Julian Leathart
Biomedicine Central Biobank Manager
- Email: julian.leathart@ncl.ac.uk
- Telephone: +44 (0) 191 222 6768
- Address: ICM
4th Fl. Leech, Medical School
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
- Anstee QM, Darlay R, Leathart JB, Clement J, Clement K, Aithal GP, Valenti L, Van Gaal L, Stickel F, Allison ME, Romero-Gomez M, Andrade RJ, Reeves H, Pihlajamaki J, Bedossa P, Kotronen A, Yki-Jarvinen H, Chalasani NP, Kleiner DE, Rotter J, Burt AD, Ratziu V, Cordell HJ, Daly AK, Day CP. Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD.
In: 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
- Al-Serri A, Anstee QM, Valenti L, Nobili V, Leathart JBS, Dongiovanni P, Patch J, Fracanzani A, Fargion S, Day CP, Daly AK. The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies.
Journal of Hepatology 2012, 56(2), 448-454.
- Biss TT, Avery PJ, Williams MD, Brandao LR, Grainger JD, Leathart JBS, Kamali F. VKORC1 and CYP2C9 genotype is associated with over-anticoagulation during initiation of warfarin therapy in children.
In: 52nd Annual Scientific Meeting of the British Society for Haematology. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
- Biss TT, Hamberg AK, Avery PJ, Wadelius M, Leathart JBS, Kamali F. Warfarin dose prediction in children using pharmacogenetics information.
In: 52nd Annual Scientific Meeting of the British Society for Haematology. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
- Ozhan G, Lochan R, Leathart JB, Charnley R, Daly AK. Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility.
Pancreas 2011, 40(8), 1289-1294.
- Howard R, Leathart JB, French DJ, Krishan E, Kohnke H, Wadelius M, van Schie R, Verhoef T, Maitland van der Zee AH, Daly AK, Barallon R. Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon(R) probes.
Clinica Chimica Acta 2011, 412(23-24), 2063-2069.
- de Alwis N, Aithal G, Bugianesi E, Leathart J, Hudson G, Pyle A, Mowbray C, Henderson E, Burt AD, Chinnery PF, Day CP. Mitochondrial DNA does not contribute to the heritability of non-alcoholic fatty liver disease.
Mitochondrion 2011, 11(1), 234-235.
- Valenti L, Nobili V, Al-Serri A, Rametta R, Leathart JB, Zappa MA, Dongiovanni P, Fracanzani AL, Alterio A, Roviaro G, Daly AK, Fargion S, Day CP. The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.
Journal of Hepatology 2011, 55(6), 1409-1414.
- Biss TT, Avery PJ, Brandao LR, Chalmers EA, Williams MD, Grainger JD, Leathart JB, Hanley JP, Daly AK, Kamali F. VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children.
Blood 2011, 119(3), 868-873.
- Gage VR, Blain PG, Leathart JBS, Daly AK, Williams FM. Association of DNA damage to human peripheral lymphocytes with age and MnSOD and OGG1 genotype.
In: Annual Congress of the British Toxicology Society. 2004, Edinburgh, Scotland: Toxicology: Elsevier.
- Saksena S, Leathart JB, Daly AK, Day CP. Manganese dependent superoxide dismutase (SOD2) targeting sequence polymorphism is associated with advanced fibrosis in patients with non-alcoholic fatty liver disease.
In: Journal of Hepatology: 38th Annual Meeting of the European Association for the Study of the Liver. 2003, Istanbul, Turkey: Elsevier BV.
- Aithal GP, Leathart JB, Dang TS, Day CP, Daly AK. Association of udp-glucuronosyltransferase (UGT) 2B7 genotype with diclofenac-induced hepatotoxicity.
In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
- Day C, Leathart J, Daly A. Genetic evidence that fatty liver is involved in the pathogenesis of advanced alcoholic liver disease.
Journal of Hepatology 2002, 36(s1), 16 abstract no. 41.
- Stewart SF, Leathart JB, Chen Y, Daly AK, Rolla R, Vay D, Mottaran E, Vidali M, Albano E, Day CP. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis.
Hepatology 2002, 36(6), 1355-1360.
- Stewart SF, Daly AK, Chen Y, Leathart JB, Jones DEJ, Rolla R, Vay D, Mottaran E, Vidali M, Albano E, Day CP. A polymorphism in CTLA-4 is associated with the presence of anti-CYP2E1 antibody titres in patients with alcoholic liver disease.
Journal of Hepatology 2001, 34(1), 200.
- Graham JC, Leathart JBS, Keegan SJ, Pearson J, Bint A, Gally DL. Analysis of Escherichia coli strains causing bacteriuria during pregnancy.
Infection and Immunity 2001, 69(2), 794-799.
- Graham JC, Leathart JBS, Keegan SJ, Pearson J, Bint A, Gally DL. Analysis of Escherichia coli strains causing bacteriuria during pregnancy: Selection for strains that do not express type 1 fimbriae.
Infection and Immunity 2001, 69(2), 794-799.
- Aithal GP, Day CP, Leathart JBS, Daly AK, Hudson M. Association of a 5'-flanking region polymorphism in the interleukin-4 gene with Crohn’s disease in a British population.
Genes and Immunity 2001, 2, 44-47.
- Aithal GP, Day CP, Leathart J, Daly AK, Hudson M. Association of a polymorphism in the interleukin-4 gene with Crohn’s diseases.
Genes and Immunity 2001, 2, 44-47.
- Aithal GP, Day CP, Leathart J, Daly AK, Hudson M. Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population.
Genes and Immunity 2001, 2(1), 44-47.
- Leathart JB, Day CP, Daly AK. No association between functional SNPs in the endotoxin receptors CD14 and TLR4 and alcoholic liver disease (ALD): Is endotoxin important in the pathogenesis of aid in humans?.
In: Hepatology. 2001, John Wiley & Sons, Inc.
- Agarwal K, Daly AK, Leathart JB, Hudson M, Day CP. Polymorphisms of immunoregulatory genes: A step towards individually tailored immunosuppression?.
In: British Association for the Study of the Liver Meeting. 2001, University of Southampton: BMJ Publishing Group Ltd.
- Vidali M, Stewart SF, Rolla R, Daly AK, Chen YN, Mottaran E, Vay D, Cipriani VE, Jones DE, Leathart JB, Day CP, Albano E. Role of CTLA-4 genetic polymorphism in the development of anti- cytochrome P4502EI auto-antibodies during alcoholic liver disease.
Hepatology 2001, 34(4), 312.
- Jacob J, Saksena S, Leathart JB, James O, Daly AK, Day CP. Single nucleotide polymorphisms (SNPs) associated with genetic susceptibility to NASH/NAFLD and ALD: Same again please!.
In: British Association for the Study of the Liver Meeting. 2001, Royal Free Hospital, London: John Wiley & Sons.
- Aithal GP, Day CP, Leathart JBS, Daly AK. Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis.
Pharmacogenetics 2000, 10(6), 511-518.
- Stewart SF, Daly AK, Chen YN, Leathart JB, Rolla R, Vay D, Mottaran E, Vidali M, Albano E, Day CP. Susceptibility to alcoholic liver disease is due to genetically determined differences in the immune response to acetaldehyde adducts.
In: HEPATOLOGY. 2000.
