Newcastle University

Introduction

Consultant in Paediatric Immunology

Background

Graduated from the Medical School, University of Sarajevo. Trained in Medical Genetics (postgraduate course, 1978-80) and Paediatrics (Specialization, 1979-83), the Medical School, University of Belgrade. British Council/WHO Visiting Fellowship in Paediatric Immunology, Great Ormond Street Hospital and Institute of Child Health, London (1986). Leading the team, jointly with Desa Lilic (wife; www.ncl.ac.uk/icm/people/profile/desa.lilic), performing the first T cell depleted (haploidenntical) BMT for SCID in Yugoslavia (1990). Moved to Newcastle, Supra-regional BMT Unit for SCID/primary immunodeficiencies (1992).

Roles and Responsibilities

Senior Consultant.

Qualifications

MD 1976, Med. School, Univ. Sarajevo, Yugoslavia
Paediatrics Board Exam 1983, Med School, Univ. Belgrade, Yugoslavia
Educational Council for Foreign Medical Graduates (ECFMG) Exam, 1983
MSc 1988, Med. School, Univ. Belgrade, Yugoslavia
DSc 1996, Med. School, Univ. Belgrade, Yugoslavia
FRCPCH 1997
FRCP 2004

Previous Positions

Consultant in Paediatric Immunology (1987) and Head, Department of Clinical Paediatric Immunology, Mother and Child Health Institute, Belgrade (1989-1992).
Assistant Professor of Paediatrics, Medical School, University of Belgrade (1991-1992).
Honorary Clinical Lecturer, Department of Child Health, The Medical School, Newcastle upon Tyne (1992-2001).

Memberships

British Society for Immunology (BSI)
British Paediatric Allergy, Immunology/Infectious Diseases Group (BPAIIDG)
British Society for Paediatric and Adolescent Rheumatology (BSPAR)
European Society for Primary Immunodeficiencies (ESID)
European Society for Paediatric Infectious Diseases (ESPID)
Paediatric Rheumatology European Society (PRES)

Honours and Awards

Professor B Zimonjic prize, Med. School, Univ. Sarajevo (top 10 students of the generation), 1976.
Honorary MRCP (London), 1998.

Languages

Serbo-croat
English
Hungarian

Research Interests

Primary Immunodeficiencies (PID)
Haematopoietic Stem Cell Transplantation (HSCT)
Paediatric Rheumatology/Autoimmune Disorders

Other Expertise

Paediatric Infectious Diseases
Allergic disoders in children

Current Work

1/ Long-term outcome: HSCT for children with primary immunodeficiency
2/ Long-term outcome: Autologous T cell depleted HSCT for children with juvenile idiopathic arthritis (JIA)
3/ Immunodeficiency resulting from mutations of NEMO gene: genotype-phenotype correlations
4/ Autosomal recessive juvenile osteopetrosis: genotype-phenotype correlations

Future Research

To contiune with current projects/collaboration.

Research Roles

Collaborator in multi-centre, national and international projects; planning, supervising and data evaluation; writing papers.

Postgraduate Supervision

Clinical research, MD theses, projects, etc.

Esteem Indicators

Chairman, Working Party for Haematopoietic Stem Cell Transplantation and Gene Therapy, European Society for Primary Immunodeficiencies -ESID (2004-) [www.esid.org]

Undergraduate Teaching

Immunology and (paediatric) infectious diseases (MBBS; SSC/Option students).

Postgraduate Teaching

Paediatric immunology and rheumatology (RCPCH; RCP; RCPath).

• Moreira D, Slatter M, Nademi Z, Brigham K, Barge D, Jackson A, Flood T, Cant A, Abinun M, Hambleton S, Gennery A. Immune reconstitution and clinical outcome after HSCT infusion for severe combined immunodeficiency in Newcastle. In: Biology of Blood and Marrow Transplantation: BMT Tandem Meeting. 2012, San Diego, California, USA: Elsevier Inc.
• Passerini L, Olek S, Di Nunzio S, Barzaghi F, Hambleton S, Abinun M, Tommasini A, Vignola S, Cipolli M, Amendola M, Naldini L, Guidi L, Cecconi M, Roncarolo MG, Bacchetta R. Forkhead box protein 3 (FOXP3) mutations lead to increased T(H)17 cell numbers and regulatory T-cell instability. Journal of Allergy and Clinical Immunology 2011, 128(6), 1376-1379.e1.
• Lane JP, Evans PTG, Slatter MA, Barge D, Jackson A, Hambleton S, Flood T, Abinun M, Cant J, Gennery A. Immune reconstitution post umbilical cord blood stem cell transplantation for primary immunodeficiency in a national centre. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Slatter MA, Angus B, Windebank K, Taylor A, Meaney C, Lester T, Norbury G, Hambleton S, Abinun M, Flood TJ, Cant AJ, Gennery AR. Polymorphous lymphoproliferative disorder with Hodgkin-like features in common gamma-chain-deficient severe combined immunodeficiency. Journal of Allergy and Clinical Immunology 2011. 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA: MOSBY-ELSEVIER, 127(2), 533-535.
• Slatter MA, Rao K, Amrolia P, Flood T, Abinun M, Hambleton S, Nademi Z, Goulden N, Davies G, Qasim W, Gaspar HB, Cant A, Gennery AR, Veys P. Treosulfan-based conditioning regimens for hematopoietic stem cell transplantation in children with primary immunodeficiency: United Kingdom experience. Blood 2011, 117(16), 4367-4375.
• Milanetti F, Abinun M, Voltarelli J, Burt R. Autologous hematopoietic stem cell transplantation for childhood autoimmune disease. Pediatric Clinics of North America 2010, 57(1), 239-271.
• Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nature Genetics 2007, 39(8), 960-962.
• Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Ayse M, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 2006, 25(5), 745-755.
• Pangrazio A, Poliani PL, Megarbane A, Lefranc G, Lanino E, Di Rocco M, Rucci F, Lucchini F, Ravanini M, Facchetti F, Abinun M, Vezzoni P, Villa A, Frattini A. Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement. Journal of Bone and Mineral Research 2006, 21(7), 1098-1105.
• De Kleer IM, Brinkman DMC, Ferster A, Abinun M, Quartier P, Van Der Net J, Ten Cate R, Wedderburn LR, Horneff G, Oppermann J, Zintl F, Foster HE, Prieur AM, Fasth A, Van Rossum MAJ, Kuis W, Wulffraat NM. Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: Analysis of clinical effects, mortality, and transplant related morbidity. Annals of the Rheumatic Diseases 2004,63 10 1318-1326.
• Wedderburn LJ, Palmer P, Abinun MA, Foster HE. Autologous stem cell transplantation as a treatment for severe juvenile arthritis. Archives Disease of Childhood 2003, 88(3), 201-205.
• Frattini A, Pangrazio A, Susani L, Sobacchi C, Mirolo M, Abinun M, Andolina M, Flanagan A, Horwitz EM, Mihci E, Notarangelo LD, Ramenghi U, Teti A, Van Hove J, Vujic D, Young T, Albertini A, Orchard PJ, Vezzoni P, Villa A. Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis. Journal of Bone and Mineral Research 2003,18 10 1740-1747.
• Lilic D, Gravenor I, Robson N, Lammas DA, Drysdale P, Calvert JE, Cant AJ, Abinun M. Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis. Infection and Immunity 2003,71 10 5690-5699.
• Wedderburn LR, Patel A, King D, Varsani H, Foster HE, Abinun MA. Long term follow up immune repertoire after severe immunosuppression and autologous stem cell transplantation (ASCT) in children with juvenile idiopathic arthritis (JIA). Clinical and Experimental Rheumatology 2003, 21(4), 537.
• Antoine C, Muller S, Cant A, Cavazzana-Calvo M, Veys P, Vossen J, Fasth A, Heilmann C, Wulffraat N, Seger R, Blanche S, Friedrich W, Abinun M, Davies G, Bredius R, Schulz A, Landais P, Fischer A, European Grp Blood Marrow Transpla. Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. Lancet 2003, 361(9357), 553-560.
• Eltringham ME, Myers A, Friswell M, Abinun MA, Kay LJ, Foster HE. Referral delays for children with juvenile idiopathic arthritis. Clinical and Experimental Rheumatology 2003, 21(4), 532.
• Das S, Patwardhan K, Taylor AEM, Carmichael AJ, Abinun M. Widespread idiopathic pyoderma gangrenosum in infancy treated successfully with infliximab. In: British Journal of Dermatology: 83rd Annual Meeting of the British Association of Dermatologists. 2003, Brighton, UK: Wiley-Blackwell Publishing Ltd.
• Arkwright PD, Abinun M, Cant AJ. Autoimmunity in human primary immunodeficiency diseases. Blood 2002, 99(8), 2694-2702.
• Gennery AR, Dickinson AM, Brigham K, Barge D, Spickett GP, Curtis A, Spencer V, Jackson A, Carter V, Palmer P, Flood TJ, Cant AJ, Abinun M. CAMPATH-1M T-cell depleted BMT for SCID: long-term follow-up of 19 children treated 1987-98 in a single center. Cytotherapy 2001, 3(3), 221-232.
• Hoare S, Bajwa RSP, Abinun M. Septic shock, meningitis and adrenal hemorrhages in a twelve-year-old. Pediatric Infectious Disease Journal 2001, 20(1), 89-90.
• Khawaja K, Gennery AR, Abinun M, Flood TJ, Cant AJ. Single Supraregional Centre Experience of Bone Marrow Transplantation for CD40L Deficiency. Archives of Disease in Childhood 2001, 84(6), 508-511.
• Doffinger R, Smahi A, Bessia C, Geissmann F, Feinberg J, Durandy A, Bodemer C, Kenwrick S, Dupuis-Girod S, Blanche S, Wood P, Rabia SH, Headon DJ, Overbeek PA, Le Deist F, Holland SM, Belani K, Kumararatne DS, Fischer A, Shapiro R, Conley ME, Reimund E, Kalhoff H, Abinun M, Munnich A, Israel A, Courtois G, Casanova JL. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappa B signaling. Nature Genetics 2001, 27(3), 277-285.
• Gennery AR, Flood TJ, Abinun M, Cant AJ. Bone marrow transplantation does not correct the hyper IgE syndrome. Bone Marrow Transplantation 2000, 25(12), 1303-1305.
• Frattini A, Orchard PJ, Sobacchi C, Giliani S, Abinun M, Mattsson JP, Keeling DJ, Andersson AK, Wallbrandt P, Zecca L, Notarangelo LD, Vezzoni P, Villa A. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nature Genetics 2000, 25(3), 343-346.
• Cole BOI, Welbury RR, Bond E, Abinun M. Dental manifestations in severe combined immunodeficiency following bone marrow transplantation. Bone Marrow Transplantation 2000, 25(9), 1007-1009.
• Srinivasan M, Abinun M, Cant AJ, Tan K, Oakhill A, Steward CG. Malignant infantile osteopetrosis presenting with neonatal hypocalcaemia. Archives of Disease in Childhood: Fetal & Neonatal 2000, 83(1), F21-F23.
• Crooks BNA, Taylor CE, Turner AJL, Osman HKE, Abinun M, Flood TJ, Cant AJ. Respiratory viral infections in primary immune deficiencies: significance and relevance to clinical outcome in a single BMT unit. Bone Marrow Transplantation 2000, 26(10), 1097-1102.
• Berrington JE, Flood TJ, Abinun M, Galloway A, Cant AJ. Unsuspected Pneumocystis carinii pneumonia at presentation of severe primary immunodeficiency. Archives of Disease in Childhood 2000, 82(2), 144-147.