People - Institute of Cellular Medicine

Dr Venetia Bigley
George Walker Clinical Fellow

Email: venetia.bigley@ncl.ac.uk

Publications

Haniffa M, Shin A, Bigley V, Teo P, See P, Wasan P, McGovern N, Wang XN, Malinarich F, Malleret B, Poidinger M, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of the human cross-presenting migratory dendritic cell. In: Meeting of the British Society for Investigative Dermatology. 2012, Exeter, UK: Wiley-Blackwell Publishing Ltd.
Haniffa M, Shin A, Bigley V, McGovern N, Wang XN, Teo P, Sng D, Won JM, Marinarich FG, Malleret B, See P, Larbi A, Zhou H, Poidinger M, Pagan S, Cookson S, Dickinson R, Connolly J, Gehring A, Bertoletti A, Collin M, Ginhoux F. CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
Bigley V, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome. Haematologica 2011, 96(8), 1081-1083.
Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Spence L, Pagan S, Carey C, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Jackson G, Dick JE, Hambleton S, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of the dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
Dickinson RE, Bigley V, Griffin H, Lakey JH, McGovern N, Chua I, Wallis J, Hambleton S, Santibanez-Koref M, Collin M. Human dendritic cell deficiency is caused by GATA-2 mutation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
Collin M, Bigley V, Haniffa M, Hambleton S. Human dendritic cell deficiency: the missing ID?. Nature Reviews Immunology 2011, 11(9), 575-583.
McGovern N, Bigley V, Allen C, Haniffa M, Wang XN, Dickinson R, Pagan S, Windebank K, McClain K, Ginhoux F, Merad M, Collin M. Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
Hambleton S, Salem S, Bustamente J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez C, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova J-L, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. New England Journal of Medicine 2011, 365(2), 127-138.
Sturgess K, Slatter M, Bigley V, Haniffa M, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Chua I, Wallis J, Lordan J, Morgan C, Cant A, Gennery A, Edmondson R, Bacon C, Black F, Kirkham N, Jackson GH, Hambleton S, Collin MP. Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Dick JE, Hambleton S, Collin M. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. Journal of Experimental Medicine 2011, 208(2), 227-234.
Hugle T, Krippner-Heidenreich A, Simpson R, Kraaij M, O'Reilly S, Bigley V, Collin M, Iversen L, van Laar JM. Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta. In: Annals of the Rheumatic Diseases: 31st European Workshop for Rheumatology Research. 2011, Amsterdam, Netherlands: BMJ Group.
Harries V, Dickinson R, Bigley V, Collin M. The Equilibration of Peripheral Blood and Tissue CD3+T Cell Engraftment Is Influenced by Graft Versus Host Disease Following Reduced Intensity Conditioning Stem Cell Transplantation. In: Blood: American Society of Hematology Annual Meeting. 2010, Orlando, Florida, USA: American Society of Hematology.
Bigley VH, Duarte RF, Gosling RD, Kibbler CC, Seaton S, Potter M. Fusarium dimerum infection in a stem cell transplant recipient treated successfully with voriconazole. BONE MARROW TRANSPLANTATION 2004, 34(9), 815-817.

Institute of Cellular Medicine Newcastle University, Newcastle upon Tyne
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Newcastle University

Institute of Cellular Medicine

Dr Venetia Bigley George Walker Clinical Fellow

Dr Venetia Bigley
George Walker Clinical Fellow