Institute of Genetic Medicine

Our Research

Our Research

Our research has its origins in clinical and developmental genetics.

We started from a base in monogenic disorders. But we now have significant expertise in complex genetics and epigenetics.

We started from a base in monogenic disorders. But we now have significant expertise in complex genetics and epigenetics.

This is closely related to the major clinical specialties of:

  • cardiovascular medicine
  • endocrinology
  • oncology
  • nephrology
  • neurological
  • muscle disease

Research into monogenic disorders still prospers. But we can now address genetics of complex disorders.

Our work includes a major presence in the fields listed above. We also look at neuromuscular disorders and ophthalmology.

We have a growing involvement in therapeutics and chemoprevention in genetic diseases.

Facilities

Underpinning our research are state-of-the-art facilities in molecular genetics and cell biology, including:

  • Sequenom automated genotyping
  • Roche GSFLX and Solexa high throughput DNA sequencing
  • laser microdissection microscopy
  • optical projection tomography
  • Nikon and Zeiss confocal microscopy with Meta upgrade
  • 14 colour FACAria fluorescence activated cell sorter

We have extensive stem cell culture suites. We also have a spacious Good Manufacturing Practice facility for preparing reagents.

The Institute hosts mouse transgenics and zebrafish units for:

  • modelling disease
  • investigating gene function
  • looking at organ and tissue development

Research themes

The principal research themes are:

You can also find out about our research into Rare Diseases and Ageing.

The Institute hosts a zebrafish unit for modelling disease among other things.
The Institute hosts a zebrafish unit for modelling disease among other things.