Dr Malcolm Brodlie
Consultant Paediatric Respiratory Physician and Intermediate Fellow

  • Email: malcolm.brodlie@ncl.ac.uk
  • Telephone: 0191 2336161 Dect 21752
  • Address: c/o Paediatric Respiratory Secretaries
    Great North Children's Hospital
    Old Children's Outpatients Department
    Newcastle upon Tyne
    United Kingdom
    NE1 4LP
Introduction 

I am a clinical academic working as a Consultant in Paediatric Respiratory Medicine at the Great North Children's Hospital (GNCH) and the Freeman Hospital in Newcastle upon Tyne. My clinical interests include cystic fibrosis (large regional service with Dr Chris O'Brien) and cardiopulmonary transplantation. I also have a general respiratory clinic jointly with Dr Mike McKean at GNCH.    

I am an Intermediate Fellow in the Respiratory Medicine grouping, Institute of Cellular Medicine, Newcastle University, where I am actively involved in laboratory-based and clinical research in Paediatric Respiratory Medicine. Please click on the research tab above for further details.

Qualifications

BSc (Hons), MB ChB, MRCPCH, PhD

Roles and responsibilities

  • Associate Editor BMC Pulmonary Medicine 
  • Member British Paediatric Respiratory Society Executive Committee, trainee representative, 2010-13
  • Member RCPCH Paediatric Respiratory Medicine CSAC, trainee representative, 2010-13
  • Organiser of Regional Paediatric Respiratory Medicine CPD meetings

 Awards

  •  Wellcome Trust Elective Prize, 2000
  •  Joint Medical Research Council/Cystic Fibrosis Trust Clinical Research Training Fellowship, 2008
  •  Best oral presentation: Northern Paediatric Research and Development Conference, 2008
  •  British Lung Foundation Travel Fellowship, 2008
  •  Cystic Fibrosis Trust Travel Award, 2009
  •  Best poster: Institute of Cellular Medicine and Institute of Ageing and Health Research Day, 2009
  •  Best oral presentation: Academic Paediatrics Association, 2009
  •  Medical Research Council, supplementary travel award, 2010
  •  European Respiratory Society Bursary for the 8th ERS Lung Science Conference, 2010
  •  British Paediatric Respiratory Society Travel Award, European Cystic Fibrosis Society Conference, 2012

 

Outline

I am actively involved in laboratory-based and clinical research in paediatric respiratory medicine. My PhD was funded by a Joint MRC/CF Trust Clinical Research Training Fellowship and led to the major focus of my research around cystic fibrosis lung disease. I am based in the Respiratory Medicine research grouping in the Institute of Cellular Medicine, Newcastle University.

Specific areas of research interest include:

Cystic fibrosis

  • Techniques to culture primary airway epithelial cells and tissue from explanted cystic fibrosis lungs
  • Neutrophilic inflammation and infection in the cystic fibrosis airway
  • Sphingolipid metabolism, effects of ceramide accumulation in cystic fibrosis airway epithelial cells and links to inflammation, infection and CFTR dysfunction
  • TH17 pathway
  • Aspiration and associated mechanisms of lung injury
  • Non-CFTR targeted approaches for cystic fibrosis therapies
  • Clinical studies in cystic fibrosis
Childhood pneumonia and empyema (collaboration with Dr Matt Thomas)
  • Aetiology of paediatric community acquired pneumonia in the northern region
  • Epidemiology of childhood empyema including national surveillance
Other clinical paediatric respiratory studies
  • Physiological study of airway pressures generated and effects on respiratory mechanics of High Flow Nasal Cannula therapy in preterm infants (Research Fellow Dr Kiran Gopakalaje, collaboration with Dr Chris O'Brien, Dr Alan Fenton and Dr Sundeep Harigopal)
  • Mepolizumab in severe asthma (GSK)

Collaborators and mentors
  • Internal, Newcastle University: Respiratory Medicine: Dr Chris Ward, Prof John Simpson, Prof Paul Corris, Dr Tony de Soyza, Prof Andy Fisher, Dr Lee Borthwick. Epithelial Research Group: Prof Jeff Pearson, Dr Mike Gray. GNCH: Dr Matt Thomas, Dr Mike McKean, Dr Chris O'Brien, Dr Samantha Moss, Dr Alan Fenton, Dr Sundeep Harigopal
  • External: Prof Stuart Elborn and Prof Cliff Taggart, Queen's University Belfast. Prof Alain Brunelle and Prof Mario Ollero, INSERM, Paris. Prof Erich Gulbins, University of Essen. Dr Albert Koulman, MRC Human Nutrition Research, Cambridge. Dr Paul McNamara, University of Liverpool


Funding

  • April 2014: 'INOVCF - Innovative non-CFTR Approaches for Cystic Fibrosis Therapy' Co-Investigator. CF Trust. £750,000
  • April 2014: 'CF Trust Clinical Research Co-ordinator' with Dr Simon Doe and Dr Anthony de Soyza
  • April 2012: 'Mucus permeating nanoparticulate drug delivery systems' Project Alexander EU FP7. €15.5 million (with Prof JP Pearson, Newcastle University split €830,000)
  • Dec 2011: ‘Functional characterisation and pharmacological manipulation of airway sphingolipids in cystic fibrosis’ Wellcome Trust/Academy of Medical Sciences: £29,921.60
  • Nov 2011: ‘Functional characterisation and pharmacological manipulation of airway sphingolipids in cystic fibrosis’ Newcastle upon Tyne Hospitals NHS Charity (the Trustees): £24,352.10
  • Nov 2011: FSF funding for Dr Jane Falconer, post-doctoral researcher salary. Newcastle upon Tyne Hospitals NHS Foundation Trust: £12,095
  • Apr 2009: ‘Investigating epithelial cell and dendritic cell interactions in cystic fibrosis’ Newcastle Hospitals Special Trustees: £50,000
  • Jun 2008 ‘The culture of primary bronchial epithelial cells from cystic fibrosis lungs – a model to investigate the role of Interleukin-17 in cystic fibrosis lung disease’ Inaugural recipient of the only personal Joint Medical Research Council/Cystic Fibrosis Trust Research Training Fellowship: £132,084
  • Mar 2007 ‘An investigation in to the role of interleukin-17 in cystic fibrosis lung disease’ Newcastle Hospitals Special Trustees: £50,000 

I am involved in the clinical teaching of medical students in paediatrics at GNCH and the supervision of SSC students in paediatric respiratory medicine.

I coordinate the regional paediatric CPD respiratory meetings and departmental educational meetings (with Dr Matt Thomas).