Author(s): Redfern CPF, Daly AK, Latham JAE, Todd C
Abstract: The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
Notes: 0014-5793 Journal Article
Keywords: Animals Carrier Proteins/biosynthesis/*genetics Cell Line Cycloheximide/pharmacology Gene Expression/*drug effects Kinetics Melanoma, Experimental Mice RNA, Messenger/genetics/isolation & purification Receptors, Retinoic Acid Research Support, Non-U.S. Gov't Stereoisomerism Tretinoin/analogs & derivatives/*pharmacology