#
Publication:

The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis (1994)

Author(s): Preiss T, Chrzanowska-Lightowlers ZM, Lightowlers RN

  • : The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis

Abstract: Cytochrome c oxidase L-form transcript-binding protein (COLBP) activity parallels the tissue-specific mRNA expression of bovine cytochrome c oxidase liver isopeptides. A similar RNA-binding activity is found in human myoblast and liver Hep G2 cell homogenates. Human COLBP activity, however, is not present in myotubes or adult skeletal muscle. It is proposed that COLBP down-regulation during muscle cell differentiation may underlie oxidase isoform switching during myogenesis.

  • Short Title: The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis
  • Date: 28-04-1994
  • Journal: Biochimica et Biophysica Acta
  • Volume: 1221
  • Issue: 3
  • Pages: 286-289
  • Publisher: Elsevier
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Animals Cattle Cell Differentiation Down-Regulation Electron Transport Complex IV/*genetics *Gene Expression Regulation, Enzymologic Glutamate Dehydrogenase/*biosynthesis Humans Liver/enzymology Muscles/*enzymology Myocardium/enzymology RNA-Binding Proteins/*biosynthesis Research Support, Non-U.S. Gov't

Staff

Professor Zofia Chrzanowska-Lightowlers
Professor of Mitochondrial Biology

Professor Robert Lightowlers
Director, ICaMB and Professor of Molecular Neuroscience