Transactions 1997, 25, S195-S195.
• M. S. Douglas, S. Ali, D. A. Rix, J. G. Zhang and J. A. Kirby. Endothelial production of MCP-1: modulation by heparin and consequences for mononuclear cell activation. Immunology 1997, 92, 512-518.
• Douglas M.S., Ali S., Rix D.A., Zhang J.G. and Kirby J.A. Endothelial production of MCP-1: modulation by heparin and consequences for mononuclear cell activation. Immunology 1997, 92, 512-518.
• M. S. Douglas, D. A. Rix, J. H. Dark, D. Talbot and J. A. Kirby. Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN- gamma). Clinical and Experimental Immunology 1997, 107, 578-584.
• M. S. Douglas, J. G. Zhang, D. A. Rix, J. V. Moy and J. A. Kirby. Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Biochemical Society Transactions 1997, 25, S194-S194.
• M. P. Leon, M. F. Bassendine, P. Gibbs, M. Thick and J. A. Kirby. Immunogenicity of biliary epithelium: Study of the adhesive interaction with lymphocytes. Gastroenterology 1997, 112, 968-977.
• S. C. Clark, B. K. Shenton, J. H. Dark and J. A. Kirby. An assay of neutrophil adhesion to fibronectin and its attenuation by pentoxifylline. Immunology 1996, 89, WI417-WI417.
• A. C. Cunningham, J. G. Zhang, J. V. Moy and J. A. Kirby. Can alveolar epithelial cells activate CD4+ lymphocytes?. Immunology 1996, 89, OJ100-OJ100.
• M. P. Leon, J. A. Kirby, P. Gibbs, M. Thick and M. F. Bassendine. Cytotoxic immune lysis of human intrahepatic biliary epithelial cells: Modulation by ICAM-1 blockade. Hepatology 1996, 23, T41-T41.
• L. V. P. Korlipara, M. P. Leon, D. A. Rix, M. S. Douglas, P. Gibbs, M. F. Bassendine and J. A. Kirby. Development of a flow cytometric assay to quantify lymphocyte adhesion to cytokine-stimulated human endothelial and biliary epithelial cells. Journal of Immunological Methods 1996, 191, 121-130.
• J. A. Kirby, M. P. Leon, M. S. Douglas and D. A. Rix. Development of a flow cytometric assay to quantify lymphocyte adhesion to endothelial and epithelial cells. Immunology 1996, 89, SI35-SI35.
• M. R. Azari, F. M. Williams, J. Kirby, P. Kelly, J. W. Edwards and P. G. Blain. Effects of nitrogen oxides on natural killer cells in glass craftsmen and braziers. Occupational and Environmental Medicine 1996, 53, 248-251.
• D. A. Rix, M. S. Douglas, M. P. Leon, S. Ali, D. Talbot and J. A. Kirby. Endothelial cells: Heparin modulates the induction of functional antigen presentation by IFN-gamma. Immunology 1996, 89, ORH2-ORH2.
• M. S. Douglas, J. G. Zhang, D. A. Rix, J. V. Moy and J. A. Kirby. Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Immunology 1996, 89, ORH1-ORH1.
• Leon M.P., Bassendine M.F., Thick M., Gibbs P., Burt A.D. and Kirby J.A. Hepatic allograft rejection: regulation of the immunogenicity of human intrahepatic biliary epithelial cells. J Liver Transpl and Surg 1996, 2, 37-45.
• M. P. Leon, M. F. Bassendine, J. L. Wilson, S. Ali, M. Thick and J. A. Kirby. Immunogenicity of biliary epithelium: Investigation of antigen presentation to CD4(+) T cells. Hepatology 1996, 24, 561-567.
• Bliss R, Kirby J, Browell D, Lennard TWJ. Inhibition of endothelial adhesion and invasion by breast carcinoma cells may contribute towards the anti-metastatic effects of tamoxifen. European Journal of Surgical Oncology 1996, 22(1), 27-33.
• C. Marshall, D. Lambert, S. M. Plusa, J. A. Kirby and B. K. Shenton. Intravascular adhesion: A novel assay to assess binding by neutrophils in whole blood. Immunology 1996, 89, SI36-SI36.
• M. P. Leon, M. F. Bassendine, J. Wilson, P. Gibbs, M. Thick and J. A. Kirby. Mixed biliary lymphocyte culture: Allostimulation of CD4(+) T cells by human intrahepatic biliary epithelial cells. Hepatology 1996, 23, T40-T40.
• H. Robertson, J. Wheeler, J. A. Kirby and A. R. Morley. Renal allograft rejection - In situ demonstration of cytotoxic intratubular cells. Transplantation 1996, 61, 1546-1549.
• D. A. Rix, M. S. Douglas, D. Talbot, J. H. Dark and J. A. Kirby. Role of glycosaminoglycans (GAGs) in regulation of the immunogenicity of human vascular endothelial cells. Clinical and Experimental Immunology 1996, 104, 60-65.