Newcastle University

Projects

• CRAFT – GSK Creative Advances in Fibrosis Therapuetics
  Project Leader(s): Professor Derek Mann, Professor Andrew Fisher, Professor Neil Sheerin, Dr Fiona Oakley, Dr Stuart Kendrick
  This project is sponsored by Glaxo Smith Kline

• Wong EKS, Brady M, Sheerin NS. Severe intestinal oedema due to nephrotic syndrome. QJM 2013, 106(2), 191-192.
• Ermini L, Goodship THJ, Strain L, Weale ME, Sacks SH, Cordell HJ, Fremeaux-Bacchi V, Sheerin NS. Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS. Molecular Immunology 2012, 49(4), 640-648.
• Ermini L, Wilson IJ, Goodship THJ, Sheerin NS. Complement polymorphisms: Geographical distribution and relevance to disease. Immunobiology 2012, 217(2), 265-271.
• Brown JH, Tellez J, Wilson V, Mackie IJ, Scully M, Tredger MM, Moore I, McDougall NI, Strain L, Marchbank KJ, Sheerin NS, O'Grady J, Harris CL, Goodship THJ. Postpartum aHUS Secondary to a Genetic Abnormality in Factor H Acquired Through Liver Transplantation. American Journal of Transplantation 2012, 12(6), 1632-1636.
• Hunze EM, Sheerin NS, Marchbank KJ. Targeting the glomerular basement membrane to control unwanted complement activation. In: XXIV. International Complement Workshop. 2012, Crete, Greece: Urban und Fischer Verlag.
• Fearn A, Sheerin NS. Complement activation drives interstitial inflammation and fibrosis in models of kidney disease. In: Creative Advances in Fibrosis Therapy Symposium. 2011, Stevenage, UK.
• Ermini L, Goodship T, Strain L, Weale M, Sacks S, Cordell H, Fremeaux-Bacchi V, Sheerin N. Genetic variants in CFH and CD46 are the major susceptibility factors for aHUS-An association study of multiple complement genes. In: Molecular Immunology: 13th European Meeting on Complement in Human Disease. 2011, Leiden, Netherlands: Pergamon.
• Hatch E, Ingham VJ, Parker L, Smith A, Kirby J, Sheerin N. Infiltrating renal T cells are activated and respond to self antigen. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Wilson CH, Brown AL, White SA, Goodship THJ, Sheerin NS, Manas DM. Successful Treatment of De Novo Posttransplant Thrombotic Microangiopathy With Eculizumab. Transplantation 2011, 92(8), E42-E43.
• Fearn A, Lisgo S, Darby S, Sheerin NS. The influence of complement activation on chronic renal inflammation and fibrosis. In: Molecular Immunology: 13th European Meeting on Complement in Human Disease. 2011, Leiden, Netherlands: Pergamon.
• Fearn A, Lisgo S, Darby S, Sheerin NS. The influence of complement activation on chronic renal inflammation and fibrosis. In: Renal Association Meeting (Joint with British Renal Society). 2011, Birmingham, UK.
• Murtagh FEM, Sheerin NS, Addington-Hall J, Higginson IJ. Trajectories of Illness in Stage 5 Chronic Kidney Disease: A Longitudinal Study of Patient Symptoms and Concerns in the Last Year of Life. Clinical Journal of the American Society of Nephrology 2011, 6(7), 1580-1590.
• Fearn A, Sheerin NS. The influence of complement activation on chronic renal inflammation and fibrosis. In: North East Post-Graduate Conference. 2010, Newcastle upon Tyne, UK.
• Ingham V, Jayawardene S, O'Donnell P, Sheerin N. Diabetic glomerular disease: Pitfalls in diagnosis. NDT Plus 2009, 2(2), 187-188.
• Newton J, Brown A, Sheerin NS. Fatigue in early renal disease. British Journal of Renal Disease 2009, 14(2).
• Murtagh FE, Murphy E, Sheerin NS. Illness trajectories: an important concept in the management of kidney failure. Nephrology, Dialysis, Transplantation 2009, 23(12), 3746-3748.
• Tapmeier TT, Chowdhury P, Karegli J, Fearn A, Sacks SH, Sheerin NS, Wong W. Role for CD4⁺ T cells in Renal Fibrosis. In: Renal Association Meeting (Joint with British Renal Society). 2009, Liverpool, UK.
• Li K, Zhou WD, Hong YZ, Sacks SH, Sheerin NS. Synergy between type 1 fimbriae expression and C3 opsonisation increases internalisation of E-coli by human tubular epithelial cells. BMC Microbiology 2009, 9(1), 64.
• Fearn A, Oakley F, Mann D, Sheerin NS. Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1. In: North East Post-Graduate Conference. 2009, Newcastle Upon Tyne, UK.
• Fearn A, Oakley F, Mann D, Sheerin NS. Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1. In: Renal Association Meeting (Joint with British Renal Society). 2009, Liverpool, UK.
• Murphy EL, Murtagh FEM, Carey I, Sheerin NS. Understanding Symptoms in Patients with Advanced Chronic Kidney Disease Managed without Dialysis: Use of a Short Patient-Completed Assessment Tool. Nephron Clinical Practice 2009, 111(1), C74-C80.
• Ting SM, Lee D, Maclean D, Sheerin NS. Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure. Cardiology 2008, 111(2), 83-86.
• Tapmeier TT, Brown KL, Tang Z, Sacks SH, Sheerin NS, Wong W. Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation. Kidney International 2008, 73(7), 885-889.
• Sheerin NS. Should Complement Activation Be a Target for Therapy in Renal Transplantation?. Journal of the American Society of Nephrology 2008, 19(12), 2250-2251.
• Sheerin NS, Risley P, Abe K, Tang Z, Wong W, Lin T, Sacks SH. Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury. FASEB Journal 2008, 22(4), 1065-1072.
• Li K, Sacks SH, Sheerin NS. The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli. Molecular Immunology 2008, 45(4), 954-962.
• Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, Harris FE. Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrology Dialysis Transplantation 2007, 22(7), 1955-1962.
• Brown KM, Sacks SH, Sheerin NS. Mechanisms of disease: the complement system in renal injury - new ways of looking at an old foe. Nature Clinical Practice Nephrology 2007, 3(5), 277-286.
• Sheerin NS, Abe K, Risley P, Sacks SH. Accumulation of Immune Complexes in Glomerular Disease Is Independent of Locally Synthesized C3. Journal of the American Society of Nephrology 2006, 17(3), 686-696.
• Li K, Feito MJ, Sacks SH, Sheerin NS. CD46 (Membrane Cofactor Protein) Acts as a Human Epithelial Cell Receptor for Internalization of Opsonized Uropathogenic Escherichia coli. Journal of Immunology 2006, 177(4), 2543-2551.
• Lin T, Zhou W, Farrar CA, Hargreaves RE, Sheerin NS, Sacks SH. Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection. American Journal of Pathology 2006, 168(4), 1241-1248.
• Brown KM, Kondeatis E, Vaughan RW, Kon SP, Farmer CK, Taylor JD, He X, Johnston A, Horsfield C, Janssen BJ, Gros P, Zhou W, Sacks SH, Sheerin NS. Influence of Donor C3 Allotype on Late Renal-Transplantation Outcome. The New England Journal of Medicine 2006, 354(19), 2014-2023.
• Chowdhury P, Sacks SH, Sheerin NS. Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clinical and Experimental Immunology 2006, 145(2), 346-56.
• Keenan N, Jeyaratnam D, Sheerin NS. Mycobacterium simiae: a previously undescribed pathogen in peritoneal dialysis peritonitis. American Journal of Kidney Diseases 2005, 45(5), e75-78.
• Kucheria R, Dasgupta P, Sacks SH, Khan MS, Sheerin NS. Urinary tract infections: new insights into a common problem. Postgraduate Medical Journal 2005, 81(952), 83-86.
• Kouki P, Marsh JE, Sacks SH, Sheerin NS. Autoimmune renal injury in C3- and C4-deficient mice: a histological and functional study. Nephron Experimental Nephrology 2004, 96(1), e14-22.
• Chowdhury P, Sacks SH, Sheerin NS. Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney international 2004, 66(4), 1334-1344.
• Abe K, Li K, Sacks SH, Sheerin NS. The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells. Clinical and Experimental Immunology 2004, 136(1), 60-66.
• Kucheria R, Sheerin NS, Dasgupta P, Khan MS. Urinary tract infections: advances and new therapies. BJU International 2004, 93(6), 690-691.
• Sheerin NS, Bhatacharia KF, Webb MC. Positron emission tomography in a patient with renal malacoplakia. American Journal of Kidney Diseases 2003, 42(3), E36-39.
• Sheerin NS, Sacks SH. Leaked protein and interstitial damage in the kidney: is complement the missing link?. Clinical Experimental Immunology 2002, 130(1), 1-3.
• Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Nature Medicine 2001, 7(7), 801-806.
• Masterson R, Sheerin N, Abbs I, Goldsmith D. Late allograft loss due to recurrence of p-ANCA-associated systemic vasculitis in a patient with relapsing polychondritis. Nephrology, Dialysis, Transplantation 2001, 16(8), 1705-1707.
• Sheerin NS, Springall T, Abe K, Sacks SH. Protection and injury: the differing roles of complement in the development of glomerular injury. European Journal of Immunology 2001, 31(4), 1255-1260.
• Jayawardene SA, Sheerin N, Pattison JM, Hartley B, Goldsmith DJ. Spontaneous Abdominal Hemorrhage with AA-amyloidosis and Vasculitis in a Patient with Rheumatoid Arthritis. Journal of Clinical Rheumatology 2001, 7(2), 86-90.
• Tahir H, Thomas G, Sheerin N, Bettington H, Pattison JM, Goldsmith DJ. Successful medical treatment of acute bilateral emphysematous pyelonephritis. American Journal of Kidney Diseases 2000, 36(6), 1267-1270.
• Sheerin NS, Springall T, Carroll M, Sacks SH. Altered distribution of intraglomerular immune complexes in C3-deficient mice. Immunology 1999, 97(3), 393-9.
• Tang S, Sheerin NS, Zhou W, Brown Z, Sacks SH. Apical Proteins Stimulate Complement Synthesis by Cultured Human Proximal Tubular Epithelial Cells. Journal of the American Society of Nephrology 1999, 10(1), 69-76.
• Sheerin NS, Sacks SH. Chronic Interstitial Damage in Proteinuria. Does Complement Mediate Tubulointerstitial Injury?. Kidney Blood Pressure Research 1999, 22(1-2), 47-52.
• Tang S, Zhou W, Sheerin NS, Vaughan RW, Sacks SH. Contribution of renal secreted complement C3 to the circulating pool in humans. Journal of Immunology 1999, 162(7), 4336-4341.
• N. S. Sheerin,P. Swift,J. Scoble. From malaria to transplantation: the evolution of treatment for the nephrotic syndrome in a single patient. Nephrol Dial Transplant 1999, 14(3), 800-1.
• Sheerin NS, Sacks SH, Fogazzi GB. In vitro erythrophagocytosis by renal tubular cells and tubular toxicity by haemoglobin and iron. Nephrol Dial Transplant 1999, 14(6), 1391-7.
• N. S. Sheerin,S. H. Sacks. The local production of complement in the pathogenesis of renal inflammation. Nephrologie 1999, 20(7), 377-82.
• D. Song,W. Zhou,S. H. Sheerin,S. H. Sacks. Compartmental localization of complement component transcripts in the normal human kidney. Nephron 1998, 78(1), 15-22.
• N. S. Sheerin,S. H. Sacks. Complement and complement inhibitors: their role in autoimmune and inflammatory diseases. Curr Opin Nephrol Hypertens 1998, 7(3), 305-10.
• N. S. Sheerin,T. Springall,M. C. Carroll,B. Hartley,S. H. Sacks. Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice. Clin Exp Immunol 1997, 110(3), 403-9.
• N. S. Sheerin,W. Zhou,S. Adler,S. H. Sacks. TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells. Kidney Int 1997, 51(3), 703-10.
• S. H. Sacks,W. Zhou,N. S. Sheerin. Complement synthesis in the injured kidney: does it have a role in immune complex glomerulonephritis?. J Am Soc Nephrol 1996, 7(11), 2314-9.
• G. B. Fogazzi,N. S. Sheerin. IgA-associated renal diseases. Curr Opin Nephrol Hypertens 1996, 5(2), 134-40.
• N. Sheerin,J. F. Bourke,J. Holder,J. North,D. A. Burns. Bullous pemphigoid following radiotherapy. Clin Exp Dermatol 1995, 20(1), 80-2.
• N. Sheerin,N. K. Harrison,M. N. Sheppard,D. M. Hansell,M. Yacoub,T. J. Clark. Obliterative bronchiolitis caused by multiple tumourlets and microcarcinoids successfully treated by single lung transplantation. Thorax 1995, 50(2), 207-9.
• P. A. Andrews,N. S. Sheerin,J. A. Hicks,D. G. Williams,S. H. Sacks. Unusual presentations of anti-glomerular basement membrane antibody mediated disease are associated with delayed diagnosis and poor outcome. Clin Nephrol 1995, 44(4), 262-5.
• N. S. Sheerin,P. N. Monk,M. Aslam,H. Thurston. Simultaneous exposure to lead, arsenic and mercury from Indian ethnic remedies. Br J Clin Pract 1994, 48(6), 332-3.