Patients with large artery occlusion (LAO) have the most severe strokes and poorest outcomes. Intravenous thrombolysis (IVT) increases the proportion of patients recanalising and achieving independence 3 months after stroke but recanalisation rates in proximal LAO are poor - 10%-33%. Recanalisation rates with IA thrombectomy (IAT) are much higher than IVT in LAO - typically now 80+%.
Current thrombectomy devices are limited in longer occlusions and where access is tortuous. A novel device (ERIC™) may enable IAT to be delivered more effectively in some patients (eg elderly with tortuous vessels).
In a randomised phase II trial we will assess safety and technical equivalence of the ERIC device compared with existing devices. We will determine clinical/imaging differences between those with LAO stroke successfully treated by thrombectomy compared with those who have successful thrombectomy without a good clinical outcome. This occurs frequently but is poorly understood.
STABILISE will explore utility of MRI post thrombectomy at detecting complications & as a predictor (biomarker) of longer term clinical outcome.
Newcastle University staff and students linked to the project: