Newcastle University

Introduction

My research programme focuses upon the integrity of the autonomic nervous system in health and disease, specifically the role of autonomic dysfunction in the pathogenesis of fatigue and its clinical consequences, namely cognitive impairment. Examining the integrity of the ANS in humans is established in my physiology laboratory using relatively simple, inexpensive, non-invasive technologies that allow evaluation of a wide range of parameters that will within the foreseeable future (i.e. in my career life time) be readily transferable into therapeutic interventions for patients. Developing and validating novel methodologies to determine subtle abnormalities in autonomic dysfunction and its consequences is the major aim of my research.

Background

March 2008 to date: Clinical Professor of Ageing and Medicine, Institute for Ageing and Health, Newcastle University and Honorary Consultant Physician, Royal Victoria Infirmary.

Roles and Responsibilities

Member of NTW CLRN Executive Board with responsibility for training
Director of the Integrated Academic Training Programme
Programme lead for Academic Clinical Fellowship Programme (Geriatric Medicine).
Academic Foundation Programme Mentor.
Chair and founding member of the Fatigue Interest group.

Qualifications

MB BS with Honours: June 1990
Diploma of Medical Science: July 1995
PhD: July 1998
CCST Geriatric Medicine and General Internal Medicine: April 2000
FRCP(UK): January 2003

Previous Positions

March 2006 to March 2008: Senior Lecturer and Honorary Consultant Physician

January 2000 to March 2006: Consultant Geriatrician, Royal Victoria Infirmary, Newcastle and Honorary Senior Lecturer in General and Geriatric Medicine, University of Newcastle.
August 1998 to January 2000: Specialist Registrar in Geriatric and General Internal Medicine, Northern Deanery.
August 1995 to August 1998: Clinical Research Associate, Department of Physiological Sciences, University of Newcastle.

Memberships

Full member of the British Geriatric Society
Full member of the British Society of Gastroenterology
Full member of the British Association for the Study of the Liver
Full member of the British Association for Parenteral and Enteral Nutrition
Secretary of the British Geriatric Society Special Interest Group in Gastroenterology and Nutrition.
Full member of the British Association for Parentral and Enteral Nutrition.
Member of the Association of Physicians of Region No 1
Fellow of the Royal College of Physicians

Honours and Awards

Sunderland Prize 1989 for communication skills.
British Geriatric Society Elizabeth Brown prize 1997 for the best scientific presentation.
Prize for the best scientific paper at the First International Meeting of Upper Gastrointestinal Disease in the Elderly, Vicenza, Italy, 1998.
Winner of Best Scientific Presentation at School Research Day 1999.
Best Poster Prize, British Geriatrics Society Meeting 2002.
European Association for the Study of the Liver, Travel Fellowship, 2002.

Vice Chancellors Distinguished Teacher 2010

Newcastle University Innovation Award 2010 

Newcastle University Learning and teaching Excellence Awards - Research Supervisor of the Year 2012 

Research Interests

Autonomic function in health and disease, particularly in understanding the pathogenesis of fatigue.

Other Expertise

MAJOR RESEARCH ACHIEVEMENTS TO DATE
a) To describe for the first time the role of autonomic dysfunction in the pathogenesis of fatigue in PBC.
b) To identify excessive daytime sleepiness as a cause of fatigue in patients with PBC, and for the first time to be able to offer patients an effective intervention.
c) To confirm that autonomic dysfunction is prevalent in CFS/ME and has potential as a diagnostic biomarker in this disease.
d) To confirm that cognitive impairment is associated with fatigue in PBC and that this is related to autonomic dysfunction, therefore offering the potential for early identification and intervention for those at risk of cognitive decline.

Current Work

i) The role of autonomic dysfunction in the pathogenesis of fatigue in PBC and other liver diseases.
ii) The role of autonomic dysfunction in the pathogenesis of cognitive impairment in Primary Biliary Cirrhosis
iii) The role of inflammation in the pathogenesis of fatigue -
iv) The relative contributions of central and peripheral mechanisms to the pathogenesis of fatigue in PBC
v) Peripheral manifestations of autonomic dysfunction in PBC
vi)The role of autonomic function and psychological factors in the fatigue of PBC
vii) The role of autonomic dysfunction in the pathogenesis and severity of fatigue in CFS/ME
viii) The prevalence of autonomic dysfunction and its role in the pathogenesis of fatigue in Parkinson’s Disease (PD)

For information about fatigueLAB visit the website Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 www.fatiguelab.org

Research Roles

Until recently - Degree Programme Director Certificate of Clinical Research

Director Integrated Academic Training Programme 

Postgraduate Supervision

Victoria Ewan registered PhD

Claire McDonald registered PhD 

Gulnar Fattakhova registered PhD

Lisa Robinson registered PhD

Chris Elliott registered PhD

Projects

• Understanding Muscle Dysfunction in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome.
  Project Leader(s): Dr Phillip Manning, Professor Julia Newton
  

  This research is funded by Action for ME and the Newcastle NIHR Biomedical Research Centre in Ageing and Age-Related Disease.

Postgraduate Teaching

Until recently - Degree Programme Director for the Masters in Clinical Research
Director of the Academic Clinical Fellowship and Clinical Lecturer Programme

Module lead for Diploma module of the Masters in Clinical Research - Designing your own research proposal

Lead for the CPD module 'Research Skills for Health Care Professionals 

• Payne BAI, Hateley CL, Ong ELC, Premchand N, Schmid ML, Schwab U, Newton JL, Price DA. HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?. HIV Medicine 2013, 14(4), 247-251.
• Anderson K, Jones DEJ, Wilton K, Newton JL. Restless leg syndrome is a treatable cause of sleep disturbance and fatigue in primary biliary cirrhosis. Liver International 2013, 33(2), 239-243.
• Carbone M, Mells GF, Pells G, Dawwas MF, Newton JL, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, Sandford RN, Alexander GJ, Jones DEJ, UK PBC Consortium. Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid. Gastroenterology 2013, 144(3), 560-569.
• Hatton AL, Dixon J, Rome K, Newton JL, Martin DJ. Altering gait by way of stimulation of the plantar surface of the foot: the immediate effect of wearing textured insoles in older fallers. Journal of Foot and Ankle Research 2012, 5(s1), 11.
• Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C, Andrews J, Emery P, Hunter J, Gupta M, Vadivelu S, Giles I, Isenberg D, Lanyon P, Jones A, Regan M, Cooper A, Moots R, Sutcliffe N, Bombardieri M, Pitzalis C, McLaren J, Young-Min S, Dasgupta B, Griffiths B, Lendrem D, Mitchell S, Ng WF, UK Primary Sjogrens Syndrome. Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. Annals of the Rheumatic Diseases 2012, 71(12), 1973-1979.
• McDonald C, Pearce M, Newton J, Kerr S. Bood pressure variability is associated with cognitive impairment in community dwelling older persons and is a predictor of cognitive decline. In: 8th World Congress on Aging and Physical Activity: A Celebration of Diversity and Inclusion in Active Ageing. 2012, Glasgow, UK: Human Kinetics.
• Hollingsworth KG, Macgowan GA, Morris L, Bates MG, Taylor R, Jones DE, Newton JL, Blamire AM. Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study. Journal of Applied Physiology 2012, 112(12), 2043-2048.
• Allen J, Murray A, Di Maria C, Newton JL. Chronic fatigue syndrome and impaired peripheral pulse characteristics on orthostasis-a new potential diagnostic biomarker. Physiological Measurement 2012, 33(2), 231-241.
• Frith J, Fattakhova G, Jones DEJ, Henderson E, Wilton K, Day CP, Newton JL. Cognitive impairment in non-cirrhotic chronic liver disease is unrelated to liver disease severity but associated with ineffective baroreflex function. Gut 2012, 61(7), 1101-1103.
• Frith J, Watson S, Maggs PHBB, Newton JL. Cognitive symptoms are common in immune thrombocytopenia and associate with autonomic symptom burden. European Journal of Haematology 2012, 88(3), 224-228.
• Raftery G, He JB, Pearce R, Birchall D, Newton JL, Blamire AM, Isaacs JD. Disease activity and cognition in rheumatoid arthritis: an open label pilot study. Arthritis Research & Therapy 2012, 14(6), R263.
• Frith J, Reeve P, Newton J. Establishing baseline systolic blood pressure when diagnosing orthostatic hypotension. In: Age and Ageing: British Geriatrics Society Autumn Meeting. 2012, Brighton: Oxford University Press.
• Frith J, Kerr S, Robinson L, Elliott CS, Wilton K, Jones DEJ, Day CP, Newton JL. Falls and Fall-Related Injury Are Common in Older People with Chronic Liver Disease. Digestive Diseases and Sciences 2012, 57(10), 2697-2702.
• Hester KL, Macfarlane JG, Tedd H, Jary H, McAlinden P, Rostron L, Small T, Newton JL, De Soyza A. Fatigue in bronchiectasis. Quarterly Journal of Medicine 2012, 105(3), 235-240.
• Hale M, Newton JL, Jones DEJ. Fatigue in primary biliary cirrhosis. British Medical Journal 2012, 345(1), e7004.
• Frith J, Zalewski P, Klawe JJ, Pairman J, Bitner A, Tafil-Klawe M, Newton JL. Impaired blood pressure variability in chronic fatigue syndrome- a potential biomarker. QJM 2012, 105(9), 831-838.
• Hollingsworth KG, Hodgson T, Macgowan GA, Blamire AM, Newton JL. Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging. Journal of Internal Medicine 2012, 271(3), 264-270.
• Hackett KL, Newton JL, Frith J, Elliott C, Lendrem D, Foggo H, Edgar S, Mitchell S, Ng F. Impaired functional status in primary Sjogren's syndrome. Arthritis Care & Research 2012, 64(11), 1760-1764.
• Hackett K, Newton J, Ng WF. Occupational therapy: a potentially valuable intervention for people with primary Sjogren's syndrome. British Journal of Occupational Therapy 2012, 75(5), 247-249.
• Ng WF, Stangroom AJ, Davidson A, Wilton K, Mitchell S, Newton JL. Primary Sjogrens syndrome is associated with impaired autonomic response to orthostasis and sympathetic failure. QJM 2012, 105(12), 1191-1199.
• Robinson L, Newton J, Dawson P. Professionals and the public: power or partnership in health research?. Journal of Evaluation in Clinical Practice 2012, 18(2), 276-282.
• Patanwala I, Walton R, Mells G, Newton J, Alexander G, Hudson M, Jones D. The clinical impact of varices and a new externally validated non-invasive inexpensive tool to predict their presence in patients with PBC. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Collerton J, Kingston A, Bond J, Davies K, Eccles MP, Jagger C, Kirkwood TBL, Newton JL. The Personal and Health Service Impact of Falls in 85 Years Olds: Cross-Sectional Findings from the Newcastle 85+ Cohort Study. PLoS One 2012, 7(3), e33078.
• Tullo E, Newton J, Clapp A. What can e-learning offer geriatric medicine in the UK?. Reviews in Clinical Gerontology 2012, 22(3), 235-242.
• Patanwala I, Walter R, Mells GF, Kometa S, Newton JL, Alexander GJ, Hudson M, Jones DE. An externally-validated clinical tool for the prediction of gastro-oesophageal varices in patients with PBC - the Newcastle varices in PBC (NVP) score. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
• Jones D, Patanwala I, Newton J. Comparison of the PBC-40 and PBC-27 tools for quality of life assessment in English speaking primary biliary cirrhosis patients. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, UK: BMJ Group.
• Newton JL, Reese JA, Watson SI, Vesely SK, Bolton-Maggs PHB, George JN, Terrell DR. Fatigue in adult patients with primary immune thrombocytopenia. European Journal of Haematology 2011, 86(5), 420-429.
• Jones DEJ, Gray J, Frith J, Newton JL. Fatigue severity remains stable over time and independently associated with orthostatic symptoms in chronic fatigue syndrome: a longitudinal study. Journal of Internal Medicine 2011, 269(2), 182-188.
• Newton JL, Elliott C, Frith J, Ghazala C, Pairman J, Jones DEJ. Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms. European Journal of Gastroenterology and Hepatology 2011, 23(7), 566-572.
• Patanwala I, Walter R, Newton JL, Hudson M, Jones DE. Morbidity and mortality associated with varices in patients with primary biliary cirrhosis. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
• Newton JL, Pairman J, Hallsworth K, Moore S, Ploetz T, Trenell MI. Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation. QJM 2011, 104(8), 681-687.
• Newton J, Powell D, Mitchell S, Griffiths B, Bowman S, Ng WF, UK Primary Sjogren's Syndrome. Potentially treatable symptoms in primary Sjogren's Syndrome - Associated fatigue. In: Rheumatology: Annual Meeting of the British Society for Rheumatology. 2011, Brighton, UK: Oxford University Press.
• Elliott C, Frith J, Pairman J, Jones DEJ, Newton JL. Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls. Transplant International 2011, 24(6), 588-595.
• Jones D, Newton J. Reply to: Do fatigue and UDCA therapy truly have independent effects on mortality in PBC?. Journal of Hepatology 2011, 55(3), 729-730.
• McDonald C, Frith J, Newton JL. Single centre experience of ivabradine in postural orthostatic tachycardia syndrome. Europace 2011, 13(3), 427-430.
• Jones DEJ, Newton JL. The Complexity of Fatigue. Hepatology 2011, 53(2), 717-718.
• Jones DE, Al-Rifai A, Frith J, Patanwala I, Newton JL. The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9 year cohort follow-up (vol 53, pg 911, 2010) [Corrigendum]. Journal of Hepatology 2011, 55(3), 737.
• Hardy T, MacDonald C, Jones DEJ, Newton JL. A follow-up study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Liver International 2010, 30(10), 1551-1552.
• Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL. Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. Journal of Internal Medicine 2010, 267(4), 394-401.
• McDonald C, Newton J, Lai HM, Baker SN, Jones DE. Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms. Journal of Hepatology 2010, 53(6), 1095-1100.
• Ewan V, Perry JD, Mawson T, McCracken G, Brown AN, Newton J, Walls A. Detecting potential respiratory pathogens in the mouths of older people in hospital. Age and Ageing 2010, 39(1), 122-125.
• Reese JA, Newton J, Watson S, Vesely SK, Maggs PB, George JN, Terrell D. Documentation of Fatigue In Patients with Immune Thrombocytopenic Purpura (ITP) and Its Association with Autonomic Dysfunction. In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
• Reese JA, Newton J, Watson S, Vesely SK, Bolton-Maggs P, George JN, Terrell D. Documentation of Fatigue In Patients with Immune Thrombocytopenic Purpura (ITP) and Its Association with Autonomic Dysfunction. In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
• Newton JL, Marsh A, Frith J, Parry S. Experience of a rapid access blackout service for older people. Age and Ageing 2010, 39(2), 265-268.
• Frith J, Newton J. Fatigue impact scale. Occupational Medicine 2010, 60(2), 159.
• Macfarlane JG, Tedd H, McAlinden P, Small T, Rostron L, Newton J, De Soyza A. Fatigue in bronchiectasis: Its relationship to pseudomonas colonisation, dyspnoea and airflow obstruction. In: Thorax: British Thoracic Society Winter Meeting. 2010, Westminster, UK: BMJ Group.
• Sutcliffe K, Gray J, Tan MP, Pairman J, Wilton K, Parry SW, Newton JL. Home orthostatic training in chronic fatigue syndrome - a randomized, placebo-controlled feasibility study. European Journal of Clinical Investigation 2010, 40(1), 18-24.
• Tan MP, Newton JL, Chadwick TJ, Gray JC, Nath S, Parry SW. Home orthostatic training in vasovagal syncope modifies autonomic tone: results of a randomized, placebo-controlled pilot study. Europace 2010, 12(2), 240-246.
• Jones DEJ, Hollingsworth K, Fattakhova G, MacGowan G, Taylor R, Blamire A, Newton JL. Impaired cardiovascular function in primary biliary cirrhosis. American Journal of Physiology: Gastrointestinal and Liver Physiology 2010, 298(5), G764-G773.
• Hollingsworth KG, Jones DEJ, Taylor R, Blamire AM, Newton JL. Impaired cardiovascular response to standing in Chronic Fatigue Syndrome. European Journal of Clinical Investigation 2010, 40(7), 608-615.
• Hollingsworth KG, Jones DEJ, Taylor R, Frith J, Blamire AM, Newton JL. Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline. Liver International 2010, 30(6), 878-885.
• Hollingsworth KG, Newton JL, Patanwala I, Taylor R, Blamire AM, Jones DE. Impaired subendocardial myofibre in primary biliary cirrhosis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Frith J, Newton JL. Liver disease in older women. Maturitas 2010, 65(3), 210-214.
• Frith J, Elliott C, Pairman J, Patanwala I, Jones DE, Newton JL. Liver transplantation is not associated with significant improvement in functional ability or symptoms. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Hollingsworth KG, Newton JL, Robinson L, Taylor R, Blamire AM, Jones DEJ. Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis. Journal of Hepatology 2010, 53(1), 155-161.
• Newton JL, Jones DEJ. Making sense of fatigue. Occupational Medicine 2010, 60(5), 326-329.
• Elliott C, Frith J, Newton J. Occupational therapy in chronic liver disease: a preliminary study to explore the views of occupational therapists and physicians working in the acute medical setting. British Journal of Occupational Therapy 2010, 73(3), 116-120.
• Costigan A, Elliott C, McDonald C, Newton JL. Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management. QJM: An International Journal of Medicine 2010, 103(8), 589-595.
• Costigan A, Elliott C, McDonald C, Newton J. Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: Implications for management. QJM 2010, 103(8), 589-595.
• McLure S, Willis M, Fox A, Newton J, Hirst B. Postgraduate opportunities in research at NEAS. Journal of Paramedic Practice 2010, 2(5), 230-232.
• Frith J, Day C, Robinson L, Elliott C, Jones D, Newton J. Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease. Journal of Hepatology 2010, 52(1), 112-116.
• Frith J, Kerr S, Robinson L, Elliott C, Ghazala C, Wilton K, Pairman J, Jones D, Newton J. Primary biliary cirrhosis is associated with falls and significant fall related injury. QJM 2010, 103(3), 153-161.
• Newton J, Jones D. Reply. Occupational Medicine 2010, 60(8), 666-667.
• Frith J, Newton JL. Response: Primary biliary cirrhosis is associated with falls and significant fall related injury. QJM: an International Journal of Medicine 2010, 103(6), 438-439.
• Frith J, Newton JL. Response: Primary biliary cirrhosis is associated with falls and significant fall related injury. QJM 2010, 103(6), 438-439.
• Fletcher EH, Johnston DE, Fisher CR, Koerner RJ, Newton JL, Gray CS. Systematic review: Helicobacter pylori and the risk of upper gastrointestinal bleeding risk in patients taking aspirin. Alimentary Pharmacology and Therapeutics 2010, 32(7), 831-839.
• Newton J. Systemic symptoms in non-alcoholic fatty liver disease. Digestive Diseases 2010, 28(1), 214-219.
• Jones DE, Al-Rifai A, Frith J, Patanwala I, Newton JL. The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9 year follow-up. Journal of Hepatology 2010, 53(5), 911-917.
• Newton J, Mabillard H, Scott A, Hoad A, Spickett G. The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same. Journal of the Royal College of Physicians Edinburgh 2010, 40(4), 304-307.
• Newton J, Jones DEJ. Variability of perceived fatigue in primary biliary cirrhosis: implications for symptom assessment. Liver International 2010, 30(2), 334.
• Duncan GW, Tan MP, Newton JL, Reeve P, Parry SW. Vasovagal syncope in the older person: differences in presentation between older and younger patients. Age and Ageing 2010, 39(4), 465-470.
• Jones DE, McDonald C, Newton JL. A Efficacy and Tolerability of Modafinil for the Treatment of Daytime Somnolence and Fatigue in Primary Biliary Cirrhosis. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Tan MP, Newton JL, Chadwick TJ, Nath S, Parry SW. A Randomized Placebo Controlled Pilot Study to Establish the Length of Training for Home Orthostatic Training in Vasosagal Syncope. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
• Newton J, Day CP. Authors' response. Gut 2009, 58(1), 150-.
• Frith J, Newton JL. Autonomic dysfunction in chronic liver disease. Liver International 2009, 29(4), 483-489.
• Hollingsworth K, Newton J, Blamire A, Taylor R, Jones D. Cardiac Muscle Bioenergetic Abnormality in Primary Biliary Cirrhosis (PBC). In: Journal of Hepatology: 44th Annual Meeting of the European Association for the Study of the Liver. 2009, Copenhagen, Denmark: Journal of Hepatology.
• Frith J, Jones D, Newton JL. Chronic liver disease in an ageing population. Age and Ageing 2009, 38(1), 11-18.
• Fattakhova GE, Jones DE, Frith J, Day CP, Newton JL. Cognitive Symptoms and Prevalent in Non-Alcoholic Fatty Liver Disease (NAFLD) and Unrelated to the Severity of Liver Disease. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Fletcher EH, Newton JL, Gray CS. Commencing antiplatelet therapy in older people after an acute ischaemic stroke. Age and Ageing 2009, 38(2), 142-144.
• Walker LJ, Newton J, Jones DEJ, Bassendine MF. Comment on Biochemical Response to Ursodeoxycholic Acid and Long-Term Prognosis in Primary Biliary Cirrhosis. Hepatology 2009, 49(1), 337-337.
• Newton JL, Pairman J, Wilton K, Jones DEJ, Day C. Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease. Clinical Autonomic Research 2009, 19(6), 319-326.
• Newton J, Brown A, Sheerin NS. Fatigue in early renal disease. British Journal of Renal Disease 2009, 14(2).
• Newton J, Day CP. Fatigue in non-alcoholic fatty liver disease: is there a role for hypothyroidism Response. Gut 2009, 58(1), 150-150.
• Al-Rifai A, Prince MI, Henderson E, Jones DE, Newton JL, Hudson M. Fatigue in PSC Patients With and Without Inflammatory Bowel Disease. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Hollingsworth KG, Jones DE, Aribisala BS, Thelwall PE, Taylor R, Newton JL, Blamire AM. Globus pallidus magnetisation transfer ratio, T1 and T2 in primary biliary cirrhosis: relationship with disease stage and age. Journal of Magnetic Resonance Imaging 2009, 29(4), 780-784.
• Parry SW, Norton M, Pairman J, Baptist M, Wilton K, Reeve P, Sutcliffe K, Newton JL. Impedance cardiography: a role in vasovagal syncope diagnosis?. Age and Ageing 2009, 38(6), 718-723.
• Flint B, Baker C, Freeston M, Newton JL. Level of psychosocial impairment predicts early response to treatment in vasovagal syncope. Europace 2009, 11(2), 231-236.
• Frith J, Newton J. Liver disease in older people. CME Journal Geriatric Medicine 2009, 11(3), 110-114.
• Frith J, Newton J. Liver transplantation in more elderly age. Transplant International 2009, 22(6), 599-600.
• Frith J, Newton J. Liver transplantation in more elderly age: Invited Commentary on Schmitt et al. Transplant International 2009, 22(6), 599-600.
• Hollingsworth KG, Newton JL, Blamire A, Taylor R, Jones DE. Loss of Capacity to Recover from Acidosis on Repeat Exercise is Strongly Associated with Fatigue in Primary Biliary Cirrhosis (PBC). In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA, Jones DEJ. Lower Ambulatory Blood Pressure in Chronic Fatigue Syndrome. Psychosomatic Medicine 2009, 71(3), 361-365.
• Frith J, Newton J. Managing abnormal liver blood tests in older people. Geriatrics and Aging 2009, 12(6), 295-300.
• Stevens S, Allen J, Murray A, Jones D, Newton J. Microvascular optical assessment confirms the presence of peripheral autonomic dysfunction in primary biliary cirrhosis. Liver International 2009, 29(10), 1467-1472.
• Frith J, Robinson L, Wilton K, Day CP, Newton JL. Non-Alcohlic Fatty Liver Disease is Associated with Recurrent Falls and Significant Injury. In: Hepatology: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Frith J, Day CP, Henderson E, Burt AD, Newton JL. Non-Alcoholic Fatty Liver Disease in Older People. Gerontology 2009, 55(6), 607-613.
• Elliott C, Newton J. Occupational therapy in chronic liver disease: A gap in service delivery. British Journal of Occupational Therapy 2009, 72(3), 133-136.
• Jones DEJ, Gray JC, Newton J. Perceived fatigue is comparable between different disease groups. QJM: An International Journal of Medicine 2009, 102(9), 617-624.
• Frith J, Jones DEJ, Newton J. Regulation of Cerebral Blood Flow is Significantly Impaired in Primary Biliary Cirrhosis. In: Journal of Hepatology: 44th Annual Meeting of the European Association for the Study of the Liver. 2009, Copenhagen, Denmark: Elsevier BV.
• Newton J. Reply. Hepatology 2009, 49(2), 698.
• Tan MP, Newton JL, Reeve P, Murray A, Chadwick TJ, Parry SW. Results of carotid sinus massage in a tertiary referral unit - is carotid sinus syndrome still relevant?. Age and Ageing 2009, 38(6), 680-686.
• Newton J, Poyner E, Jones DEJ. Serum anti-mitochondrial antibodies and fatigue in primary biliary cirrhosis. Liver International 2009, 29(8), 1285-1286.
• Parry SW, Reeve P, Lawson J, Shaw FE, Davison J, Norton M, Frearson R, Kerr S, Newton JL. The Newcastle protocols 2008: an update on head-up tilt table testing and the management of vasovagal syncope and related disorders. Heart 2009, 95(5), 416-420.
• Parry SW, Tan MP, Newton JL, Chadwick TJ. The Relationship Between Baroreflex Sensitivity and the Hemodynamic Responses to Carotid Sinus Massage. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
• Parry SW, Gray JC, Newton JL, Reeve P, O'Shea D, Kenny RA. 'Front-loaded' head-up tilt table testing: Validation of a rapid first line nitrate-provoked tilt protocol for the diagnosis of vasovagal syncope. Age and Ageing 2008, 37(4), 411-415.
• Newton JL, Pairman J, Sutcliffe K, Wilton K, Jones DEJ. A Predictive Model for Fatigue and Its Etiologic Associations in Primary Biliary Cirrhosis. Clinical Gastroenterology and Hepatology 2008, 6(2), 228-233.
• Jones DEJ, Sutcliffe K, Pairman JE, Wilton KJA, Newton JL. An integrated care pathway improves quality of life in Primary Biliary Cirrhosis. QJM 2008, 101(7), 535-543.
• Newton JL, Elliott C, Frith J, Robinson L, Jungerious D, Jones DE, Day CP. Appreciation of the benefits of exercise programmes in non-alcoholic liver disease: implications of fatigue and impact upon activities of daily living. In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, CA, USA: Hepatology: John Wiley & Sons.
• Newton JL, Hollingsworth KG, Blamire AM, Taylor R, Pearce R, Jones DE. Autonomic dysfunction: A potential modifiable risk factor for cognitive decline in primary biliary cirrhosis. Journal of Hepatology 2008, 48(Supplement 2), S325 no. 866.
• Tan MP, Newton JL, Chadwick T, Parry SW. Changes in baroreflex sensitivity with home orthostatic training in vasovagal syncope - a randomized, placebo controlled pilot study. In: Hypertension: 13th Annual Meeting of the European Council for Cardiovascular Research. 2008, Nice, France: Lippincott Williams & Wilkins.
• Newton JL, Hollingsworth KG, Taylor R, El-Sharkawy AM, Khan ZU, Pearce R, Sutcliffe K, Okonkwo O, Davidson A, Burt J, Blamire AM, Jones DEJ. Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology. Hepatology 2008, 48(2), 541-549.
• Ewan V, Newton JL. Diagnosis and management of constipation in older people. Prescriber 2008, 19(3), 12-21.
• Parry SW, Frearson R, Steen N, Newton JL, Tryambake P, Kenny RA. Evidence-based algorithms and the management of falls and syncope presenting to acute medical services. Clinical Medicine 2008, 8(2), 157-162.
• Frith J, Robinson L, Pairman J, Wilton K, Jones DE, Newton JL. Falls are common in primary biliary cirrhosis and associate with dysautonomia and distal lower limb weakness. In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, CA, USA: Hepatology: John Wiley & Sons.
• Newton JL, Pairman J, Wilton K, Jones DE, Day CP. Fatigue in non-alcoholic fatty liver disease (NAFLD) associates with hypotension and autonomic dysfunction. In: Hepatology: 59th Annual Meeting of the American Association for the Study of Liver-Diseases. 2008, San Francisco, CA: John Wiley & Sons, Inc.
• Newton JL, Jones DEJ, Henderson E, Kane L, Wilton K, Burt AD, Day CP. Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut 2008, 57(6), 807-813.
• Newton JL. Fatigue in Primary Biliary Cirrhosis. Clinics in Liver Disease 2008, 12(2), 367-383.
• Legge H, Norton M, Newton JL. Fatigue is significant in vasovagal syncope and is associated with autonomic symptoms. Europace 2008, 10(9), 1095-1101.
• Hollingsworth K, Jones DE, Aribisala BS, Taylor R, Blamire A, Newton JL. Globus pallidus abnormalities in MRI T2 relaxation time in primary biliary cirrhosis are associated with impaired cerebral autoregulation: implications for the pathogenesis of cognitive decline. In: Hepatology: 59th Annual Meeting of the American Association for the Study of Liver-Diseases. 2008, San Francisco, CA: John Wiley & Sons, Inc.
• Ewan V, Newton JL. Management of Clostridium difficile infection. Journal of the Royal College of Physicians of Edinburgh 2008, 38, 144-147.
• Michel J-P, Newton JL, Kirkwood TBL. Medical challenges of improving the quality of a longer life. JAMA - Journal of the American Medical Association 2008, 299(6), 688-690.
• Newton JL, Hollingsworth KG, Palmer JM, McDonald CM, Taylor R, Blamire AM, Jones DE. Mitochondrial dysfunction and muscle PH abnormality post-exercise: A two-hit mechanism for fatigue pathogenesis in primary biliary cirrhosis. Journal of Hepatology 2008, 48(Supplement 2), S325 no. 865.
• Frith J, Robinson L, Jungerius D, Pairman J, Wilton K, Jones DEJ, Newton JL. Orthostatic grading scale is better than timed up and go at identifying fallers with primary biliary cirrhosis. In: Age and Ageing: British Geriatrics Society Spring Meeting. 2008, Brighton: Oxford University Press.
• Hollingsworth KG, Newton JL, Taylor R, McDonald C, Palmer JM, Blamire AM, Jones DEJ. Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis. Clinical Gastroenterology and Hepatology 2008, 6(9), 1041-1048.
• Hoad A, Spickett G, Elliott J, Newton J. Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome. QJM: An International Journal of Medicine 2008, 101(12), 961-965.
• Newton JL, Day CP, Gibson GJ, Tomlinson M, Henderson E. Recurrent noctural hypoxaemia is associated with progressive non-alcoholic fatty liver disease (NAFLD). In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, CA, USA: Hepatology: John Wiley & Sons.
• Ross R, Parry S, Norton M, Newton JL. Self-reported symptom burden; outcome in 418 patients from the Newcastle Vasovagal (Neurocardiogenic) cohort. QJM 2008, 101(2), 127-135.
• Ewan VC, Newton JL. The management of C. Difficile infection. Journal of the Royal College of Physicians of Edinburgh 2008, 38, 144-147.
• Tan MP, Newton JL, Chadwick TJ, Parry SW. The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study. Europace 2008, 10(12), 1400-1405.
• Stevens S, Allen J, Murray A, Jones DE, Newton JL. Vascular optical assessment of peripheral autonomic dysfunctino (AD) in primary biliary cirrhosis. In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, CA, USA: Hepatology: John Wiley & Sons.
• Jones DEJ, Newton JL. An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Alimentary Pharmacology and Therapeutics 2007, 25(4), 471-476.
• Jones DEJ, Newton JL. An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Alimentary Pharmacology and Therapeutics 2007, 25(4), 471-476.
• Jones DEJ, Newton JL. Association between fatigue and decreased survival in primary biliary cirrhosis - Reply. Gut 2007, 56(8), 1166-1166.
• Jones DEJ, Newton JL. Authors' reply [2]. Gut 2007, 56(8), 1166-.
• Newton JL, Davidson A, Kerr S, Bhala N, Pairman J, Burt J, Jones DEJ. Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity. European Journal of Gastroenterology and Hepatology 2007, 19(2), 125-132.
• Hollingsworth K, Jones DE, El-Sharkawy A, Khan Z, Taylor R, Blamire A, Newton JL. Autonomic dysfunction in primary biliary cirrhosis is associated with structural brain abnormalities, particularly in the globus pallidus. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, MA: Hepatology, Wiley-Blackwell.
• McDonald C, Baker S, Lai M, Jones DE, Newton JL. Central cerebral activation is reduced in primary biliary cirrhosis and associated with excessive daytime sleepiness. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, MA: Hepatology, Wiley-Blackwell.
• Donaldson P, Veeramani S, Baragiotta A, Floreani A, Venturi C, Pearce S, Wilson V, Jones D, James O, Taylor J, Newton J, Bassendine M. Cytotoxic T-Lymphocyte-Associated Antigen-4 Single Nucleotide Polymorphisms and Haplotypes in Primary Biliary Cirrhosis. Clinical Gastroenterology and Hepatology 2007, 5(6), 755-760.
• Newton JL, Jones DE, Kane L, Henderson E, Pairman J, Wilton K, Burt AD, Day CP. Fatigue in NAFLD is severe and associates with excessive daytime somnolence but not with liver disease severity or insulin resistance. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, MA: Hepatology, Wiley-Blackwell.
• Jones DEJ, Newton JL. Fatigue-associated mortality in Primary Biliary Cirrosis is principally a problem of the over 65’s. Gut 2007, 56, 1166.
• Newton JL, Hudson M, Tachtatzis P, Sutcliffe K, Pairman J, Burt JA, Jones DEJ. Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology 2007, 45(6), 1496-1505.
• Newton JL, Jones DEJ. Population prevalence of autonomic dysfunction in Primary Biliary Cirrhosis. Hepatology 2007, 45(6), 1496-1505.
• Ewan V, Norton M, Newton JL. Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine. Europace 2007, 9(12), 1202-.
• Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ. Symptoms of autonomic dysfunction in chronic fatigue syndrome. QJM 2007, 100(8), 519-526.
• Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ. Symptoms of autonomic dysfunction in chronic fatigue syndrome. QJM: an international journal of medicine 2007, 100(8), 519-526.
• Blackburn P, Freeston M, Baker CR, Jones DEJ, Newton JL. The role of psychological factors in the fatigue of primary biliary cirrhosis. Liver International 2007, 27(5), 654-661.
• Murtagh MJ, Stobbart L, Fay M, Thomson RG, Newton JL. Trust, respect and responsibility: rationalities of care in decision making. Health 2007, Forthcoming.
• Murtagh MJ, Stobbart L, Fay M, Thomson RG, Newton J. Understanding the context of older people's decision making: a qualitative study of decision making about prevention and treatment of falls and fractures. Health Expectations 2007.
• Newton JL, Jones DEJ, Wilton K, Pairman J, Parry SW, Francis RM. Calcaneal bone mineral density in older patients who have fallen. QJM 2006, 99(4), 231-236.
• Newton JL, Jones DEJ, Wilton K, Pairman J, Parry SW, Francis RM. Calcaneal bone mineral density in older patients who have fallen. QJM: An International Journal of Medicine 2006, 99(4), 231-236.
• Newton JL, Bhala N, Burt J, Jones DEJ. Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. Journal of Hepatology 2006, 44(4), 776-783.
• Okonkwo OC, Burt J, Jones DE, Newton JL. Cognitive impairment in primary biliary cirrhosis (PBC) is related to sympathetic autonomic nervous system dysfunction. In: 57th Annual Meeting of the American Association for the Study of Liver Diseases. 2006, Boston, MA: Hepatology: John Wiley & Sons Inc.
• Coiffait L, Bevan RM, Newton J, Redfern CPF, Wolff K. Elucidating the movements of migratory birds through the combined use of stable isotope ‘signatures’ and DNA markers. In: Boere, G.C.; Galbraith, C.A.; Stroud, D.A, ed. Waterbirds Around the World. Edinburgh: The Stationery Office, 2006, pp.506-507.
• Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology 2006, 44(1), 91-98.
• Newton JL, Burt JA, Pairman J, Jones DEJ. Fatigue in Primary Biliary Cirrhosis is Associated with Symptomatic Abnormalities in Blood Pressure Regulation. Gut 2006. In Press.
• Jones DEJ, Bhala N, Burt J, Goldblatt J, Prince M, Newton JL. Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort. Gut 2006, 55(4), 536-541.
• Johns C, Newton JL, Westley BR, May FEB. Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm. Peptides 2006, 27(6), 1341-1348.
• Newton JL, Jones DE. Modafinil is an effective treatment for excessive daytime somnolence and fatigue in primary biliary cirrhosis (PBC). In: 57th Annual Meeting of the American Association for the Study of Liver Diseases. 2006, Boston, MA: Hepatology: John Wiley & Sons Inc.
• Jones DEJ, Newton JL. Primary biliary cirrhosis. Horizons in Medicine 2006, 17, 307-315.
• Newton JL, Allen J, Kerr S, Jones DEJ. Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis. Liver International 2006, 26(2), 197-202.
• Jones DEJ, Bhala N, Newton JL. Reflections on therapeutic trials in primary biliary cirrhosis: A qualify of life oriented counter-view. Hepatology 2006, 43(3), 633.
• Ross R, Parry SW, Norton M, Newton JL. Self reported symptom burden: 418 patients from teh Newcastle VVS Cohort. European Heart Journal (in revision) 2006.
• Newton JL, Kyle P, Liversidge P, Robinson G, Wilton K, Reeve P. The costs of falls in the community to the North East Ambulance Service. Emergency Medical Journal 2006, 23(6), 479-481.
• Jaafer A, Baptist M, Wilton K, Newton JL. The Relative Effectiveness of Physical Counter Manoeuvres in Older People. Europace 2006, (submitted).
• Gracie J, Newton JL, Norton M, Baker C, Freeston M. The role of psychological factors in response to treatment in neurocardiogenic (vasovagal) syncope. Europace 2006, 8(8), 636-643.
• Newton JL, Donaldson P, Parry S, Kenny RA, Smith J, Gibson AM, Morris C. Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope. Europace 2005, 7(4), 396-399.
• Lawson J, Johnson I, Bamiou DE, Newton JL. Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit. QJM: An International Journal of Medicine 2005, 98(5), 357-364.
• Murtagh M, Stobbart L, Fay M, Newton JL, Law L, Thomson RG. Can you have agency and not choose? Older people’s involvement in decision making about prevention and treatment of falls and fractures. In: International Critical Health Psychology Conference. 2005, Sheffield, UK.
• Morton JA, Newton J, Gray CS. Counting the true cost of antiplatelet therapy for stroke prevention. Age and Ageing 2005, 34(3), 212-214.
• Jacoby A, Rannard A, Buck D, Bhala N, Newton JL, James OFW, Jones DEJ. Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut 2005, 54(11), 1622-1629.
• Newton JL. Effect of age-related changes in gastric physiology on tolerability of medications for older people. Drugs and Aging 2005, 22(8), 655-661.
• Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM. Familial neurocardiogenic (vasovagal) syncope. American Journal of Medical Genetics: Part A 2005, 133(2), 176-179.
• Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM. Familial neurocardiogenic (Vasovagal) syncope. American Journal of Medical Genetics 2005, 133(2), 176-179.
• Newton JL, Bhala N, Burt JA, Jones DEJ. Fatigue in primary biliary cirrhosis is associated with symptoms of autonomic dysfunction. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2005, Birmingham, UK: BMJ Group.
• Murtagh M, Stobbart L, Fay M, Newton JL, Law L, Thomson RG. Older people’s involvement in decision making about prevention and treatment of falls and fractures. In: International Shared Decision Making Conference. 2005, Ottawa, Ontario, USA.
• Stobbart L, Murtagh MJ, Fay M, Newton JL, Law L, Thomson RG. Older people’s involvement in decision making about prevention and treatment of falls and fractures in an outpatient setting. In: UK Public Health Forum. 2005, Gateshead, UK.
• Stobbart L, Murtagh M, Newton J, Fay A, Thomson R. Older people’s involvement in decision making about prevention and treatment of falls and fractures in an outpatient setting. In: British Sociological Association Medical Sociology Conference. 2005, York, UK.
• Newton JL. Problems in the elderly. In: Weinstein, Hawkey, Bosch, ed. Gastroenterology and Hepatology: The Modern Physicians Guide. 2005. In Press.
• Newton JL. Problems in the primary care. In: Weinstein, Hawkey, Bosch, ed. Gastroenterology and Hepatology: The Modern Physicians Guide. 2005. In Press.
• Johns CE, Newton JL, Westley BR, May FEB. The diurnal rhythm of the cytoprotective human trefoil protein TFF2 is reduced by factors associated with gastric mucosal damage: Ageing, Helicobacter pylori Infection, and sleep deprivation. American Journal of Gastroenterology 2005, 100(7), 1491-1497.
• Bhala N, Newton JL. Upper gastrointestinal alarms in older people. Lancet 2005, 366(9490), 982-983.
• Johns CE, May FEB, Newton JL. "Anorexia of ageing": Are gut hormones the answer?. In: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow: BMJ Group.
• Hartland S, Newton JL, Griffin SM, Donaldson PT. A Functional Polymorphism in the Interleukin-1 Receptor-1 Gene Is Associated with Increased Risk of Helicobacter pylori Infection but Not with Gastric Cancer. Digestive Diseases and Sciences 2004, 49(9), 1545-1550.
• Allan L, Johns E, Doshi M, Kenny RA, Newton JL. Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope. Europace 2004, 6(3), 192-198.
• Johns CE, Newton JL, Westley BR, May FEB. Ageing and H pylori infection alter the diurnal rhythm of the gastric cytoprotective trefoil protein TFF2. In: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow: Gut.
• Burton L, Norton M, Newton JL. Are some antihypertensives more prone to induce hypotensive side effects than others?. Age and Ageing 2004, 33(6), 626-628.
• Newton JL, Bhalla N, Jones DE. Autonomic dysfunction is common in both cirrhotic and precirrhotic primary biliary cirrhosis. In: Hepatology: 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2004, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Newton JL. Changes in upper gastrointestinal physiology with age. Mechanisms of Ageing and Development 2004, 125(12), 867-870.
• Ross R, Newton JL. Heart rate and blood pressure changes during gastroscopy in healthy older subjects. Gerontology 2004, 50(3), 182-186.
• Hampton JL, Parry SW, Kenny RA, Newton JL. Lower 24 hour urinary sodium concentrations are associated with more severe symptoms in subjects with vasovagal syncope. Heart 2004, 90(6), 687-688.
• Newton J, Olde Rikkert MGM, Rigaud A-S. Prevention of malnutrition in older people during and after hospitalisation: Results from a randomised controlled trial. Age and Ageing 2004, 33(1), 87.
• Newton JL. Re: Guidelines for the diagnosis and management of PMR/GCA - Reply. Age and Ageing 2004, 33(2), 211-211.
• Newton JL, Bhalla N, Jones DE. Risk factors for sudden cardiac death in primary biliary cirrhosis. In: Hepatology: 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2004, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Newton J, Johns CE, May FEB. The ageing bowel and intolerance to aspirin. Alimentary Pharmacology and Therapeutics 2004, 19(1), 39-45.
• Newton JL, James OFW, Williams GV, Allen A. The diurnal profile of gastric pepsin activity is reduced with Helicobacter pylori infection. Digestive Diseases and Sciences 2004, 49(7-8), 1103-1108.
• Gieroba ZJ, Newton JL, Parry SW, Norton M, Lawson J, Kenny RA. Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: A review of 10 years' experience. Journal of the American Geriatrics Society 2004, 52(11), 1913-1915.
• Newton JL, Kenny RA, Frearson R, Francis RM. A prospective evaluation of bone mineral density measurement in females who have fallen. Age and Ageing 2003, 32(5), 497-502.
• Newton JL, Kenny RA, Baker CR. Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope - A pilot study. Europace 2003, 5(3), 299-301.
• Eccles M, Rousseau N, McColl E, Newton J, Grimshaw J. Computerised evidence based guidelines in primary care - Computerised decision support and reflection in action - Reply. British Medical Journal 2003, 326(7398), 1088-1088.
• Johns CE, Newton JL, Westley BR, May FEB. Expression of the cytoprotective trefoil protein TFF2 in human gastric and duodenal biopsies. In: Annual meeting of the British-Society-of-Gastroenterology. 2003, Birmingham: Gut.
• Marr S, Steele K, Swallow VM, Craggs S, Procter S, Newton J, Sen B, McNabb A. Mapping the range and scope of emergency nurse practitioner services in the Northern and Yorkshire Region: A telephone survey. Emergency Medicine Journal 2003, 20(5), 414-417.
• Frearson R, Cassidy T, Newton J. Polymyalgia rheumatica and temporal arteritis: evidence and guidelines for diagnosis and management in older people. Ageing and Society 2003, 32(4), 370-374.
• Newton JL, Kenny R, Lawson J, Frearson R, Donaldson P. Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives: Preliminary data for the Newcastle cohort. Clinical Autonomic Research 2003, 13(1), 22-26.
• Armstrong VL, Lawson J, Kamper AM, Newton J, Kenny RA. The use of an implantable loop recorder in the investigation of unexplained syncope in older people. Age and Ageing 2003, 32(2), 185-188.
• Hampton JL, Kenny RA, Newton JL. Effective interventions to prevent falls in older people. British Journal of General Practice 2002, 52(484), 884-886.
• Newton J, Jones D. Osteoporosis in primary biliary cirrhosis. Panminerva Medica 2002, 44(4), 335-341.
• Newton JL, James OFW, Bassendine MF, Jones DEJ. Osteoporosis is not a specific complication of primary biliary cirrhosis. Gut 2002, 50, 898-899.
• Harbison J, Newton JL, Seifer C, Kenny RA. Stokes Adams attacks and cardiovascular syncope. Lancet 2002, 359(9301), 158-160.
• Newton JL. Care of the elderly with gastrointestinal problems in family practice. Best Practice & Research: Clinical Gastroenterology 2001, 15(6), 1013-1025.
• Newton JL, Allan L, Baptist M, Kenny R. Defecation syncope associated with splanchnic sympathetic dysfunction and cured by permanent pacemaker insertion [12]. American Journal of Gastroenterology 2001, 96(7), 2276-2278.
• Semple J, Newton JL, Westley BR, May FEB. Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice. Gut 2001, 48(5), 648-655.
• Johns E, Goldblatt J, Jones DE, Newton JL. Fatigue in primary biliary cirrhosis is associated with early autonomic failure. In: Hepatology. 2001, John Wiley & Sons, Inc.
• Newton J, Francis R, Prince M, James O, Bassendine M, Rawlings D, Jones D. Osteoporosis in primary biliary cirrhosis revisited. Gut 2001, 49(2), 282-287.
• Newton JL. Action stat. Amiodarone overdose. Nursing 2000, 30(2), 33.
• Newton JL, Rawlings D, Prince MI, James OFW, Bassendine MF, Jones DEJ. Osteoporosis is not a specific complication of primary biliary cirrhosis (PBC). In: JOURNAL OF HEPATOLOGY. 2000.
• Newton JL, Jones DE, Metcalf JV, Park JB, Burt AD, Bassendine MF, James OFW. Presentation and mortality of primary biliary cirrhosis in older patients. Age and Ageing 2000, 29(4), 305-309.
• Newton JL, Jordan N, Pearson J, Williams GV, Allen A, James OFW. The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori. Gerontology 2000, 46(3), 153-157.
• Newton JL, Allen A, Westley BR, May FEB. The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. Gut 2000, 46(3), 312-320.
• May FEB, Semple J, Newton JL, Westley BR. The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach. Gut 2000, 46(4), 454-459.
• Eccles M, Deverill M, McColl E, Newton J, Verrill J. Audit across interfaces. In: Baker, R., Hearnshaw, H.M., Robertson, N, ed. Implementing Change with Clinical Audit. Chichester: Wiley-Blackwell, 1999, pp.95-117.
• Jones DEJ, Watt FE, Grove J, Newton JL, Daly AK, Gregory WL, Day CP, James OFW, Bassendine MF. Tumour necrosis factor-α promoter polymorphisms in primary biliary cirrhosis. Journal of Hepatology 1999, 30(2), 232-236.
• Jordan N, Newton J, Pearson J, Allen A. A novel method for the visualization of the in situ mucus layer in rat and man. Clin Sci (Lond) 1998, 95(1), 97-106.
• Newton JL, Jordan N, Oliver L, Strugala V, Pearson J, James OFW, Allen A. Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised. Gut 1998, 43(4), 470-475.
• Newton JL, Burt AD, Park JB, Mathew J, Bassendine MR, James OFW. Autoimmune hepatitis in older patients. Age and Ageing 1997, 26(6), 441-444.
• Oliver L, Newton JL, Jordan N, Goddard P, Dettmar P, Pearson JP, Allen A. Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier. In: 660th Meeting of the Biochemical Society/Joint Congress with the British Society for Immunology. 1997, Harrogate, UK: Biochemical Society Transactions: Portland Press.
• Allen A, Newton J, Oliver L, Jordan N, Strugala V, Pearson JP, Dettmar PW. Mucus and H. pylori. J Physiol Pharmacol 1997, 48(3), 297-305.
• Newton J, Haimes E. The work of trainer groups: as seen by an observer. In: North of England Study of Standards and Performance in General Practice Research Team, ed. North of England Study of Standards and Performance in General Practice: Final Report. Volume 1: Setting clinical standards within small groups. Newcastle upon Tyne: Health Care Research Unit, University of Newcastle upon Tyne, 1990, pp.113-140.