PhD and postdoc supervisor
Laurea in Biological Sciences, Univ of Milan, Italy, Dr
Postgrad AIRC Fellow: Cell biology & Physiology, Univ. of Milan, Italy
1) Investigation of the functional, cellular and molecular mechanisms of synaptic and network activity relevant to glutamate and glycine receptor protein and mRNA localisation in neurons.
2) Characterisation of the physiology and neurochemistry of synchronised neuronal networks in various areas of the central nervous system (e.g. inferior colliculus, hippocampus, cortex and cerebellum). In particular, we aim to identify the key properties of neuronal networks in these areas in order to understand their functional roles in normal and pathological states, with reference to schizophrenia and epilepsy;
3) Neuroanatomical and functional characterisation of gap junctions between neurons within networks. Electrical synapses: their spatial location and regulation with respect to synaptic and neuronal network activity.
The lab research focuses on a multidisciplinary approach: immunocytochemical techniques at the light and electron microscopy levels are combined to electrophysiological experiments.
1) Biology and physiology of neurotransmitter receptors, in particular GluRs and GlyRs:
- role of neurotransmitter receptors in synaptic transmission
- targeting of neurotransmitter receptor subunit mRNAs and local protein synthesis in the neuronal dendritic tree
2) Functional and molecular mechanisms responsible for synaptic and neuronal network remodelling,
3) Electrical synapses: their spatial location and regulation with respect to synaptic and neuronal network activity.
John Grady (PhD 2010-13)
Dorcas Eden (PhD 2009)
Olivia Skrobot (PhD 2008)
Anita Roopun (PhD 2006)
Steven Middleton (PhD 2005)
David Cox (PhD, University College London)