Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia (2012)

Author(s): Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT

    Abstract: The objective of this study was to determine the neuropathological correlates of regional medial temporal lobe volume measures on magnetic resonance imaging (MRI) in subjects with Lewy body dementia (LBD). Twenty-three autopsy-confirmed LBD cases with an MRI scan close to death (mean 1.5 years) were studied. MRI-based volumetric measures were calculated for total intracranial volume, hippocampus, entorhinal cortex, and amygdala. Quantitative neuropathological analysis of plaques, tangles, and Lewy bodies were carried out in the same regions. Spearman's rho was used to examine correlations between MRI volumes and neuropathology measures and linear regression to assess the relationship between neuropathology and MRI volumes. A significant inverse correlation was observed between normalized amygdala volume and percent area of Lewy bodies in the amygdala (r = −0.461, p = 0.035). There were no other significant correlations between regional MRI volume and measures of neuropathology. Lewy body, but not Alzheimer's disease (AD) pathology was associated with reduced amygdala volume in pathologically-verified LBD cases but neither Lewy body nor Alzheimer's disease pathology was associated with volume loss in the hippocampus or entorhinal cortex, suggesting other neuropathological factors account for atrophy in these structures in LBD.

      • Date: 24-02-2011
      • Journal: Neurobiology of Aging
      • Volume: 33
      • Issue: 7
      • Pages: 1228-1236
      • Publisher: Elsevier Inc.
      • Publication type: Article
      • Bibliographic status: Published

      Keywords: Lewy body dementia; Amygdala; MRI; Neuropathology


      Dr Robert Barber
      Honorary Clinical Senior Lecturer

      Dr Evelyn Jaros
      Honorary Senior Research Associate; Clinical Scientist in Neuropathology

      Dr Elizabeta Mukaetova-Ladinska
      Clinical Senior Lecturer/Consultant

      Professor John O'Brien
      Strategic Research Advisor