Cerebral amyloid angiopathy in Lewy body disease (2008)

Author(s): Jellinger KA, Attems J

    Abstract: While Alzheimer and Lewy body pathologies are discussed as major substrates of dementia in Parkinson's disease (PD/Lewy body disease of brainstem type), the incidence and impact of cerebral amyloid angiopathy (CAA) and its association with cognitive decline in PD and dementia with Lewy bodies (DLB) are unknown. The severity of CAA and other Alzheimer lesions were assessed in 68 cases of autopsy-confirmed PD, 32 of them with dementia (PDD), and in 20 cases of DLB. PDD patients were significantly older than those without dementia (mean age 84.5 vs 77.6 years; p

    Notes: Jellinger, K A Attems, J Research Support, Non-U.S. Gov't Austria Journal of neural transmission (Vienna, Austria : 1996) J Neural Transm. 2008;115(3):473-82. Epub 2008 Feb 26.

      • Date: 26-02-2008
      • Journal: Journal of Neural Transmission
      • Volume: 115
      • Issue: 3
      • Pages: 473-482
      • Publisher: Springer Wien
      • Publication type: Article
      • Bibliographic status: Published

      Keywords: Aged Aged, 80 and over Amyloid beta-Protein Brain/*pathology Cerebral Amyloid Angiopathy/*complications/epidemiology/*pathology Cognition Disorders/complications Female Humans Lewy Body Disease/*complications/*pathology Male Middle Aged Prevalence Senile Plaques/pathology


      Professor Johannes Attems
      Professor of Neuropathology, Honorary Consultant Pathologist