Newcastle University

Background

Professor of Clinical Medicine, University of Newcastle
Clinical Sub-Dean for Teesside
Honorary Consultant Physician, South Tees Acute Trust
Chairman, Professional Advisory Council Executive, Diabetes UK (ex British Diabetic Association)
Chairman, Specialist Advisory Committee, Diabetes & Endocrinology, JCHMT

Qualifications

MB, University of London, MD University of London, FRCP

Research Interests

Diabetic nephropathy, hypertension in diabetes, clinical diabetes.

Renal structural analysis using light and electron microscopy and stereological morphometry. Renal functional estimates including GFR (isotopic and non-isotopic methods) and urinary protein excretion. Experienced investigator in clinical trials of anti-hypertensive therapy in diabetic nephropathy. National co-ordinator of Irbesartan Diabetic Nephropathy Trial (a large multi-centre study in 1650 Type 2 diabetic patients with nephropathy comparing Irbesartan v Amlodopine v placebo). Also principal investigator for planned Lipids in Diabetes Study, and currently involved in several ongoing studies using insulin analogues.

Undergraduate Teaching

Lead for delivery of Stages 3 - 5 MB BS programme on Teesside
Chairman Nutrition Metabolism & Endocrinology Module Phase 1 MB BS University Durham Queen's Campus

• The ACE Inhibitors in Diabetic Nephropathy Trialist Group. Should All Patients with Type 1 Diabetes Mellitus and Microalbuminuria Receive Angiotensin-Converting Enzyme Inhibitors? A Meta-Analysis of Individual Patient Data. Annals of Internal Medicine 2001, 134(5), 370-379.
• White KE, Bilous RW, Marshall SM, El Nahas M, Remuzzl G, Piras G, De Cosmo S, Vlberti G. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002,51 10 3083-3089.
• Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR. Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney International 2003, 63(1), 225-232.
• White KE, Bilous RW. Estimation of podocyte number: A comparison of methods. Kidney International 2004,66 2 663-667.
• White KE, Bilous RW. Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrology, Dialysis, Transplantation 2004, 19(6), 1437-1440.
• Krimholtz MJ, Karalliedde J, Thomas S, Bilous R, Viberti GC. Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease. Journal of the American Society of Nephrology 2005,16 Supplement 1 S42-S47.
• Bell R, Glinianaia S, Tennant PWG, Bilous R, Rankin J. Peri-conception hyperglycaemia and nepthropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study. Diabetologia 2012, 55(4), 936-947.
• Bell R, Glinianaia SV, Tennant P, Bilous R, Rankin J. Predictors of birth weight in singleton offspring of mothers with pre-gestational diabetes [Abstract]. In: Abstracts of Diabetes UK Professional Conference. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Tennant PWG, Prapathan S, Bilous R, Bell R. Recurrence of adverse pregnancy outcomes in women with pre-gestational diabetes [abstract]. Journal of Epidemiology & Community Health 2011, 65(s1), A214-A215.
• Setti G, Hayward A, Dessapt C, Barone F, Buckingham R, White K, Bilous R, Hiroshi K, Gruden G, Viberti G, Gnudi L. Peroxisome proliferator-activated receptor-γ agonist rosiglitazone prevents albuminuria but not glomerulosclerosis in experimental diabetes. American Journal of Nephrology 2010, 32(5), 393-402.
• Gnudi L, Davis B, Cas AD, White KE, Bilous R, Viberti G. Podocyte inducible angiopoietin-2 overexpression results in albuminuria and glomerulosclerosis in transgenic mice. In: Diabetologia: 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD). 2006, Copenhagen, Denmark: Springer.
• Baines LA, White KE, Viberti G, Marshall SM, Bilous RW. Blood pressure even within the normal range is related to the change in renal structure and function in type I diabetic patients with albuminuria. In: Journal of the American Society of Nephrology: 36th Annual Meeting of the American Society of Nephrology. 2003, San Diego, California, USA: American Society of Nephrology.
• Ashwell S, Amiel S, Bilous R, Heller S, Hepburn D, Home P. Improvement in overall blood glucose control with insulin glargine plus insulin lispro in comparison with NPH insulin plus unmodified human insulin in people with Type 1 diabetes. In: Diabetologia: 18th Congress of the International Diabetes Federation. 2003, Paris, France: Springer.
• White KE, Jones SE, Flyvbjerg A, Bilous RW, Marshall SM. The relationship between glomerular number and volume is altered in the streptozotocin-induced diabetic rat. In: Journal of the American Society of Nephrology: 36th Annual Meeting of the American Society of Nephrology. 2003, San Diego, California, USA: American Society of Nephrology.
• White KE, Bilous RW. Podocyte number in normotensive, albuminuric type 1 diabetic patients treated with enalapril or placebo for 3 years. Journal of the American Society of Nephrology 2002, 13(supplement), 470A-471A.
• White KE, Bilous RW. Structural alterations to the glomerular filtration barrier result in podocyte loss in type 2 diabetic patients with nephropathy. Journal of the American Society of Nephrology 2002, 13(supplement), 471A.
• Wahid ST, Nag S, Bilous RW, Marshall SM, Robinson ACJ. Audit of influenza and pneumococcal vaccination uptake in diabetic patients attending secondary care in the Northern Region. Diabetic Medicine 2001, 18(7), 599-603.
• Jones SE, Nyengaard JR, Flyvbjerg A, Bilous RW, Marshall SM. Birth weight has no influence on glomerular number and volume. Pediatric Nephrology 2001, 16(4), 340-345.
• White KE, Pinel N, Cordonnier DJ, Bilous RW. Does ACE inhibition slow progression of glomerulopathy in patients with Type 2 diabetes mellitus?. Diabetic Medicine 2001, 18(11), 933-936.
• Jones SC, Bowes D, Hall E, Connolly V, Kelly WF, Bilous RW. HOPE for patients with Type 2 diabetes: an application of the findings of the MICRO-HOPE substudy in a British hospital diabetes clinic. Diabetic Medicine 2001, 18(8), 667-670.
• White KE, Bilous RW, ESPRIT Study Grp. Increase in mesangial and endothelial cells but no change in podocyte number in type 1 diabetic patients with nephropathy. In: 37th Annual Meeting of the EASD. 2001, Glasgow, UK: Springer.
• Jones SE, Bilous RW, Flyvbjerg A, Marshall SM. Intra-uterine environment influences glomerular number and the acute renal adaptation to experimental diabetes. Diabetologia 2001, 44(6), 721-728.
• Wahid ST, Lilic D, Newman PK, Bilous RW. Meningoencephalitis following streptokinase treatment. Journal of Neurology, Neurosurgery and Psychiatry 2001, 70, 132-133.
• Connolly VM, Roper NA, Unwin NC, Bilous RW, Kelly WF. The impact of material deprivation on mortality in a population with diabetes. In: Diabetes UK Annual Professional Conference. 2001, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Connolly V, Unwin N, Sherriff P, Bilous R, Kelly W. Diabetes prevalence and socioeconomic status: A population based study showing increased prevalence of type 2 diabetes mellitus in deprived areas. Journal of Epidemiology and Community Health 2000, 54(3), 173-177.
• Macleod JM, White KE, Tate H, Bilous RW. Measurement of glomerular volume in needle biopsy specimens. Nephrology Dialysis Transplantation 2000, 15(2), 239-243.
• Bilous R. Blood pressure control in type 2 diabetes - What does the United Kingdom prospective diabetes study (UKPDS) tell us?. Nephrology, Dialysis, Transplantation 1999, 14(11), 2562-2564.