Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications (2005)

Author(s): Berger W, Setinek U, Hollaus P, Zidek T, Steiner E, Elbling L, Cantonati H, Attems J, Gsur A, Micksche M

    Abstract: PURPOSE: The aim of this retrospective study was to comparatively investigate the expression of the three drug-resistance genes P-glycoprotein (P-gp), multidrug-resistance protein 1 (MRP1), and lung resistance protein (LRP), in non-small cell lung cancer (NSCLC) tissues, and to assess possible associations with clinicopathologic features. METHODS: Tumor specimens from 126 patients were analyzed by immunohistochemistry and, in selected cases, by reverse transcriptase polymerase chain reaction (RT-PCR), and data were statistically analyzed by SPSS. RESULTS: The mean expression levels of tumor tissues in the case of P-gp and LRP did not exceed the one of normal epithelia, while MRP1 was significantly enhanced in NSCLC. A weak association was observed between higher grading and P-glycoprotein expression (p

    Notes: Berger, Walter Setinek, Ulrike Hollaus, Peter Zidek, Thomas Steiner, Elisabeth Elbling, L Cantonati, H Attems, Johannes Gsur, Andrea Micksche, Michael Comparative Study Research Support, Non-U.S. Gov't Germany Journal of cancer research and clinical oncology J Cancer Res Clin Oncol. 2005 Jun;131(6):355-63. Epub 2005 Jan 27.

      • Date: 01-06-2005
      • Journal: Journal of Cancer Research and Clinical Oncology
      • Volume: 131
      • Issue: 6
      • Pages: 355-363
      • Publisher: Springer
      • Publication type: Article
      • Bibliographic status: Published

      Keywords: Adenocarcinoma, Bronchiolo-Alveolar/metabolism/pathology Antineoplastic Combined Chemotherapy Protocols Bronchi/metabolism/pathology Carcinoma, Non-Small-Cell Lung/*metabolism/pathology *Drug Resistance, Multiple Epithelial Cells/metabolism/pathology Female Humans Immunoenzyme Techniques Lung Neoplasms/*metabolism/pathology Male Middle Aged Neoplasm Proteins/*metabolism Neoplasm Staging P-Glycoprotein/genetics/*metabolism P-Glycoproteins/*metabolism Prognosis Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Survival Rate Tumor Cells, Cultured Tumor Markers, Biological/*metabolism Vault Ribonucleoprotein Particles/*metabolism


      Professor Johannes Attems
      Professor of Neuropathology, Honorary Consultant Pathologist