Newcastle University

Introduction

I graduated in 2005 from the University of Newcastle upon Tyne medical school with MBBS honours with distinction, having intercalated an MRes in Biomolecular Sciences with distinction.

Having gained full GMC registration and completed the membership exams for the Royal College of Physicians, I have started my research work at the Institute for Human Genetics

Background

I graduated in 2005 from the University of Newcastle upon Tyne medical school with MBBS honours with distinction, having intercalated an MRes in Biomolecular Sciences with distinction.

Having gained full GMC registration and completed the membership exams for the Royal College of Physicians, I have started my research work at the Institute for Human Genetics

Qualifications

Bachelor of medicine and bachelor of surgery (MBBS) - honours with distinction-July 2005.
Master of research in biomolecular sciences (MRes) - distinction-December 2004.
Membership to the Royal College of Physicians (MRCP UK)-July 2008.

Previous Positions

Foundation doctor - northern deanery - August 2005 - August 2007.
Academic clinical fellow - northern deanery - August 2007 - present.

Memberships

Royal College of Physicians UK

Honours and Awards

The Goyder Memorial Scholarship - June 2005.
Wolfson Intercalated Research Scholarship - June 2004.
The Sewell Prize for Excellence in Examinations in Stage 2 MBBS - July 2001

Languages

English as a first language.
French as a second language (qualification - A level grade A)

Research Interests

Clinical and translational research

Other Expertise

During my MRes, I did some laboratory work with the mitochondrial research group.

Current Work

Laboratory genotyping work on a cohort of samples from patients with Addison's disease.
I am also currently involved in a clinical pilot study running through the Clinical Research Facility at the RVI.

Future Research

Endocrinology

Undergraduate Teaching

I have been involved in delivering undergraduate medical teaching in formal lectures and informal teaching at the bedside on the wards.

Postgraduate Teaching

I have been involved in teaching postgraduate medical students both through presentations and on the wards.

• Mitchell AL, Pearce SHS. Autoimmune Addison disease: pathophysiology and genetic complexity. Nature Reviews Endocrinology 2012, 8(5), 306-316.
• Mitchell AL, Pearce SHS. "Grading" subclinical thyroid disease may be misleading: Authors' response to Goichot, Vinzio and Luca. Clinical Endocrinology 2011, 74(1), 137-138.
• Mitchell AL, Dwyer A, Pitteloud N, Quinton R. Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. Trends in Endocrinology and Metabolism 2011, 22(7), 249-258.
• Swalwell H, Kirby DM, Blakely EL, Mitchell A, Salemi R, Sugiana C, Compton AG, Tucker EJ, Ke X, Lamont PJ, Turnbull DM, McFarland R, Taylor RW, Thorburn DR. Respiratory chain complex I deficiency caused by mitochondrial DNA mutations. European Journal of Human Genetics 2011, 19(7), 769-775.
• Gan EH, Mitchell AL, MacArthur K, Pearce SHS. The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis. Clinical Endocrinology 2011, 75(2), 165-168.
• Mitchell AL, Pearce SHS. How should we treat patients with low serum thyrotropin concentrations?. Clinical Endocrinology 2010, 72(3), 292-296.
• Mitchell AL, Pearce SHS. An elderly woman with weight loss and diarrhoea. British Medical Journal 2009, 338, b1721.
• Mitchell AL, Cordell HJ, Soemedi R, Owen K, Skinningsrud B, Wolff AB, Ericksen M, Undlien D, Husebye E, Pearce SHS. Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison's Disease and Graves' Disease Susceptibility. Journal of Clinical Endocrinology and Metabolism 2009, 94(12), 5139-5145.
• Mitchell AL, Hickey B, Hickey JL, Pearce SHS. Trends in thyroid hormone prescribing and consumption in the UK. BMC Public Health 2009, 9, 132.
• Mitchell AL. The treatment of nausea and vomiting in pregnancy. Crown, 2008. Available at: http://www.toxbase.org/.
• Mitchell AL, Elson JL, Howell N, Taylor RW, Turnbull DM. Sequence variation in mitochondrial complex I genes: Mutation or polymorphism?. Journal of Medical Genetics 2006, 43(2), 175-179.
• Blakely EL, Mitchell AL, Fisher N, Meunier B, Nijtmans LG, Schaefer AM, Jackson MJ, Turnbull DM, Taylor RW. A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast. FEBS Journal 2005, 272(14), 3583-3592.