|Semester 1 Credit Value:||20|
• To consider the principle that nearly all human disease has a genetic component.
• To consider the principle that common disease do not fit into simple Mendelian patterns of inheritance but fall into the category of disease genetists term “complex disease”.
• To consider how the genetic (heritable) component of a complex disease (CD) can be assessed and how genes responsible for CD can be identified.
• To explain how knowledge of the genetics of CD is/and will be used in: diagnosis, patient management (determining prognosis and selection of optimal therapy) and in the development of new therapies.
• To consider the relationship between inherited variation in the genes that regulate the human immune response (especially the major histocompatibility complex) and disease risk.
• To consider the role of inherited variation in the genes and drug metabolism (pharmacogenetics).
• To explain how knowledge of disease genetics informs the debate about disease pathogenesis.
• To provide an understanding of the genetic basis of common human diseases with particular examples: Hirschprung’s Disease, Inflammatory Bowel Disease (Ulcerative Colitis and Crohn’s disease), Autoimmune Diseases: (including: Insulin Dependent Diabetes Mellitus; Rheumatoid Arthritis; Autoimmune liver disease & Systemic Lupus Erythematosus), Infectious Diseases: (including Hepatitis C virus, HIV-AIDS, TB, Leprosy & Malaria), Cancer: Breast Cancer.
• To consider the social and ethical issues that can arise from the genome project and from the use and misuse of genetics and genetic information.
This module aims to address one of the major areas of current medical research and to provide students with an understanding of the strengths and weakness of both the current subject knowledge in this area and the practical approaches to it. Understanding the genetics of common (complex) disease has been identified as a major post-genome challenge. The module aims to equip H level students with the necessary skills to understand and critically evaluate research strategies used to investigate the inheritance of complex diseases.
The module covers the following broad issues:
•Definition of complex diseases
•How to identify and assess the heritable component of a complex disease
•Selecting and applying different research strategies
•Linkage versus association analysis
•Immunogenetics and pharmacogenetics
•Knowledge of key examples of complex diseases.
•Social and Ethical issues arising from the study of complex diseases.
|Scheduled Learning And Teaching Activities||Lecture||20||1:00||20:00||N/A|
|Scheduled Learning And Teaching Activities||Small group teaching||2||1:00||2:00||Tutorial|
|Scheduled Learning And Teaching Activities||Small group teaching||2||1:00||2:00||Seminar|
|Guided Independent Study||Independent study||1||176:00||176:00||N/A|
This is an undergraduate module based on an area of research excellence within the University. The module is mostly based on lectures with open discussion of key concepts. The learning outcomes are predominantly knowledge based with key skills in critical evaluation and written communication of that knowledge being assessed. In addition there is assessment of data interpretation which will test the students understanding of key principles on which the taught material is based and basic numeracy. The seminars provide the students with an opportunity to have a broad based discussion of some of the major issues in medical science in the presence of their peers.
The format of resits will be determined by the Board of Examiners
|Written Examination||120||2||A||80||Unseen examination (2 essays from a choice of 4)|
|Written exercise||1||M||20||Critique of current primary literature.|
The examination provides evidence of knowledge and understanding of the topics. The critique of a scientific paper tests the analytical and research skills of the students.