Publication:

Genetic analysis of autoimmune type 1 diabetes mellitus in mice (1991)

Author(s): J. A. Todd;T. J. Aitman;R. J. Cornall;S. Ghosh;J. R. Hall;C. M. Hearne;A. M. Knight;J. M. Love;M. A. McAleer;J. B. Prins;et al.

  • : Genetic analysis of autoimmune type 1 diabetes mellitus in mice

Abstract: Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.

  • Short Title: Genetic analysis of autoimmune type 1 diabetes mellitus in mice
  • Journal: Nature
  • Volume: 351
  • Issue: 6327
  • Pages: 542-7.
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Animal Autoimmune Diseases/*genetics Chromosome Mapping Diabetes Mellitus, Experimental/*genetics Diabetes Mellitus, Insulin-Dependent/*genetics Genes, Structural Islets of Langerhans/pathology Linkage (Genetics) Mice Mice, Mutant Strains Pancreatitis/genetics/pathology Polymorphism, Restriction Fragment Length Repetitive Sequences, Nucleic Acid Support, Non-U.S. Gov't

Staff

Dr Andrew Knight
Lecturer