Newcastle University

Musculoskeletal Disease

Musculoskeletal Research Group

The research focus of the Musculoskeletal Research Group is the causes and management of arthritis, bone and joint diseases. We are a mixture of biochemists, immunologists, geneticists and molecular biologists. Our diverse portfolio includes studies of the degradation of articular cartilage, to the use of nanotechnology in the design of future joint prostheses to the generation of novel immunotherapies. We are a close-knit group that benefits from cross-disciplinary interactions and research programmes.

Matrix biology, osteoarthritis and bone

One group focus on the enzymes that destroy articular cartilage in osteoarthritis (OA) and rheumatoid arthritis (RA) from the perspective of their biochemistry, gene regulation and signalling pathways. A key interest is the changes that occur with ageing. John Loughlin studies the genetic predisposition to OA and the effects of associated alleles on gene activity and protein function. (Rowan, Cawston, Young and Milner)

Another group study the outcomes of joint replacement and methods for improving integration with host tissue. In particular they are actively seeking ways to adapt nanoscale science for the coating of prosthetic surfaces. (Birch and McCaskie)

The third group focus on osteoporosis, metabolic bone disease and the epidemiology of musculoskeletal disease in the elderly. (Francis, Datta and Birrell)

Immunotherapy and immune modulation

This focusses on the disturbed and perturbed immune system in autoimmune arthritis. Our goal is the development of novel immunomodulatory therapies, including cellular therapies, and the assessment of disturbances of the immune system particularly in autoimmunity. (Isaacs, van Laar, Robinson, Hilkens, Ng, Lilic, Hambleton)

We have a strong commitment in musculoskeletal education and have developed learning tools that are used by all medical students in the UK and, increasingly, overseas. Paediatric rheumatology (Foster) also has an education interest and the barriers to achieving timely referral of patients with childhood arthritis. Furthermore, there is major link with UK clinical research strategy in paediatric rheumatology (through the Arthritis Research Campaign/ Medicines for Children Research Network clinical studies group) and exploring challenges to engagement in clinical research within clinical practice.