#
Publication:

Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies (2004)

Author(s): McKeith IG, Wesnes KA, Perry E, Ferrara R

  • : Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies

Abstract: The aim of this analysis of the effects of cholinergic therapy in dementia with Lewy bodies was to determine whether rivastigmine-induced benefits in attention and memory could be predicted by the presence of visual hallucinations. At study entry, 74% of patients were hallucinators and 26% were non-hallucinators. The population was analyzed for two-factor scores: power of attention (PoA) and quality of memory (QoM). A significant effect over placebo on PoA was observed in hallucinators at weeks 12 (p = 0.023) and 20 (p = 0.0019), while no treatment effects were seen in non-hallucinators. Significant treatment effects on QoM were not observed in either subgroup. Visual hallucinations predicted greater improvements in PoA, but not QoM. This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement.

  • Short Title: Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies
  • Date: 2004
  • Journal: Dementia and Geriatric Cognitive Disorders
  • Volume: 18
  • Issue: 1
  • Pages: 94-100
  • Publisher: S. Karger AG
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Aged Attention/*drug effects Carbamates/*therapeutic use Disease Progression Double-Blind Method Female Hallucinations/*psychology Humans Lewy Body Disease/*drug therapy/*psychology Male Neuroprotective Agents/*therapeutic use Neuropsychological Tests Nootropic Agents/*therapeutic use *Phenylcarbamates Prospective Studies Reaction Time/drug effects Research Support, Non-U.S. Gov't Risk Factors

Staff

Professor Ian McKeith
Senior Research Investigator