Newcastle University

Introduction

 Ann Le Couteur is the Professor of Child and Adolescent Psychiatry at Newcastle University and an Honorary Consultant Child and Adolescent Psychiatrist for Northumberland, Tyne & Wear NHS Trust where she leads the North East Regional Complex Neurodevelopmental Disorders Service. Her clinical and research work has focused on understanding the aetiology, assessment, diagnosis, management and treatment of Autism Spectrum Disorders (ASD) and other complex mental health disorders (such as Early Onset Bipolar Disorder) in children, young people, adults and their families/carers. She co-leads the Newcastle University Autism Research Team within the Lifecourse, Development and Ageing Group, Institute of Health & Society, co-ordinating programmes of work studying the genetics of ASD and the broader autism phenotype; the development of assessment and outcome measures across the lifespan; evaluation of interventions for children and families; and the promotion of evidence based models of best practice for ASD services including transition to adult services. 

Professor Le Couteur is one of the authors of Autism Diagnostic Interview-Revised (ADI-R)(1996,2003), an internationally recognised trainer for the Autism Diagnostic Observation Schedule (ADOS) and led the British Twin Study of Autism (1995,1996). She chaired the work for The National Autism Plan for Children (2003) in the UK; is a member of two ASD NICE guideline development groups (2011; 2013), and was an external advisor to the Department of Health Adult Autism Strategy/Statutory Guidance (2009,2010). She co-leads (with Jeremy Parr) the International Molecular Genetic Study of Autism Consortium (IMGSAC) and is a member of the Autism Genome Project, she sits on the scientific/medical advisory board of several UK research charities for individuals  young people with complex needs (including Autism Spectrum Disorders).

Qualifications

BSc. (Hons) Psychology London University    1974

MBBS (London)                                                 1977

MRC Psych.                                                       1982

FRC Psych.                                                        1997

FRCPCH                                                            1998

GMC Number 2406055

Approved Clinician under Mental Health Act, 2011 – 2016

Previous Positions

1987 – 1990 Lecturer in Child & Adolescent Psychiatry, Institute of Psychiatry, Honorary Consultant in Child & Adolescent Psychiatry, The Maudsley Hospital, London.

1993 – 2002 Honorary Senior Lecturer, Institute of Psychiatry, London.

1990-1995 Consultant in Child & Adolescent Psychiatry, Enfield Community Care NHS Trust & Honorary Senior Lecturer, Royal Free Hospital Medical School & Tavistock Clinic, London.

1995 - Professor of Child and Adolescent Psychiatry, Newcastle University. Visiting Professor of Child &Adolescent Psychiatry, Durham University. Honorary Consultant Child and Adolescent Psychiatrist, Northumberland Tyne & Wear NHS Foundation Trust.

Memberships

Royal College of Psychiatrists.
Royal College of Paediatrics & Child Health.
Association of Child and Adolescent Mental Health.
British Medical Association.
Child Psychiatry Research Society.
Young Minds.

Research Interests

Research interests include the study of ASD and other complex mental health and neurodevelopmental disorders across the lifespan. The ASD research team has a number of related on-going programmes of work including: autism genetics; the investigation of repetitive behaviours in normally developing children and individuals with ASD; possible cognitive underpinning of co-morbid disorders particularly anxiety; the development and evaluation of both diagnostic assessment procedures and robust outcome measures ( including identifying appropriate modifications for individuals with hearing impairment) and the identification of evidence based models for effective service provision  for young people with ASD and other complex healthcare needs as they transition to adult services . The research team also undertake evaluation studies of interventions for children, young people with ASD and their families, and the management of co-morbid mental health disorders.

Postgraduate Supervision

Three PhD (one awarded 2012) and two MD students. Prof Le Couteur supervises students on the Clinical Doctorate course in Clinical Psychology and senior trainees on the Northern Regional Child and Adolescent Psychiatry training Scheme.

Esteem Indicators 

• Member of the MRC College of Experts (2006 - 2009).
• Member of DfES Autism Research Co-ordination Group (2006 - 2009).
• Member of the Scientific Advisory Committee, Research Autism (2006 -).
• External advisor and expert peer reviewer for the Scottish Intercollegiate Guidelines Network (SIGN): ASD guideline and the New Zealand ASD Guideline (2006 - 2009).
• Independent Autism Specialist for North East Autism Consortium (2008).
• Member of DH External Reference Group for the Adult Autism Strategy (2008 - 2010).
• Member of Research Advisory Group, UK Brain Bank for Autism & Related Developmental Research (2008 -).
• Member of Medical Advisory Group, Contact a Family (2008 -).
• Chair, Child & Adolescent Family Public Education Board (CAFPEB), Royal College of Psychiatrists (2009 -).
• Member of External Reference Group, Young People's Mental Health Transition Project, National Mental Health Development Unit. (2010 - 2011).
• Member of National Advisory Board, Transition to Adult Services & Adulthood for Young People with ASC, Social Policy Research Unit (SPRU) York University (2010-2012).
• Member of ASD Strategy Group and Trust lead for Transition, NTW NHS FT (2010 -).
• Member of Scientific Review Panel Member, Autistica (2010 -).
• Member of NICE GDG on Autism Spectrum Disorders in children and young people, recognition, referral and diagnosis (CG 128) (2009 - 2011).
• External Advisor to the National Autistic Society Child and Adolescent Mental Health Research Project (2009 - 2011).
• Member of NICE GDG on Management and support of children and young people with autism and their families from birth to 19 years (2011 - 2013).
• Chair of the Science Committee for European Autism Action (2010 - 2011).
• National Clinical lead for Autism Spectrum Disorders Specialist Services Commissioning Group (2012 -).
• Academic Secretary for Faculty of Child & Adolescent Psychiatry, Royal College of Psychiatrists (2012 -).

Funding      

• Pre-school Autism Communication Trial (PACT 7-11) Study. Newcastle PI: MRC (lead: Prof Jonathan Green, Unviersity of Manchester) 2013-2015 £672,637.
• Diagnostic Instruments for Autism in Deaf Children Study (DIADS). Co-applicant: MRC (lead: Dr Barry Wright, York University) 2013-2016 £472,678.
• Feasibility Study of new parent group intervention to manage repetitive behaviour in young children with ASD (MRB). Co-applicant: RfPB (lead: Dr Vicki Grahame) 2012-2015 £232,800.
• How can health services contribute most effectively to facilitating successful transition of young people with complex health needs from childhood to adulthood? Co-applicant: NIHR Programme Grant. (lead: Allan Colver) 2012-2017 £1999,697.
• India Database for Children with Autism Spectrum Disorder. Co-applicant: Autistica. (lead Jeremy Parr) 2012-2014 £88,174.
• MeASURe: Measurement in autism spectrum disorder under review. Co-applicant: NIHR HTA. (lead Helen McConachie) 2012-2013 £259,946.
• Fifteen to twenty five years. Co-applicant: NHS North-East-SHA. (lead: Dorothy Newbury-Birch) 2010-2013 £58,481.
• ASD Transition (PI): Northumberland, Tyne and Wear, NHS Trust. 2010-2011 £28,669.
• How can health services contribute most effectively to facilitating successful transition of young people with complex health needs from childhood to adulthood? Co-applicant: NIHR Development Grant. 2009-2011 £96,315.
• Effective therapy for anxiety in young people with autism spectrum disorder. Co-applicant: NIHR, RfPB. 2009-2011 £228,857.
• Social Attention in Autism Spectrum Disorder. Experimental Findings and Methodological Techniques. Co-applicant: ESRC. 2009-2011 £84,178.
• Parents and professionals attitudes to dietary interventions in ASD (PADIA). (PI): Autism Speaks. 2008-2010 $109,658.
• The Development of Repetitive Behaviours in Young Children. Co-applicant: ESRC. 2007. £46,402.
• International Molecular Genetic Study of Autism Consortium (IMGSAC). Co-applicant. 2006-2010 40,025 Euros.
• Test Foods Development Study. (PI): Research Autism. 2006-2009 £45,000.
• The Pre-school Autism Communication Trial (PACT). Co-applicant: MRC, DfES. 2005-2009 £1,204,538 (NHS costs £517,704).
• The development of algorithms for Autism and ASD. (PI): The Health Foundation. 2003-2007 £96,216.
• Establishment of a Registry of Children with Autistic Spectrum Disorder in Northeast England. Co-applicant: Northern Rock Foundation. 2002-2009 £176,461.

Projects

• Gateshead Millennium Study : A longitudinal cohort study of children born in Gateshead 1999-2000
  Project Leader(s): Professor Ashley Adamson
• How can health services contribute most effectively to facilitating successful transition of young people with complex health needs from childhood to adulthood?
  Project Leader(s): Professor Allan Colver
• Pilot trial of a new parent group intervention to manage repetitive behaviours in young children with ASD
  Project Leader(s): Professor Ann Le Couteur

Undergraduate Teaching

Professor Le Couteur oversees the Medical student curriculum teaching in Child & Adolescent Mental Health within Child Health stage 3 & 4/5 Teaching Modules and supervises 3-6 option student placements on diagnosis and management of Autism Spectrum Disorders and severe mental health conditions in children and young people within the Complex Neurodevelopmental Disorder Service.

Postgraduate Supervision

She is academic lead for the Northern Regional Senior Training Scheme in Child and Adolescent Psychiatry.  

• Maskey M, Warnell F, Parr J, LeCouteur A, McConachie H. Emotional and Behavioural Problems in Children with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders 2013, 43(4), 851-859.
• Garralda ME, McConachie H, LeCouteur A, Sriranjan S, Chakrabarti I, Guglieri M, Cirak S, Bushby K, Muntoni F. Emotional impact of genetic trials in progressive paediatric disorders: a dose-ranging exon-skipping trial in Duchenne muscular dystrophy. Child: Care, Health and Development 2013, (epub ahead of print).
• Pickles A, Parr JR, Rutter ML, De Jonge MV, Wallace S, Le Couteur AS, van Engeland H, Wittemayer K, McConachie H, Roge B, Mantolan C, Pedersen L, Isager T, Poustka F, Bolte P, Bolton P, Weisblatt E, Green J, Papanikolauo K, Bailey AJ. New Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure. Journal of Autism and Developmental Disorders 2013, (epub ahead of print).
• Barrett B, Byford S, Sharac J, Hudry K, Leadbitter K, Temple K, Aldred C, Slonims V, Green J, PACT consortium. Service and Wider Societal Costs of Very Young Children with Autism in the UK. Journal of Autism & Development Disorders 2013, (epub ahead of print).
• Casey J, Maqalhaes T, Conroy J, Regan R, et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics 2012, 131(4), 565-579.
• Parkinson KN, Drewett RF, Le Couteur A, Adamson AJ, The GMS Core Team. Earlier predictors of eating disorder symptoms in 9-year old children. A longitudinal Study. Appetite 2012, 59(1), 161-167.
• Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny GP, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund SC, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza GK, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JAS, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI, Oliveira G, Parr JR, Pericak-Vance MA, Piven J, Schellenberg GD, Scherer S, Vicente AM, Wassink TH, Wijsman EM, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson AD, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B. Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Human Molecular Genetics 2012, 21(21), 4781-4792.
• Camilleri N, Phinn E, Le Couteur A, Meyer TD, Newbury-Birch D, Thirk T, McArdle P. The feasibility of identifying, treating and improving outcomes in ‘hard-to-reach’ young people with multiple complex mental disorders. In: 20th European Congress of Psychiatry. 2012, Prague, Czech Republic: Elsevier Masson.
• Wigham S, McConachie H, Tandos J, LeCouteur A, Gateshead Millennium Study core team. The reliability and validity of the Social Responsiveness Scale in a UK general child population. Research in Developmental Disabilities 2012, 33(3), 944-950.
• Palmer E, Ketteridge C, Parr J, Baird G, LeCouteur A. ASD diagnostic assessments: Improvements since NAP-C publication. Archives A Disease of Childhood 2011, 96, 473-475.
• Parkinson KN, Pearce M, Dale A, Reilly JJ, Drewett RF, Wright CM, Relton CL, McArdle P, Le Couteur AS, Adamson AJ. Cohort Profile: The Gateshead Millennium Study. International Journal of Epidemiology 2011, 40(2), 308-317.
• McArdle P, Young R, Quibell T, Moseley D, Johnson R, Le Couteur A. Early intervention for at risk children: 3-year follow-up. European Child & Adolescent Psychiatry 2011, 20(3), 111-120.
• Spence J, Carson V, Casey L, Boule N, GMS team. Examining behavioural susceptibility to obesity among Canadian pre-school children: The role of eating behaviours. International Journal Of Pediatric Obesity 2011, 6(2-2), E501-E507.
• Watson R, Parr J, Joyce C, May C, LeCouteur A. Models of transitional care for young people with complex health needs: a scoping review. Child: Care, Health and Development 2011, 37(6), 780-791.
• Wright C, Inskip H, Godfrey K, Williams A, Ong K, GMS team. Monitoring head size and growth using the new UK-WHO growth standard. Archives of Disease in Childhood 2011, 4(4), 386-388.
• Robertson J, Puckering C, Parkinson K, Corlett L, Wright C, GMS team. Mother-child feeding interactions in children with and without weight faltering; nested case control study. Appetite 2011, 56(3), 753-759.
• Fisher A, Saxton J, Hill C, Webber L, Purslow L, Wardle J, GMS team. Psychosocial correlates of objectively measured physical activity in children. European Journal of Public Health 2011, 21(2), 145-150.
• Pagnamenta AT, Khan H, Walker S, Gerrelli D, Wing K, Bonaglia MC, Giorda R, Berney T, Mani E, Molteni M, Pinto D, Le Couteur A, Hallmayer J, Sutcliffe JS, Szatmari P, Paterson AD, Scherer SW, Vieland VJ, Monaco AP. Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability. Journal of Medical Genetics 2011, 48(1), 48-54.
• Basterfield L, Adamson AJ, Pearce MS, Reilly JJ, GMS team. Stability of habitual physical activity and sedentary behaviour monitoring by accelerometry in 6-8 year olds. Journal of Physical Activity & Health 2011, 8(4), 543-547.
• Green D, Lingam R, Mattocks C, Riddoch C, Ness A, Emond A, GMS team. The risk of reduced physical activity in children with probable Developmental Coordination Disorder: A prospective longitudinal study. Research in Developmental Disabilities 2011, 32(4), 1332-1342.
• Parr J, Le Couteur A. What is the Broader Autism Phenotype?. In: Bolte, S., Hallmayer, J, ed. Autism Spectrum Conditions: FAQs on Autism, Asperger Syndrome, and Atypical Autism Answered by International Experts. Cambridge, Massachusetts, USA: Hogrefe Publishing, 2011, pp.521-524.
• Parkinson KN, Drewett RF, Jones AR, Wright CM, Dale A, Pearce NS, Adamson AJ, Gateshead Millennium Study Core Team. When do mothers think their child is overweight?. International Journal of Obesity 2011, 35(4), 510-516.
• Parkinson KN, Drewett RF, le Couteur A, Adamson AJ. Do maternal ratings of appetite in infants predict later Child Eating Behviour Questionnaire scores and body mass index?. Appetite 2010, 54(1), 186-190.
• Parr J, Le Couteur A, Baird G, Rutter M, Pickles A, Fombonne E, Bailey A, The International Molecular Genetic Study of Autism Consortium (IMGSAC). Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample. Journal of Autism and Developmental Disorders 2010, 41(3), 332-340.
• Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Berney T, Le Couteur A, McConachie H, Parr JR. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010, 466, 368–372.
• Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder E, Kantojarvi K, Jarvela I, Klauck SM, Poustka F, Bailey AJ, Monaco AP, The International Molecular Genetic Study of Autism Consortium, Newcastle Site: Le Couteur, A. Principal Investigator. Linkage and Candidate Gene Studies of Autism Spectrum Disorders in European Populations. European Journal of Human Genetics 2010, 18(9), 1013-1019.
• Green J, Charman T, McConachie H, Aldred C, Slonims V, Howlin P, Le Couteur A, Leadbitter K, Hudry K, Byford S, Barrett B, Temple K, Macdonald W, Pickles A. Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial. Lancet 2010, 375(9732), 2152-2160.
• Arnott B, McConachie H, Meins E, Fernyhough C, LeCouteur A, Turner M, Parkinson K. The frequency of restricted and repetitive behaviours in a community sample of 15-month-old infants. Journal of Developmental and Behavioral Pediatrics 2010, 31(3), 223-229.
• Clifford S, Hudry K, Brown L, Pasco G, Charman T, PACT team. The Modified-Classroom Observation Schedule to Measure Intentional Communication M-COSMIC): Evaluation of realiability and Validity. Research in Autism Spectrum Disorders 2010, 4(3), 509-525.
• McConachie H, Barry R, Spencer A, Parker L, Le Couteur AS, Colver AF. Daslⁿe: The challenge of developing a regional database for autism spectrum disorder. Archives of Disease in Childhood 2009, 94(1), 38-41.
• Jones AR, Hyland RM, Parkinson KN, Adamson AJ, The Gateshead Millennium Study Core Team. Developing a focus group approach for exploring parents' perspectives on childhood overweight. Nutrition Bulletin 2009, 34(2), 214–219.
• Yates K, LeCouteur A. Diagnosing Autism. Paediatrics & Child Health 2009, 19(2), 55-59.
• Sharma AN, Neely J, Le Couteur AS, Grunze H, Nicholls D, James A, Graham P, Lynn R, Scott J, Ferrier IN. Study of pediatric bipolar disorder in UK and ROI: development of a case definition and pilot data from North East England. Bipolar Disorders 2009, 11(Supplement 1), 79 P182.
• Gong X, Bacchelli E, Blasi F, Toma C, Betancur C, Chaste P, Delorme R, Durand CM, Fauchereau F, Botros HG, Leboyer M, Mouren-Simeoni M-C, Nygren G, Anckarsäter H, Rastam M, Gillberg IC, Gillberg C, Moreno-De-Luca D, Carone S, Nummela I, Rossi M, Battaglia A, The International Molecular Genetic Study of Autism Consortium (IMGSAC), Jarvela I, Maestrini E, Bourgeron T. Analysis of X chromosome inactivation in autism spectrum disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008, 147B(6), 830-835.
• Le Couteur A, Haden G, Hammal D, McConachie H. Diagnosing autism spectrum disorders in pre-school children using two standardised assessment instruments: The ADI-R and the ADOS. Journal of Autism and Developmental Disorders 2008, 38(2), 362-372.
• Hutton J, Goode S, Murphy M, Le Couteur A, Rutter M. New Psychiatric Disorders in Individuals with Autism. Autism 2008, 12(4), 373-390.
• Honey E, McConachie H, Randle V, Shearer H, Le Couteur AS. One-year change in repetitive behaviours in young children with communication disorders including autism. Journal of Autism and Developmental Disorders 2008, 38(8), 1439-1450.
• Sharma A, Le Couteur AS, Nicholls D, Graham P, Lynn R, Ferrier IN. Paediatric Bipolar Disorder: A Way Forward. British Journal of Psychiatry 2008, 192, 150-152.
• Le Couteur A, Gardner F. Use of Structured Interviews and Observational Methods in Clinical Settings. In: Rutter, M; Bishop, D; Pine, D; Scott, S; Stevenson, JS; Taylor, EA; Thapar, A, ed. Rutter's Child and Adolescent Psychiatry. Oxford: WileyBlackwell, 2008, pp.289-298.
• Tiffin PA, Shah P, Le Couteur A. Diagnosing Pervasive Developmental Disorders in a Forensic Adolescent Mental Health Setting. The British Journal of Forensic Practice 2007, 9(3), 31–40.
• McClure I, LeCouteur A. Evidence-based approaches to autism spectrum disorders. Child: Care, Health and Development 2007, 33(5), 509-512.
• Dover CJ, Le Couteur A. How to diagnose autism. Archives of Disease in Childhood 2007, 92(6), 540-545.
• Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu X-Q, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, LaJonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu C-E, Roge B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bolte S, Feineis-Matthews S, Herbrecht E, Schmotzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, De Jonge M, Kemner C, Koop F, Langemeijer M, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson J-A, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics 2007, 39(3), 319-328.
• Leekam S, Tandos J, McConachie H, Meins E, Parkinson K, Wright C, Turner M, Arnott B, Vittorini L, Le Couteur AS. Repetitive behaviours in typically developing 2-year-olds. Journal of Child Psychology and Psychiatry and Allied Disciplines 2007, 48(11), 1131-1138.
• Blasi F, Bacchelli E, Pesaresi G, Carone S, Bailey AJ, Maestrini E, International International Molecular Genetic Study of Autism Consortium. Absence of coding mutations in the X-linked genes Neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 2006, 141B(3), 220-221.
• Margetts JK, Le Couteur AS, Croom S. Families in a state of flux: The experience of grandparents in autism spectrum disorder. Child: Care, Health and Development 2006, 32(5), 565-574.
• Honey E, McConachie H, Randle V, Shearer H, Le Couteur A. One-year Change in Repetitive Behaviours in Young Children with Communication Disorders Including Autism. Journal of Autism and Developmental Disorders 2006, 38(8), 1439-1450.
• Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ, Maestrini E, International Molecular Genetic Study of Autism Consortium (IMGSAC). SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. European Journal of Human Genetics 2006, 14(1), 123-126.
• Darke J, Bushby K, Le Couteur A, McConachie H. Survey of behaviour problems in children with neuromuscular diseases. European Journal of Paediatric Neurology 2006, 10(3), 129-134.
• McConachie H, Randle V, Hammal D, Le Couteur A. A controlled trial of a training course for parents of children with suspected autism spectrum disorder. Journal of Pediatrics 2005, 147(3), 335-340.
• McConachie H, Couteur AL, Honey E. Can a diagnosis of asperger syndrome be made in very young children with suspected autism spectrum disorder?. Journal of Autism and Developmental Disorders 2005, 35(2), 167-176.
• Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poutska F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos E, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, Engeland H, Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP, Internation Molecular Study of Autism (IMGSAC). Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. European Journal of Human Genetics 2005, 13(2), 198-207.
• Tiffin P, Le Couteur A. Pervasive Developmental Disorders. In: Gowers, S, ed. Seminars in Child and Adolescent Psychiatry. London, UK: Gaskell, 2005, pp.124-144.
• Honey E, McConachie H, Le Couteur A. Will it Ever Stop? How parents deal with children's behaviours. Communication (London, 1967): the magazine of the National Autistic Society 2005, 39(2), 45-47.
• Haq I, Le Couteur A. Autism Spectrum Disorder. Medicine 2004, 32(8), 61-63.
• D'Adamo P, Bacchelli E, Blasi F, Lipp HP, Toniolo D, Maestrini E, International Molecular Genetic Study of Autism Consortium (IMGSAC). DNA variants in the human RAB3A gene are not associated with autism. Genes, Brain and Behavior 2004, 3(2), 123-124.
• Rutter M, Lord C, Le Couteur A. Autism Diagnostic Interview Revised Manual. 2003. Torrance, California, USA: Wester Psychological Services.
• Dixon L, Le Couteur A. Early assessment and intervention with the 'More than Words@ Hanen programme for parents of children with autism spectrum disorders. Good Autism Practice 2003, 4(1), 29-34.
• Bonora E, Lamb JA, Abbott A, Redhead N, Ragoussis I, Bailey A, Monaco AP, International Molecular Genetic Study of Autism (IMGSAC). Linkage to the AUTS1 locus and analysis of candidate genes for autism on chromosome 7q. American Journal of Human Genetics 2003, Abstract 108.
• Le Couteur A (chair of the Core Working Group). National autism plan for children (NAPC): Plan for the identification, assessment, diagnosis and access to early interventions for pre-school and primary school aged children with autism spectrum disorders (ASD). London, UK: The National Autistic Society, 2003.
• Le Couteur A. National Autism Plan for children : Development of UK guidelines for local multi-agency services for children with suspected ASD. Interventions for Individuals with Asperger's Syndrome. ACPP Occasional Papers 2003, (21), 15-23.
• Charman T, Howlin P, Aldred C, Baird G, Degli Espinosa F, Diggle T, Kovshoff H, Law J, Le Couteur A, MacNiven J, Magiati I, Martin N, McConachie H, Peacock S, Pickles A, Randle V, Slonims V, Wolke D. Research into early intervention for children with autism and related disorders: Methodological and design issues. Autism 2003, 7(2), 217-225.
• Bacchelli E, Blasi F, Biondolillo M, Lamb JA, Bonora E, Barnby G, Parr J, Beyer KS, Klauck SM, Poustka A, Bailey AJ, Monaco AP, Maestrini E, International Molecular Genetic Study of Autism (IMGSAC). Screening of nine candidate genes for autism on chromosome 2q reveals rare non-synonymous variants in the cAMP-GEFII gene. Molecular Psychiatry 2003, 8(11), 916-924.
• Standart S, Le Couteur A. The quiet child - a literature review of selective mutism. Child and Adolescent Mental Health 2003, 8(4), 154-160.
• Steyn B, Le Couteur A. Understanding autism spectrum disorders. Current Paediatrics 2003, 13(4), 274-278.
• Le Couteur A. Assessment and Diagnosis in Pervasive Developmental Disorders. J Child Neurology issue of Autism 2002.
• Newbury DF, Bonora E, Lamb JA, Fisher SE, Lai CSL, Baird G, Slonims V, Stott CM, Merricks MJ, Bolton PF, Bailey AJ, Monaco AP, International Molecular Consortium. FOXP2 Is Not a Major Susceptibility Gene for autism or Specific Language Impairment. American Journal of Human Genetics 2002, 70(5), 1318-1327.
• Beyer KS, Blasi F, Bacchelli E, Klauck SM, Maestrini E, Poustka A, International Molecular Genetic Study of Autism Consortium (IMGSAC). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Human Genetics 2002, 111(4-5), 305-309.
• Bonora E, Bacchelli E, Levy ER, Blasi F, Marlow A, Monaco AP, Maestrini E, International Molecular Genetic Study of Autism Consortium (IMGSAC). Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. Molecular Psychiatry 2002, 7(3), 289-301.
• Parr J, Baird G, Le Couteur A, Rutter M, Bailey A, IMGSAC. Phenotypic characteristics of autistic regression in an international multiplex sample. In: American Journal of Medical Genetics: 10th World Congress of Psychiatric Genetics. 2002, Brussels, Belgium: John Wiley & Sons, Inc.
• McArdle P, Moseley D, Quibell T, Johnson R, Allen A, Hammal D, Le Couteur A. School-based indicated prevention: a randomised trial of group therapy. Journal of Child Psychology and Psychiatry 2002, 43(6), 705-712.
• Palferman S, Matthews N, Turner M, Moore J, Hervas A, Aubin A, Wallace S, Michelotti J, Wainhouse C, Paul A, Thompson E, Gupta R, Garner C, Murin M, Freitag C, Ryder N, Cottington E, Parr J, Pickles A, Rutter M, Bailey A, Barnby G, Lamb JA, Marlow A, Scudder P, Monaco AP, Baird G, Cox A, Docherty Z, Warburton P, Green EP, Abbs SJ, Le Couteur A, McConachie HR, Berney T, Kelly TP, De Vries PJ, Bolton PF, Green J, Gilchrist A, Whittacker J, Bolton B, Packer R, Maestrini E, Blasi F, Van Engeland H, De Jonge MV, Kemner C, Klauck SM, Beyer KS, Epp S, Poustka A, Benner A, Goethe JW, Poustka F, Ruhl D, Schmotzer G, Boolte S, Feineis-Matthews S, Fombonne E, Rogee B, Fremolle-Kruck J, Pienkowski C, Tauber MT, Pedersen L, Nielsen KB, Eriksen G, Haracopos D, Cotterill RMJ, Tsiantis J, Papanikolaou K, Lord C, Corsello C, Guter S, Leventhal B, Cook E, Smalley SL, Bailey J, McGough J, Levitt J, Pauls D, Volkmar F, Weeks DE, Int Mol Genetic Study Autism Cons. A genomewide screen for autism: Strong evidence for linkage to chromosomes 2q, 7q, and 16p. American Journal of Human Genetics 2001, 69(3), 570-581.
• Le Couteur A. An appreciation of Professor Sir Michael Rutter. In: Special commemoratory publication of proceedings of Festschrift held September 1998. 2001.
• Gilchrist A, Green J, Cox A, Burton D, Rutter M, Le Couteur A. Development and current functioning in adolescents with Asperger syndrome: A comparative study. Journal of Child Psychology and Psychiatric and Allied Disciplines 2001, 42(2), 227-240.
• Palferman S, Matthews N, Turner H, Moore J, Hervas A, Aubin A, Wallace S, Michelotti J, Wainhouse C, Paul A, Thompson E, Murin M, Gupta R, Garner C, Pickles A, Rutter M, Bailey A, Lamb JA, Marlow A, Scudder P, Barnby G, Monaco AP, Baird G, Cox A, Docherty Z, Warburton P, Green EP, Abbs SJ, Le Couteur A, McConachie HR, Berney T, Kelly TP, De Vries PJ, Bolton P, Green J, Gilchrist A, Whittacker J, Bolton B, Packer R, Maestrini E, Van Engeland H, De Jonge MV, Kemner C, Klauck SM, Beyer KS, Epp S, Poustka A, Benner A, Poustka F, Ruhl D, Schmotzer G, Bolte S, Feineis-Matthews S, Fombonne E, Roge B, Fremolle-Kruck J, Pienkowski C, Tauber MT, Pedersen L, Brondum-Nielsen K, Eriksen G, Haracopos D, Cotterill RMJ, Tsiantis J, Papanikolaou K, Lord C, Corsello C, Guter S, Leventhal B, Cook E, Smalley S, Bailey J, Liu A, Dedricks M, Chrzanowski L, Levitt J, Pauls D, Volkmar F, Weeks DE, Intl Molecular Genetic Study Autis. Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q. Human Molecular Genetics 2001, 10(9), 973-982.
• Westgarth S, Le Couteur A. How to handle parents concerns about autism. Pulse 2001, 61(11).
• Croom S, Procter S, Le Couteur A. Developing a concept analysis of control for use in child and adolescent mental health nursing. Journal of Advanced Nursing 2000, 31(6), 1324-1332.
• Clough J, Le Couteur A. Research Report for Fathers Plus Engaging Parents in a primary school setting Sept 1999-Sept 2000. 2000.
• Clough J, Richardson A, Le Couteur A. The involvement of Parents in Primary Schools, with special Reference to Fathers. In: White,K, ed. The Changing Face of Child Care: NCVCCO Annual Review Journal. London: NCVCCO, 2000, pp.154-166.
• Trowell J, Ugarte B, Kolvin I, Berelowitz M, Sadowski H, Le Couteur A. Behavioural psychopathology of child sexual abuse in schoolgirls referred to a tertiary centre: A North London study. European Child & Adolescent Psychiatry 1999, 8(2), 107-116.
• Maestrini E, Lai C, Marlow A, Matthews N, Wallace S, Bailey A, Cook EH, Weeks DE, Monaco AP, International Molecular Genetic Study of Autism Consortium. Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. American Journal of Medical Genetics 1999, 88(5), 492-496.
• Richardson, A. and Le Couteur, A. The role of fathers in realising children's potential. In: Proceedings of the Excellence in Early Years Conference, University of Newcastle upon Tyne. 1999.
• International Molecular Genetic Study of Autism Consortium (Newcastle site: Le Couteur A., Berney T., Cooper H. and Kelly T.). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Human Molecular Genetics 1998, 7, 571-578.
• Le Couteur A. Autism: the broader phenotype. Association of Child Psychology and Psychiatry Occasional Papers 1998, 15, 21-30.
• Bailey A., Palferman S., Heavey L. and Le Couteur A. Autism: the phenotype in relatives. Journal of Autism and Developmental Disorders 1998, 28, 369-392.
• Cooper, H., Kelly, T. and Le Couteur, A. The development of executive function in early school age autistic children. In: Psychopathology of Autism: current research and practice. 1998.
• Prosser, J.G.S., and Le Couteur, A. Autism and the pervasive developmental disorders. Current Paediatrics 1997, 7, 158-162.
• Le Couteur, A. and Sowter, M. Early assessment and intervention in autism: adapting the family focussed Hanen Parent Programme for preschool children with autism spectrum disorders. In: Living and Learning with autism: perspective from the individual, the family and professional. 1997, pp.29-41.
• Le Couteur, A. Recognising Asperger's syndrome. Pulse Feature 75 1997.
• Kolvin I., Trowell J., Le Couteur A., Bakaraki S. and Morgan J. The origins of selective mutism: some strategies in attachment and bonding research. Association of Child Psychology and Psychiatry Occasional Papers 1997, 14, 17-26.
• Cooper, H., Kelly, T and Le Couteur, A. Toilet training in autism. In: Living and Learning with Autism. 1997, pp.295-300.
• Le Couteur., Bailey, A., Goode, S., Pickles, A., Robertson, A., Gottesman, I. and Rutter, M. A broader phenotype of autism: the clinical spectrum in twins. Journal of Child Psychology and Psychiatry and Allied Disciplines 1996, 37, 785-801.
• Woodhouse W., Bailey A., Rutter M., Bolton P., Baird G. and Le Couteur A. Head circumference and pervasive developmental disorders. Journal of Child Psychology and Psychiatry and Allied Disciplines 1996, 37, 665-671.
• Le Couteur, A. The clinical manifestations of the broader phenotype of autism - evidence from the British twin and family studies. In: Therapeutic Intervention in Autism: perspectives from research and practice. 1996, pp.57-77.
• Bailey, A., Le Couteur, A., Gottesman, I., Siminoff, E. and Rutter M. Autism as a strongly genetic disorder: evidence from a British twin study. Psychological Medicine 1995, 25, 63-78.
• Bolton, A., Pickles, A., Butler, L., Summers, D., Webb, T., Lord, C., Le Couteur, A., Bailey, A. and Rutter, M. Fragile X in families multiplex for autism and related phenotypes: prevalence and criteria for cytogenetic diagnosis. Psychiatric Genetics 1995, 2, 277-300.
• Pickles, A., Bolton, P., Macdonald, H., Bailey, A., Le Couteur, A., Sim, C.H., and Rutter, M. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism. American Journal of Human Genetics 1995, 57, 717-726.
• Rutter, M., Bailey, A., Bolton, P. and Le Couteur, A. Autism and known medical conditions: myth and substance. Journal of Child Psychology and Psychiatry and Allied Disciplines 1994, 35, 311-322.
• Lord, C., Rutter, M., and Le Couteur, A. Brief report: Autism Diagnostic Interview - Revised version of a diagnostic interview for care givers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 1994, 24, 659-685.
• Bailey, A., Luthert, P., Bolton, P., Le Couteur, A., Rutter, M. and Harding, B. Autism is associated with megalocephaly. The Lancet (letter) 1993, 341, 1225-1226.
• Le Couteur, A. Autism: changing perspectives. British Journal of Hospital Medicine 1993, 50, 159.
• Rutter, M., Bailey, A., Bolton, P. and Le Couteur, A. Autism: syndrome definition and possible genetic mechanisms. In: R.Plomin and G.E. McLearn, ed. Nature, Nurture and Psychology. Washington D.C: APA Books, 1993, pp.269-28.
• Le Couteur, A. Clinical syndromes in early childhood. In: D. Black and D.Cottrell, ed. Seminars in Child and Adolescent Psychiatry. 1993.
• Bailey, A., Bolton, P., Le Couteur, A., Murphy, M., Scott, S., Webb, T. and Rutter, M. Prevalence of the fragile X anomaly amongst autistic twins and singletons. Journal of Child Psychology and Psychiatry and Allied Disciplines 1993, 34, 673-688.
• Le Couteur, A. Autism: current understanding and management. British Journal of Hospital Medicine 1990, 43, 448-452.
• Everall, I. and Le Couteur, A. Fire setting in an adolescent boy with Asperger's syndrome. British Journal of Psychiatry 1990, 157, 284-287.
• Rutter, M., Macdonald, H., Le Couteur, A., Harrington, R., Bolton, P. and Bailey, A. Genetic factors in child psychiatric disorders. II: Empirical findings. Journal of Child Psychology and Psychiatry and Allied Disciplines, Annual Research Review 1990, 31, 39-84.
• Rutter, M., Bolton, P., Harrington, R., Le Couteur, A., Macdonald, H. and Siminoff. Genetic factors in child psychiatric disorders. I: A review of research strategies. Journal of Child Psychology and Psychiatry and Allied Disciplines, Annual Research Review 1990, 31, 3-37.
• Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M. and McLennan, J. Autism Diagnostic Interview: a standardized investigator based instrument. Journal of Autism and Development Disorders 1989, 19, 363-387.
• Macdonald, H., Rutter, M., Howlin, P., Rios, P., Le Couteur, A., Evered, C. and Folstein, S. Recognition and expression of emotional cues by autistic and normal adults. Journal of Child Psychology and Psychiatry and Allied Disciplines 1989, 30, 865-875.
• Herold, S., Frackowiak, R.S.J., Le Couteur, A., Rutter, M. and Howlin, P. Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychological Medicine 1988, 18, 823-831.
• Rutter, M., Le Couteur, A., Lord, C., Macdonald, H., Rios, P. and Folstein, S. Diagnosis and sub classification of autism: concepts and instrument development. In: E.Schopler and G.Mesibov, ed. In Diagnostic and Assessment Issues in Autism. New York: Plenum, 1988, pp.239-259.
• Le Couteur, A., Rutter, M., Summers, D and Butler, L. Fragile X in female autistic twins. Journal of Autism and Developmental Disorders 1988, 18, 458-460.
• Le Couteur, A., Trygstad, O., Gillberg, C., & Rutter M. Infantile autism and urinary excretion of peptides and protein associated peptide complexes. Journal of Autism and Developmental Disorders 1988, 18, 181-190.
• Jacobson, R., Le Couteur, A., Howlin, P. and Rutter, M. Selective subcortical abnormalities in autism. Psychological Medicine 1988, 18, 39-48.
• Le Couteur, A. The role of genetics in the aetiology of autism, including findings of the links with fragile X syndrome. In: L.Wing, ed. In: Aspects of Autism: Biological Research. London: Gaskell Psychiatry Series, 1988, pp.38-52.