Newcastle University

Ophthalmology

Our work arises out of a clinical context and has the aim of directly improving the health services offered to individuals with visual conditions and visual impairment.

There are 4 main themes to our work which are detailed in the accompanying webpages:

• Vision and Cognition
  Investigates the impact of cognitive impairment and dementia on visual symptoms and visual impairment
• Children’s Vision
  Aims to improve the delivery of treatment to children with amblyopia and strabismus (squint).
• Mitochondria and the Eye
  Aims to develop new treatments for eye disorders due to mitochondrial disease.
• Limbal stem cell deficiency and its management
  Aims to develop new treatments for eyes with limbal cell deficiency

Staff:

Selected Publications:

Vision and Cognition:

• Mosimann UP, Collerton D, Dudley R, Meyer TD, Graham G, Dean JL, Bearn D, Killen A, Dickinson L, Clarke MP,
  McKeith IG. A semi-structured interview to assess visual hallucinations in older people. Int J Geriatr
  Psychiatry. 2008; 23(7):712-8
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. The retina in Parkinson’s disease. Brain 2009;
  132(Pt5):1128-45. Epub 2009 Mar 31
• Jefferis JM, Mosimann UP, Clarke MP. Cataract and cognitive impairment: A review of the literature. British
  Journal of Ophthalmology. 2011; 95(1):17-23. Epub 2010 Aug 31
• Graham G, Dean J, Mosimann UP, Colbourn C, Dudley R, Clarke M, Collerton D. Specific attentional
  impairments and complex visual hallucinations in eye disease. Int J Geriat Psychiatry. 2011; 26(3):263-7
  Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Retinal thickness in Parkinson’s disease. Parkinsonism Relat
  Disord. Epub (ahead of print) 2011 Mar 29
• Jefferis JM, Mosimann UP, Taylor JP, Clarke MP. “Do your eyes play tricks on you?” Asking older people about visual hallucinations in a general eye clinic. Int Psychogeriatr. Epub (ahead of print) 2011 May 6:1-2

Children's Vision:

• The Newcastle Control Score: a new method of grading the severity of intermittent exotropia. Haggerty H, Richardson S, Hrisos S, Strong NP, Clarke MPBritish Journal of Ophthalmology 2004 88(2):233-5
  Surgery for Intermittent Exotropia Richardson SR, Clarke MP. International Review of Modern Surgery. 2004 36 – 37
• Frisby Davis distance stereoacuity values in normal children. Adams WE, Hrisos S, Richardson S, Davis H, Frisby JP, Clarke MP. Br. J. Ophthalmol. 2005 89(11): 1438-1441.
• Distance Stereoacuity in Intermittent Exotro
  pia. Hatt SR, Haggerty H, Buck D, Adams W, Strong NP, Clarke MP
  Br. J. Ophthalmol. 2007; 91(2): p. 219-221
  The use of the Newcastle Control Score in the management of Intermittent Exotropia. Buck D, Hatt SR, Haggerty H, Hrisos S, Strong NP, Steen NI, Clarke MP. Br. J. Ophthalmol. 2007; 91(2): p. 215-218
• Intermittent Exotropia. Clarke, MP. J Pediatr Ophthalmol Strabismus 2007 44(3) 153-157
• Intermittent Exotropia. Clarke MP, Strong N, Buck D, Powell C, Tiffin P, Davis H, Dawson E, Sloper J, Rahi J
  Ophthalmology 2007; 114(7):1416; author reply 1416 (letter).
• Intermittent and Basic Exotropia In Current Ocular Therapy 6th edition Chapter 218 p 405-407 Eds F Hampton Roy, Frederick W Fraunfelder. Elsevier Inc 2008
• Grading the severity of intermittent distance exotropia: the Revised Newcastle Control Score. Buck D, Clarke MP, Haggerty H, Hrisos S, Powell C, Sloper J, Strong NP. Br J Ophthalmol 2008;92 577
• Presenting Features and Early Management of Childhood Intermittent Exotropia in the UK: Inception Cohort Study. Deborah Buck, Christine Powell, Phillipa Cumberland, Robert Taylor, John Sloper, Peter Tiffin, Helen Davis, Jugnoo Rahi, and Michael P Clarke. Br J Ophthalmol 2009;93:1620-1624
• Visual Suppression in Intermittent Exotropia during Binocular Alignment. Ignacio Serrano-Pedraza, Vina Manjunath, Olaoluwakitan Osunkunle, Michael P. Clarke, and Jenny C. A. Read. Invest. Ophthalmol. Vis. Sci. 2011; 52(5): p. 2352-2364
• Single vision during ocular deviation in intermittent exotropia. Ignacio Serrano-Pedraza, Michael P Clarke, Jenny CA Read. Ophthalmic and Physiological Optics Volume 31, Issue 1, pages 45–55, January 2011
• Use of the PedsQL in childhood intermittent exotropia: estimates of feasibility, internal consistency reliability and parent–child agreement. Deborah Buck, Michael P. Clarke, Christine Powell, Peter Tiffin and Robert F. Drewett. Quality of Life Research DOI: 10.1007/s11136-011-9975-7Online First™
• Vitreoretinal traction is a major factor in causing the haemorrhagic retinopathy of abusive head injury? – No
  Clarke MP. Eye. 2009 Sep;23(9):1761-3.
• Pre School Vision Screening: A Prospective Comparative Evaluation. Bray LC, Clarke MP, Jarvis SM, Francis PM, Colver A. Eye 1996 10: 714-718

Mitochondria and the Eye:

• Klopstock K, Yu Wai Man P, Dimitriadis K, Rouleau J, Heck S, Atawan A, Chattopadhyay S, Bailie M, Schubert M, Rummey C, Metz G, Leinonen M, Griffiths PG, Meier T, Chinnery PF. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain. 2011; epub ahead of print.
• Yu Wai Man P, Griffiths PG, Chinnery PF. Inherited optic neuropathies – Disease mechanisms and therapeutic strategies. Progress in Retinal and Eye Research. 2011;30(2):81-114.
• Yu Wai Man P, Shankar SP, Biousse V, Miller NR, Bean LJH, Coffee B, Hegde M, Newman NJ. Genetic screening for OPA1 and OPA3 mutations in patients with suspected inherited optic neuropathies. Ophthalmology. 2011;118(3):558-63.
• Yu Wai Man P, Sitarz KS, Samuels DC, Griffiths PG, Reeve AK, Bindoff LA, Horvath R, Chinnery PF. OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules. Human Molecular Genetics. 2010;19(15):3043-52.
• Yu Wai Man P, Griffiths PG, Gorman GS, Lourenco CM, Wright AF, Auer-Grumbach M, Toscano A, Musumeci O, Valentino ML, Caporali L, Lamperti C, Tallaksen CM, Duffey P, Miller J, Whittaker RG, Baker MR, Jackson MJ, Clarke MP, Dhillon B, Czermin B, Stewart JD, Hudson G, Reynier P, Bonneau D, Marques W Jr, Lenaers G, McFarland R, Taylor RW, Turnbull DM, Votruba M, Zeviani M, Carelli V, Bindoff LA, Horvath R, Amati-Bonneau P, Chinnery PF. Multi-system neurological disease is common in patients with OPA1 mutations. Brain. 2010;133(3):771-86.
• Yu Wai Man P, Lai-Cheong JE, Borthwick GM, He L, Taylor GA, Greaves LC, Taylor RW, Griffiths PG, Turnbull DM. Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles. Investigative Ophthalmology and Visual Science. 2010;51(7):3347-53.

Limbal stem cell deficiency and its management:

• Baylis O, Figueiredo F, Henein C, Lako M, Ahmad S. "13 Years of Cultured Limbal Epithelial Cell Therapy: A Review of the Outcomes". Journal of Cellular Biochemistry. 2011;9999:1-11.
• Ahmad S, Kolli S, Lako M, Figueiredo F, Daniels J. "Stem cell therapies for ocular surface disease" has been accepted for publication in Drug Discov Today. 2010 Apr; 15(7-8): 306-13. Epub 2010 Feb 10.
• Kolli S, Ahmad S, Lako M, Figueiredo F. Successful Clinical Implementation of Corneal Epithelial Stem Cell Therapy for Treatment of Unilateral Limbal Stem Cell Deficiency. Stem Cells. 2010 Mar 31; 28(3): 597-610.
• Ahmad S, Kolli S, Li D, Paiva C, Pryzborski S, Dimmick I, Armstrong L, Figueiredo F, Lako M. A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. Regenerative Medicine 2008; 26(6): 1609-19.
• Kolli S, Lako M, Figueiredo F, Ahmad S. Loss of corneal epithelial stem cell properties in outgrowths from human limbal explants cultured on intact amniotic membrane. Regenerative Medicine 2008; 3(3): 329-42.
• Ahmad S, Stewart R, Yung S, Kolli S, Armstrong L, Stojkovic M, Figueiredp F, Lako M. Differentiation Of Human Embryonic Stem Cells Into Corneal Epithelial Like Cells By In Vitro Replication Of The Corneal Epithelial Stem Cell Niche. Stem Cells, 2007; 25 (5): 1145-1155 and front cover Stem Cells 25 (5).
• Ahmad S, Figueiredo F, Lako M. Corneal epithelial stem cells: characterization, culture and transplantation. Regenerative Med. 2006, 1: 1-15.