Research in the Institute of Genetic Medicine had its origins in clinical and developmental genetics. Starting from a base in monogenic disorders, we now have critical mass in complex genetics and epigenetics, closely related to the major Clinical Specialties of cardiovascular medicine, endocrinology, oncology, nephrology, neurological and muscle disease. While research into monogenic disorders still prospers, we have acquired a capacity to address the genetics of complex disorders. Work in genetic medicine includes a major presence in the fields of cardiovascular medicine, endocrinology, nephrology, neuromuscular disorders, oncology and ophthalmology. An exciting new dimension is a growing involvement in therapeutics and chemoprevention in genetic diseases.
Underpinning our research are state-of-the-art facilities in molecular genetics and cell biology, including Sequenom automated genotyping, Roche GSFLX and Solexa high throughput DNA sequencing, laser microdissection microscopy, optical projection tomography, Nikon and Zeiss confocal microscopy with Meta upgrade, and the 14 colour FACAria fluorescence activated cell sorter. Extensive stem cell culture suites are supplemented by an adjacent spacious GMP facility for preparing reagents suitable for clinical administration. The Institute also hosts mouse transgenics and zebrafish units for modelling disease and investigating gene function and organ and tissue development.
The principal research themes are: