Publication:

Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice (1992)

Author(s): J. M. Thomason;R. A. Seymour;M. D. Rawlins

  • : Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice

Abstract: This investigation examines the incidence of phenytoin-induced gingival overgrowth in a population of epileptic patients who attend General Medical Practices for treatment of their epilepsy and compares the gingival changes with an otherwise healthy group of patients. The plaque score, gingival index, and gingival overgrowth did not differ significantly between the two groups (P > 0.05). A significant correlation was observed between plaque score and gingival overgrowth in the phenytoin-treated patient, but in this group there was no correlation between gingival overgrowth and salivary concentration of the drug. The overall incidence of clinically significant overgrowth (13%) is considerably less than in other studies.

Notes: 0301-5661 (Print) Journal Article

  • Short Title: Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice
  • Date: Oct
  • Journal: Community Dent Oral Epidemiol
  • Volume: 20
  • Issue: 5
  • Pages: 288-91
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Adolescent Adult Aged Analysis of Variance Child Dental Plaque Index England/epidemiology Epilepsy/drug therapy Female Gingival Hyperplasia/*chemically induced/epidemiology Gingival Pocket/complications Humans Incidence Male Middle Aged Oral Hygiene Periodontal Index Phenytoin/*adverse effects/analysis Research Support, Non-U.S. Gov't Saliva/chemistry

Staff

Professor J Mark Thomason
Professor of Prosthodontics & Oral Rehabilitation