Haematopoietic stem cell transplantation is the transplantation of bone marrow or peripheral blood stem cells in patients with blood cancer and other diseases. Although one of the most powerful treatments for leukaemia, stem cell transplantation still has a high risk of toxicity and does not always cure the underlying disease.
Our work aims to improve this first through developing new ways to predict which patients will suffer complications of transplantation and second, finding new strategies to control the outcome of transplantation. Through these efforts we have identified genes which appear to control the outcome of transplantation. We have also made progress in identifying particular cells that trigger immune reactions between the donor and recipient. Both these efforts may give us new diagnostic tools or avenues of treatment in the future.
If you are concerned that you might suffer from a blood disease you should contact your doctor to discuss it. If you are interested in finding out more about blood disease, and our research into its causes and treatments, or are interested in participating in our research you are encouraged to contact Dr Matthew Collin.