Publication:
The biological activity of retinoids in melanoma cells: Induction of expression of retinoic acid receptor-β by retinoic acid in S91 melanoma cells (1990)
Author(s): Redfern CPF, Daly AK, Latham JAE, Todd C
- : The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells
Abstract: The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
Notes: 0014-5793 Journal Article
- Short Title: The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells
- Date: 29-10-1990
- Journal: FEBS Letters
- Volume: 273
- Issue: 1-2
- Pages: 19-22
- Publication type: Article
- Bibliographic status: Published
- Author Address: Department of Dermatology, Medical School, University of Newcastle upon Tyne, UK.
- URL: http://dx.doi.org/10.1016/0014-5793(90)81041-L
- DOI: 10.1016/0014-5793(90)81041-L
- ISSN (electronic): 1873-3468
Keywords: Animals Carrier Proteins/biosynthesis/*genetics Cell Line Cycloheximide/pharmacology Gene Expression/*drug effects Kinetics Melanoma, Experimental Mice RNA, Messenger/genetics/isolation & purification Receptors, Retinoic Acid Research Support, Non-U.S. Gov't Stereoisomerism Tretinoin/analogs & derivatives/*pharmacology
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Professor Ann Daly
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