Institute of Neuroscience

Staff Profile

Dr Amy Vincent

Research Associate

Background

I previously completed my MSci in Biochemistry and Genetics at The University of Nottingham (2013).

Following this I moved to Newcastle University where I completed my PhD in the Wellcome Centre for Mitochondrial Research under Professors Doug Turnbull and Robert Taylor and Dr Rita Barresi.

I am now a research assistant in the Wellcome Trust Centre for Mitochondrial Research group where I am extending the investigation from my PhD.




Research

Mitochondrial DNA mutations and mitochondrial respiratory chain deficiency arise in a mosaic pattern within the skeletal muscle of patients with mitochondrial myopathy. However, they are also found in a number of other myopathies and in aging skeletal muscle.
My work looks to investigate mitochondria dysfunction and associated pathogenic mechanisms in both mitochondrial and other myopathies. This is being approached from three angles:
1) Characterising mitochondrial dysfunction in myofibrillar myopathy, dysferlinopathy and centronucelar myopathy and looking for potential links to disease pathology.
2) Attempting to understand mechanisms and factors effecting clonal expansion of mitochondrial DNA mutations.
3) Looking to make links between mitochondrial morphology, ultrastructure and function.

Teaching

I am regularly involved with supervision and teaching of project students within the lab.

Publications