Our research has its origins in clinical and developmental genetics.
We started from a base in monogenic disorders. But we now have significant expertise in complex genetics and epigenetics.
This is closely related to the major clinical specialties of:
- cardiovascular medicine
- muscle disease
Research into monogenic disorders still prospers. But we can now address genetics of complex disorders.
Our work includes a major presence in the fields listed above. We also look at neuromuscular disorders and ophthalmology.
We have a growing involvement in therapeutics and chemoprevention in genetic diseases.
Underpinning our research are state-of-the-art facilities in molecular genetics and cell biology, including:
- Sequenom automated genotyping
- Roche GSFLX and Solexa high throughput DNA sequencing
- laser microdissection microscopy
- optical projection tomography
- Nikon and Zeiss confocal microscopy with Meta upgrade
- 14 colour FACAria fluorescence activated cell sorter
We have extensive stem cell culture suites. We also have a spacious Good Manufacturing Practice facility for preparing reagents.
The Institute hosts mouse transgenics and zebrafish units for:
- modelling disease
- investigating gene function
- looking at organ and tissue development
The principal research themes are:
- Complex Disease & Quantitative Genetics
- Developmental Genetics & Gene Expression
- Endocrine & Renal Genetics
- Neurological & Neuromuscular Genetics
- Stem Cell Biology & Cellular Therapy
Research Excellence Framework (REF) 2014Research Excellence Framework (REF) 2014
The Research Excellence Framework (REF) 2014 assessed the quality of research in the UK’s higher education institutions.
The review process is managed by the Higher Education Funding Council for England (HEFCE) and is made on three main criteria:
- quality of research outputs
- impact of research (beyond the University)
- vitality of the research environment
Our Institute submitted to Unit of Assessment (UoA) 1 and the results are now published.
In previous analysis, the Research Assessment Exercise (RAE) 2008 produced the following results for Newcastle University.