Louise Reynard graduated from the University of Cambridge with a MA Cantab in Natural Sciences, specialising in Genetics. She completed her PhD studies in Developmental Genetics at the MRC National Institute for Medical Research. Louise joined Newcastle University in 2009 when she began her postdoctoral training with Professor John Loughlin. She has now been promoted to Research Fellow status
Dr Reynard’s research is focused on the functional characterisation of OA susceptibility loci that have been identified by the arcOGEN consortium. Elucidating the molecular mechanisms that underlie the susceptibility mediated by these genes will increase our understanding of OA etiology, potentially aid diagnosis and treatment, and will suggest relevant targets for therapeutic investigation. Louise is also interested in the molecular interplay between genetics and epigenetics in OA susceptibility, in particular, how DNA methylation can modulate the effect of genetic variation on disease penetrance and severity.
As a STEMNET Ambassador, Louise has spoken about her research at several public events including two events at the Centre for Life museum in Newcastle organised by the Xplore Health consortium funded by the European commission. She supervises several PhD students and postdoctoral scientists within Professor Loughlin’s group. Louise’s research is funded by Arthritis Research UK, the Dr William Harker Foundation, and the JGW Patterson Foundation. She is a member of the MRC-ARUK Centre for Integrated Research into Musculoskeletal Ageing and of the European Commission FP7 D-Board consortium that aims to identify and validate novel biomarkers of OA.
Rushton MD1, Reynard LN1, Young DA, Shepherd C, Darlay R, Cordell H,
Loughlin J. Methylation quantitive trait locus (meQLT) analysis of
osteoarthritis links epigenetics with genetic risk. In press at Hum Mol
- Johnson K, Reynard
LN, Loughlin J. Functional characterisation of the osteoarthritis
susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.
BMC Medical Genetics 16(1):81.
- Rogers E, Reynard
LN, Loughlin J. The role of inflammation-related genes in osteoarthritis.
In press at Osteoarthritis Cartilage.
- Gee F, Rushton MD, Loughlin J, Reynard LN. The
osteoarthritis susceptibility that maps to chromosome 20q13 correlates with an
expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism
rs116855380. In press at Arthritis Rheumatol.
- Rushton MD, Young DA, Loughlin J, Reynard LN. Differential DNA methylation and expression of
inflammatory and zinc transporter genes defines sub-groups of osteoarthritis
hip patients. Ann Rheum Dis. 201574(9):1778-1782.
- Loughlin J, Reynard
LN. Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.
Nat Rev Rheumatol 2015 Jan;11(1):6-7.
- Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson
N, Zhang Q, Griffin H, Sanderson S, Lakey J, Morgan N, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge
T, Hall JM, Cant AJ, Matthews HF, Santibanez-Koref MF, Simon AK, Korolchuk VI,
Lenardo MJ, Hambleton S and Su HC. Dual proteolytic pathways govern glycolysis
and immune competence. Cell 2014;159(7):1578-90.
- Reynard LN, Bui C, Syddall CM and Loughlin J. CpG methylation
regulates allelic expression of GDF5 by
modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis SNP
rs143383. Hum Genet 2014;133(8):1059-73.
- Rushton MD, Reynard
LN, Barter MJ, Refaie R, Rankin KS, Young DA and Loughlin J.
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis.
Arthritis Rheumatol 2014;66(9):2450-60.
- Raine EV, Reynard
LN, van der Laar IM, Bertoli-Avelia AM, and Loughlin J. Identification and
analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in
the aneurysms and osteoarthritis syndrome. Osteoarthritis Cartilage
- Gee F, Clubbs CF, Raine EV, Reynard LN and Loughlin J. Allelic expression analysis of the
osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals
cis-acting eQTLs at GNL3 and SPCS1. BMC Med Genet 2014;15(1):53.
Syddall CM, Reynard
LN, Young DA and Loughlin J. The identification of trans-acting factors
that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP
rs143383. PLoS Genet 2013; 9(6).
- Raine EV, Dodd AW, Reynard LN and Loughlin J. Allelic expression analysis of the
osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC
Musculoskelet Disord 2013 Mar 8;14:85
- Reynard LN and Loughlin J. Insights from human genetic studies
into the cellular and molecular switches involved in osteoarthritis etiology.
Nature Reviews Rheumatology. 2013 9(10):573-83
- Reynard LN and Loughlin J.
The genetics and functional analysis of primary osteoarthritis susceptibility.
Expert Rev Mol Med. 2013 Feb 18;15.
E, Wreglesworth N, Dodd A, Reynard LN
and Loughlin J. Gene expression analysis reveals HBP1 as a key target for the
osteoarthritis susceptibility locus that maps to chromosome 7q22. Ann Rheum Dis.2012
C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard
LN, Rowan AD and Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG
demethylation leads to the elevated expression of the matrix metalloproteinase
13 in human articular chondrocytes and osteoarthritis. FASEB J. 2012
M, Reynard LN, Raine EV, Santibanez-Koref
M and Loughlin J. Allelic expression analysis of the osteoarthritis
susceptibility locus that maps to MICAL3.
BMC Med Genet. 2012 Mar 2;13(1):12
- Reynard LN and Loughlin J.
Genetics and epigenetics of osteoarthritis. Maturitas. 2012 March;71(3):200-4.
RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH,
Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis
J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref
M and Collin M. Exome sequencing identifies GATA-2 mutation as the cause of
dendritic cell, monocyte, B and NK lymphoid deficiency. Blood. 2011 Sep
- Reynard LN, Bui C, Canty-Laid
EG, Young DA and Loughlin J. Expression of the osteoarthritis-associated gene
GDF5 is modulated epigenetically by DNA methylation. Hum Mol Genet
AW, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino JJ, Tsezou A, Reynard
LN, Gonzalez A and Loughlin J. Deep sequencing of GDF5 reveals the absence
of rare variants at this important osteoarthritis susceptibility locus.
Osteoarthritis Cartilage. 2011 Apr;19(4):430-4.