BMS3012 : Cancer Biology and Therapy

  • Offered for Year: 2013/14
  • Module Leader(s): Prof. Steven Clifford
  • Owning School: Biomedical Sciences
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

i)       To inform students about the genetic and molecular basis of cancer.
ii)       To examine the mechanisms of action of oncogenes and tumour suppressor genes.
iii)       To understand the role of cell cycle disruption in cancer development.
iv)       To understand the processes of metastasis and angiogenesis.
v)       To understand the roles of cell signalling pathways in cancer.
vi)       To understand the roles that chromosomal instability, DNA damage and repair play in carcinogenesis.
vii)       To understand the basic mechanisms of apoptosis and their relevance to cancer.
viii)       To provide an introduction to current technologies used in cancer detection, diagnostics and molecular pathology.
ix)       To discuss how experimental models and imaging techniques are being applied to advance our understanding of cancer.
x)       To understand the basis of and problems associated with cancer treatments.
xi)       To provide students with an understanding of cancer stem cells.

In Summary:
Cancer is one of the major causes of mortality. This module provides a background to the molecular basis of cancer and its therapy. The various causes, cellular and genetic processes central to the development of cancer will be discussed, alongside how this understanding is being exploited for disease detection, diagnosis and therapy.

Outline Of Syllabus

- An introduction to the molecular basis of cancer
- Oncogenes
- Tumour suppressor genes (TSGs) I: Identification
- Tumour suppressor genes II: Mechanisms of action
- Metastases and Angiogenesis
- Cell signalling in cancer
- Viruses and Cancer
- Carcinogenesis and apoptosis
- DNA repair and cancer predisposition syndroms
- Genetic instability and cancer
- Cancer treatments and drug resistance
- Targeted therapies & drug development strategies
- Treatment-related late effects
- The Pathology of Cancer
- Molecular studies linking genomic arrays, diagnostics and pathology in cancer detection
- Systems biology, bioinformatic and next-generation approaches to understanding cancer biology
- Cancer stem cells
- Application of experimental models and imaging in cancer
- Leukaemia and its therapy
- Therapy for Prostate Cancer

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture241:0024:00N/A
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Tutorial
Guided Independent StudyIndependent study1175:00175:00N/A
Total200:00
Teaching Rationale And Relationship

Lectures will provide students with key information. Tutorials will encourage increased understanding of the material through discussion. Private study will allow students to extend their knowledge through reading of journal articles and other recommended references.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1202A80Unseen examination ( 2 essays from a choice of 4).
Exam Pairings
Module Code Module Title Semester Comment
BGM3024The Molecular Basis of Cancer2N/A
Other Assessment
Description Semester When Set Percentage Comment
Essay1M20Extended essay
Assessment Rationale And Relationship

The examination provides evidence of knowledge and understanding of the topics.
The open-book essay supports the students’ development of literature-based research, written communication and presentation skills, supplements the main areas of teaching delivered, and helps prepare them for the examination.

Reading Lists

Timetable

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