Newcastle University

More information can be found on our lab website at

http://www.hudendritic.org/home/people/muzlifah-haniffa

Projects

• Origin and function of human dermal dendritic cells
  Project Leader(s): Dr Muzlifah Haniffa
  This research ahs been funded by the Wellcome Trust and the British Skin Foundation

• Verykiou S, McGovern N, Milne P, Collin M, Menon G, Haniffa M. Enhancing diagnostic sensitivity for cutaneous blastic plasmacytoid dendritic cell neoplasia. In: 92nd Annual Meeting of the British Association of Dermatologists. 2012, Birmingham, UK: Wiley-Blackwell Publishing Ltd.
• Collin M, Dickinson RE, Haniffa MA, McGovern N, Griffin H, Reynard L, Lakey J, Hambleton S, Santibanez-Koref MA, Bigley V. Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation. In: European Congress of Immunology. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Bigley V, Dickinson R, Gennery A, Griffin H, Haniffa M, McGovern N, Milne P, Cant A, Santibanez-Koref M, Hambleton S, Collin M. Human dendritic cell deficiency. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
• Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141(hi) Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103(+) Nonlymphoid Dendritic Cells. Immunity 2012, 37(1), 60-73.
• Haniffa M, Shin A, Bigley V, Teo P, See P, Wasan P, McGovern N, Wang XN, Malinarich F, Malleret B, Larbi A, Poidinger M, Jarrett R, Connolly J, Chan J, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of a novel cross-presenting migratory dendritic cell in the human skin: the key cell for rational vaccine strategies. In: 92nd Annual Meeting of the British Association of Dermatologists. 2012, Birmingham, UK: Wiley-Blackwell Publishing Ltd.
• Haniffa M, Shin A, Bigley V, Teo P, See P, Wasan P, McGovern N, Wang XN, Malinarich F, Malleret B, Poidinger M, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of the human cross-presenting migratory dendritic cell. In: Meeting of the British Society for Investigative Dermatology. 2012, Exeter, UK: Wiley-Blackwell Publishing Ltd.
• Sturgess K, Slatter M, Bigley V, Dickinson R, Haniffa M, McGovern N, Jardine L, Jackson G, Cant A, Gennery A, Hambleton S, Collin M. Reduced-intensity haematopoietic stem cell transplant rescues immune function and corrects pulmonary alveolar proteinosis in DCML deficiency/GATA 2 mutation. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Haniffa M, Shin A, Bigley V, McGovern N, Wang XN, Teo P, Sng D, Won JM, Marinarich FG, Malleret B, See P, Larbi A, Zhou H, Poidinger M, Pagan S, Cookson S, Dickinson R, Connolly J, Gehring A, Bertoletti A, Collin M, Ginhoux F. CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Spence L, Pagan S, Carey C, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Jackson G, Dick JE, Hambleton S, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of the dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
• Collin M, Bigley V, Haniffa M, Hambleton S. Human dendritic cell deficiency: the missing ID?. Nature Reviews Immunology 2011, 11(9), 575-583.
• McGovern N, Bigley V, Allen C, Haniffa M, Wang XN, Dickinson R, Pagan S, Windebank K, McClain K, Ginhoux F, Merad M, Collin M. Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Hambleton S, Salem S, Bustamente J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez C, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova J-L, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. New England Journal of Medicine 2011, 365(2), 127-138.
• Sturgess K, Slatter M, Bigley V, Haniffa M, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Chua I, Wallis J, Lordan J, Morgan C, Cant A, Gennery A, Edmondson R, Bacon C, Black F, Kirkham N, Jackson GH, Hambleton S, Collin MP. Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
• Ingersoll M, Spanbroek R, Lottaz C, Gautier E, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht A, Ziegler-Heitbrock L, Randolph G. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 2010, 115(3), e10-e19.
• Ingersoll M, Spanbroek R, Lottaz C, Gautier E, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht A, Ziegler-Heitbrock L, Randolph G. Comparison of gene expression profiles between human and mouse monocyte subsets (Blood (2010) 115, 3 (e10-e19)). Blood 2010, 116(5), 857.
• Haniffa M, Ginhoux F, Wang XN, Bigley V, Abel M, Dimmick I, Bullock S, Grisotto M, Booth T, Taub P, Hilkens C, Merad M, Collin M. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. Journal of Experimental Medicine 2009, 206(2), 371-85.
• Haniffa MA, Collin MP, Buckley CD, Dazzi F. Mesenchymal stem cells: The fibroblasts' new clothes?. Haematologica 2009, 94(2), 258-263.
• Haniffa MA, Ginhoux F, Abel M, Alshemali S, Bullock S, Taub P, Merad M, Collin MP. Human factor XIIIa+ melanophages outlive all other cutaneous antigen-presenting cells, including Langerhans cells, after haematopoietic transplantation. In: British Journal of Dermatology: Annual Meeting of the British Society for Investigative Dermatology. 2008, Oxford, UK: Wiley-Blackwell Publishing Ltd.
• Sayers B, Haniffa M, Diboll J, Isaacs J, Hilkens C. Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties. In: Arthritis Research & Therapy: 6th Global Arthritis Research Network Meeting (GARN). 2007, Zurich, Switzerland: BioMed Central Ltd.
• Haniffa MA, English JS. The frequency of positive patch test reactions in non atopic vs. atopic patients. In: British Journal of Dermatology: Annual meeting of the British Society for Investigative Dermatology. 2003, Southampton, UK: Wiley-Blackwell Publishing Ltd.
• Haniffa MA, Angus B, Meggitt SJ. Warty granuloma faciale. In: British Journal of Dermatology: 83rd Annual Meeting of the British Association of Dermatologists. 2003, Brighton, UK: Wiley-Blackwell Publishing Ltd.