Newcastle University

I am a researcher with an international reputation in economic evaluation and health technology assessment and have contributed significantly to the growth in the use of systematic reviews and economic modelling in this field.  This expertise is built on over 15 years of health economics experience.  I currently hold the Health Foundation Chair in Health Economics at Newcastle University where I lead the Health Economics Group.  Prior to joining Newcastle University I led an independent academic group that conducted appraisals of new and existing diagnostic and therapeutic interventions for the National Institute of Health and Clinical Excellence (NICE).

I am the Chairman of the joint economic methods group of the international Cochrane and Campbell Collaborations, which develop the methods and conduct systematic reviews of interventions in health care and other policy areas.  I have considerable managerial and supervisory experience and a proven record in attracting research funds, completing projects to a high standard and in a timely fashion.  I have extensive links with policy makers and researchers throughout the UK and internationally.  Since 2000, I have secured approximately £30 million in research fund including a substantial number as Principal Investigator.  In addition, I have a strong publication record with over 130 papers in peer-reviewed journals, 4 books, 15 book chapters and almost 80 other significant reports.

Key research interests are:

• Economic evlauation as part of randomised controlled trials and Health Technology Assessments for national and international agencies such as NICE
• Use of economic evaluation techniques in the design of complex interventions and health technologies
• Development of methods for the incorporation of discrete choice experiments and willingness to pay estimates into economic evaluation 

Projects

• How can health services contribute most effectively to facilitating successful transition of young people with complex health needs from childhood to adulthood?
  Project Leader(s): Professor Allan Colver
• INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?: a pragmatic multicentre pilot study to assess the feasibility of a future randomised controlled trial
  Project Leader(s): Chief Investigator: Mr Paul Hilton (Newcastle upon Tyne Hospitals NHS Trust)

• Close A, Robertson C, Rushton S, Shirley M, Vale L, Ramsay C, Pickard R. Comparative cost-effectiveness of Robot-assisted and standard Laparoscopic Prostatectomy as Alternatives to Open Radical Prostatectomy for Treatment of Men with Localised Prostate Cancer: A Health Technology Assessment from the Perspective of the UK National Health Service. European Urology 2013, (epub ahead of print).
• Vale L. Economics of hernia repair. In: Kingsnorth, A., Le Blank, K, ed. Management of Abdominal Wall Hernias. Amsterdam, Netherlands: Springer, 2013, pp.79-90.
• Kilonzo M, Hislop J, Elders A, Fraser C, Bissett D, McClinton S, Mowatt G, Vale L. Pazopanib for the First-Line Treatment of Patients with Advanced and/or Metastatic Renal Cell Carcinoma. Pharmacoeconomics 2013, 31(1), 15-24.
• Pickard R, Vale L. Valuing interventions for localised prostate cancer. BJU International 2013, 111(3), 366-367.
• Lourenco T, Grant AM, Burr JM, Vale L. A framework for the evaluation of new interventional procedures. Health Policy 2012, 104(3), 234-240.
• Spence S, Shen J, Delve J, White M, Vale L, Adamson AJ. An evaluation of the effect of the New School Food Policy on children's nutritional intake and socio-economic consequences in North East England. In: 56th Annual Scientific Meeting of the Society for Social Medicine. 2012, London: BMJ Group.
• Pickard R, Lam T, MacLennan G, Starr K, Kilonzo M, mcPherson G, Gillies K, McDonald A, Walton K, Buckley B, Glazener C, Boachie C, Burr J, Norrie J, Vale L, Grant A, N'Dow J. Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial. Lancet 2012, 380(9857), 1927-1935.
• The CLASS Trial. Comparison of LAser Surgery and foam Sclerotherapy. The Lancet 2012. In Press.
• Vale L, Cody J, Daly C, Campbell MK, Donaldson C, Grant A, Khan IH, Lawrence P, MacLeod A. Continuous ambulatory eritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults. The Cochrane Database of Systematic Reviews 2012, (4). In Press.
• Ternent L, Vale L, Boachie C, Burr JM, Lois N, Full-Thickness Macular Hole and Internal Limiting Membrane Peeling Study (FILMS) Group. Cost-effectiveness of internal limiting membrane peeling versus no peeling for patients with an idiopathic full-thickness macular hole: results from a randomised controlled trial. British Journal of Opthalmology 2012, 96(3), 438-443.
• Simoens S, Vale L. Health technology assessment and economic evaluation across across jurisdictions and Health technology assessment and economic evaluation: arguments for a national approach. Value in Health 2012. In Press.
• Andrews PJD, Avenell A, Noble DW, Campbell MK, Croal BL, Simpson WG, Vale LD, Battison CG, Jenkinson DJ, Cook JA, SIGNET Trials Group. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition or critically ill patients. British Medical Journal 2012, 342, d1542.
• Buck D, McColl E, Powell CJ, Shen J, Sloper J, Steen N, Taylor R, Tiffin P, Vale L, Clarke MP. Surgery versus Active Monitoring in Intermittent Exotropia (SamExo): study protocol for a pilot randomised controlled trial. Trials 2012, 13, 192.
• Ramsay C, Pickard R, Robertson C, Close A, Vale L, Armstrong N, Barocas DA, Eden CG, Fraser C, Gurung T, Jenkinson D, Jia X, Lam TB, Mowatt G, Nea DE, Robinson MC, Royle J, Rushton SP, Sharma P, Shirley MDF, Soomro N. Systematic review and economic modelling of the relative clinical benefit and cost-effectiveness of laparoscopic surgery and robotic surgery for removal of the prostate in men with localised prostate cancer. Health Technology Assessment 2012, 16(41), xiv, 313.
• Hislop J, Mowatt G, Sharma P, Fraser C, Elders A, Jenkinson D, Vale L, Petty R. Systematic Review of Escalated Imatinib Doses Compared with Sunitinib or Best Supportive Care, for the Treatment of People with Unresectable/Metastatic Gastrointestinal Stromal Tumours Whose Disease has Progressed on the Standard Imatinib Dose. Journal of Gastrointest Cancer 2012, 43(2), 168-176.
• Hislop J, Adewuyi T, Vale L, Harrild K, Altman D, Briggs A, Fayers P, Norrie J, Ramsay C, Buckley B, Harvey I, Cook J. Systematic Review Of Methods For Specifying The Target Difference In Randomised Controlled Trials (Delta Review). In: Health Technology Association International (HTAi) Annual Meeting. 2012, Bilbao, Spain: Elsevier Doyma.
• Vale L, Quayyum Z, The Eagle Trial team. The Effectiveness of Early Lens Extraction with Intraocular Lens Implantation for the treatment of Primary Angle Closure Glaucoma: A Randomised Controlled Trial. Trial Protocol. The Lancet 2012, 23(12), 133. In Press.
• Hoddinott P, Craig L, Maclennan G, Boyers D, Vale L, NHS Grampian, Univ Aberdeen. The FEeding Support Team (FEST) randomised, controlled feasibility trial of proactive and reactive telephone support for breastfeeding women living in disadvantaged areas. BMJ Open 2012, 2(2), e000652.
• Lourenco T, Grant AM, Burr JM, Vale L. The introduction of new interventional procedures in the British National Health Service-a qualitative study. Health Technology Assessment 2012, 100(1), 35-42.
• Pickard R, Lam T, MacLennan G, Starr K, Kilonzo M, McPherson G, Gillies K, McDonald A, Walton K, Buckley B, Glazener C, Boachie C, Burr J, Norrie J, Vale L, Grant A, N'Dow J. Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation: multicentre randomised controlled trial and economic evaluation of antimicrobial- and antiseptic-impregnated urethral catheters (the CATHETER trial). Health Technology Assessment 2012, 16(47), 1-197.
• Vale L, Wyness L, McCormack K, McKenzie L, Brazzelli M, Stearns SC. A systematic review of the effectiveness and cost-effectiveness of metal on hip resurfacing arthroplasty for the treatment of hip disease. Health Technology Assessment 2011, 6, 15.
• Hislop J, Quayyum Z, Elders A, Fraser C, Jenkinson D, Mowatt G, Sharma P, Vale L, Petty R. Clinical effectiveness and cost-effectiveness of imatinib dose escalation for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours that have progressed on treatment at a dose of 400 mg/day: a systematic review and economic evaluation. Health Technology Assessment 2011, 15(25), 178.
• Glazener C, Boachie C, Buckley B, Cochran C, Dorey G, Grant A, Hagen S, Kilonzo M, McDonald A, McPherson G, Moore K, N'Dow J, Ramsay C, Vale L. Conservative treatment for urinary incontinence in men after prostate surgery (MAPS). Health Technology Assessment 2011, 15(24), 1-296.
• Burr JM, Campbell MK, Campbell SE, Francis JJ, Greene A, Hernandez R, Hopkins D, McCann SK, Vale LD. Developing the clinical components of a complex intervention for a glaucoma screening trial: a mixed methods study. BMC Medical Research Methodology 2011, 11(1), 54.
• Vale L, Adamson A, Critchley J, Rushton S, Kelly S, Shen J, Shirley M, Mason H, Donaldson C, Armstrong N. Economic evaluation: evaluating the short-term impacts of the school food policy and experimental modelling of longer term impacts. London: Newcastle University and the University of Stirling as part of the Public Health Research Consortium, 2011. B5-07A.
• Cook JA, Ramsay CR, Vale LD. Guidance on minimally important clinical difference and trial size is needed. BMJ 2011, 343, d4375.
• Murdoch M, McColl EM, Howel D, Deverill M, Buckley B, Lucas M, Chapple CR, Tincello DG, Armstrong N, Brennand C, Shen J, Vale L, Hilton P. INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?): study protocol for a mixed methods study to assess the feasibility of a future randomised controlled trial of the clinical utility of invasive urodynamic testing. Trials 2011, 12(1), 169.
• Cook JA, Ramsay CR, Vale LD, DELTA Project Grp. Measuring Clinical Difference: Guidance on minimally important clinical difference and trial size is needed. British Medical Journal 2011, 343, d4375.
• Mowatt G, N'Dow J, Vale L, Nabi G, Boachie C, Cook JA, Fraser C, Griffiths TR. Photodynamic diagnosis of bladder cancer compared with white light cystoscopy: systematic review and meta-analysis. International Journal of Technology Assessment in Health Care 2011, 27(1), 3-10.
• Andrews PJ, Avenell A, Noble DW, Campbell MK, Croal BL, Simpson WG, Vale L, Battison CG, Jenkinson DJ, Cook JA, SIGNET. Randomised trial of glutamine, selenium, or both, to supplement parental nutrition for critically ill patients. BMJ 2011, 342(d1542), 1-8.
• Robertson C, Ragupathy SK, Boachie C, Fraser C, Heys SD, Maclennan G, Mowatt G, Thomas RE, Gilbert FJ, Vale L, Mammographic Surveillance Health Technology Assessment Group. Surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer: a systematic review. European Radiology 2011, 21(12), 2484-2491.
• Robertson C, Boachie C, Dixon M, Fraser C, Hernandez R, Heys S, Jack W, Kerr G, Ragupathy S, Lawrence G, MacLennan G, Maxwell A, McGregor J, Mowatt G, Pinder S, Ternent L, Thomas R, Vale L, Wilson R, Zhu S, Gilbert F. The clinical effectiveness and cost-effectiveness of different surveillance mammography regimes after the treatment of primary breast cancer: systematic reviews registry database analyses and economic evaluation. Health Technology Assessment 2011, 15(34), 1-322.
• Azuara-Blanco A, Burr JM, Cochran C, Ramsay C, Vale L, Foster P, Friedman D, Quayyum Z, Lai J, Nolan W, Aung T, Chew P, McPherson G, McDonald A, Norrie J. The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. Trials 2011, 23(12), 133.
• Glazener C, Boachie C, Buckley B, Cochran C, Dorey G, Grant A, Hagen S, Kilonzo M, McDonald A, McPherson G, Moore K, Norrie J, Ramsay C, Vale L, N'Dow J. Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials. Lancet 2011, 378(9788), 328-337.
• MacLennan SJ, MacLennan SJ, Imamura M, Omar MI, Vale L, Lam T, Royle P, Royle J, Swami S, Pickard R, McClinton S, Griffiths TR, Dahm P, N'Dow J, UCAN Care Pathway Development Group. Urological cancer care pathways: development and use in the context of systematic reviews and clinical practice guidelines. World Journal of Urology 2011, 29(3), 291-301.
• Glazener C, Boachie C, Buckley B, Cochran C, Dorey G, Grant A, Hagen S, Kilonzo M, Moore K, N'Dow J, Ramsay C, Vale L. A randomised controlled trial of conservative treatment (pelvic floor muscle training and bladder training) for urinary incontinence in men after prostate surgery (MAPS). In: ICS/IUGA 2010 Annual Meeting. 2010, Toronto, Canada.
• Kilonzo M, Vale L, Zhu S, Mowatt G, Boachie C, N'Dow J, Griffiths T, Cook J, Nabi G, Fraser C. Economic evaluation of photodynamic diagnosis and urinary biomarkers for detection and follow-up of bladder cancer. In: Health Technology Assessment International. 2010, Dublin, Ireland: HTAi.
• McKenzie L, deVerteuil R, Cook J, Shanmugam V, Loudon M, Watson A, Vale L. Economic evaluation of the treatment of Grade II haemorrhoids: a comparison of stabled haemorrhoidopexy and rubber band ligation. Colorectal Disease 2010, 12(6), 587-593.
• Imamura M, Jenkinson D, Glazener C, Vale L. Effectiveness of non-surgical interventions for women with stress urinary incontinence: systematic review and meta-analysis of randomised controlled trials. In: ICS/IUGA 2010 Annual Meeting. 2010, Toronto, Canada.
• Vale L. Evidence-based decisions an economics: lessons for practice. In: Shemilt, I., Mugford, M., Donaldson, C., Vale, L., Marsh, K, ed. Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice. London: Wiley Books, 2010, pp.173-178.
• Shemilt I, Mugford M, Vale L, Marsh K, Donaldson C, ed. Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice. London, UK: Wiley Books, 2010.
• Vale L. Evidence-based decisions and economics: lessons for practice. In: Shemilt, I., Mugford, M., Vale, L., Marsh, K., Donaldson, C, ed. Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice. London, UK: Wiley Books, 2010, pp.173-178.
• Mugford M, Shemilt I, Vale L, Marsh K, Donaldson C, Mallender J. From effectiveness to efficiency? An introduction to evidence-based decisions and economics. In: Shemilt, I., Mugford, M., Vale, L., Marsh, K., Donaldson, C, ed. Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice. London, UK: Wiley Books, 2010, pp.1-7.
• Mugford M, Shemilt I, Vale L, Marsh K, Donaldson C, Mallender J. From effectiveness to efficiency? An introduction to evidence-based decisions and economics for healthcare, socia, welfare, education and criminal justice. In: Shemilt, I., Mugford, M., Donaldson, C., Vale, L., Marsh, K, ed. Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice. London: Wiley Books, 2010, pp.1-7.
• Vale L. Health technology assessment and economic evaluation: arguments for a national approach. Value in Health 2010, 13(6), 859-861.
• Lourenco T, Grant A, Burr J, Vale L. Local decision-makers views of national guidance on interventional procedures in the UK. Journal of Health Services Research and Policy 2010, 15(s2), 3-11.
• Cuthbertson B, Campbell M, Stott S, Vale L, Norrie N, Kinsella J, Cook J, Brittenden J, Grant A. Pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol. Trials 2010, 11(1), 41.
• Cuthbertson B, Roughton S, Jenkinson D, MacLennan G, Vale L. Quality of Life in the five years after intensive care - a cohort study. Critical Care 2010, 14(1), R6.
• Shanmugam V, Muthukumarasamy G, Cook J, Vale L, Watson A, Loudon MA. Randomised Controlled Trial Comparing Rubber Band Ligation with Stapled Haemorrhoidopexy for Grade II Circumferential Haemorrhoids Long Term Results. Colorectal Disease 2010, 12(6), 579-586.
• Imamura M, Abrams P, Bain C, Buckley B, Cardozo L, Cody J, Cook J, Eustice S, Glazener C, Grant A, Hay-Smith J, Hislop J, Jenkinson D, Kilonzo M, Nabi G, N'Dow J, Pickard R, Ternent L, Wallace S, Wardle J, Zhu S, Vale L. Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence. Health Technology Assessment 2010, 14(40), 1-188, iii-iv.
• Mowatt G, N'Dow J, Zhu S, Kilonzo M, Boachie C, Fraser C, Nabi G, Cook J, Vale L, Griffiths TRL. Systematic review and meta-analysis of photodynamic diagnosis of bladder cancer compared with white light cystoscopy. In: Health Technology Assessment International. 2010, Dublin, Ireland: HTAi.
• Mowatt G, Zhu S, Kilonzo M, Boachie C, Fraser C, Griffiths TRL, N'Dow J, Nabi G, Cook J, Vale L. Systematic review of the clinical and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer. Health Technology Assessment 2010, 14(4), 1-356.
• Vale L. Value of HTAs and systematic reviews of health economic evidence. Panel Session. In: Health Technology Assessment International. 2010, Dublin, Ireland: HTAi.
• Sullivan F, Swan IRC, Donnan P, Morrison JM, Smith BH, McKinstry B, Davenport RJ, Vale L, Clarkson JE, Hernandez R, Stewart K, Hammersley V, Hayavi S, McAteer A, Gray D, Daly F. A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study. Health Technology Assessment 2009, 13(47), 1-154.
• de Verteuil R, Vale L, Imamura M, Zhu S, Glazener C, Fraser C, Munro N, Hutchinson J, Grant A. A systematic review of the clincial effectiveness and cost-effectiveness and economic modelling of minimal incision total hip replacement approaches in the management of arthritic disease of the hip. Journal of Bone Joint Surgery 2009, 91(5), 1279.
• Hernandez RA, Sullivan F, Donnan P, Swan I, Vale L. Economic evaluation of early administration of prednislone and/or aciclovir for the treatment of Bell's palsy. Family Practice 2009, 26(2), 137-144.
• Ternent L, Vale L, Buckley B, Glazener C. Measuring outcomes of importance to women with stress urinary incontinence. British Journal of Obstetrics and Gynaecology 2009, 116(5), 719-725.
• Hislop J, Cody DJ, Glazener C, Imamura M, Jenkinson DJ, Wallace S, Vale L. Questionable reproduciblity of systematic reviews: A case study of treatment for stress urinary incontinence. Paper presentation. In: 6th Annual Meeting of Health Technology Assessment International Society. 2009, Singapore: HTAi.
• Armstrong N, Vale L, Deverill M, Nabi G, McClinton S, N'Dow J, Pickard R. Surgical treatments for men with benign prostatic enlargement: cost effectiveness study. British Medical Journal 2009, 338, b1288.
• Mowatt G, Houston G, Hernandez R, deVerteuil R, Fraser C, Cuthbertson B, Vale L. Systematic review of the clinical effectiveness and cost-effectiveness of oesophageal Doppler monitoring in critically ill and high risk surgical patients. Health Technology Assessment 2009, 13(1), 7.
• Jenkinson D, Imamura M, Hislop J, Vale L. [Paper presentation] Non-surgical treatment for stress urinary incontinence in women: a systematic review incorporating a mixed treatment comparison analysis. In: 6th Annual Meeting of Health Technology Assessment International Society. 2009, Singapore: HTAi.
• Brittenden J, Burr J, Campbell M, Chetter I, Cotton S, Earnshaw J, Francis J, Gough M, McDonald A, McPherson G, Ramsay C, Ternent L, Vale L. [Protocol Review] The CLASS Study: Comparison of LAser, Surgery and foam Sclerotherapy as a treatment for varicose veins. The Lancet Publishing Group, 2009. Available at: http://www.thelancet.com/protocol-reviews/09PRT-2275.
• Lourenco T, Pickard R, Vale L, Grant A, Fraser C, Maclennan G, N'dow J. Alternative approaches to endoscopic ablation for benign enlargement of the prostate: systematic review of randomised controlled trials. British Medical Journal 2008, 337, a449.
• Lois N, Burr J, Norrie J, Vale L, Cook J, McDonald A, Full-Thickness macular hole and Internal Limiting Membrane peeling Study (FILMS) Group. Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial: FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study). Trials 2008, 9(1), 61.
• Hernandez R, Burr JM, Vale L. Economic evaluation of screening for open angle glaucoma. International Journal of Technology Assessment in Health Care 2008, 24(2), 203-211.
• Shemilt I, Byford S, Drummond M, Eisenstein E, Knapp M, Mallender J, McDaid D, Mugford M, Vale L, Walker D. Incorporating Economics Evidence. In: Higgins, J., Green, S, ed. Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: Hohn Wiley & Sons, 2008, pp.449-480.
• Lois N, Burr J, Norrie J, Vale L, Cook J, McDonald A. Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial. Trials 2008, 9:61.
• Lourenco T, Murray A, Grant A, McKinley A, Krukowski Z, Vale L. Laparoscopic surgery for colorectal cancer: safe and effective? - A systematic review. Surgical Endoscopy 2008, 22(5), 1146-1160.
• Lourenco T, Pickard R, Vale L, Grant A, Fraser C, MacLennan G, N'Dow J, The BPE Team. Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trials. British Medical Journal 2008, 337, a1662.
• Hernandez R, Rabindranath K, Fraser C, Vale L, Azuara-Blanco A, Burr J. Screening for open angle glaucoma: systematic review of cost-effectiveness studies. Journal of Glaucoma 2008, 17(3), 159-168.
• Lourenco T, Armstrong N, N'Dow J, Nabi G, Deverill M, Pickard R, Vale L, MacLennan G, Fraser C, McClinton S, Wong S, Coutts A, Mowatt G, Grant A. Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement. Health Technology Assessment 2008, 12(35), 1-168.
• Hernandez R, de Verteuil R, Fraser C, Vale L. Systematic review of economic evaluations of laparascopic surgery for colorectal cancer. Colorectal Disease 2008, 10(9), 859-868.
• deVerteuil R, Imamura M, Zhu S, Glazener C, Fraser C, Munro N, Hutchinson J, Grant A, Coyle D, Coyle K, Vale L. Systematic review of the clinical effectiveness and cost-effectiveness and economic modelling of minimal incision total hip replacement approaches in the management of arthritic disease of the hip. Health Technology Assessment 2008, 12(26), iii-iv, ix-223.
• The REFLUX Trial Group. The effectiveness and cost-effectiveness of minimal access surgery amongst people with gastro-oesophageal reflux disease – a UK collaborative study. The REFLUX trial. Health Technology Assessment 2008, 12(31), 1-214.
• Rabindradranath K, Ali TZ, MacLeod AM, Vale L. Automated vs continuous ambulatory peritoneal dialysis: A systematic review of randomized controlled trial. Nephrology Dialysis and Transplantation 2007, 22(10), 2991-2998.
• Rabindranath KS, Ali TZ, MacLeod AM, Vale L, Cody J, Wallace SA, Daly C. Continuous ambulatory peritoneal dialysis versus automated peritoneal dialysis for end-stage renal disease. The Cochrane Database of Systematic Reviews 2007, (2), CD006515.
• Burr J, Kilonzo M, Vale L, Ryan M. Developing a Preference Based Glaucoma Utility Index using a Discrete Choice Experiment. Optometry and Vision Science 2007, 84(8), 797-808.
• Sullivan F, Swan I, Donnan P, Morrison J, Smith B, McKinstry B, Davenport R, Vale L, Clarkson J, Hammersley V, Hayavi S, McAteer A, Stewart K, Daly F. Early Treatment with Prednisolone or Acyclovir and Recovery in Bell's Palsy. New England Journal of Medicine 2007, 357(16), 1598-1607.
• de Verteuil R, Hernandez R, Vale L. Economic evaluation of laparoscopic surgery for colorectal cancer. International Journal of Technology Assessment in Health Care 2007, 23(4), 464-472.
• McNeill G, Avenell A, Campbell MK, Cook JA, Hannaford PC, Kilonzo MM, Milne AC, Ramsay CR, Seymour DG, Stephen AI, Vale L. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. Biomed Central Nutrition Journal 2007, 6:10.
• Vale L, Thomas R, MacLennan G, Grimshaw J. Systematic review of economic evaluations and cost analyses of guideline implementation strategies. European Journal of Health Economics 2007, 8(2), 111-121.
• McCormack K, Rabindranath K, Kilonzo M, Vale L, Fraser C, McIntyre L, Thomas S, Rothnie H, Fluck N, Gould I, Wagh N. Systematic review of the effectiveness of preventing and treating Staphylococcus aureus carriage on peritoneal catheter-related infections. Health Technology Assessment 2007, 11(23), iii-iv; ix-x; 1-66.
• Burr J, Mowatt G, Rehman-Siddiqui M, Hernandez R, Cook J, Lourenco T, Ramsay C, Vale L, Fraser C, Azura-Blanco A, Deeks J, Cairns J, Wormold R, McPherson S, Wright D, Rabindranath K, Grant A. The clinical and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic model. Health Technology Assessment 2007, 11(41).
• Kilonzo M, Vale L, Cook J, Milne A, Stephen A, Avenell A. The cost-effectieness of multivitamin and multimineral supplements in men and women aged 65 years and over. Clinical Nutrition 2007, 26(3), 364-370.
• Avenell A, Campbell M, Cook J, Milne A, Ramsay C, Hannaford P, Kilonzo M, Vale L, McNeill G, Seymour G. The key role of micronutrients. Clinical Nutrition 2007, 26(1), 159-159.
• Hernandez R, Vale L. The value of myocardial perfusion scintigraphy in the diagnosis and management of angina and myocardial infarction: a probabilistic analysis. Medical Decision Making 2007, 27(6), 772-788.
• Murray A, Lourenco T, Verteuil R, Hernandez R, Fraser C, McKinley A, Krukowski Z, Vale L, Grant A. Clinical effectivenss and cost-effectiveness of laparoscopic surgery for colorectal cancer: systematic reviews an economic evaluation. Health Technology Assessment 2006, 10(45), xi, 160 p.
• Shemilt I, Mugford M, Eisenstein E, Mallender J, McDaid D, Vale L, Walker D. Economics methos in Cohrane systematic reviews of health promotion and public halth related interventions. BMC Medical Research Methodology 2006, 6(1), 55.
• Grimshaw J, Eccles M, Thomas R, MacLennan G, Ramsay C, Fraser C, Vale L. Toward evidence-based quality improvement: Evidence (and its limitations) of the effectiveness of guideline dissemination and implementation strategies 1966-1998. Journal of General Internal Medicine 2006, 21(2), S14-S20.
• Donaldson C, Vale L. Being systematic about economic evaluation and systematic review. In: Cochrane Colloquium. 2005, Melbourne, Australia.
• MacLeod A, Daly C, Khan IH, Vale L, Campbell MK, Wallace S, Cody J, Donaldson C, Fitzhugh K, Lawrence P. Cellulose, modified cellulose and synthetic membranes in haemodialysis of patients with end-stage renal disease. Cochrane Database of Systematic Reviews 2005, (3), CD003234.
• Hartwell D, Colquitt J, Loveman E, Clegg AJ, Brodin H, Wagh N, Royle P, Davidson P, Vale L, MacKenzie L. Clinical effectiveness and cost-effectiveness ofimmediate angioplasty for acute myocardial infarction: systematic review and economic evaluation. Health Technology Assessment 2005, 9(17), 1-99.
• Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, Whitty P, Eccles MP, Matowe L, Shirran L, Wensing M, Dijkstra R, Donaldson C. Effectiveness and efficiency of guideline dissemination and implementation strategies. International Journal of Technology Assessment in Health Care 2005, 21(1), 149.
• Cody J, Daly C, Campbell MK, Donaldson C, Grant A, Khan IH, Pennington S, Vale L, Wallace S, MacLeod A. Frequency of administration of recombinant human erythropoietin for anaemia in end-stage renal disease in dialysis patients. Cochrane Database of Systematic Reviews 2005, (3), CD003895.
• Gonzalez-Perez JG, Vale L, Stearns SC, Wordsworth S. Hemodialysis for end-stage renal disease: a cost-effectiveness analysis of treatment-options. International Journal Technology Assessment in Health Care 2005, 21(1), 32-39.
• Pandian Z, Bhattacharaya S, Vale L, Templeton A. In vitro fertilisation for unexplained subfertility. Cochrane Database Systematic Reviews 2005, (2), CD003357.
• McCormack K, Wake B, Perez J, Fraser C, McIntosh E, Vale L, Grant A. Laparoscopic surgery for inguinal hernia repair: systematic review of effectiveness and economic evaluation. Health Technology Assessment 2005, 9(14), 1-203.
• Cuthbertson BH, Scott J, Strachan M, Kilonzo M, Vale L. Quality of life before and after inensive care. Anaesthesia 2005, 60(4), 332-339.
• McCormack K, Wake BL, Fraser C, Vale L, Perez J, Grant A. Transabdominal pre-peritneal (TAPP) versus totally extraperitoneal (TEP) laparoscopic techniques for inguinal hernia repair: a systematic review. Hernia 2005, 9(2), 109-114.
• Brazzelli M, Shirran E, Vale L. Absorbent products for containing urinary and/or faecal incontinence in adults (Cochrane Review). The Cochrane Database of Systematic Reviews 2004, (4).
• Kilonzo M, Vale L, Stearns SC, Grant A, Cody J, Glazener CM, Wallace S, McCormack K. Cost effectiveness oftension-free vaginal tape for th surgical management of female stress incontinence. International Journal Technology Assessment in Health Care 2004, 20(4), 455-463.
• Gilbert F, Grant A, Gillan MGC, Vale L, Scott N, Campbell MK, Wardlaw D, Knight D, McIntosh E, Porter R. Does early magnetic resonance imaging influence management or improve outcome in patients with low back pain? A pragmatic randomised controlled trial. Health Technology Assessment 2004, 8(17), iii, 1-131.
• Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay C, Vale L, Whitty P, Eccles M, Matowe L, Shirran E, Wensing M, Dijkstra R, Donaldson C. Effectiveness and efficiency of guidelin dissemination and implementation strategies. Health Technology Assessment 2004, 8(6), 94.
• Mowatt G, Vale L, Brazzelli M, Hernandez R, Murray A, Scott N, Fraser C, McKenzie L, Gemmell H, Hillis G, Metcalfe M. Systematic review of teh effectiveness and cost-effectiveness, and economic evaluation, of myocardial perfusion scintigraphy for the diagnosis of angina and myocardial infarction. Health Technology Assessment 2004, 8(30), 1-222.
• Mowatt G, Vale L, MacLeod A. Systematic review of the effectiveness of home versus hospital or satellite unit hemodialysis for people with end-stage renal failure. International Journal of Technology Assessment in Health Care 2004, 20(3), 258-268.
• Vale L, Steffens H, Donaldson C. The costs and benefits of community thrombolysis for acute myocardial infarction: A decision-analytic model. PharmacoEconomics 2004, 22(14), 943-954.
• Wyness L, Vale L, McCormack K, Grant A, Brazzelli M. The effectiveness of metal on metal hip resurfacing: a systematic review of theavailable evidence published before 2002. BMC Health Services Research 2004, 4(1), 39.
• Foy R, Ramsay CR, Grimshaw JM, Penney GC, Vale L, Thomson A, Greer IA. The impact of guidelines on mild hypertension in pregnancy: Time series analysis. BJOG: An International Journal of Obstetrics and Gynaecology 2004, 111(8), 765-770.
• Vale L, Grant A, Ludbrook A. Assessing the costs and consequences of laparoscopic versus open methods of hernia repair: a systematic review. Surgical Endoscopy 2003, 18(6), 844-849.
• Grimshaw J, Thomas R, Eccles M, MacLennan J, Fraser C, Ramsay C, Vale L. Guidelines can improve process and outcomes of healthcare. Journal of Royal College of Physicians Edinburgh 2003, 34, 72-78.
• McKenzie L, Vale L, Stearns SC, McCormack K. Metal on metal hip resurfacing arthroplasty: an economic analysis. European Journal of Health Economics 2003, 4(2), 122-129.
• Cody J, Wyness L, Wallace S, Glazener CMA, Kilonzo M, Stearns SC, McCormack K, Vale L, Grant A. Systematic review of the clinical effectiveness and cost-effectiveness of tension-free vaginal tape (TVT) for treatment of urinary stress incontinence. Health Technology Assessment 2003, 7(21).
• Mowatt G, Vale L, Gonzalez-Perez JG, Wyness L, Fraser C, MacLeod A, Daly C, Stearns SC. Systematic review of the effectiveness and cost-effectiveness, and economic evaluation, of home versus hospital or satellite unit haemodialysis for people with end-stage renal failure. Health Technology Assessment 2003, 7(2).
• Grimshaw JM, McAuley L, Bero LA, Grilli R, Oxman AD, Ramsay C, Vale L, Zwaranstein M. Sytematic reviews of the effectiveness of quality improvement strategies and programs. Quality and Safety in Health Care 2003, 12, 298-303.
• Pandian Z, Bhattacharya S, Nikolaou D, Vale L, Templeton A. The effectiveness of in vitro fertilisation in unexplained fertility: a systematic review. Human Reproduction 2003, 18(10), 2001-2007.
• Shirran E, Brazelli M, Vale L. Absorbent products for containing urinary and/or fecal incontinence in adults. Journal of Wound, Ostomy, and Continence Nursing 2002, 29(1), 45-54.
• Donaldson C, Mugford M, Vale L, ed. Evidence Based Health Economics: From Effectiveness to Efficiency in Systematic Review. London: Wiley-Blackwell, 2002.
• Jefferson T, Demicheli V, Vale L. Quality of systematic reviews of economic evaluations in health care. Journal of the American Medical Association 2002, 287(21), 2809-2812.
• Donaldson C, Mugford M, Vale L. Using systematic reviews in economic evaluation: the basic principles. In: Donaldson, C., Mugford, M., Vale, L, ed. Evidence Based Health Economics: From Effectiveness to Efficiency in Systematic Review. London: Wiley-Blackwell, 2002, pp.10-24.
• Kirby L, Vale L. Dialysis for end-stage renal disease: determining a cost-effective approach. International Journal of Technology Assessment in Health Care 2001, 17(2), 181-89.
• Daly C, Campbell MK, MacLeod A, Cody J, Vale L, Grant A, Wallace S, Donaldson C, Lawrence P, Khan IH. Do the Y-set and double-bag systems reduce the incidence of CAPD peritonitis?. Nephorology Dialysis Transplantation 2001, 16(2), 341-347.
• Miller P, Vale L. Programme approach to managing informed commissioning. Health Services Management Research 2001, 14, 159-164.
• Cody J, Daly C, Campbell MK, Donaldson C, Grant A, Khan IH, Pennington S, Vale L, Wallace S, MacLeod A. Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients. The Cochrane Database of Systematic Reviews 2001, (4).
• Campbell M, Daly C, Wallace S, Cody J, Donaldson C, Grant A, Khan I, Lawrence P, Vale L, MacLeod A. Evidence based medicine in nephrology: identifying and critically appraising the literature. Nephrology Dialysis and Transplantation 2000, 15(12), 1950-1955.
• Vale L, Donaldson C, Campbell MK, Cody J, Grant A, Khan IH, Lawrence P, Wallace S, MacLeod AM. Evidence Medicine and Health Economics: A case study of end stage renal disease. Health Economics 2000, 9(4), 337-351.
• Mugford M, Vale L, Donaldson C. The Cochrane Economic Methods Group. Oxford: The Cochrane Library, 2000.
• Penney G, Thomson M, Norman J, McKenzie H, Vale L, Smith R, Imrie M. A randomised comparison of strategies for reducing infective complications of abortions. British Journal of Obstetrics and Gynaecology 1998, 105(6), 599-604.
• MacLeod AM, Grant AM, Donaldson C, Khan IH, Campbell MK, Daly C, Lawrence P, Wallace S, Vale L, Cody J, Fitzhugh K, Montague G, Ritchie C. Effectiveness and efficiency of methods of dialysis therapy for end stage renal disease: a review. Health Technology Assessment 1998, 2(5).
• Scott A, Vale L. Increased general practice workload due to a primary care led National Health Service: the need for evidence to support rhetoric. British Journal of General Practice 1998, 48(428), 1085-1088.
• Vale L, Silcock J, Rawles J. An economic evaluation of thrombolysis in a remote rural community. British Medical Journal 1997, 314, 570-572.
• Rawles J, Vale L. Cost-effectiveness of prehospital thrombolysis in the Grampian region early anistreplase trial. Scottish Medical Journal 1997, 42, 93-93.
• Penney G, Vale L, Souter V, Templeton A. Endometrial assessment procedures: an audit of current practice in Scotland. Human Reproduction 1997, 12(9), 2041-2045.
• Bodner C, Vale L, Ratcliffe J, Farrar S. Using economics alongside medical audit. A case study of the management of endometriosis. Health Bulletin 1996, 54(3), 204-211.