Newcastle University

Roles and Responsibilities

Honorary Consultant Physician, Newcastle upon Tyne  Hospitals NHS Foundation Trust

UCAS selector

Member, Faculty Ethics Committee

Associate Editor, Diabetologia

Editorial Board Member, Diabetic Medicine

Qualifications

BSc with First Class Honours in Biochemistry, University of Glasgow, 1975
MB, ChB, University of Glasgow, 1978
MRCP (UK) 1981
MD, University of Glasgow, 1990
FRCP (G) 1994
FRCP (L) 1994

Previous Positions

Lecturer, then Senior Lecturer, then Reader Department of Medicine, University of Newcastle upon Tyne 1986-1997
MRC Travelling Fellow, University of Aarhus, Denmark 1988-1989
MRC Training Fellow, University of Newcastle upon Tyne, 1984-1985.

Memberships

Vice-President, European Diabetic Nephropathy Study Group, 2000 -2003
Chair, Renal Group, Evidence based guidelines for management of Type 2 diabetes. NICE / RCP/ RCGP/ Diabetes UK
Member, Renal group, Diabetes NSF, Department of Health
Member, Research Committee, Diabetes UK

Research Interests

Major interset in diabetic nephropathy - genetics, cellular biology, natural history and management

Other Expertise

Diabetes and pregnancy

Current Work

Reader in Diabetes, University of Newcastle
Honorary Consultant Physician, Newcastle upon Tyne Acute Hospitals Trust and Newcastle Primary Care Trust
Chair, Renal Group, UK Guidelines for the Management of Type 2 diabetes (NICE, RCP, RCGP, BDA)

Member, Renal Group, Diabetes National Service Framework (Department of Health)
Vice-President, European Diabetic Nephropathy Study Group
Member, Academic Committee, Royal College of Physicians

Associate Editor, Diabetic Medicine

• Thelwall PE, Taylor R, Marshall SM. Non-invasive Investigation of Kidney Disease in Type 1 Diabetes by Magnetic Resonance Imaging. Diabetologia 2011, 54(9), 2421-2429.
• Viswanathan GN, Nelson AJ, Thompson L, Marshall SM, Zaman AG. Thrombus burden and response to clopidogrel in patients with type 2 diabets mellitus presenting with non ST elevation acute coronary syndrome. In: European Heart Journal: ESC Congress. 2010, Stockholm, Sweden: Oxford University Press.
• Marshall SM. Recent advances in diabetic nephropathy. Postgraduate Medical Journal 2004, 80(949), 624-633.
• Marshall SM, Amlodipine Investigators. A comparison of amlodipine and bendrofluazide as add-on therapy to ACE inihibition in hypertensive, Type 2 diabetic patients. In: Diabetologia: 18th Congress of the International Diabetes Federation. 2003, Paris, France: Springer.
• Baines LA, White KE, Viberti G, Marshall SM, Bilous RW. Blood pressure even within the normal range is related to the change in renal structure and function in type I diabetic patients with albuminuria. In: Journal of the American Society of Nephrology: 36th Annual Meeting of the American Society of Nephrology. 2003, San Diego, California, USA: American Society of Nephrology.
• Fischbacher CM, Bhopal R, Rutter MK, Unwin NC, Marshall SM, White M, Alberti KGMM. Microalbuminuria is more frequent in South Asian than in European origin populations: A comparative study in Newcastle, UK. Diabetic Medicine 2003, 20(1), 31-36.
• Arun CS, Stoddart J, Mackin P, MacLeod JM, New JP, Marshall SM. Significance of microalbuminuria in long-duration type 1 diabetes. Diabetes Care 2003, 26(7), 2144-2149.
• White KE, Jones SE, Flyvbjerg A, Bilous RW, Marshall SM. The relationship between glomerular number and volume is altered in the streptozotocin-induced diabetic rat. In: Journal of the American Society of Nephrology: 36th Annual Meeting of the American Society of Nephrology. 2003, San Diego, California, USA: American Society of Nephrology.
• Taylor R, Lee C, Kyne-Grzebalski D, Marshall SM, Davison JM. Clinical outcomes of pregnancy in women with Type 1 diabetes: a single center study of 109 pregnancies. American Journal of Obstetrics & Gynecology 2002, 99(4), 537-541.
• Advani A, Marshall SM, Thomas TH. Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary. Diabetologia 2002, 45(5), 719-727.
• White KE, Bilous RW, Marshall SM, El Nahas M, Remuzzl G, Piras G, De Cosmo S, Vlberti G. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002, 51(10), 3083-3089.
• Rutter MK, Wahid ST, McComb JM, Marshall SM. Significance of silent ischemia and microalbuminuria in predicting coronary events in asymptomatic patients with type 2 diabetes. Journal of the American College of Cardiology 2002, 40(1), 56-61.
• Jones SE, Nyengaard JR, Flyvbjerg A, Bilous RW, Marshall SM. Birth weight has no influence on glomerular number and volume. Pediatric Nephrology 2001, 16(4), 340-345.
• Jones SE, Bilous RW, Flyvbjerg A, Marshall SM. Intra-uterine environment influences glomerular number and the acute renal adaptation to experimental diabetes. Diabetologia 2001, 44(6), 721-728.
• Marshall SM. HOPE for all people with diabetes?. Diabetic Medicine 2000, 17(2), 9-10.
• Rutter MK, McComb JM, Forster J, Brady S, Marshall SM. Increased left ventricular mass index and nocturnal systolic blood pressure in patients with Type 2 diabetes mellitus and microalbuminuria. Diabetic Medicine 2000, 17(4), 321-325.
• Marshall SM, Barth JH. Standardization of HbA(1c) measurements - A consensus statement. Diabetic Medicine 2000, 17(1), 5-6.
• Marshall SM, Barth JH. Standardization of HbA(1c) measurements: A consensus statement. Annals of Clinical Biochemistry 2000, 37(1), 45-46.
• T. A. Chowdhury, P. H. Dyer, S. Kumar, S. P. Gibson, B. R. Rowe, S. J. Davies, S. M. Marshall, P. J. Morris, G. V. Gill, S. Feeney, P. Maxwell, D. Savage, A. J. M. Boulton, J. A. Todd, D. Dunger, A. H. Barnett and S. C. Bain. Association of apolipoprotein epsilon 2 allele with diabetic nephropathy in Caucasian subjects with IDDM. Diabetes 1998, 47, 278-280.
• M. K. Rutter, J. M. McComb, S. Brady and S. M. Marshall. Autonomic neuropathy in asymptomatic subjects with non-insulin- dependent diabetes mellitus and microalbuminuria. Clinical Autonomic Research 1998, 8, 251-257.
• Marshall S.M. for the Professional Advisory Committee, British Diabetic Association. British Diabetic Association Guidelines on genetic and immune screening for Type 1 diabetes mellitus. Diabetic Medicine 1998, 15, 897-899.
• J. P. New, S. M. Marshall and R. W. Bilous. Renal autoregulation is normal in newly diagnosed, normotensive, NIDDM patients. Diabetologia 1998, 41, 206-211.
• S. M. Marshall. Sildenafil: a revolutionary therapy?. Diabetic Medicine 1998, 15, 897-899.
• P. P. deAlmeida, A. deLeiva, A. Ericsson, E. Ferrannini, A. Green, P. D. Home, D. Hemmann, S. M. Marshall, E. Standl, P. VanCrombrugge and H. YkiJarvinen. A strategy for arterial risk assessment and management in type 2 (non-insulin-dependent) diabetes mellitus. Diabetic Medicine 1997, 14, 611-621.
• Dorrell L., Hassan I., Marshall S., Chakraverty P., Ong E. Clinical and serological responses to an inactivated influenza vaccine in adults with HIV infection, diabetes, obstructive airways disease, elderly adults and healthy volunteers. Int J STD and AIDS 1997, 8, 776-779.
• Rutter M.K., Marshall S.M., McComb J.M. Coronary artery disease and diabetes. Heart 1997, 78, 527-527.
• European Pimagedine Trial Group. Early closure of European Pigmagedine trial. Lancet 1997, 350, 214-215.
• P. Mackin, K. E. White, R. W. Bilous and S. M. Marshall. Effects of angiotensin-converting enzyme inhibition on glomerular volume in experimental diabetes. Kidney International 1997, 52, 270-270.
• Chowdhury T.A., Dyer P.H., Kumar S., Gough S.C.L., Gibson S.P., Rowe B.R., Smith P.R., Dronsfield M.J., Marshall S.M., Mackin P., Dean J.D., Morris P.J., Davies S., Duger D.B., Boulton A.J.M., Barnett A.H., Bain S.C. Lack of association of angiotensin II Type 1 receptor gene polymorphism with diabetic nephropathy in insulin-dependent diabetes mellitus. Diabetic Medicine 1997, 14, 837-840.
• Saran R., Marshall S.M., Madsen R., Tapson J.S. Long-term follow-up of kidney donors: A longitudinal study. Nephrology, Dialysis and Transplantation 1997, 12, 1615-1621.
• Gibb I., Parnham A.J., Lord C., Steffes M.W., Bucksa J., Marshall S. Standardisation of glycated haemoglobin assays throughout the Northern Region of England: A pilot study. Diabetic Medicine 1997, 14, 584-588.
• Purcell I.F., Burke S.J., Marshall S.M. Use of cyclophosphamide in severe steroid resistant bronchioloitis obliterans organizing pneumonia. Respiratory Medicine 1997, 91, 175-177.
• A. E. Gold and S. M. Marshall. Cortical blindness and cerebral infarction associated with severe hypoglycemia. Diabetes Care 1996, 19, 1001-1003.
• Marshall S.M., Hansen K.W., Osterby R., Frystyk J., Orskov H., Flyvbjerg A. Effects of Heparin on renal morphology and albulminuria in experimental diabetes. American Journal of Physiology 1996, 271, E326-E332.
• T. A. Chowdhury, M. J. Dronsfield, S. Kumar, S. L. C. Gough, S. P. Gibson, A. Khatoon, F. MacDonald, B. R. Rowe, D. B. Dunger, J. D. Dean, S. J. Davies, J. Webber, P. R. Smith, P. Mackin, S. M. Marshall, D. Adu, P. J. M. Morris, J. A. Todd, A. H. Barnett, A. J. M. Boulton and S. C. Bain. Examination of two genetic polymorphisms within the renin- angiotensin system: No evidence for an association with nephropathy in IDDM. Diabetologia 1996, 39, 1108-1114.
• J. P. New, J. P. Canavan, A. Flyvbjerg, G. Hamon, R. W. Bilous and S. M. Marshall. Renal enlargement and insulin-like growth factor-1 accumulation in the Wistar rat model of experimental diabetes is not prevented by angiotensin converting enzyme inhibition. Diabetologia 1996, 39, 166-171.
• P. Mackin, J. M. Macleod, J. P. New and S. M. Marshall. Renal function in long-duration type I diabetes. Diabetes Care 1996, 19, 249-251.
• Viberti G-C., Marshall S., Beech R., Brown V., Derben P., Higson N., Home P., Keen H., Plant M., Walls J. Report on renal disease in diabetes. Diabetic Medicine 1996, 13 (Suppl 4), S6-S12.
• Marshall S.M. Strategies for monitoring diabetic nephropathy. Current Medical Literature 1996, 13, 67-72.
• Marshall S.M. The peri-operative management of diabetes. Care of the Critically Ill 1996, 12, 64-68.
• HAMMAN RF, FRANKLIN GA, MAYER EJ, MARSHALL SM, MARSHALL JA, BAXTER J, KAHN LB. MICROVASCULAR COMPLICATIONS OF NIDDM IN HISPANICS AND NON-HISPANIC WHITES - SAN LUIS VALLEY DIABETES STUDY. In: DIABETES CARE. 1991.
• Viswanathan GV, Harper A, Balasubramaniam K, Badimon JJ, Marshall SM, Zaman AZ. Blood thrombogenicity is inversely related to coronary lesion severity in patients with non ST-elevation acute coronary syndrome and type 2 diabetes mellitus. In: Annual Conference of the British Cardiovascular Society (BCS). 2012, Manchester, UK: BMJ Group.
• Little S, Chadwick T, Choudhary P, Brennand C, Stickland J, Barendse S, Olateju T, Leelarathna L, Walkinshaw E, Tan HK, Marshall SM, Thomas RM, Heller S, Evans M, Kerr D, Flanagan D, Speight J, Shaw JAM. Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial). BMC Endocrine Disorders 2012, 12(1), 33.
• Marshall SM. Diabetic Nephropathy in Type 1 diabetes: Has the Outlook Improved Since the 1980’s?. Diabetologia 2012, 55(9), 2301-2306.
• Viswanathan GN, Balasubramaniam K, Harper AG, Bawamia B, Marshall SM, Badimon JJ, Zaman AG. Higher thrombus, altered clot kinetics and fibrin architecture in patients with type 2 diabetes mellitus after non ST elevation acute coronary syndrome. In: Congress of the European Society of Cardiology (ESC). 2012, Munchen, Germany: Oxford University Press.
• Balasubramanian K, Viswanathan GN, Marshall SM, Zaman AG. Increased atherothrombotic burden in patients with diabetes mellitus and acute coronary syndrome: a review of antiplatelet therapy. Cardiology Research and Practice 2012, 909154.
• Viswanathan GN, Marshall SM, Balasubramanian K, Badimon JJ, Zaman AG. Increased blood thrombogenicity in optimally treated patients with type 2 diabetes mellitus after non ST elevation acute coronary syndrome. Thrombosis and Haemostasis 2012. In Press.
• Viswanathan GN, Marshall SM, Schechter CB, Balasubramaniam K, Badimon JJ, Zaman AG. Thrombus and antiplatelet therapy in type 2 diabetes mellitus: A prospective study after non-ST elevation acute coronary syndrome and a randomised, blinded, placebo-controlled study in stable angina. Thrombosis and Haemostasis 2012, 108(5), 937-945.
• Natarajan A, Marshall SM, Kesteven PJ, McComb JM, Rutter MK. Impact of biomarkers for endothelial dysfunction and procoagulant state on 10-year cardiovascular risk in Type 2 diabetes. Diabetic Medicine 2011, 28(10), 1201-1205.
• Viswanathan GN, Natarajan A, Marshall SM, Badimon JJ, Zaman AG. Higher Thrombus Burden and Impaired Clot Kinetics in Patients with Type 2 Diabetes Mellitus following Non ST-Elevation Acute Coronary Syndrome. In: American Heart Association Scientific Sessions. 2010, Chicago, Illinois, USA: Lippincott Williams & Wilkins.
• Taylor R, Lee C, Kyne-Grzebalski D, Marshall SM, Davison JM. Clinical outcomes of pregnancy in women with type 1 diabetes. Obstetrics and Gynecology 2002, 99(4), 537-541.
• Advani A, Marshall SM, Thomas TH. Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary granule exocytosis in Type II diabetes. Diabetologia 2002, 45(5), 719-727.
• Advani A, Marshall SM, Thomas TH. Monocyte integrin CD11b expression and actin assembly are abnormal in Type 2 diabetes. In: Diabetologia: 38th EASD Annual Meeting of the European Association for the Study of Diabetes. 2002, Budapest, Hungary: Springer.
• Rawling L, Advani A, Marshall SM, Thomas TH. Neutrophil actin assembly and trafficking of cell surface antigens is impaired in first-degree relatives of patients with Type 2 diabetes. In: Diabetologia: 38th EASD Annual Meeting of the European Association for the Study of Diabetes. 2002, Budapest, Hungary: Springer.
• Rutter MK, Viswanath S, McComb JM, Kesteven P, Marshall SM. QT prolongation in patients with Type 2 diabetes and microalbuminuria. Clinical Autonomic Research 2002, 12(5), 366-372.
• Advani A, Marshall SM, Thomas TH. Abnormal neutrophil actin assembly is associated with increased beta2integrin expression in Type 2 diabetes. In: 37th Annual Meeting of the EASD. 2001, Glasgow, UK: Springer.
• Wahid ST, Nag S, Bilous RW, Marshall SM, Robinson ACJ. Audit of influenza and pneumococcal vaccination uptake in diabetic patients attending secondary care in the Northern Region. Diabetic Medicine 2001, 18(7), 599-603.
• Advani A, Thomas TH, Marshall SM. Enhanced neutrophil integrin expression in patients with type 2 diabetes and microalbuminuria occurs through a cytoskeletal-dependent trafficking defect. In: European Heart Journal: XXIII Congress of the European Society of Cardiology. 2001, Stockholm, Sweden: Oxford University Press.
• Wahid ST, Marshall SM, Thomas TH. Increased platelet and erythrocyte external cell membrane phosphatidylserine in type 1 diabetes and microalbuminuria. Diabetes Care 2001, 24(11), 2001-2003.
• Taylor R, Lee C, Kyne-Grzebalski D, Marshall SM, Davison JM. Neonatal hypoglycaemia relates to control in labour not HbA1c in type 1 diabetic pregnancy. In: 37th Annual Meeting of the EASD. 2001, Glasgow, UK: Springer.
• Baines LA, Macleod JM, White KE, Marshall SM, Bilous RW. Albuminuria, even in the absence of hypertension, indicates established glomerulopathy in insulin dependent diabetic patients. In: The Renal Association Meeting. 1999, London, England: Nature Publishing Group.
• Marshall S. Blood pressure control, microalbuminuria and cardiovascular risk in Type 2 diabetes mellitus. Diabetic Medicine 1999, 16(5), 358-372.
• Senior PA, Marshall SM, Thomas TH. Dysregulation of PMN antigen expression in type 2 diabetes may reflect a generalized defect of exocytosis: Influence of hypertension and microalbuminuria. Journal of Leukocyte Biology 1999, 65(6), 800-807.
• Kyne-Grzebalski D, Wood L, Marshall SM, Taylor R. Episodic hyperglycaemia in pregnant women with well-controlled Type 1 diabetes mellitus: a major potential factor underlying macrosomia. Diabetic Medicine 1999, 16(8), 702-706.
• Rutter MK, McComb JM, Brady S, Marshall SM. Silent myocardial ischemia and microalbuminuria in asymptomatic subjects with non-insulin-dependent diabetes mellitus. American Journal of Cardiology 1999, 83(1), 27-31.
• MARSHALL SM, HOME PD, TAYLOR R, ALBERTI KGMM. CONTINUOUS SUBCUTANEOUS INSULIN INFUSION VERSUS INJECTION THERAPY - A RANDOMIZED CROSSOVER TRIAL UNDER USUAL DIABETIC CLINIC CONDITIONS. DIABETIC MEDICINE 1987, 4(6), 521-525.
• MARSHALL SM, APPLETON DR. THE PREVALENCE AND CORRELATES OF ALBUMIN EXCRETION IN TYPE-1 (INSULIN-DEPENDENT) DIABETES. In: DIABETOLOGIA. 1987.
• TAYLOR R, HUSBAND DJ, MARSHALL SM, ALBERTI KGMM. ADIPOCYTE INSULIN BINDING AND INSULIN SENSITIVITY IN BRITTLE DIABETES. In: DIABETOLOGIA. 1983.