Keratins: a structural scaffold with emerging functions (2003)

Author(s): Reichelt J; Kirfel J; Magin TM

  • : Keratins: a structural scaffold with emerging functions

Abstract: Intermediate filament proteins form an essential part of the cytoskeleton and provide topological order to cells and tissues. These features result from their intrinsic property of self-organization and their response to extrinsic cues. Keratins represent the largest subgroup among all intermediate filament proteins and are differentially expressed as pairs of type I and type II intermediate filament proteins in epithelia. Their primary function is to impart mechanical strength to cells. This function is illustrated by patients with keratin mutations and by gene-deficient mice. Additional functions include their participation in the response to stress, cell signalling and apoptosis, and thus the keratin cytoskeleton appears far more dynamic than previously anticipated. This may result from hyperphosphorylation and possibly from interaction with associated proteins. How signalling networks affect keratin organization, turnover and function and vice versa will be a major challenge for future investigations.

  • Short Title: Keratins: a structural scaffold with emerging functions
  • Date: 19-01-2004
  • Journal: Cellular and Molecular Life Sciences
  • Volume: 60
  • Issue: 1
  • Pages: 56-71
  • Publication type: Review
  • Bibliographic status: Published

Keywords: Amino Acid Sequence Animals Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 17 Forecasting Humans Intermediate Filaments/chemistry/genetics/ultrastructure Keratin/chemistry/genetics/*metabolism Keratinocytes/cytology/metabolism Mutation Protein Structure, Tertiary Pseudogenes Research Support, Non-U.S. Gov't


Dr Julia Reichelt