1987 BSc Biochemistry (1st class Hons), University of London
1990 MBBS (Hons), University of London
1993 MRCP (UK), London
2000 PhD, University of London
2010 FRCP, London
1999-2002 Wingate Lecturer, Nephrology and Transplantation, King’s College London
2002-2005 Wellcome Advanced Fellow, King's College London
2005-2007 Senior Lecturer, King’s College London
Britist Transplant Society
Association of Physicians of UK and Northern Ireland
UK Kidney Research Collaboration (UKKRC)
Renal Specialty Group lead for Northumberland, Tyne and Wear
The complement system is an integral part of the immate immune system. In health it is responsinble for the elimination of pathogens and immune complexes. Excessive activation can lead to to tissue injury. I am interested in the role played by complememt in various types of kidney injury including, glomerular disease, interstitial inflammation and ischaemia reperfusion injury.
Fibrosis is the common pathway that leads to organ failure in many diverse diseases affecting different organs. In the kidney interstitial fibrsosis is characteristic of all progressive nephropathies that lead to renal failure. Becasue of the importance of fibrosis in clinical disease it is vital that we understand the mechanisms of renal fibrosis so that novel therapeutic targets can be identified and drugs developed. My group is studying the underlying pathological processes that lead to kidney fibrosis. This includes the role of chronic inflammation, including the complement system, the cell signalling pathways that initiate a fibrotic response and testing novel therapeutic interventions in pre-clinical model systems of fibrosis. Work is also underway to identify new non-invasive biomarkers that identifypatients with progressive renal fibrosis.
I lead the renal clinical research group at the Freeman. This is a team of research nurses, a study co-ordinator and data manager. We actively participate in a wide range of NIHR portfolio clinical trials in all aspects of Nephrology and Transplantation. The infrastructure and research staff support allows clinical staff to develop their own clinical studies and for clinicians to be part of important national studies. My own clinical resarch integrates with basic science, but also includes studying the severity and cause of the symptoms experienced by patients with kidney disease.
I am the Senior Tutor for Intercalation with responsibility for medical students during their intercalated year.
I established and am the Degree Programme Director for the Post Graduate Certificate in Transplantation.
I also lead the teaching on Renal Week which provides nephrology teaching to year 4 students on the MBBS programme.