Publication:

The biological activity of retinoids in melanoma cells: Induction of expression of retinoic acid receptor-β by retinoic acid in S91 melanoma cells (1990)

Author(s): Redfern CPF, Daly AK, Latham JAE, Todd C

  • : The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells

Abstract: The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.

Notes: 0014-5793 Journal Article

  • Short Title: The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells
  • Date: 29-10-1990
  • Journal: FEBS Letters
  • Volume: 273
  • Issue: 1-2
  • Pages: 19-22
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Animals Carrier Proteins/biosynthesis/*genetics Cell Line Cycloheximide/pharmacology Gene Expression/*drug effects Kinetics Melanoma, Experimental Mice RNA, Messenger/genetics/isolation & purification Receptors, Retinoic Acid Research Support, Non-U.S. Gov't Stereoisomerism Tretinoin/analogs & derivatives/*pharmacology