Newcastle University

Roles and Responsibilities

Honorary Consultant Interventional Cardiologist, Freeman Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust 

Qualifications

FESC Fellow of the European Society of Cardiology

FACC Fellow of the American College of Cardiology

FRCP Fellow of Royal College of Physicians Edinburgh

MD Newcastle University

MRCP Royal College of Physicians Edinburgh

MBBS 

Postgraduate and Academic Training

General and Internal Medicine, Northern Deanery, UK

General and Interventional Cardiology, Northern Deanery, UK

Research Scholar: TIMI/PERFUSE Angiographic Core Lab, Brigham and Women's Hospital/Harvard Medical School, Boston MA, USA

Research Registrar: The James Cook University Hospital, Middlesbrough, UK 

Other Responsibilities

Academic lead- MSc Cardiac Science Module, Newcastle University

Academic lead for Cardiology- NIHR Academic Clinical Fellowship, Northern Deanery

Academic lead- Cardiology Training Programme Northern Deanery

Associate Fellow- Graduate School, Newcastle University 

Supervisor- MBBS Stage 4 SSC in Cardiology and Clinical Cardiology Research 

Section Editor, Society for Cardiovascular Angiography and Intervention's (SCAI) SecondsCount Editorial Board

Member, Women in Innovations 

Invited Peer Reviewer

The American Journal of Cardiology

Heart

Herz

Catheterization and Cardiovascular Intervention

Journal of Interventional Cardiology

The Lancet 

Memberships

British Cardiovascular Society

British Cardiovascular Intervention Society

European Society of Cardiology

Society for Coronary Angiography and Interventions

European Association of Percutaneous Cardiovascular Interventions

American College of Cardiology 

American Heart Association 

Awards

Finalist, TCT 2010, Thomas J Linnemeier Young Investigator Award- Washington DC. 

Chief Investigator:

ICON 1 Study- A Study to Improve Cardiovascular Outcomes in High Risk PatieNts with Acute Coronary Syndrome : UKCRN ID 12742.

Co-workers:

Dr. Murugu Veerasamy MBBS MRCP Clinical Research Associate in Cardiology, Newcastle University  

Dr. Weiliang Qiu PhD- Instructor/Biostatistician, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, USA

Dr. Bilal Bawamia MBBS MRCP- Core Medical Trainee, Northern Deanery 

Dr. Hannah Sinclair MBBS MRCP- BRC Clinical Research Fellow in Cardiology, Newcastle University

Mr. Joseph Dunford- Stage 4 Medical Student, Newcastle University

Undergraduate Teaching and Supervision

Supervisor: Student Selected Components (SSC) Stage 4 Medical Students- Newcastle University

Personal Tutor: Stage 1 and Stage 3 Medical Students- Newcastle University

Postgraduate Teaching

Academic Lead Cardiology/Instructor: Modernising Scientific Careers MSc in Cardiovascular Science, Newcastle University

• Navarese EP, Buffon A, Kozinski M, Obonska K, Rychter M, Kunadian V, Austin D, De Servi S, Sukiennik A, Kubica J. A critical overview on ticagrelor in acute coronary syndromes. QJM: An International Journal of Medicine 2013, 106(2), 105-115.
• Noman A, Das R, Balasubramaniam K, Kunadian V, Ivanauskiene T, Zaman A. Admission heart rate predicts mortality following Primary PCI for ST Elevation Myocardial Infarction: An observational study. Cardiovascular Therapeutics 2013. In Press.
• Kunadian V, James S, Wojdyla D, Zorkun C, Wu J, Storey RF, Steg G, Katus H, Emanuelsson H, Horrow J, Maya H, Wallentin L, Harrington R, Gibson CM. Angiographic Outcomes in the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Journal of the American College of Cardiology Cardiovascular Interventions 2013. In Press.
• Sinclair H, Sutton A, Dangas G, Kunadian V. Aspirin, Platelet P2Y12 Receptor Inhibitors and other Oral Antiplatelets: Comparative Pharmacology and Role in Elective PCI. Interventional Cardiology Clinics 2013. Submitted.
• Kunadian V, Harper A, Bawamia B, Zaman A. Drug eluting stents versus bare metal stents in primary PCI. Future Medicine 2013. In Press.
• Navarese EP, Austin D, Gurbel PA, Andreotti F, Tantry U, James S, Buffon A, Kozinski M, Obonska K, Bliden K, Jeong YH, Kubica J, Kunadian V. Drug-coated balloons in treatment of in-stent restenosis: a meta-analysis of randomised controlled trials. Clinical Research in Cardiology 2013, 102(4), 279-287.
• Ghoorah K, De Soyza A, Kunadian V. Increased Cardiovascular Risk in Patients with Chronic Obstructive Pulmonary Disease and the Potential Mechanisms Linking the Two Conditions: A Review. Cardiology in Review 2013, (epub ahead of print).
• Kunadian V, Qiu W, Bawamia B, Jamieson S, Zaman A. Primary PCI for ST Elevation Myocardial Infarction in patients with cardiogenic shock: Declining mortality with absence of gender difference. American Journal of Cardiology 2013. Submitted.
• Bawamia B, Mehran R, Qiu W, Kunadian V. Risk scores in acute coronary syndrome and percutaneous coronary intervention: A review. American Heart Journal 2013. In Press.
• Kunadian V, Dunford J, Swarbrick D, Halaby R, Patrick W, Maddaleni M, Gibson CM. Triple antiplatelet therapy and combinations with oral anticoagulants after stent implantation. Interventional Cardiology Clinics 2013. Submitted.
• Vlachojannis G, Kunadian V, Sweeny J, Mehran R. Antithrombotic therapy in non–ST-segment elevation acute coronary syndromes. In: Moliterno, D.J., Kristensen, S.D., De Caterina, R, ed. Therapeutic Advances in Thrombosis. Oxford: Blackwell Publishing Ltd, 2012, pp.205-212.
• Pride YB, Mohanavelu S, Zorkun C, Kunadian V, Giugliano RP, Newby LK, Braunwald E, Califf RM, Harrington R, Gibson CM. Association between Angiographic Complications and Clinical Outcomes among Patients with Acute Coronary Syndrome undergoing Percutaneous Coronary Intervention: An EARLY ACS Angiographic Substudy. Journal of the American College of Cardiology: Cardiovascular Interventions 2012, 5(9), 927-935.
• Kunadian V, Coats L, Kini A, Mehran R. Cardiogenic Shock in Women. Interventionals Cardiology Clinics 2012, 1(2), 231-243.
• Kunadian V, Austin D, Bland J. In-hospital Mortality Following Primary Angioplasty in the Setting of Cardiac Arrest is High and Varies Depending on Patient Location at the Time of Arrest: A UK Registry Database Study. In: Transcatheter Cardiovascular Therapeutics (TCT) Symposium. 2012, Miami, Florida, USA: Elsevier Inc.
• Kunadian V, Veerasamy M, Zaman A. Lack of gender difference and improved in-hospital mortality rates in patients with cardiogenic shock following primary percutaneous coronary intervention: a UK tertiary cardiac centre registry study. In: Congress of the European Society of Cardiology (ESC). 2012, Munchen, Germany: Oxford University Press.
• Kunadian V, Pugh A, Zaman AG, Qiu WL. Percutaneous coronary intervention among patients with left ventricular systolic dysfunction: a review and meta-analysis of 19 clinical studies. Coronary Artery Disease 2012, 23(7), 469-479.
• Bundhoo SS, Earp E, Ivanauskiene T, Kunadian V, Freeman P, Edwards R, Kinnaird TD, Zaman A, Anderson RA. Saphenous vein graft percutaneous coronary intervention via radial artery access: Safe and effective with reduced hospital length of stay. American Heart Journal 2012, 164(4), 468-472.
• Pugh A, Bourke JP, Kunadian V. Sudden cardiac death among competitive adult athletes: a review. Postgraduate Medical Journal 2012, 88(1041), 382-390.
• Kunadian V, Gibson CM. Thrombolytics and Myocardial Infarction. Cardiovascular Therapeutics 2012, 30(2), e81-e88.
• Kunadian V, Pride YB, Buris J, Ciaglo L, Morrow D, Gibson CM. Coronary Flow Reserve Varies Depending Upon the Location Within the Artery it is Assessed and the TIMI Myocardial Perfusion Grade: A PROTECT TIMI-30 Analysis. Journal of Thrombosis and Thrombolysis 2011, 32(4), 448-452.
• Kunadian V, Zorkun C, James S, Wu J, Muhammad A, Storey R, Steg G, Katus H, Emanuelsson H, Horrow J, Maya J, Wallentin L, Harrington R, Gibson CM. Angiographic outcomes in the platelet inhibition and platelet outcomes (PLATO) trial. In: American College of Cardiology: American College of Cardiology i2 summit. 2011, New Orleans, Los Angeles, USA: Elsevier Inc.
• Pride YB, Mohanavelu S, Giugliano RP, Newby LK, Zorkun C, Kunadian V, Braunwald E, Califf RM, Harrington RA, Gibson CM. Association Between Angiographic Complications During Percutaneous Coronary Intervention and Clinical Outcomes Among Patients with Acute Coronary Syndrome: An EARLY ACS Angiographic Substudy. In: American Heart Association Annual Congress. 2011, Orlando, Florida.
• Kunadian V, Pugh A, Qiu WL. Percutaneous Coronary Intervention in Patients with Severe Left Ventricular Dysfunction: A Meta-analysis of 19 Studies. In: Journal of the American College of Cardiology: 23rd Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium. 2011, San Francisco, California, USA: Elsevier Inc.
• Kunadian V, Morley R, Adam Z, Muir D, Sutton A, Wright R, Hall J, Carter J, Swanson N, de Belder M. Percutaneous coronary intervention using radial access is associated with less radiation exposure to patients compared with femoral access. In: European Society of Cardiology Congress. 2011, Paris, France.
• Kunadian V, Gibson CM. Recombinant tissue-type plasminogen activators: "Time Matters". Drugs of Today 2011, 47(7), 559-570.
• Kunadian V, Zaman A, Qiu WL. Revascularization among patients with severe left ventricular dysfunction: a meta-analysis of observational studies. European Journal of Heart Failure 2011, 13(7), 773-784.
• Best PJ, Skelding KA, Mehran R, Chieffo A, Kunadian V, Madan M, Mikhail GW, Mauri F, Takahashi S, Honye J, Hernández-Antolín R, Weiner BH. SCAI consensus document on occupational radiation exposure to the pregnant cardiologist and technical personnel. Heart, Lung & Circulation 2011, 20(2), 83-90.
• Best PJ, Skelding KA, Mehran R, Chieffo A, Kunadian V, Madan M, Mikhail GW, Mauri F, Takahashi S, Honye J, Hernández-Antolín R, Weiner BH. SCAI Consensus Document on Occupational Radiation Exposure to the Pregnant Cardiologist and Technical Personnel. Eurointervention 2011, 6(7), 866-874.
• Best PJ, Skelding KA, Mehran R, Chieffo A, Kunadian V, Madan M, Mikhail GW, Mauri F, Takahashi S, Honye J, Hernández-Antolín R, Weiner BH. SCAI consensus document on occupational radiation exposure to the pregnant cardiologist and technical personnel. Catheterization and Cardiovascular Interventions 2011, 77(2), 232-241.
• Kunadian V, Zaman A, Spyridopoulos I, Qiu W. Sodium bicarbonate for the prevention of contrast induced nephropathy: A meta-analysis of published clinical trials. European Journal of Radiology 2011, 79(1), 48-55.
• Kunadian V, Qiu W. Coronary Artery Bypass Surgery among Patients with Severely Impaired Left Ventricular Systolic Function is Associated with Improved Long-term Survival: A Meta-analysis of Observational Studies. In: Journal of the American College of Cardiology: Transcatheter Cardiovascular Therapeutics. 2010, Washington DC, USA: Elsevier Inc.
• Gibson CM, Pride YB, Aylward PE, Col JJ, Goodman SG, Gulba D, Bergovec M, Kunadian V, Zorkun C, Buros JL, Murphy SA, Antman EM. Association of Non-Steroidal Anti-Inflammatory Drugs with Outcomes in Patients with ST-Segment Elevation Myocardial Infarction Treated with Fibrinolytic Therapy: An ExTRACT-TIMI 25 Analysis. Journal of Thrombosis and Thrombolysis 2009, 27(1), 11-17.
• Kunadian V, Zaman A, Qiu W. Sodium Bicarbonate For The Prevention Of Contrast Induced Nephropathy: A Meta-Analysis. In: SCAI’s 32nd Annual Scientific Sessions. 2009, Las Vegas, Nevada, USA.
• Kunadian V, Harrigan C, Zorkun C, Palmer AM, Ogando KJ, Biller LH, Lord EE, Williams SP, Lew ME, Ciaglo LN, Buros JL, Marble SJ, Gibson WJ, Gibson CM. Use of the TIMI Frame Count in the Assessment of Coronary Artery Blood Flow and Microvascular Function Over the Past 15 years. Journal of Thrombosis and Thrombolysis 2009, 27(3), 316-328.
• Kunadian V, De Belder MA. Angiographic and physiologic assessment of coronary flow and myocardial perfusion in the cardiac catheterization laboratory. Acute Cardiac Care 2008, 10(2), 69-78.
• Gibson CM, Zorkun C, Kunadian V. Intracoronary Administration of Abciximab in ST elevation Myocardial Infarction. Circulation 2008, 118(1), 6-8.
• Kunadian V, Zorkun C, Williams SP, Biller LH, Palmer AM, Ogando KJ, Lew ME, Nethala N, Gibson WJ, Marble SJ, Buros JL, Gibson CM. Intracoronary Pharmacotherapy in the Management of Coronary Microvascular Dysfunction. Journal of Thrombosis and Thrombolysis 2008, 26(3), 234-242.
• Ciaglo L, Karmpaliotis D, Kunadian V, Gibson W, Buros J, Zorkun C, Lew M, Harrington R, Palmer A, Ogando K, Biller L, Lord E, Williams S, Marble S, Alexander J, Gibson CM. Larger Saphenous Vein Grafts in Relation to Native Artery are Associated with Reduced TIMI Grade 3 Flow but Improved Myocardial Perfusion at 1 Year: A PREVENT IV Analysis . In: Circulation: American Heart Association Scientific Sessions. 2008, Orlando, Florida, USA: Lippincott Williams & Wilkins.
• Kunadian V, Griffiths A, Hasan A, O'Sullivan J. Late hazards after repair of coarctation of the aorta. British Medical Journal 2008, 336(7647), 772-773.
• Hobson AR, McKenzie DB, Kunadian V, Purcell I, Zaman A, Dawkins KD, Curzen N. Malignancy: An unrecognized risk factor for coronary stent thrombosis?. Journal of Invasive Cardiology 2008, 20(4), E120-E123.
• Gibson CM, Pride YB, Buros JL, Kunadian V, Southard MC, Harrigan CJ, Ciaglo LN, Sabatine MS, Cannon CP, Braunwald E. Relation of hyperemic epicardial flow to outcomes among patients with ST segment elevation myocardial infarction receiving fibrinolytic therapy. American Journal of Cardiology 2008, 101(9), 1232-1238.
• Kunadian B, Kunadian V, Dunning J, Sutton AG, Muir DF, Wright RA, Hall JA, de Belder MA. Rescue angioplasty after failed fibrinolysis for acute myocardial infarction: predictors of a failed procedure and 1-year mortality. Catheterization and Cardiovascular Interventions 2008, 71(2), 138-145.
• Thambyrajah J, Kunadian V, Graham RJ, Turley AJ, de Belder MA, Stewart MJ. Strain rate imaging pre- and post-percutaneous coronary intervention: a potential role in the objective detection of ischaemia in exercise stress echocardiography. European Journal of Echocardiography 2008, 9(5), 646-54.
• Kunadian V, Zorkun C, Gibson WJ, Nethala N, Harrigan C, Palmer AM, Ogando KJ, Biller LH, Lord EE, Williams SP, Lew ME, Ciaglo LN, Buros JL, Marble SJ, Gibson CM. Transfusion Associated Microchimerism: A Heretofore Little Recognized Complication Following Transfusion. Journal of Thrombosis and Thrombolysis 2008, 27(1), 57-67.
• Kunadian V, Kunadian B, Wright RA, Hall JA, Stewart MJ, Davies A, Sutton A, de Belder MA. A prospective randomised controlled trial to determine the early and late reactions after the use of iopamidol 340 (Niopam) and iomeprol 350 (Iomeron) in cardiac catheterisation. European Journal of Radiology 2007, 61(2), 342-350.
• Kunadian V, Kelly D, Chapple CL, Williams D, Wright R, Stewart MJ, Hall JA, Sutton A, Davies A, Haywood J, de Belder MA. Cardiac catheterisation: radiation doses and lifetime risk of malignancy. Heart 2007, 93(3), 370-371.
• Kunadian B, Sutton AGC, Vijayalakshmi K, Thornley AR, Gray JC, Grech ED, Hall JA, Harcombe AA, Wright RA, Smith RH, Murphy JJ, Shyam-Sundar A, Stewart MJ, Davies A, Linker NJ, de Belder MA. Early invasive versus conservative treatment in patients with failed fibrinolysis-no late survival benefit: The final analysis of the Middlesbrough Early Revascularisation to Limit Infarction (MERLIN) randomized trial. American Heart Journal 2007, 153(5), 763-771.
• Kunadian V, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Somasundram U, Stewart MJ, Sutton A, Davies A, de Belder MA. Impact of catheter sizes and intracoronary glyceryl trinitrate on the TIMI frame count when digital angiograms are acquired at lower frame rates during elective angiography and PCI. Acute Cardiac Care 2007, 9(4), 231-238.
• Kunadian V, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Sutton A, Muir D, de Belder MA. Intra-aortic counterpulsation does not improve coronary flow early after PCI in a high-risk group of patients: observations from a randomized trial to explore its mode of action. Journal of Invasive Cardiology 2007, 19(8), 339-346.
• Kunadian B, Dunning J, Kunadian V, Thornley AR, de Belder MA. Meta-analysis of randomized trials comparing anti-embolic devices with standard PCI for improving myocardial reperfusion in patients with acute myocardial infarction. Catheterization and Cardiovascular Interventions 2007, 69(4), 488-496.
• Kunadian B, Kunadian V, Thornley AR, de Belder MA, Hunter S, Kendall S, Graham R, Stewart M, Thambyrajah J, Dunning J. Meta-analysis of valve hemodynamics and left ventricular mass regression for stentless versus stented aortic valves. Annals of Thoracic Surgery 2007, 84(1), 73-78.
• Kunadian B, Kunadian V, Dunning J, Thornley AR, Sutton AG, Muir DF, Wright RA, Hall JA, de Belder MA. Should patients in cardiogenic shock undergo rescue angioplasty after failed fibrinolysis: comparison of primary versus rescue angioplasty in cardiogenic shock patients. Journal of Invasive Cardiology 2007, 19(5), 217-223.
• Kunadian B, Kunadian V, Balasubramanian S, Dunning J. Should the tricuspid valve be replaced with a mechanical or biological valve?. Interactive Cardiovascular and Thoracic Surgery 2007, 6, 551-557.
• Kunadian V, Kunadian B, Whittaker VJ, Williams D, Wright RA, Sutton AG, Hall JA, de Belder MA. The impact of chronically diseased coronary arteries and stenting on the corrected TIMI frame count in elective coronary angiography and percutaneous coronary intervention procedures. Catheterization and Cardiovascular Interventions 2007, 70(5), 691-700.
• Kunadian B, Kunadian V, Dunning J, Sutton A, de Belder MA. Towards an understanding of the role of rescue angioplasty for failed fibrinolysis: comparison of the MERLIN, RESCUE and REACT trials. Journal of Invasive Cardiology 2007, 19(9), 359-368.
• Kunadian B, Kunadian V, de Belder MA. Treatment of restenosis after bare-metal and drug-eluting stenting of an aorto-ostial lesion: challenges associated with excessive stent overhang. Journal of Cardiovascular Medicine (Hagerstown) 2007, 8(9), 744-747.
• Kunadian V, Whittaker VJ, Sutton A, Campbell P, Wright RA, Hall JA, Harcombe AA, Linker NJ, Stewart MJ, Davies A, de Belder MA. A randomized trial of prophylactic antiarrhythmic agents (amiodarone and sotalol) in patients with atrial fibrillation for whom direct current cardioversion is planned. American Heart Journal 2006, 151(4), 863.e1-863.e6.
• Kunadian V, Whittaker VJ, Kunadian B, Graham J, Wright RA, Hall J, Sutton A, de Belder MA. Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes. Heart 2006, 92(9), 1278-1284.
• Kunadian V, Kunadian B, Wright RA, Sutton AG, Hall JA, de Belder MA. Successful thrombus extraction with the Rescue thrombus management system during acute percutaneous coronary intervention improves flow but does not necessarily restore optimal myocardial tissue perfusion. Catheterization and Cardiovascular Interventions 2006, 67(6), 879-886.
• Kunadian V, Williams D, Wright RA, Hall JA, Harcombe AA, Linker NJ, Stewart MJ, Davies A, de Belder MA. A prospective, randomized trial to determine the early and late reactions after the use of iopamidol 340 (Niopam) and iobitridol 350 (Xenetix) in cardiac catheterization. Journal of Invasive Cardiology 2004, 16(12), 707-711.
• Kunadian V, Ashton VJ, Wright RA, Hall JA, Stewart MJ, Davies A, de Belder MA. Corrected TIMI frame count: applicability in modern digital catheter laboratories when different frame acquisition rates are used. Catheterization and Cardiovascular Interventions 2004, 63(4), 426-432.