Institute of Neuroscience

Staff Profile

Dr Antoneta Granic

Interdisciplinary AGE Research Fellow

Background

Introduction

I joined the Newcastle University as a Post-Doctoral Research Associate in October 2012. With the funding from the Newcastle Biomedical Research Centre, I am investigating the role of blood-based biomarkers, diet, dietary patterns in physical and cognitive decline (sarcopenia and dementia) in older adults.

Qualifications

  • PhD (Aging Studies/Gerontology), University of South Florida, Tampa, USA; December 2011
  • MA (Gerontology), University of South Florida, Tampa, USA; August 2008

Roles and Responsibilities

  • Research fellow for the Ageing, Geriatrics & Epidemiology (AGE) Research Group (PI: Professor Avan A Sayer) 
  • Researcher, Prevention Of  Malnutrition In Senior Subjects (PROMISS) in the EU (Horizon 2020, Project Leader: Professor Marjolein Visser, VA University Amsterdam); WP1: 'Dietary characteristics, daily food intake patterns and clinical outcomes' (WP1 lead: Professor Carol Jagger).  

Honours and Awards 

  • University of South Florida H. Edward and Mildred E. Greely Endowed Fellowship in Aging Studies; 2010 and 2011
  • USF Health Postdoctoral Research Day best poster award; 2012
  • Croatian Congress of Neuroscience best poster award; 2013  
  • United Kingdom Molecular Epidemiology Group travel award; 2013 
  • IHS Applied Epidemiology Research Day best poster award; 2015
  • Norman Exton-Smith Prize for best scientific poster presentation, British Geriatric Society Autumn Meeting, 2016

 

 

               

 

 

Research

My research interest is in the field of physical and cognitive ageing approached from an interdisciplinary perspective, and includes the development of a broad understanding of bio-modulators and risk factors of physical and cognitive impairment (sarcopenia and dementia), and the key biological pathways that lead to decline in muscle function and neurodegeneration, respectively. Utilising prospective data from the Newcastle 85+ Study, I am currently investigating the role of biomarkers and diet in physical and cognitive decline and survival in very old adults.

Research interests

  • Determinants of muscle strength decline (grip strength), sarcopenia and frailty in very old adults
  • The role of diet, dietary patterns and malnutrition in physical and cognitive functioning and decline in older adults  
  • Blood-based biomarkers and the risk of physical and cognitive decline in older adults
  • Novel biomarkers of sarcopenia
  • Genomic instability and chromosome mis-segregation in neurodegenerative and age-related diseases

Projects

  • MIlk Intervention Muscle AgeiNg (MIlkMAN): pilot study (February 2018-May 2019). PI: Antoneta Granic, Co-PI: Karen Davies, Emma Stevenson, Terry Asprey, and Avan A Sayer. Founder: NIHR Newcastle BRC.  
  • AGE Research Group (PI: Professor Avan A Sayer): Predictors of muscle strength and physical performance decline in older adults (April 2015-Present)
  • Horizon 2020: Prevention Of Malnutrition In Senior Subjects (PROMISS) in the EU. Project Leader(s): Principal: Professor Marjolein Visser, Collaborator (Epidemiology Team): Professor Carol Jagger (April 2016-Present)
  • Confidence in Concept Project: Muscle and Ageing Science Study (MASS), Evaluation of novel biomarkers of mitochondrial function and dystrophin expression in sarcopenia through integration of expertise in muscle disease, imaging and population-based studies of the very old. Project Leader(s): Principal Investigator: Professor Avan A Sayer,  Co-PI: Dr Karen Davies (January 2016-Present)
  • Diet as a Driver of Longevity and Healthy Cognitive Ageing: Lessons from the Newcastle 85+ Study
    Project Leader(s): Principal: Professor C Jagger, Collaborator: Professor JC Mathers (October 2012-October 2014)

Teaching

Undergraduate

  • Sociocultural Aspects of Aging (GEY 3625), University of South Florida; 2010
  • Biology of Ageing 2014 (BMS2014): Epidemiology of Ageing & Healthy Ageing, School of Biomedical Sciences, Faculty of Medicine, Newcastle University; Biomedical Sciences BSc; 2015; 2017; 2018.
  • MBBS Life Cycle 3 (PDS4.7): Epidemiology of Ageing, School of Medical Education, Newcastle University;  2017; 2018.
  • NUT3006, School of Biomedical Sciences, Food and Human Nutrition BSc, Newcastle University; Co-supervising students’ research projects: Association between the Mediterranean dietary pattern, diabetes mellitus and cardiovascular health in the very old: the Newcastle 85+ Study; Lead: Tom R. Hill; October 2017-May 2018.  

Graduate

  • Instructing molecular and cell biology techniques in the Alzheimer's disease research laboratory, University of South Florida; 2006-2012 

  • NIHR/ESRC Doctoral Training Programme: Analysis of Large Datasets and Advanced Statistics in Health Research, Institute of Health and Society, Newcastle University; 2015.

  • Introduction to quantitative research methods (HSC8053): Cohort studies in epidemiology. Graduate course. Faculty of Medical Sciences, FMS Graduate School, Newcastle University; 2016.
  • MSc in Health Policy Programme (Module 3): Ageing and Health, Imperial College, London. Masters in Science. Guest speaker; 2015.
  • Newcastle BRC PhD studentship (2017-2020). Co-supervisor; PhD thesis: ‘Cellular senescence in muscle ageing’; Ageing Biology Centre (Lead: Joao Passos).
  • CIMA PhD studentship;  The MRC – Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (2018-2021): Co-supervisor; PhD thesis: ‘Whole food approaches to enhance exercise recovery, muscle strength and functional performance in older adults’; Institute for Cellular medicine, Faculty of Medical Sciences, Newcastle University (Lead: Emma Stevenson).
  • NIHR Newcastle BRC training network; Supporting role for BRC PhD students (2017-2020): training opportunities and development within the Newcastle BRC.


 



  


Publications