Newcastle University

Introduction 

I am an Academic Clinical Lecturer in Paediatric Respiratory Medicine at the Institute of Cellular Medicine, Newcastle University and an Honorary SpR in Paediatric Respiratory Medicine at the Great North Children’s Hospital, Newcastle upon Tyne. 

Qualifications

BSc (Hons), MB ChB, MRCPCH, PhD

Roles and responsibilities

•  Member British Paediatric Respiratory Society Executive Committee, trainee representative
•  Member RCPCH Paediatric Respiratory Medicine CSAC, trainee representative
•  Organiser of Regional Paediatric Respiratory Medicine CPD meetings

 Awards

•  Wellcome Trust Elective Prize, 2000
•  Joint Medical Research Council/Cystic Fibrosis Trust Clinical Research Training Fellowship, 2008
•  Best oral presentation: Northern Paediatric Research and Development Conference, 2008
•  British Lung Foundation Travel Fellowship, 2008
•  Cystic Fibrosis Trust Travel Award, 2009
•  Best poster: Institute of Cellular Medicine and Institute of Ageing and Health Research Day, 2009
•  Best oral presentation: Academic Paediatrics Association, 2009
•  Medical Research Council, supplementary travel award, 2010
•  European Respiratory Society Bursary for the 8^th ERS Lung Science Conference, 2010
•  British Paediatric Respiratory Society Travel Award, European Cystic Fibrosis Society Conference, 2012

Research interests 

• Translational cystic fibrosis research
• Techniques for primary airway epithelial cell culture
• Investigation of the mechanisms of neutrophilic inflammation, airway remodelling and dendritic-epithelial  cell interactions in CF lung disease
• Aspiration
• Clinical paediatric respiratory medicine research, including severe asthma, lung transplantation and cough

Funding

• April 2012: 'Mucus permeating nanoparticulate drug delivery systems' Project Alexander EU FP7. €15.5 million (with Prof JP Pearson, Newcastle University split €830,000)
• Dec 2011: ‘Functional characterisation and pharmacological manipulation of airway sphingolipids in cystic fibrosis’ Wellcome Trust/Academy of Medical Sciences: £29,921.60
• Nov 2011: ‘Functional characterisation and pharmacological manipulation of airway sphingolipids in cystic fibrosis’ Newcastle upon Tyne Hospitals NHS Charity (the Trustees): £24,352.10
• Nov 2011: FSF funding for Dr Jane Falconer, post-doctoral researcher salary. Newcastle upon Tyne Hospitals NHS Foundation Trust: £12,095
• Apr 2009: ‘Investigating epithelial cell and dendritic cell interactions in cystic fibrosis’ Newcastle Hospitals Special Trustees: £50,000
• Jun 2008 ‘The culture of primary bronchial epithelial cells from cystic fibrosis lungs – a model to investigate the role of Interleukin-17 in cystic fibrosis lung disease’ Inaugural recipient of the only personal Joint Medical Research Council/Cystic Fibrosis Trust Research Training Fellowship: £132,084
• Mar 2007 ‘An investigation in to the role of interleukin-17 in cystic fibrosis lung disease’ Newcastle Hospitals Special Trustees: £50,000 

• Parikh S, Brownlee IA, Robertson AG, Manning NT, Johnson GE, Brodlie M, Corris PA, Ward C, Pearson JP. Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?. Journal of Heart and Lung Transplantation 2013, (Epub ahead of print).
• Liew Z, McKean MC, Townshend J, O'Brien CJ, Brodlie M. Oesophageal foreign body presenting with stridor associated with feeding. Archives of Disease in Childhood 2013, (Epub ahead of print).
• Borthwick LA, Corris PA, Mahida R, Walker A, Gardner A, Suwara M, Johnson GE, Moisey EJ, Brodlie M, Ward C, Perry JD, de Soyza A, Mann DA, Fisher AJ. TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis. American Journal of Transplantation 2013, 13(3), 621-633.
• Aseeri A, Brodlie M, Lordan J, Corris P, Pearson J, Ward C, Manning N. Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2012, 185(4), 463-463.
• Brodlie M, Graham C, McKean MC. Childhood cough. British Medical Journal 2012, 344, e1177.
• Brodlie M, Corris PA, Lordan J, Ward C. Interleukin-17 and Cystic Fibrosis Lung Disease. American Journal of Respiratory and Critical Care Medicine 2012, 185(1), 108-109.
• Bates MG, Nesbitt V, Kirk R, He L, Blakely EL, Alston CL, Brodlie M, Hasan A, Taylor RW, McFarland R. Mitochondrial respiratory chain disease in children undergoing cardiac transplantation: A prospective study. International Journal of Cardiology 2012, 155(2), 305–306.
• Brodlie M, Spencer DA. Omalizumab for the Treatment of Paediatric Asthma. European Respiratory Disease 2012, 8(1), 19-22.
• Gardner A, Fisher AJ, Richter C, Johnson GE, Moisey EJ, Brodlie M, Ward C, Krippner-Heidenreich A, Mann DA, Borthwick LA. The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation. American Journal of Pathology 2012, 180(6), 2293-2308.
• Brodlie M, Flood T, Spencer DA. The importance of thorough investigation of children with wet cough. London, UK: BMJ Group, 2012. Available at: http://adc.bmj.com/content/97/5/478/reply#archdischild_el_10645.
• Brodlie M, McKean MC, Moss S, Spencer DA. The oral corticosteroid-sparing effect of omalizumab in children with severe asthma. Archives of Disease in Childhood 2012, 97(7), 604-609.
• Brodlie M, Abdelgalil S, Mansour S, Spencer DA. Use of somatostatin analogues to treat chylothorax in a child with Generalised Lymphatic Dysplasia. Respiratory Medicine CME 2012, 5, 76-77.
• Brodlie M, Orchard WA, Reeks GA, Pattman S, McCabe H, O'Brien CJ, Thomas MF, Spencer DA. Vitamin D in children with cystic fibrosis. Archives of Disease in Childhood 2012, 97(11), 982-984.
• Borthwick LA, Sunny SS, Oliphant V, Perry J, Brodlie M, Johnson GE, Ward C, Gould K, Corris PA, De Soyza A, Fisher AJ. Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway. European Respiratory Journal 2011, 37(5), 1237-1247.
• Brodlie M, Lordan J, Ward C. Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?. Thorax 2011, 66(12), 1096.
• Brodlie M, Lordan JL, Ward C. Ceramide and cystic fibrosis lung disease. American Journal of Respiratory and Critical Care Medicine 2011, 183(1), 133.
• Brodlie M, Barwick SC, Wood KM, McKean MC, Welch A. Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations. Journal of Laryngology and Otology 2011, 125(8), 865-868.
• Borthwick LA, Botha P, Verdon B, Brodlie MJ, Gardner A, Bourn D, Johnson GE, Gray MA, Fisher AJ. Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?. PLoS One 2011, 6(8).
• Brodlie M, McKean MC, Johnson GE, Gray J, Fisher AJ, Corris PA, Lordan JL, Ward C. Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease. American Journal of Respiratory and Critical Care Medicine 2010, 182(3), 369-375.
• Brodlie M, McKean M. Exhaled nitric oxide in the diagnosis of childhood asthma. British Medical Journal 2010, 340(7738), 113-114.
• Borthwick LA, McIlroy EI, Gorowiec MR, Brodlie M, Johnson GE, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ. Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair. American Journal of Transplantation 2010, 10(3), 498-509.
• Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C. Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs. Experimental Lung Research 2010, 36(2), 101-110.
• Brodlie M, McKean MC, Johnson GE, Anderson AE, Hilkens CM, Fisher AJ, Corris PA, Lordan JL, Ward C. Raised interleukin-17 is immuno-localised to neutrophils in cystic fibrosis lung disease. European Respiratory Journal 2010, 37(6), 1378-1385.
• Gardner A, Brodlie MJ, Mann DA, Borthwick LA, Fisher AJ. The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis. In: Thorax: British Thoracic Society Winter Meeting. 2010, Westminster, UK: BMJ Group.
• Brodlie M, Eger K, Hilkens CMU, Ward C. Airway epithelial cells as guardians of immune homeostasis?. Thorax 2009, 64(11), 1009.
• Ward C, Eger K, Diboll J, Jones D, Haniffa MA, Fisher A, Brodlie M, Lordan JL, Corris PA, Hilkens CM. Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells. Thorax 2009, 64, 430-435.
• Brodlie M, Spencer D. Bronchomalacia occurring in monozygotic twins - Further information about its inheritance. Acta Paediatrica, International Journal of Paediatrics 2009, 98(9), 1531-1533.
• Brodlie M, Spencer DA. Bronchomalacia occurring in monozygotic twins - further information about its inheritance. Acta Paediatrica 2009, 98(9), 1531-1533.
• Brodlie M, McKean MC, Johnson GE, Fisher AJ, Corris PA, Lordan JL, Ward C. Ceramide is increased and associated with neutrophilic inflammation in the lower airway epithelium of people with cystic fibrosis. In: Thorax: Winter Meeting of the British Thoracic Society. 2009, London, UK: BMJ Group.
• Brodlie M, Flood T, Spencer DA. Heterogeneity in the clinical manifestations of mannose-binding lectin deficiency. Journal of Pediatrics 2009, 155(5), 764-765.
• Brodlie M, Flood T, Black F, Spencer D. Lymphoid bronchiolitis presenting at birth in an immunocompetent child: Chronic interstitial lung disease of unknown aetiology. Pediatric Pulmonology 2009, 44(6), 622-624.
• Brodlie M, Mckean M. Picture quiz: Dyspnoea and cough in a toddler. British Medical Journal 2009, 339(7730), 1120-1151.
• Brodlie M, McKean MC, Johnson GE, Fisher AJ, Corris PA, Lordan JL, Ward C. Reticular basement membrane thickening in end-stage cystic fibrosis lung disease. In: Thorax: Winter Meeting of the British Thoracic Society. 2009, London, UK: BMJ Group.
• Brodlie M, Spencer D. Growth recovery after withdrawal of inappropriate inhaled fluticasone proprionate. Pediatric Pulmonology 2008, 43(3), 307-308.
• Brodlie M, Muller M, Byrne N, Mitchell L, Spencer DA. High-resolution computed tomography in children with confirmed post-infectious obliterative bronchiolitis. In: British Thoracic Society Winter Meeting 2008. 2008, London: Thorax: BMJ Publishing Group.
• Chaudhari M, Brodlie M, Hasan A. Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes. Acta Paediatrica, International Journal of Paediatrics 2008, 97(12), 1755-1757.
• Brodlie M, Chaudhari M, Hasan A. Prostaglandin therapy for ductal patency: how long is too long?. Acta Paediatrica, International Journal of Paediatrics 2008, 97(9), 1303-1304.
• Brodlie M, McKean MC. Strategies to screen for adrenal suppression in children with asthma: there is no consensus among UK centres. Thorax 2008, 63(9), 841-842.
• Brodlie M, McKean MC, Perry J, Nicholson A, Johnson GE, Pearson JP, Fisher A, Corris PA, Lordan JL, Ward C. The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease. In: British Thoracic Society Winter Meeting 2008. 2008, London: Thorax: BMJ Publishing Group.
• Brodlie M, Cunningham S. Compliance with inhaled corticosteroids is important when considering adrenal suppression. Archives of Disease in Childhood 2007, 92(4), 372.
• Brodlie M, Robertson D, Wyllie J. Interference of electrocardiographic recordings by a mobile telephone. Cardiology in the Young 2007, 17(3), 328-329.
• Brodlie M, McMurray A, Crofton PM, Bath L, Cunningham S. Strategies to screen for adrenal suppression in children with asthma should take account of compliance with inhaled corticosteroids. European Journal of Pediatrics 2007, 166(5), 493-494.
• Harkensee C, Brodlie M, Embleton ND, Mckean M. Passive immunisation of preterm infants with palivizumab against RSV infection. Journal of Infection 2006, 52(1), 2-8.
• Brodlie M, Laing IA, Keeling JW, McKenzie KJ. Ten years of neonatal autopsies in tertiary referral centre: retrospective study. British Medical Journal 2002, 324(7340), 761-763.
• March JB, Clark J, Brodlie M. Characterization of Strains of Mycoplasma mycoides subsp. mycoides Small Colony Type Isolated from Recent Outbreaks of Contagious Bovine Pleuropneumonia in Botswana and Tanzania: Evidence for a New Biotype. Journal of Clinical Microbiology 2000, 38(4), 1419-1425.
• March JB, Brodlie M. Comparison of the virulence of European and African isolates of Mycoplasma mycoides subspecies mycoides small colony type. Veterinary Record : Journal of the British Veterinary Association 2000, 147(1), 20-21.