Complex Disease and Quantitative Genetics
Following
on from successes in mapping of disease genes for rare Mendelian traits, a major
research focus of the IHG is now the identification of genetic determinants
for common, complex disorders. Our research groups are involved in studying
the genetic basis of autoimmune disease, complex cardiovascular traits, renal
disorders and analysis of gene expression. We also develop new statistical methods
and tools for analyzing genetic data. Research pages for academic staff engaged
in research in this area are given below:
Key Researchers
Professor Heather Cordell
- Development of statistical methodology for detection and characterisation
of genetic factors in complex disease
Professor Bernard Keavney - Finding
gene that cause heart and circulatory disease
Professor Simon Pearce - Autoimmune endocrine
disease and subclinical hyperthyroidism
Dr Caroline Relton - Epigenetic variation in common complex disease
Dr Mauro Santibanez-Koref
- Using allelic expression differences to ascertain cis-acting functional polymorphisms
Dr Ian Wilson - Development of Statistical Methods for Population Genomic Data
